LOCUS       NM_009258                422 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus serine peptidase inhibitor, Kazal type 1 (Spink1),
            mRNA.
ACCESSION   NM_009258
VERSION     NM_009258.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 422)
  AUTHORS   Liu,M., Ma,L., An,W., Yang,Y., Liu,J., Jiang,H., Yuan,J., Sun,X.,
            Zhu,J., Yan,M., Wang,L., Li,Z., Liao,Z. and Sun,C.
  TITLE     Heterozygous Spink1 c.194+2T>C mutation promotes chronic
            pancreatitis after acute attack in mice
  JOURNAL   Pancreatology 24 (5), 677-689 (2024)
   PUBMED   38763786
  REMARK    GeneRIF: Heterozygous Spink1 c.194+2T>C mutation promotes chronic
            pancreatitis after acute attack in mice.
REFERENCE   2  (bases 1 to 422)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 422)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 422)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   5  (bases 1 to 422)
  AUTHORS   Ramachandran,S.S., Balu,R., Vilwanathan,R., Jeyaraman,J. and
            Paramasivam,S.G.
  TITLE     A mouse testis serine protease, TESP1, as the potential SPINK3
            receptor protein on mouse sperm acrosome
  JOURNAL   Mol Hum Reprod 27 (10) (2021)
   PUBMED   34524424
  REMARK    GeneRIF: A mouse testis serine protease, TESP1, as the potential
            SPINK3 receptor protein on mouse sperm acrosome.
REFERENCE   6  (bases 1 to 422)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   7  (bases 1 to 422)
  AUTHORS   Lai,M.L., Chen,S.W. and Chen,Y.H.
  TITLE     Purification and characterization of a trypsin inhibitor from mouse
            seminal vesicle secretion
  JOURNAL   Arch Biochem Biophys 290 (2), 265-271 (1991)
   PUBMED   1929395
REFERENCE   8  (bases 1 to 422)
  AUTHORS   Needham,M., Mills,J.S. and Parker,M.G.
  TITLE     Organization and upstream DNA sequence of the mouse protease
            inhibitor gene
  JOURNAL   Nucleic Acids Res 16 (13), 6229 (1988)
   PUBMED   3399394
REFERENCE   9  (bases 1 to 422)
  AUTHORS   Mills,J.S., Needham,M. and Parker,M.G.
  TITLE     A secretory protease inhibitor requires androgens for its
            expression in male sex accessory tissues but is expressed
            constitutively in pancreas
  JOURNAL   EMBO J 6 (12), 3711-3717 (1987)
   PUBMED   3428272
REFERENCE   10 (bases 1 to 422)
  AUTHORS   Small,J.A., Khoury,G., Jay,G., Howley,P.M. and Scangos,G.A.
  TITLE     Early regions of JC virus and BK virus induce distinct and
            tissue-specific tumors in transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 83 (21), 8288-8292 (1986)
   PUBMED   2430282
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA481615.1 and AV048854.1.
            
            On Oct 6, 2007 this sequence version replaced NM_009258.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV048854.1, DV072077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               CA481615.1         38-443
            407-422             AV048854.1         297-312
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 23.47 cM"
     gene            1..422
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /note="serine peptidase inhibitor, Kazal type 1"
                     /db_xref="GeneID:20730"
                     /db_xref="MGI:MGI:106202"
     exon            1..143
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..331
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /note="serine protease inhibitor Kazal-type 3; prostatic
                     secretory glycoprotein; serine peptidase inhibitor, Kazal
                     type 3; serine protease inhibitor Kazal-type 1"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 1
                     precursor"
                     /protein_id="NP_033284.1"
                     /db_xref="CCDS:CCDS37803.1"
                     /db_xref="GeneID:20730"
                     /db_xref="MGI:MGI:106202"
                     /translation="MKVAVIFLLSALALLSLAGNTFSAKVTGKEASCHDAVAGCPRIY
                     DPVCGTDGITYANECVLCFENRKRIEPVLIRKGGPC"
     exon            144..178
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..285
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /inference="alignment:Splign:2.1.0"
     exon            286..422
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      390..395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /note="hexamer: AATAAA"
     polyA_site      409
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /note="major polyA site"
ORIGIN      
        1 ttaccatctg cctatatgac cactcctcag tttctgaaga gaagcaccct gtatagttct
       61 tctggctttt gcacccagat cttcgacaat gaaggtggct gtcatctttc ttctcagtgc
      121 tttggccctg ctgagtttag caggtaacac tttttcagct aaggtgactg gaaaagaggc
      181 tagttgccat gatgcagtgg cgggatgtcc cagaatttat gatcctgtgt gtgggactga
      241 cggaattact tatgccaatg aatgtgttct gtgctttgaa aacaggaaac gcatagagcc
      301 tgtcctcatt cgaaaaggtg ggccttgctg aaagtcaaga ttttgaactc tgttatggct
      361 accgtaatgt ttggcaagtg ggttcgttga ataaatgcat ctgaacatac cttgttcttc
      421 cc
//
