LOCUS       NM_144550               4324 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus spindle and centriole associated protein 1 (Spice1),
            transcript variant 1, mRNA.
ACCESSION   NM_144550 XM_358843
VERSION     NM_144550.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4324)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125191.4 and AC147045.2.
            
            On Feb 22, 2023 this sequence version replaced NM_144550.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048789.1, AY099108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC125191.4         168979-169064
            87-182              AC125191.4         176998-177093
            183-230             AC125191.4         177703-177750
            231-374             AC125191.4         179318-179461
            375-477             AC125191.4         187142-187244
            478-584             AC125191.4         188091-188197
            585-700             AC125191.4         189191-189306
            701-840             AC125191.4         191438-191577
            841-981             AC125191.4         191796-191936
            982-1247            AC125191.4         192238-192503
            1248-1379           AC125191.4         194092-194223
            1380-1530           AC147045.2         108963-109113       c
            1531-1755           AC147045.2         107733-107957       c
            1756-2240           AC147045.2         105415-105899       c
            2241-2424           AC147045.2         102553-102736       c
            2425-2527           AC147045.2         99982-100084        c
            2528-2615           AC147045.2         99049-99136         c
            2616-4324           AC147045.2         96261-97969         c
FEATURES             Location/Qualifiers
     source          1..4324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.67 cM"
     gene            1..4324
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="spindle and centriole associated protein 1"
                     /db_xref="GeneID:212514"
                     /db_xref="MGI:MGI:1196252"
     exon            1..86
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2669
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 52; coiled-coil
                     domain containing 52"
                     /codon_start=1
                     /product="spindle and centriole-associated protein 1
                     isoform 1"
                     /protein_id="NP_653133.3"
                     /db_xref="CCDS:CCDS37345.1"
                     /db_xref="GeneID:212514"
                     /db_xref="MGI:MGI:1196252"
                     /translation="MSLIRVNRFGPRGGGRKTLKVKKKAAVRQEWDNTVNDLTVHRAT
                     PEDLVRRHEMHKSKNRALVHWELQEKALKRKWKKQKPETSSLEKRKLSIMKEILSDQY
                     LTQDVLEKSDHLMAAAKGLFADVPRKRTGFPNVTRAPDSSQSHTGINQDPVTQSILNE
                     SIIEPQALNEVDDAGEQSTAHSQSEDSENELPNSLSQHSNRSTERFLHQLKEENSELI
                     NQLWTDIQQKIATQSQRTPPGSPSSELSAEDQKAALNATDAVKRIQAGPQPEEAAEPV
                     DFSSSYLGQVLNTRKQKPLLAKVKRKQDMHAASKQKTNMLSSSTASADRPSSTGSSLD
                     VLKHVIHEVEHEMEEYERCTGREVTGLQGGQGLTGFTLSLVSSLCRLVRYLKESEIQL
                     RKEVETRQQLEQMLGDHRELIDALTAEILSLREENSTMQARLQQYMVTTDEQLISLTH
                     AIKNCPVINNSRQESQAPERAAMGRRLVDNVEGPVISSNGSMPLMFRGEEVVEFPQEE
                     LPVKLSQGPTPTENLNLANNFPTHIFEPAVMLTPPRQKSNSEFSPLQDVLRRTVQTRP
                     APRIPPTVEVIEKEQNWEKKALPIDPDIQNSSEENRLFTQRWRVSHMGEDLENKGQPA
                     FVSLSQPPCSSLPSTQQPRNPVLSEEPTVLGDGQQLRTSEALVQRKDIMARIAELTLQ
                     NSAIKAHLNNITSSGGEQGDGLREPRKQGSASEVSTNFPAVQSLTPSSMEERIAELNR
                     QSMEARSKLLQLIEQQKLVGLNLSSSPVSPVESPLRAWAEEGKRTIEVSVPGMEASES
                     SKCNTVSPVSGNSSRRSSGAISNSCSPLNATSGSGKFTPVNPRTKTEKKNEEGWFALS
                     AHIP"
     exon            87..182
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            183..230
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            231..374
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            375..477
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            478..584
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            585..700
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            701..840
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            841..981
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1247
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1379
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1530
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1755
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2240
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2424
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2527
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2615
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..4324
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3040..3045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="hexamer: AATAAA"
     polyA_site      3067
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="major polyA site"
     regulatory      4195..4200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="hexamer: AGTAAA"
     polyA_site      4217
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
     regulatory      4300..4305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="hexamer: AATAAA"
     polyA_site      4324
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
ORIGIN      
        1 actttccgcg ttcccccgtg gcgggctctg tggttctgga ggctgaactt ttagtcgggg
       61 cggaggcaca gtcggccagc ggcaagatgt cattgatcag agtgaaccgc tttggtcccc
      121 ggggaggtgg aagaaaaact ctgaaagtaa agaagaaagc tgcagtgagg caagaatggg
      181 ataatactgt gaatgatcta acagttcacc gggcaactcc tgaagatcta gtgcgccgtc
      241 atgagatgca caagtcaaag aatagagcat tggtgcactg ggaacttcaa gaaaaagctt
      301 tgaagagaaa atggaagaag cagaaaccag aaacttcaag tcttgaaaaa agaaagttat
      361 ctatcatgaa ggagattctc tctgatcaat acctgacaca ggatgtgctg gaaaagtccg
      421 atcatctgat ggctgcagcc aaaggtctgt ttgctgatgt tcctcgtaag cgcacagggt
      481 ttccaaatgt aacaagggct ccagattcct cacagagcca cactggaata aatcaagacc
      541 ctgtcaccca gtctatcctt aatgaatcaa tcatagagcc tcaggctctt aatgaagtcg
      601 acgatgcagg ggagcagagc actgctcaca gccagtcaga agacagcgag aatgaattgc
      661 ctaactccct cagccagcat tctaacagga gtacagagag gtttcttcac caactaaagg
      721 aagagaattc cgagttaatc aatcaactgt ggactgatat tcagcagaaa atcgctaccc
      781 agtcacaaag aactcctcca ggatctccgt cctcggagct ttcagccgag gatcagaaag
      841 ctgctctgaa tgcaacggat gctgtcaaga gaatccaggc tgggcctcag cctgaggagg
      901 ctgctgagcc tgtagacttc agctccagct acctgggaca ggtgctaaac acaaggaagc
      961 aaaagccgct gctagctaaa gtgaaaagaa aacaagatat gcatgctgcc tccaagcaga
     1021 agacaaacat gctgtcctcc agcacagcct ctgcagacag acccagtagc actggctcca
     1081 gcctggacgt tctcaaacac gtgatccatg aagtggagca cgagatggaa gagtatgagc
     1141 ggtgcacagg gcgtgaggtc acggggctgc agggtggtca gggactcaca ggcttcaccc
     1201 tgtccctggt gagctctctc tgccgcctgg ttcggtacct taaagagagt gaaatccaac
     1261 ttcggaaaga agtagagaca aggcagcagc tggaacagat gttaggtgat caccgagagc
     1321 tcattgatgc cctgacagct gaaatcctct ccctcagaga agagaatagt accatgcagg
     1381 cgagacttca gcagtacatg gttaccacag atgagcagct catatcgctc acacatgcca
     1441 ttaagaactg tcctgtgata aataactcca gacaagaaag tcaagcacca gaaagggcag
     1501 ctatgggtag aagacttgtg gataatgtag agggtcctgt tataagcagt aatggctcca
     1561 tgccattgat gttcagaggg gaagaagtgg ttgaattccc acaggaagag ttgcctgtta
     1621 aactatctca ggggccaacc cccacagaaa acttgaatct ggccaataat ttcccaaccc
     1681 atattttcga gccagctgtg atgctaacac cacccaggca gaagagcaac tcagaattct
     1741 ctcctctcca ggatgttctg aggaggactg ttcagactcg tccggcccca cgaattcccc
     1801 ccactgtgga agttatagag aaggagcaga actgggaaaa gaaggccctg cctattgatc
     1861 cagacattca gaactcaagt gaggaaaacc gtctcttcac tcagaggtgg agagtctcgc
     1921 acatgggaga agacctggag aacaaagggc agccagcatt tgttagcctg tcacagccgc
     1981 cttgtagttc ccttcccagc actcagcagc caagaaaccc cgtgttgtca gaggagccca
     2041 ctgtgcttgg agatgggcag cagctcagaa catcggaggc cctggtgcag aggaaggaca
     2101 ttatggcccg gatcgccgag ctcacactgc agaattcagc catcaaggcc cacctgaaca
     2161 atattaccag ctcaggggga gagcaaggtg atggactgcg ggagccacgc aaacagggaa
     2221 gtgccagtga agtgtctact aatttcccag cagttcagtc tttaacgcca agtagcatgg
     2281 aggagcggat tgcagagttg aaccgacaga gcatggaggc gcgcagcaaa ctgctccagc
     2341 tgatagagca gcagaaactt gtgggcttga acctttcctc atcaccggtg tcacccgtgg
     2401 agtcacctct cagagcgtgg gccgaagaag gaaagcgaac catcgaggtg tctgttccag
     2461 gaatggaggc ttcagagagt tcaaaatgca atactgtgtc tcctgtcagt gggaacagtt
     2521 caagaagatc gtcaggggcg atcagcaatt cttgttctcc actaaacgcc acctcaggaa
     2581 gtgggaagtt cacaccagtt aatccaagaa caaagactga aaaaaaaaat gaagaaggtt
     2641 ggtttgctct ctctgcccac ataccgtaag tgaagcccca gcagagagtg tcctcagtga
     2701 cttattcctg gcctttcctt cgcacttcac agattccatt tcaagttaat aacatttttc
     2761 ttcagataaa acctgcatag gtatcctgta tttatggaaa cagaaaaaag aattatttta
     2821 atattttacc ttttcaaatg ttttttcaac aaagcacctc taattccctg tgagtaaagc
     2881 tttgcaggag tttaagtttt atatttgttt agccttgtta aatgcattag tgatacattg
     2941 ttacttttgt cattttggtt gaatgtttgt ttgttattta gtgcatctta aatgcaatca
     3001 ccttcccaca agaactaatt ggctttatgt ataacttaaa ataaagttgt tctggctttc
     3061 agaaaaacgt gatacttttt ttttctatta tccatcattt caaattgaat gtacagcttt
     3121 aagaaaacta aaggctgggg ctgtggtgca cacctataat cttaatgttg acttagaagc
     3181 cggaggcaag ggctgtgtag tatataatga gttccacacc agtctgagct ccgtagagaa
     3241 ccctgtctca acaaaagaac gggaagtggg tggaggaatg tctattttct ttaagcacgt
     3301 aaaagtagct atgtgtttaa taaaaatctt atggagtttt taagtgtgaa aatttcaaaa
     3361 tgataatgcc catctagtaa gtaatgattg ttggggtcca gtagttgccc cacaaaccac
     3421 acagtcactg ccctcagtca gacaggaatg gttaattgaa cgcacaccct gaaactgatc
     3481 agtcaaggcc atagcttaga gttcagggct gaggctatga ccctgagcat ctttctctgt
     3541 cagcttatta aggctaaaac tgtaaaaacc acagtgagct catatgcagg agcagaaagt
     3601 gctgcccagt aggctgactc aagccatttc agatctaaca gttcatactg acctttaatt
     3661 tgatgggtcc tacctaaagc tttgtggcat ttcttaagat aaacaaacct cagaacatag
     3721 gaaacataac agggtatgtg gtcagcatga acctgctctg agtcaattat ttttctgtgt
     3781 cagtaactgg caagcatatt atagcaacga tatgaagttg ttggcaggca tggaacaaaa
     3841 tggctacagc tatcctgggg gttgggccgg cctcaacaat ggtaatgacc attttgttca
     3901 aatgtctaaa tgcagtacac tgattttatg attatgttag aaacttagaa aaagaaatat
     3961 aaaaaactgt tagtcatttc cttgccctaa cttacctaaa atggattgtc tttcatgtac
     4021 tgactgtttc tcaaatgttg gcttctgttt tcagtttgtc tcagtgataa ctgccatgct
     4081 atgttagtaa ttttcaactt gagtgagttg ggagggggaa agggtcacac tgaagctccc
     4141 ctgactcagc gctcccctcc cctcccctcc ctgggcttct aaattacagc aaaaagtaaa
     4201 atgattttct tctggcactg gtgaagttgt gtggagtctg tatttgtttt acgtcttgca
     4261 gatgtcgtcc cctcgtcctg tacattttgt aagttgttta ataaagactg tctggtggct
     4321 tgaa
//
