LOCUS       NM_011462               4144 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus spindlin 1 (Spin1), transcript variant 1, mRNA.
ACCESSION   NM_011462 XM_992233 XM_992254 XM_992281
VERSION     NM_011462.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Dias Mirandela,M., Zoch,A., Leismann,J., Webb,S., Berrens,R.V.,
            Valsakumar,D., Kabayama,Y., Auchynnikava,T., Schito,M.,
            Chowdhury,T., MacLeod,D., Xiang,X., Zou,J., Rappsilber,J.,
            Allshire,R.C., Voigt,P., Cook,A.G., Barau,J. and O'Carroll,D.
  TITLE     Two-factor authentication underpins the precision of the piRNA
            pathway
  JOURNAL   Nature 634 (8035), 979-985 (2024)
   PUBMED   39294378
  REMARK    GeneRIF: Two-factor authentication underpins the precision of the
            piRNA pathway.
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4144)
  AUTHORS   Chai,T., Liu,J., Liu,Z. and Fan,R.
  TITLE     Exosome-transported of circ_0081069 induces SPIN1 production by
            binding to miR-195-5p to inhibit radiosensitivity in esophageal
            squamous cell carcinoma
  JOURNAL   J Biochem Mol Toxicol 38 (2), e23659 (2024)
   PUBMED   38348706
  REMARK    GeneRIF: Exosome-transported of circ_0081069 induces SPIN1
            production by binding to miR-195-5p to inhibit radiosensitivity in
            esophageal squamous cell carcinoma.
REFERENCE   4  (bases 1 to 4144)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4144)
  AUTHORS   Greschik,H., Duteil,D., Messaddeq,N., Willmann,D., Arrigoni,L.,
            Sum,M., Jung,M., Metzger,D., Manke,T., Gunther,T. and Schule,R.
  TITLE     The histone code reader Spin1 controls skeletal muscle development
  JOURNAL   Cell Death Dis 8 (11), e3173 (2017)
   PUBMED   29168801
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4144)
  AUTHORS   Yuan,H., Zhang,P., Qin,L., Chen,L., Shi,S., Lu,Y., Yan,F., Bai,C.,
            Nan,X., Liu,D., Li,Y., Yue,W. and Pei,X.
  TITLE     Overexpression of SPINDLIN1 induces cellular senescence,
            multinucleation and apoptosis
  JOURNAL   Gene 410 (1), 67-74 (2008)
   PUBMED   18201843
  REMARK    GeneRIF: SPINDLIN1 is an important gene for mammalian mitotic
            chromosome functions, and disrupted regulation results in abnormal
            cell division, a mechanism that may be involved in tumorigenesis
REFERENCE   7  (bases 1 to 4144)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 4144)
  AUTHORS   Gao,Y., Yue,W., Zhang,P., Li,L., Xie,X., Yuan,H., Chen,L., Liu,D.,
            Yan,F. and Pei,X.
  TITLE     Spindlin1, a novel nuclear protein with a role in the
            transformation of NIH3T3 cells
  JOURNAL   Biochem Biophys Res Commun 335 (2), 343-350 (2005)
   PUBMED   16098913
  REMARK    GeneRIF: spindlin1 gene may contribute to tumorigenesis
REFERENCE   9  (bases 1 to 4144)
  AUTHORS   Oh,B., Hampl,A., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     SPIN, a substrate in the MAP kinase pathway in mouse oocytes
  JOURNAL   Mol Reprod Dev 50 (2), 240-249 (1998)
   PUBMED   9590541
REFERENCE   10 (bases 1 to 4144)
  AUTHORS   Oh,B., Hwang,S.Y., Solter,D. and Knowles,B.B.
  TITLE     Spindlin, a major maternal transcript expressed in the mouse during
            the transition from oocyte to embryo
  JOURNAL   Development 124 (2), 493-503 (1997)
   PUBMED   9053325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160122.2.
            
            On Mar 28, 2023 this sequence version replaced NM_011462.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC160122.2         114235-114299
            66-319              AC160122.2         120795-121048
            320-553             AC160122.2         125740-125973
            554-4144            AC160122.2         130400-133990
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.04 cM"
     gene            1..4144
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="spindlin 1"
                     /db_xref="GeneID:20729"
                     /db_xref="MGI:MGI:109242"
     exon            1..65
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..753
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="isoform 1 is encoded by transcript variant 1; 30000
                     Mr metaphase complex; spindlin1"
                     /codon_start=1
                     /product="spindlin-1 isoform 1"
                     /protein_id="NP_035592.1"
                     /db_xref="GeneID:20729"
                     /db_xref="MGI:MGI:109242"
                     /translation="MASASSPASCPRKHRTSVGPSKPVSQPRRNIVGCRIQHGWREGN
                     GPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRIS
                     DAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLL
                     DDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKP
                     SVYFIKFDDDFHIYVYDLVKTS"
     exon            66..319
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     exon            320..553
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     exon            554..4144
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      788..793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="hexamer: ATTAAA"
     polyA_site      814
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="major polyA site"
     regulatory      1644..1649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="hexamer: AATAAA"
     polyA_site      1668
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="major polyA site"
     regulatory      4121..4126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="hexamer: AATAAA"
     polyA_site      4144
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
ORIGIN      
        1 ggggaagcaa gccagtaaga aacatcctcc atggcctctg cgtcaagtcc tgcttcctgc
       61 cccagaaaac atcggaccag tgtgggacca agcaagcctg tgtcccaacc ccggcggaac
      121 atcgtaggct gcaggatcca gcatggatgg agagagggca atggccctgt tacccagtgg
      181 aaggggactg tcctggacca ggtgcctgtg aatccttccc tgtatcttat aaagtacgat
      241 ggatttgact gtgtttatgg actagaactt aataaggatg aaagagtttc tgcactggaa
      301 gtcctccctg atagagttgc aacatctcgg atcagcgatg cacacttagc ggacacaatg
      361 atcggcaaag cagtggagca catgtttgag acagaggacg gctctaaaga tgagtggagg
      421 gggatggtct tggcacgggc gcctgtcatg aacacatggt tttacatcac ctatgagaaa
      481 gaccctgtct tgtacatgta ccagctcctc gatgactaca aagaaggcga cctccgcatc
      541 atgcctgatt ccaatgattc gcctccagca gaaagggagc caggagaagt tgtggacagc
      601 ctggtaggca agcaagtgga atatgccaaa gaagacggct cgaaaaggac tggcatggtc
      661 atccaccaag tagaggccaa gccctctgtc tatttcatca agtttgatga cgatttccat
      721 atttacgtct acgatttggt gaaaacatcc tagatgtcat cacaaacttt gccaaatttg
      781 tggaactatt aaatgtataa tttgtagaca taaagacttg attgctttcc agtttaatga
      841 aagcttagat gtccctgcga acccacaatc tccaccagca gagctggtgt tgttctgaat
      901 agtgcagact gattcgaaca caaggcatct gtgaggggag tcctccctct tcaaagcatc
      961 tgtgtgaggg ggtcttccct cttacaagaa agctgtctgt tgggggttac aagcaaggtg
     1021 gtaaacgtta agctagtatc atagtcattt aaacctggat agattgtaac cattttccct
     1081 tcactctgac actgtcttat tctgctgcca caatgcaagc atagtttgtt atttttgtta
     1141 ctgccttttt tgagagatta tgtatctata tagctacctg tctagatctg catctgtgtg
     1201 cctatgtata tattatacac acacagaggc actcaccgct ggctctcctt tccttgggga
     1261 ttggggtggg ggtgataacg ttttctccag ttcaacagga gtgcttgacc caagtcagtc
     1321 atatttataa tatgcctgct ctttgtttaa aattaaattt gggcacagga agcacacaga
     1381 gacatttagg ttgtttaaaa agtcagaatt tctgagtacc atttcagtct ggaggctttt
     1441 agctgagtcc aggtataaat tagccataaa cagtcaatga cccacagtag tctttagtaa
     1501 actgttgaga aatctgggta aaaggctgcc ttcaattcta agctttgttt ttttgtggtt
     1561 tttgttatta tttgtttctg ttgtttactc tttaatcgta agtactttta aaccacgacc
     1621 caggtccttg gttcacatgg aataataaag atgtgttttt agatggcaca ttggtccatt
     1681 tgtacacacc tgtcatcggg atcttagtac atggacttaa aaggcaacac tacatcaatg
     1741 gtttgtatat gtggtgaatt cctgcaagaa cagtgcattt gtattagaaa tgtaagtttt
     1801 aaggatggcc ttgttgcctt ctatcaagtt ctctgggact ttgtaatttt gattactact
     1861 attgatacat ggttatggtc agaaggcctc ttctcccttc ctccctcact ccctctcctc
     1921 ctagctttcc ccacagagaa tgttagacca gtatggcttc ttgccttgat cctgttgtgg
     1981 cagtgtctgt tcctgcccca ggtgtgctat tcacgcaggt ttattccctc catggcctcc
     2041 gggctttgca tgtctatgat gtgtgtgtcg ctgggaaggt catgcttgcc agttatgggt
     2101 ggatcgcagc tcttcgccat caagtgcatt caggattatt cctgggaggt tgcttaaagc
     2161 tgaaatagaa ctgaaatgca gttggtagac tagccaaaca tctgcttgct ctcactttgt
     2221 tttggaagaa ccatggtagc ttgtcagctg gtagaaagat ggtttgtaaa aaccagtttc
     2281 tcacggaggt tgaacctatc tgtggctgga cagtcttgga tactgtcaag caaacaccag
     2341 aggcttggcc aagtatagtt acaattacct agttggggtt cttcctgatg caagaaattt
     2401 ttcactgttc gaggcacatg gttattggct atccatttag ttttcacaga ggctgaccac
     2461 cttacactgc tgggtggtca caactgctca ccatgtgaac atagtacctc agttctgtcc
     2521 ttggctgcaa tcgttgtgtg ctcagtgttt tctcataggc accagggaca ggcttctcaa
     2581 ggcagtatga tataccctag tctttggtgc ctctagtata tgtgaccagg tgtcgtcctg
     2641 catgtaaatc tccgagctga gtctgactca cagcccatgc tgtcatctgt ggcacaagtg
     2701 ggtgtgagta cgtcctgcat gcactaacgg tgcagaacat ggcatggtga ctagaaagta
     2761 aaactccttt tgaagtgtcc caaggactgg gtcagttaga acctgtctgc cactatctga
     2821 tgacttacat tgtggttttc tacaagccac ctcagttaac tttggttccc cgtggactcc
     2881 caggctggag gaggaaagcg tgaggacggg gatgattttg atcacgattc catttattgc
     2941 ctttacataa ggttgaggga aggggaaggt ttggtttgtt tgtcttttaa ttgttttttt
     3001 tttctttttt ttttttttaa ttcccccacc ccaccctctt tcttttggtg gcttccacca
     3061 cccttaatgg tgacagactc ctgggcctgc caccttggac ttcccttagg ctcacagttc
     3121 agatctgcat gcattgcttg cattgttctg gtatctgaat gttgattcct catttaggag
     3181 ttcagcatta atttccaaaa ttttcatggg gcttgtggca acacgggccg tgaatctgtg
     3241 tataaaattt actggccttc ttcacttacc tgctctagta tcgtatcgtg tgtgcgtgcg
     3301 tgtgtgacgt caggctgcca cgtaaacttc agagaagaac cttaaagcag accatccatt
     3361 tttgcatgct ctcttctaag tagaatgttc aatgtaacta aaactaaaat tgcatgtcaa
     3421 agagacctag gttctttctt tctttctttc tctctttctt tcagtttgct tttggtttcc
     3481 tgtatatttg cttactgtgc tgttctagtg gttgtagggt aaagacgaac tggtgaagca
     3541 gtcgtagcgc cgaccgaagg tgattccagt tgtatatgtc acgcagcatt cgaagggact
     3601 gtgcacgctc taaagatcac agttgcttct aagccagatt tcatttctat tcttgtttta
     3661 tgtgccaaac cccaaagtgc attgggcctg aatctctgaa cactgtagac ccattagaag
     3721 gaagattgtt ctgaccgtca caaattgtag tgcctgaaaa cacttaacac tgattgtcta
     3781 agagatgaaa gtcctccaaa gatgacacag gaaaaatact acaagtaatt gtggtggaaa
     3841 tgtctgtgtt ccttgggaat gctgcgctct ctgtagtttc catcattggt gcagttcgaa
     3901 cgaatgagta gagttcagag gtcttcgtgt tcacatttaa aactagataa atgacctcat
     3961 tttcttgagc ttgaattcat ttttaatttt aattttattt tatacaacgt gtagacggtt
     4021 ccctgttctc tgcatttaga agtatacaca gtacaactgt taattctgta agtaattttt
     4081 ataattatga tgtaactctt atccttcctt aaaacattaa aataaaccct ttatgtgcaa
     4141 cttg
//
