LOCUS       NM_001419140            4691 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus spindlin 1 (Spin1), transcript variant 8, mRNA.
ACCESSION   NM_001419140
VERSION     NM_001419140.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4691)
  AUTHORS   Dias Mirandela,M., Zoch,A., Leismann,J., Webb,S., Berrens,R.V.,
            Valsakumar,D., Kabayama,Y., Auchynnikava,T., Schito,M.,
            Chowdhury,T., MacLeod,D., Xiang,X., Zou,J., Rappsilber,J.,
            Allshire,R.C., Voigt,P., Cook,A.G., Barau,J. and O'Carroll,D.
  TITLE     Two-factor authentication underpins the precision of the piRNA
            pathway
  JOURNAL   Nature 634 (8035), 979-985 (2024)
   PUBMED   39294378
  REMARK    GeneRIF: Two-factor authentication underpins the precision of the
            piRNA pathway.
REFERENCE   2  (bases 1 to 4691)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4691)
  AUTHORS   Chai,T., Liu,J., Liu,Z. and Fan,R.
  TITLE     Exosome-transported of circ_0081069 induces SPIN1 production by
            binding to miR-195-5p to inhibit radiosensitivity in esophageal
            squamous cell carcinoma
  JOURNAL   J Biochem Mol Toxicol 38 (2), e23659 (2024)
   PUBMED   38348706
  REMARK    GeneRIF: Exosome-transported of circ_0081069 induces SPIN1
            production by binding to miR-195-5p to inhibit radiosensitivity in
            esophageal squamous cell carcinoma.
REFERENCE   4  (bases 1 to 4691)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4691)
  AUTHORS   Greschik,H., Duteil,D., Messaddeq,N., Willmann,D., Arrigoni,L.,
            Sum,M., Jung,M., Metzger,D., Manke,T., Gunther,T. and Schule,R.
  TITLE     The histone code reader Spin1 controls skeletal muscle development
  JOURNAL   Cell Death Dis 8 (11), e3173 (2017)
   PUBMED   29168801
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4691)
  AUTHORS   Yuan,H., Zhang,P., Qin,L., Chen,L., Shi,S., Lu,Y., Yan,F., Bai,C.,
            Nan,X., Liu,D., Li,Y., Yue,W. and Pei,X.
  TITLE     Overexpression of SPINDLIN1 induces cellular senescence,
            multinucleation and apoptosis
  JOURNAL   Gene 410 (1), 67-74 (2008)
   PUBMED   18201843
  REMARK    GeneRIF: SPINDLIN1 is an important gene for mammalian mitotic
            chromosome functions, and disrupted regulation results in abnormal
            cell division, a mechanism that may be involved in tumorigenesis
REFERENCE   7  (bases 1 to 4691)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 4691)
  AUTHORS   Gao,Y., Yue,W., Zhang,P., Li,L., Xie,X., Yuan,H., Chen,L., Liu,D.,
            Yan,F. and Pei,X.
  TITLE     Spindlin1, a novel nuclear protein with a role in the
            transformation of NIH3T3 cells
  JOURNAL   Biochem Biophys Res Commun 335 (2), 343-350 (2005)
   PUBMED   16098913
  REMARK    GeneRIF: spindlin1 gene may contribute to tumorigenesis
REFERENCE   9  (bases 1 to 4691)
  AUTHORS   Oh,B., Hampl,A., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     SPIN, a substrate in the MAP kinase pathway in mouse oocytes
  JOURNAL   Mol Reprod Dev 50 (2), 240-249 (1998)
   PUBMED   9590541
REFERENCE   10 (bases 1 to 4691)
  AUTHORS   Oh,B., Hwang,S.Y., Solter,D. and Knowles,B.B.
  TITLE     Spindlin, a major maternal transcript expressed in the mouse during
            the transition from oocyte to embryo
  JOURNAL   Development 124 (2), 493-503 (1997)
   PUBMED   9053325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160122.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.215600.1,
                                           SRR12282455.16496851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC160122.2         82282-82428
            148-362             AC160122.2         102894-103108
            363-563             AC160122.2         104526-104726
            564-612             AC160122.2         109363-109411
            613-866             AC160122.2         120795-121048
            867-1100            AC160122.2         125740-125973
            1101-4691           AC160122.2         130400-133990
FEATURES             Location/Qualifiers
     source          1..4691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.04 cM"
     gene            1..4691
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="spindlin 1"
                     /db_xref="GeneID:20729"
                     /db_xref="MGI:MGI:109242"
     exon            1..147
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     exon            148..362
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     exon            363..563
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..1300
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="isoform 2 is encoded by transcript variant 8; 30000
                     Mr metaphase complex; spindlin1"
                     /codon_start=1
                     /product="spindlin-1 isoform 2"
                     /protein_id="NP_001406069.1"
                     /db_xref="GeneID:20729"
                     /db_xref="MGI:MGI:109242"
                     /translation="MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRTSVGPSK
                     PVSQPRRNIVGCRIQHGWREGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLEL
                     NKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAP
                     VMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQV
                     EYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS"
     exon            564..612
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     exon            613..866
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1100
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..4691
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="hexamer: ATTAAA"
     polyA_site      1361
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="major polyA site"
     regulatory      2191..2196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="hexamer: AATAAA"
     polyA_site      2215
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="major polyA site"
     regulatory      4668..4673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
                     /note="hexamer: AATAAA"
     polyA_site      4691
                     /gene="Spin1"
                     /gene_synonym="Spin; SSEC P"
ORIGIN      
        1 gcagtgcgcg tgcgccgtgg cggccggggg gcgggcggcg gccgcggcga ggagcggggg
       61 tggggaggcg ccgtctggct cgggctgggc cggcggggag cacgagcgaa ccacggcggc
      121 cccgtgggca gcctcggtgg ccgacagcag tcccctggga agatgaggat gggaggatcc
      181 ccagcagctc atggggtcag gcacagctaa agaagacaga cagggcaggg tgaagactga
      241 tggacactcc aggctgccct cagatttctg cacccctgtt ctgcatgctc gtaaacaatg
      301 tatatacaca cgacaacaga aaacagaaga cccgtgcttc aagtcctcag tttctcttaa
      361 agagtgcttg ggatcccgtg tgtttttgct gaacttgtaa aggagacatc tggatggtgg
      421 attaacacga acctgtgggc agcctcatag ctgagaacat tggattttca ccctagtcca
      481 gcagctctgc tgctcacata gatacagatg aatgaagacc ccattcggga agacacctgg
      541 ccaacggtcc agagctgatg caggccatgc tggagtatct gcaaacatga tgaagaagag
      601 gacatctcac aaaaaacatc ggaccagtgt gggaccaagc aagcctgtgt cccaaccccg
      661 gcggaacatc gtaggctgca ggatccagca tggatggaga gagggcaatg gccctgttac
      721 ccagtggaag gggactgtcc tggaccaggt gcctgtgaat ccttccctgt atcttataaa
      781 gtacgatgga tttgactgtg tttatggact agaacttaat aaggatgaaa gagtttctgc
      841 actggaagtc ctccctgata gagttgcaac atctcggatc agcgatgcac acttagcgga
      901 cacaatgatc ggcaaagcag tggagcacat gtttgagaca gaggacggct ctaaagatga
      961 gtggaggggg atggtcttgg cacgggcgcc tgtcatgaac acatggtttt acatcaccta
     1021 tgagaaagac cctgtcttgt acatgtacca gctcctcgat gactacaaag aaggcgacct
     1081 ccgcatcatg cctgattcca atgattcgcc tccagcagaa agggagccag gagaagttgt
     1141 ggacagcctg gtaggcaagc aagtggaata tgccaaagaa gacggctcga aaaggactgg
     1201 catggtcatc caccaagtag aggccaagcc ctctgtctat ttcatcaagt ttgatgacga
     1261 tttccatatt tacgtctacg atttggtgaa aacatcctag atgtcatcac aaactttgcc
     1321 aaatttgtgg aactattaaa tgtataattt gtagacataa agacttgatt gctttccagt
     1381 ttaatgaaag cttagatgtc cctgcgaacc cacaatctcc accagcagag ctggtgttgt
     1441 tctgaatagt gcagactgat tcgaacacaa ggcatctgtg aggggagtcc tccctcttca
     1501 aagcatctgt gtgagggggt cttccctctt acaagaaagc tgtctgttgg gggttacaag
     1561 caaggtggta aacgttaagc tagtatcata gtcatttaaa cctggataga ttgtaaccat
     1621 tttcccttca ctctgacact gtcttattct gctgccacaa tgcaagcata gtttgttatt
     1681 tttgttactg ccttttttga gagattatgt atctatatag ctacctgtct agatctgcat
     1741 ctgtgtgcct atgtatatat tatacacaca cagaggcact caccgctggc tctcctttcc
     1801 ttggggattg gggtgggggt gataacgttt tctccagttc aacaggagtg cttgacccaa
     1861 gtcagtcata tttataatat gcctgctctt tgtttaaaat taaatttggg cacaggaagc
     1921 acacagagac atttaggttg tttaaaaagt cagaatttct gagtaccatt tcagtctgga
     1981 ggcttttagc tgagtccagg tataaattag ccataaacag tcaatgaccc acagtagtct
     2041 ttagtaaact gttgagaaat ctgggtaaaa ggctgccttc aattctaagc tttgtttttt
     2101 tgtggttttt gttattattt gtttctgttg tttactcttt aatcgtaagt acttttaaac
     2161 cacgacccag gtccttggtt cacatggaat aataaagatg tgtttttaga tggcacattg
     2221 gtccatttgt acacacctgt catcgggatc ttagtacatg gacttaaaag gcaacactac
     2281 atcaatggtt tgtatatgtg gtgaattcct gcaagaacag tgcatttgta ttagaaatgt
     2341 aagttttaag gatggccttg ttgccttcta tcaagttctc tgggactttg taattttgat
     2401 tactactatt gatacatggt tatggtcaga aggcctcttc tcccttcctc cctcactccc
     2461 tctcctccta gctttcccca cagagaatgt tagaccagta tggcttcttg ccttgatcct
     2521 gttgtggcag tgtctgttcc tgccccaggt gtgctattca cgcaggttta ttccctccat
     2581 ggcctccggg ctttgcatgt ctatgatgtg tgtgtcgctg ggaaggtcat gcttgccagt
     2641 tatgggtgga tcgcagctct tcgccatcaa gtgcattcag gattattcct gggaggttgc
     2701 ttaaagctga aatagaactg aaatgcagtt ggtagactag ccaaacatct gcttgctctc
     2761 actttgtttt ggaagaacca tggtagcttg tcagctggta gaaagatggt ttgtaaaaac
     2821 cagtttctca cggaggttga acctatctgt ggctggacag tcttggatac tgtcaagcaa
     2881 acaccagagg cttggccaag tatagttaca attacctagt tggggttctt cctgatgcaa
     2941 gaaatttttc actgttcgag gcacatggtt attggctatc catttagttt tcacagaggc
     3001 tgaccacctt acactgctgg gtggtcacaa ctgctcacca tgtgaacata gtacctcagt
     3061 tctgtccttg gctgcaatcg ttgtgtgctc agtgttttct cataggcacc agggacaggc
     3121 ttctcaaggc agtatgatat accctagtct ttggtgcctc tagtatatgt gaccaggtgt
     3181 cgtcctgcat gtaaatctcc gagctgagtc tgactcacag cccatgctgt catctgtggc
     3241 acaagtgggt gtgagtacgt cctgcatgca ctaacggtgc agaacatggc atggtgacta
     3301 gaaagtaaaa ctccttttga agtgtcccaa ggactgggtc agttagaacc tgtctgccac
     3361 tatctgatga cttacattgt ggttttctac aagccacctc agttaacttt ggttccccgt
     3421 ggactcccag gctggaggag gaaagcgtga ggacggggat gattttgatc acgattccat
     3481 ttattgcctt tacataaggt tgagggaagg ggaaggtttg gtttgtttgt cttttaattg
     3541 tttttttttt cttttttttt tttttaattc ccccacccca ccctctttct tttggtggct
     3601 tccaccaccc ttaatggtga cagactcctg ggcctgccac cttggacttc ccttaggctc
     3661 acagttcaga tctgcatgca ttgcttgcat tgttctggta tctgaatgtt gattcctcat
     3721 ttaggagttc agcattaatt tccaaaattt tcatggggct tgtggcaaca cgggccgtga
     3781 atctgtgtat aaaatttact ggccttcttc acttacctgc tctagtatcg tatcgtgtgt
     3841 gcgtgcgtgt gtgacgtcag gctgccacgt aaacttcaga gaagaacctt aaagcagacc
     3901 atccattttt gcatgctctc ttctaagtag aatgttcaat gtaactaaaa ctaaaattgc
     3961 atgtcaaaga gacctaggtt ctttctttct ttctttctct ctttctttca gtttgctttt
     4021 ggtttcctgt atatttgctt actgtgctgt tctagtggtt gtagggtaaa gacgaactgg
     4081 tgaagcagtc gtagcgccga ccgaaggtga ttccagttgt atatgtcacg cagcattcga
     4141 agggactgtg cacgctctaa agatcacagt tgcttctaag ccagatttca tttctattct
     4201 tgttttatgt gccaaacccc aaagtgcatt gggcctgaat ctctgaacac tgtagaccca
     4261 ttagaaggaa gattgttctg accgtcacaa attgtagtgc ctgaaaacac ttaacactga
     4321 ttgtctaaga gatgaaagtc ctccaaagat gacacaggaa aaatactaca agtaattgtg
     4381 gtggaaatgt ctgtgttcct tgggaatgct gcgctctctg tagtttccat cattggtgca
     4441 gttcgaacga atgagtagag ttcagaggtc ttcgtgttca catttaaaac tagataaatg
     4501 acctcatttt cttgagcttg aattcatttt taattttaat tttattttat acaacgtgta
     4561 gacggttccc tgttctctgc atttagaagt atacacagta caactgttaa ttctgtaagt
     4621 aatttttata attatgatgt aactcttatc cttccttaaa acattaaaat aaacccttta
     4681 tgtgcaactt g
//
