LOCUS       NP_033284                 80 aa            linear   ROD 03-JUN-2025
DEFINITION  serine protease inhibitor Kazal-type 1 precursor [Mus musculus].
ACCESSION   NP_033284
VERSION     NP_033284.1
DBSOURCE    REFSEQ: accession NM_009258.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 80)
  AUTHORS   Liu,M., Ma,L., An,W., Yang,Y., Liu,J., Jiang,H., Yuan,J., Sun,X.,
            Zhu,J., Yan,M., Wang,L., Li,Z., Liao,Z. and Sun,C.
  TITLE     Heterozygous Spink1 c.194+2T>C mutation promotes chronic
            pancreatitis after acute attack in mice
  JOURNAL   Pancreatology 24 (5), 677-689 (2024)
   PUBMED   38763786
  REMARK    GeneRIF: Heterozygous Spink1 c.194+2T>C mutation promotes chronic
            pancreatitis after acute attack in mice.
REFERENCE   2  (residues 1 to 80)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 80)
  AUTHORS   Chen,W., Imasaka,M., Lee,M., Fukui,H., Nishiura,H. and Ohmuraya,M.
  TITLE     Reg family proteins contribute to inflammation and pancreatic
            stellate cells activation in chronic pancreatitis
  JOURNAL   Sci Rep 13 (1), 12201 (2023)
   PUBMED   37500741
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 80)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 80)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   6  (residues 1 to 80)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   7  (residues 1 to 80)
  AUTHORS   Lai,M.L., Chen,S.W. and Chen,Y.H.
  TITLE     Purification and characterization of a trypsin inhibitor from mouse
            seminal vesicle secretion
  JOURNAL   Arch Biochem Biophys 290 (2), 265-271 (1991)
   PUBMED   1929395
REFERENCE   8  (residues 1 to 80)
  AUTHORS   Needham,M., Mills,J.S. and Parker,M.G.
  TITLE     Organization and upstream DNA sequence of the mouse protease
            inhibitor gene
  JOURNAL   Nucleic Acids Res 16 (13), 6229 (1988)
   PUBMED   3399394
REFERENCE   9  (residues 1 to 80)
  AUTHORS   Mills,J.S., Needham,M. and Parker,M.G.
  TITLE     A secretory protease inhibitor requires androgens for its
            expression in male sex accessory tissues but is expressed
            constitutively in pancreas
  JOURNAL   EMBO J 6 (12), 3711-3717 (1987)
   PUBMED   3428272
REFERENCE   10 (residues 1 to 80)
  AUTHORS   Small,J.A., Khoury,G., Jay,G., Howley,P.M. and Scangos,G.A.
  TITLE     Early regions of JC virus and BK virus induce distinct and
            tissue-specific tumors in transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 83 (21), 8288-8292 (1986)
   PUBMED   2430282
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA481615.1 and AV048854.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV048854.1, DV072077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..80
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 23.47 cM"
     Protein         1..80
                     /product="serine protease inhibitor Kazal-type 1
                     precursor"
                     /note="serine protease inhibitor Kazal-type 3; prostatic
                     secretory glycoprotein; serine peptidase inhibitor, Kazal
                     type 3; serine protease inhibitor Kazal-type 1"
                     /calculated_mol_wt=6126
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2380
     mat_peptide     24..80
                     /product="Serine protease inhibitor Kazal-type 1.
                     /id=PRO_0000016568"
                     /note="propagated from UniProtKB/Swiss-Prot (P09036.1)"
                     /calculated_mol_wt=6126
     Region          39..80
                     /region_name="KAZAL_PSTI"
                     /note="Kazal-type pancreatic secretory trypsin inhibitors
                     (PSTI) and related proteins, including the second domain
                     of the ovomucoid turkey inhibitor and the C-terminal
                     domain of the esophagus cancer-related gene-2 protein
                     (ECRG-2), are members of the...; cd01327"
                     /db_xref="CDD:238648"
     Site            42..43
                     /site_type="other"
                     /note="Reactive bond for trypsin.
                     /evidence=ECO:0000269|PubMed:14645103,
                     ECO:0000269|PubMed:1929395; propagated from
                     UniProtKB/Swiss-Prot (P09036.1)"
     Site            42..43
                     /site_type="active"
                     /note="protease cleavage site [active]"
                     /db_xref="CDD:238648"
     Site            42
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238648"
     Site            44..45
                     /site_type="other"
                     /note="Necessary for sperm binding.
                     /evidence=ECO:0000269|PubMed:9828198; propagated from
                     UniProtKB/Swiss-Prot (P09036.1)"
     CDS             1..80
                     /gene="Spink1"
                     /gene_synonym="p12; Spink3"
                     /coded_by="NM_009258.5:89..331"
                     /db_xref="CCDS:CCDS37803.1"
                     /db_xref="GeneID:20730"
                     /db_xref="MGI:MGI:106202"
ORIGIN      
        1 mkvaviflls alallslagn tfsakvtgke aschdavagc priydpvcgt dgityanecv
       61 lcfenrkrie pvlirkggpc
//
