LOCUS       NM_146068               3303 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus scaffolding protein involved in DNA repair (Spidr),
            transcript variant 1, mRNA.
ACCESSION   NM_146068 XM_358767
VERSION     NM_146068.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3303)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3303)
  AUTHORS   Huang,T., Wu,X., Wang,S., Bao,Z., Wan,Y., Wang,Z., Li,M., Yu,X.,
            Lv,Y., Liu,Z., Chen,X., Chan,W.Y., Gao,F., Lu,G., Chen,Z.J. and
            Liu,H.
  TITLE     SPIDR is required for homologous recombination during mammalian
            meiosis
  JOURNAL   Nucleic Acids Res 51 (8), 3855-3868 (2023)
   PUBMED   36938872
REFERENCE   3  (bases 1 to 3303)
  AUTHORS   Prakash,R., Sandoval,T., Morati,F., Zagelbaum,J.A., Lim,P.X.,
            White,T., Taylor,B., Wang,R., Desclos,E.C.B., Sullivan,M.R.,
            Rein,H.L., Bernstein,K.A., Krawczyk,P.M., Gautier,J., Modesti,M.,
            Vanoli,F. and Jasin,M.
  TITLE     Distinct pathways of homologous recombination controlled by the
            SWS1-SWSAP1-SPIDR complex
  JOURNAL   Nat Commun 12 (1), 4255 (2021)
   PUBMED   34253720
  REMARK    GeneRIF: Distinct pathways of homologous recombination controlled
            by the SWS1-SWSAP1-SPIDR complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3303)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3303)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146053.1, AK044836.1 and BC089026.1.
            
            On Aug 9, 2013 this sequence version replaced NM_146068.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146053.1, AK044836.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK146053.1         1-18
            19-3279             AK044836.1         2-3262
            3280-3303           BC089026.1         3217-3240
FEATURES             Location/Qualifiers
     source          1..3303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.09 cM"
     gene            1..3303
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /note="scaffolding protein involved in DNA repair"
                     /db_xref="GeneID:224008"
                     /db_xref="MGI:MGI:1924834"
     exon            1..107
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2876
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     repair-scaffolding protein; scaffolding protein involved i
                     DNA repair"
                     /codon_start=1
                     /product="DNA repair-scaffolding protein isoform 1"
                     /protein_id="NP_666180.2"
                     /db_xref="CCDS:CCDS27980.1"
                     /db_xref="GeneID:224008"
                     /db_xref="MGI:MGI:1924834"
                     /translation="MSGARRPGTSKRKRNWHIEHPSFREERSQQLRRGNFKTVEAADS
                     LSKAWLKCGEGFQDTSEILSLASEKTGITEKHLELSPKPKTETTSKNASELPNIIWSS
                     SESDFSDEDKTLPALQRDGRHGPRADRLGDRTISCPEDEDIEDELQVIDWEVNSDKED
                     PGGPSECEDDKGTLDISDCDSCASLTSDDRLCEPSEPISTEILEYSSDSEKEEDPEHS
                     LFIDSESPHKYQADFKSDARWCLVSQTDSEANSAEPTLTPQKYTVKFPKTPEYSVTKK
                     KLLRGGLAERLQELQNRKRSAISLWRHRCVSYQMTPLGRKSGVLTVKILELHEECSMQ
                     VAVCEQLAGPPITSPPGGLAPRPGAYLKVLFTRETADHLMGHPQDIIYIFPPWQKLLI
                     PNGSCSIILNTYFCQKAIAKETVREDLYSPDISLSRRNITLAQTFRIKDITDNSSINQ
                     TTYDSLATPGTGWTHGHEKAEQHLIVAAPLRNSLLDIVESQRAGLWSGVRVQVVVQRV
                     YSLLSRDGARSQQGHTVGHADASGAWSCLLVQDACGMFGEVFLNSTLWKSRQLEGKSC
                     SMSGVKVLQKATRGRTPGLFSLIDSLWPPVISLTEPSCGQPSGETKTYLPPPIFCYIF
                     SAHPTLGQIDAIEDHISKLYQPPVVRCLKEILQTNECSTRCSFYARVIYQKPQLKNLL
                     AQKEIWLLVTDITLQTQDERDHSLPKTLPVYIAPSCVLGPEVVEELALLVSYNLLFRD
                     AFKDNGQIVCIERTVILPQKPLLCVPSASCDLPSPVTLDELSALTPVNSICSVQGTVV
                     DVDESTAFSWPVCDRCGNGRLEQKPEDGGTFSCGDCSQLVLSPLQERHLHVFLDCPTR
                     PESTVKVKLLESSISLLLMSAASEDGSYEVESVLGKEMGPLLCFVQSITTQQSSCVVT
                     LEEIELLSTEGATAAQPPP"
     exon            108..263
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            264..330
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            331..507
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            508..662
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            663..913
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1014
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1234
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1424
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1675
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1816
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1904
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2045
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2105
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2310
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2457
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2551
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2666
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2720
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..3282
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3264..3269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /note="hexamer: AATAAA"
     polyA_site      3282
                     /gene="Spidr"
                     /gene_synonym="2310008H04Rik; Kiaa0146"
                     /note="major polyA site"
ORIGIN      
        1 gagggaaggg ggcggggcgc gtgatgggcg gcttccggat ggggcggcga gcaggaagac
       61 tgtgcacgta ggagatgtct ggagcccgcc gccccggcac gtccaagagg aaaaggaatt
      121 ggcatataga acacccatcc tttcgagaag agaggtcaca gcagttgaga cggggaaatt
      181 tcaagacagt ggaagcagct gactctctct ctaaagcatg gctcaagtgt ggagaaggat
      241 ttcaggacac ctctgagatc ctgtcattag caagtgaaaa gacaggtatt actgaaaagc
      301 acctggaatt atctccaaaa ccaaagacag aaactacaag taagaatgct agtgagcttc
      361 caaatataat atggagttcc agtgaaagtg atttctccga tgaagataag acacttcctg
      421 cattacagag agatggtagg catggcccta gagccgacag gcttggtgac aggactatct
      481 catgtcccga agacgaagac attgaagatg aattacaggt tattgactgg gaggttaaca
      541 gtgacaaaga agatcctggt gggcctagtg agtgtgaaga tgataagggt accctggaca
      601 tctcagattg tgattcctgt gcaagtctga caagtgatga caggctatgt gagccttctg
      661 agccaatttc tacagaaatt ttggagtatt catcagatag tgaaaaagaa gaagacccag
      721 aacattccct gttcattgat tcagaatccc ctcacaaata ccaggcggat tttaaatctg
      781 atgcaagatg gtgtttggtt agtcagactg actcagaagc aaattcagct gagcctacat
      841 tgacacccca gaaatatacg gtcaagtttc cgaagactcc agaatattca gtaacaaaga
      901 agaagctttt aaggggcggg ctagcagaaa gactccaaga actgcagaat cgaaagagat
      961 ctgccatttc tttgtggaga catcgatgtg tttcttacca aatgacacca ttaggcagaa
     1021 aatctggtgt attaactgtg aaaattctag aactgcatga ggaatgcagc atgcaagttg
     1081 cagtatgtga gcagttagca gggcctccaa tcaccagccc tcccggagga ctagctccta
     1141 gaccaggagc ctacctgaag gtactcttca ccagagagac tgcagaccac ttgatggggc
     1201 atccccagga catcatttac atcttccctc cttggcaaaa acttcttatc ccaaatggaa
     1261 gttgctccat tattctgaat acttattttt gtcagaaagc tattgcaaaa gaaacagtgc
     1321 gcgaagacct atacagtccg gacatatctc tttcaaggag aaatataact ttggcccaga
     1381 catttagaat taaggacata acagacaatt catccatcaa tcagactaca tatgatagcc
     1441 tggccacccc tggcacaggc tggacccacg gacatgagaa ggcagagcaa catcttatag
     1501 ttgctgctcc cctgaggaat tctcttctgg acattgtgga aagccaaaga gctggcctat
     1561 ggtctggagt cagggtccaa gtagtagtgc agagggtgta ctctcttctc agcagagatg
     1621 gtgccaggag ccagcaaggg cacacagtgg gacatgcaga tgcctctgga gcatggtcct
     1681 gccttctagt gcaggatgcc tgtggcatgt tcggggaagt gttcttgaac agcaccctct
     1741 ggaagagcag acagttagaa gggaagtcct gcagcatgtc gggagtgaag gttctacaga
     1801 aagctacaag aggaaggaca ccagggctct tcagtttaat tgacagtttg tggcccccag
     1861 tgatatctct gactgagcct tcctgtggcc agcccagtgg agagacaaag acttatctgc
     1921 ctcctcctat cttctgttat atcttctctg cacatccaac actgggacaa attgatgcaa
     1981 ttgaagacca catttccaag ctttaccagc ctccagttgt ccgctgctta aaagaaatcc
     2041 tccagactaa tgagtgcagt acacgttgca gcttctatgc cagagtgatt tatcaaaaac
     2101 cacagctaaa gaatcttttg gcgcaaaagg aaatctggct gctggtgact gacatcactc
     2161 tgcaaacaca ggatgaaagg gaccactctc ttcccaaaac cctgcctgtc tatatagccc
     2221 cctcgtgtgt gctgggccca gaggttgtag aagaacttgc cttgctggtg tcttataact
     2281 tactcttcag ggacgctttt aaggacaacg gtcagattgt ttgtattgaa cggacagtca
     2341 tcctacccca gaaacctctc ttgtgtgtac cttctgcttc ctgtgacttg cccagcccag
     2401 tgacactgga tgaactgagt gccctcacac ctgtcaactc catttgcagt gtgcaaggta
     2461 ctgtggttga tgtagatgag agcactgctt tctcgtggcc tgtgtgtgac cggtgtggca
     2521 atgggagact ggaacagaag ccagaagatg gaggcacctt ctcctgtggg gactgttccc
     2581 aactggtcct gtcacctctt caagagaggc acctgcatgt ctttctggac tgtcccacga
     2641 gacctgagag tactgtgaag gtcaagctat tggagagcag tatttcttta cttctgatgt
     2701 ctgctgcctc tgaggatggg agttatgaag tggagagcgt ccttgggaag gagatgggac
     2761 ctttactctg ctttgtccag tccatcacta cacagcagag cagctgtgtc gtcaccctgg
     2821 aagagattga gctgctgagt acagagggag ccactgctgc tcagcctcct ccctgacatc
     2881 tgtgcgcttg gcaaggggct gtgtgttaac tcagtgtttc tgtttttaaa tttagtgggt
     2941 ttcttttctt tcttttttct ggtaaagaga ttaataggat agttttaaat taaaaatcaa
     3001 gatacctcta atacacattt ttttaaactt taccttccta caagtttgat aacatgtttc
     3061 tttgagtgtt tctcatgtct tctgtgtctt cattttgcag ctacttgggc ttaggaaatg
     3121 tgctttgttg tagctttaaa gtagttacaa tttatcaata ttatatatgt tttttctttg
     3181 cagtatctaa tattctctgc tagattgttc tgtaaagctt cagccagtat ctcatattga
     3241 aatattactg ttctgttaca ataaataaat gtccaaccta aaaaaaaaaa aaaaaaaaaa
     3301 aaa
//
