LOCUS       NM_001416916            4386 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus spindle and centriole associated protein 1 (Spice1),
            transcript variant 3, mRNA.
ACCESSION   NM_001416916 XM_017316923
VERSION     NM_001416916.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4386)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4386)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125191.4 and AC147045.2.
            
            On Feb 22, 2023 this sequence version replaced XM_017316923.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.298497.1,
                                           SRR17253014.3069258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC125191.4         168979-169064
            87-148              AC125191.4         169566-169627
            149-244             AC125191.4         176998-177093
            245-292             AC125191.4         177703-177750
            293-436             AC125191.4         179318-179461
            437-539             AC125191.4         187142-187244
            540-646             AC125191.4         188091-188197
            647-762             AC125191.4         189191-189306
            763-902             AC125191.4         191438-191577
            903-1043            AC125191.4         191796-191936
            1044-1309           AC125191.4         192238-192503
            1310-1441           AC125191.4         194092-194223
            1442-1592           AC147045.2         108963-109113       c
            1593-1817           AC147045.2         107733-107957       c
            1818-2302           AC147045.2         105415-105899       c
            2303-2486           AC147045.2         102553-102736       c
            2487-2589           AC147045.2         99982-100084        c
            2590-2677           AC147045.2         99049-99136         c
            2678-4386           AC147045.2         96261-97969         c
FEATURES             Location/Qualifiers
     source          1..4386
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.67 cM"
     gene            1..4386
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="spindle and centriole associated protein 1"
                     /db_xref="GeneID:212514"
                     /db_xref="MGI:MGI:1196252"
     exon            1..86
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            87..148
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2731
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="isoform 1 is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 52; coiled-coil
                     domain containing 52"
                     /codon_start=1
                     /product="spindle and centriole-associated protein 1
                     isoform 1"
                     /protein_id="NP_001403845.1"
                     /db_xref="GeneID:212514"
                     /db_xref="MGI:MGI:1196252"
                     /translation="MSLIRVNRFGPRGGGRKTLKVKKKAAVRQEWDNTVNDLTVHRAT
                     PEDLVRRHEMHKSKNRALVHWELQEKALKRKWKKQKPETSSLEKRKLSIMKEILSDQY
                     LTQDVLEKSDHLMAAAKGLFADVPRKRTGFPNVTRAPDSSQSHTGINQDPVTQSILNE
                     SIIEPQALNEVDDAGEQSTAHSQSEDSENELPNSLSQHSNRSTERFLHQLKEENSELI
                     NQLWTDIQQKIATQSQRTPPGSPSSELSAEDQKAALNATDAVKRIQAGPQPEEAAEPV
                     DFSSSYLGQVLNTRKQKPLLAKVKRKQDMHAASKQKTNMLSSSTASADRPSSTGSSLD
                     VLKHVIHEVEHEMEEYERCTGREVTGLQGGQGLTGFTLSLVSSLCRLVRYLKESEIQL
                     RKEVETRQQLEQMLGDHRELIDALTAEILSLREENSTMQARLQQYMVTTDEQLISLTH
                     AIKNCPVINNSRQESQAPERAAMGRRLVDNVEGPVISSNGSMPLMFRGEEVVEFPQEE
                     LPVKLSQGPTPTENLNLANNFPTHIFEPAVMLTPPRQKSNSEFSPLQDVLRRTVQTRP
                     APRIPPTVEVIEKEQNWEKKALPIDPDIQNSSEENRLFTQRWRVSHMGEDLENKGQPA
                     FVSLSQPPCSSLPSTQQPRNPVLSEEPTVLGDGQQLRTSEALVQRKDIMARIAELTLQ
                     NSAIKAHLNNITSSGGEQGDGLREPRKQGSASEVSTNFPAVQSLTPSSMEERIAELNR
                     QSMEARSKLLQLIEQQKLVGLNLSSSPVSPVESPLRAWAEEGKRTIEVSVPGMEASES
                     SKCNTVSPVSGNSSRRSSGAISNSCSPLNATSGSGKFTPVNPRTKTEKKNEEGWFALS
                     AHIP"
     exon            149..244
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            245..292
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            293..436
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            437..539
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            540..646
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            647..762
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            763..902
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1043
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1309
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1441
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1592
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1817
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2302
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2486
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2589
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2677
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..4386
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3102..3107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="hexamer: AATAAA"
     polyA_site      3129
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="major polyA site"
     regulatory      4257..4262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="hexamer: AGTAAA"
     polyA_site      4279
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
     regulatory      4362..4367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
                     /note="hexamer: AATAAA"
     polyA_site      4386
                     /gene="Spice1"
                     /gene_synonym="Ccdc52; D16Ertd480e"
ORIGIN      
        1 actttccgcg ttcccccgtg gcgggctctg tggttctgga ggctgaactt ttagtcgggg
       61 cggaggcaca gtcggccagc ggcaagtggg ctccattaaa atcttacgag ggagtaaaac
      121 gttgagatcc ctgtatccct gtatccggat gtcattgatc agagtgaacc gctttggtcc
      181 ccggggaggt ggaagaaaaa ctctgaaagt aaagaagaaa gctgcagtga ggcaagaatg
      241 ggataatact gtgaatgatc taacagttca ccgggcaact cctgaagatc tagtgcgccg
      301 tcatgagatg cacaagtcaa agaatagagc attggtgcac tgggaacttc aagaaaaagc
      361 tttgaagaga aaatggaaga agcagaaacc agaaacttca agtcttgaaa aaagaaagtt
      421 atctatcatg aaggagattc tctctgatca atacctgaca caggatgtgc tggaaaagtc
      481 cgatcatctg atggctgcag ccaaaggtct gtttgctgat gttcctcgta agcgcacagg
      541 gtttccaaat gtaacaaggg ctccagattc ctcacagagc cacactggaa taaatcaaga
      601 ccctgtcacc cagtctatcc ttaatgaatc aatcatagag cctcaggctc ttaatgaagt
      661 cgacgatgca ggggagcaga gcactgctca cagccagtca gaagacagcg agaatgaatt
      721 gcctaactcc ctcagccagc attctaacag gagtacagag aggtttcttc accaactaaa
      781 ggaagagaat tccgagttaa tcaatcaact gtggactgat attcagcaga aaatcgctac
      841 ccagtcacaa agaactcctc caggatctcc gtcctcggag ctttcagccg aggatcagaa
      901 agctgctctg aatgcaacgg atgctgtcaa gagaatccag gctgggcctc agcctgagga
      961 ggctgctgag cctgtagact tcagctccag ctacctggga caggtgctaa acacaaggaa
     1021 gcaaaagccg ctgctagcta aagtgaaaag aaaacaagat atgcatgctg cctccaagca
     1081 gaagacaaac atgctgtcct ccagcacagc ctctgcagac agacccagta gcactggctc
     1141 cagcctggac gttctcaaac acgtgatcca tgaagtggag cacgagatgg aagagtatga
     1201 gcggtgcaca gggcgtgagg tcacggggct gcagggtggt cagggactca caggcttcac
     1261 cctgtccctg gtgagctctc tctgccgcct ggttcggtac cttaaagaga gtgaaatcca
     1321 acttcggaaa gaagtagaga caaggcagca gctggaacag atgttaggtg atcaccgaga
     1381 gctcattgat gccctgacag ctgaaatcct ctccctcaga gaagagaata gtaccatgca
     1441 ggcgagactt cagcagtaca tggttaccac agatgagcag ctcatatcgc tcacacatgc
     1501 cattaagaac tgtcctgtga taaataactc cagacaagaa agtcaagcac cagaaagggc
     1561 agctatgggt agaagacttg tggataatgt agagggtcct gttataagca gtaatggctc
     1621 catgccattg atgttcagag gggaagaagt ggttgaattc ccacaggaag agttgcctgt
     1681 taaactatct caggggccaa cccccacaga aaacttgaat ctggccaata atttcccaac
     1741 ccatattttc gagccagctg tgatgctaac accacccagg cagaagagca actcagaatt
     1801 ctctcctctc caggatgttc tgaggaggac tgttcagact cgtccggccc cacgaattcc
     1861 ccccactgtg gaagttatag agaaggagca gaactgggaa aagaaggccc tgcctattga
     1921 tccagacatt cagaactcaa gtgaggaaaa ccgtctcttc actcagaggt ggagagtctc
     1981 gcacatggga gaagacctgg agaacaaagg gcagccagca tttgttagcc tgtcacagcc
     2041 gccttgtagt tcccttccca gcactcagca gccaagaaac cccgtgttgt cagaggagcc
     2101 cactgtgctt ggagatgggc agcagctcag aacatcggag gccctggtgc agaggaagga
     2161 cattatggcc cggatcgccg agctcacact gcagaattca gccatcaagg cccacctgaa
     2221 caatattacc agctcagggg gagagcaagg tgatggactg cgggagccac gcaaacaggg
     2281 aagtgccagt gaagtgtcta ctaatttccc agcagttcag tctttaacgc caagtagcat
     2341 ggaggagcgg attgcagagt tgaaccgaca gagcatggag gcgcgcagca aactgctcca
     2401 gctgatagag cagcagaaac ttgtgggctt gaacctttcc tcatcaccgg tgtcacccgt
     2461 ggagtcacct ctcagagcgt gggccgaaga aggaaagcga accatcgagg tgtctgttcc
     2521 aggaatggag gcttcagaga gttcaaaatg caatactgtg tctcctgtca gtgggaacag
     2581 ttcaagaaga tcgtcagggg cgatcagcaa ttcttgttct ccactaaacg ccacctcagg
     2641 aagtgggaag ttcacaccag ttaatccaag aacaaagact gaaaaaaaaa atgaagaagg
     2701 ttggtttgct ctctctgccc acataccgta agtgaagccc cagcagagag tgtcctcagt
     2761 gacttattcc tggcctttcc ttcgcacttc acagattcca tttcaagtta ataacatttt
     2821 tcttcagata aaacctgcat aggtatcctg tatttatgga aacagaaaaa agaattattt
     2881 taatatttta ccttttcaaa tgttttttca acaaagcacc tctaattccc tgtgagtaaa
     2941 gctttgcagg agtttaagtt ttatatttgt ttagccttgt taaatgcatt agtgatacat
     3001 tgttactttt gtcattttgg ttgaatgttt gtttgttatt tagtgcatct taaatgcaat
     3061 caccttccca caagaactaa ttggctttat gtataactta aaataaagtt gttctggctt
     3121 tcagaaaaac gtgatacttt ttttttctat tatccatcat ttcaaattga atgtacagct
     3181 ttaagaaaac taaaggctgg ggctgtggtg cacacctata atcttaatgt tgacttagaa
     3241 gccggaggca agggctgtgt agtatataat gagttccaca ccagtctgag ctccgtagag
     3301 aaccctgtct caacaaaaga acgggaagtg ggtggaggaa tgtctatttt ctttaagcac
     3361 gtaaaagtag ctatgtgttt aataaaaatc ttatggagtt tttaagtgtg aaaatttcaa
     3421 aatgataatg cccatctagt aagtaatgat tgttggggtc cagtagttgc cccacaaacc
     3481 acacagtcac tgccctcagt cagacaggaa tggttaattg aacgcacacc ctgaaactga
     3541 tcagtcaagg ccatagctta gagttcaggg ctgaggctat gaccctgagc atctttctct
     3601 gtcagcttat taaggctaaa actgtaaaaa ccacagtgag ctcatatgca ggagcagaaa
     3661 gtgctgccca gtaggctgac tcaagccatt tcagatctaa cagttcatac tgacctttaa
     3721 tttgatgggt cctacctaaa gctttgtggc atttcttaag ataaacaaac ctcagaacat
     3781 aggaaacata acagggtatg tggtcagcat gaacctgctc tgagtcaatt atttttctgt
     3841 gtcagtaact ggcaagcata ttatagcaac gatatgaagt tgttggcagg catggaacaa
     3901 aatggctaca gctatcctgg gggttgggcc ggcctcaaca atggtaatga ccattttgtt
     3961 caaatgtcta aatgcagtac actgatttta tgattatgtt agaaacttag aaaaagaaat
     4021 ataaaaaact gttagtcatt tccttgccct aacttaccta aaatggattg tctttcatgt
     4081 actgactgtt tctcaaatgt tggcttctgt tttcagtttg tctcagtgat aactgccatg
     4141 ctatgttagt aattttcaac ttgagtgagt tgggaggggg aaagggtcac actgaagctc
     4201 ccctgactca gcgctcccct cccctcccct ccctgggctt ctaaattaca gcaaaaagta
     4261 aaatgatttt cttctggcac tggtgaagtt gtgtggagtc tgtatttgtt ttacgtcttg
     4321 cagatgtcgt cccctcgtcc tgtacatttt gtaagttgtt taataaagac tgtctggtgg
     4381 cttgaa
//
