LOCUS       NM_011461               1266 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Spi-C transcription factor (Spi-1/PU.1 related)
            (Spic), mRNA.
ACCESSION   NM_011461
VERSION     NM_011461.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1266)
  AUTHORS   Lamacova,L., Jansova,D., Jiang,Z., Dvoran,M., Aleshkina,D.,
            Iyyappan,R., Jindrova,A., Fan,H.Y., Jiao,Y. and Susor,A.
  TITLE     CPEB3 Maintains Developmental Competence of the Oocyte
  JOURNAL   Cells 13 (10), 850 (2024)
   PUBMED   38786074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1266)
  AUTHORS   Mirzadeh Azad,F., Struys,E.A., Wingert,V., Hannibal,L., Mills,K.,
            Jansen,J.H., Longley,D.B., Stunnenberg,H.G. and Atlasi,Y.
  TITLE     Spic regulates one-carbon metabolism and histone methylation in
            ground-state pluripotency
  JOURNAL   Sci Adv 9 (33), eadg7997 (2023)
   PUBMED   37595034
  REMARK    GeneRIF: Spic regulates one-carbon metabolism and histone
            methylation in ground-state pluripotency.
REFERENCE   3  (bases 1 to 1266)
  AUTHORS   Xu,L.S., Zhu,J.T., Raczkowski,H.L., Batista,C.R. and DeKoter,R.P.
  TITLE     Spi-C and PU.1 Counterregulate Rag1 and Igkappa Transcription to
            Effect Vkappa-Jkappa Recombination in Small Pre-B Cells
  JOURNAL   J Immunol 211 (1), 71-80 (2023)
   PUBMED   37195219
  REMARK    GeneRIF: Spi-C and PU.1 Counterregulate Rag1 and Igkappa
            Transcription to Effect Vkappa-Jkappa Recombination in Small Pre-B
            Cells.
REFERENCE   4  (bases 1 to 1266)
  AUTHORS   Tao,X., Zhang,R., Du,R., Yu,T., Yang,H., Li,J., Wang,Y., Liu,Q.,
            Zuo,S., Wang,X., Lazarus,M., Zhou,L., Wang,B., Yu,Y. and Shen,Y.
  TITLE     EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic
            stellate cells in a murine liver fibrosis model
  JOURNAL   J Exp Med 219 (5) (2022)
   PUBMED   35420633
REFERENCE   5  (bases 1 to 1266)
  AUTHORS   Okreglicka,K., Iten,I., Pohlmeier,L., Onder,L., Feng,Q., Kurrer,M.,
            Ludewig,B., Nielsen,P., Schneider,C. and Kopf,M.
  TITLE     PPARgamma is essential for the development of bone marrow
            erythroblastic island macrophages and splenic red pulp macrophages
  JOURNAL   J Exp Med 218 (5) (2021)
   PUBMED   33765133
REFERENCE   6  (bases 1 to 1266)
  AUTHORS   Kosmider,O., Denis,N., Lacout,C., Vainchenker,W., Dubreuil,P. and
            Moreau-Gachelin,F.
  TITLE     Kit-activating mutations cooperate with Spi-1/PU.1 overexpression
            to promote tumorigenic progression during erythroleukemia in mice
  JOURNAL   Cancer Cell 8 (6), 467-478 (2005)
   PUBMED   16338660
  REMARK    GeneRIF: The Kit-activating mutations cooperate with Spi-1/PU.1
            overexpression to promote tumorigenic progression during
            erythroleukemia in mice.
REFERENCE   7  (bases 1 to 1266)
  AUTHORS   Carlsson,R., Persson,C. and Leanderson,T.
  TITLE     SPI-C, a PU-box binding ETS protein expressed temporarily during
            B-cell development and in macrophages, contains an acidic
            transactivation domain located to the N-terminus
  JOURNAL   Mol Immunol 39 (16), 1035-1043 (2003)
   PUBMED   12749910
REFERENCE   8  (bases 1 to 1266)
  AUTHORS   Carlsson,R., Hjalmarsson,A., Liberg,D., Persson,C. and
            Leanderson,T.
  TITLE     Genomic structure of mouse SPI-C and genomic structure and
            expression pattern of human SPI-C
  JOURNAL   Gene 299 (1-2), 271-278 (2002)
   PUBMED   12459275
REFERENCE   9  (bases 1 to 1266)
  AUTHORS   Hashimoto,S., Nishizumi,H., Hayashi,R., Tsuboi,A., Nagawa,F.,
            Takemori,T. and Sakano,H.
  TITLE     Prf, a novel Ets family protein that binds to the PU.1 binding
            motif, is specifically expressed in restricted stages of B cell
            development
  JOURNAL   Int Immunol 11 (9), 1423-1429 (1999)
   PUBMED   10464163
REFERENCE   10 (bases 1 to 1266)
  AUTHORS   Bemark,M., Martensson,A., Liberg,D. and Leanderson,T.
  TITLE     Spi-C, a novel Ets protein that is temporally regulated during B
            lymphocyte development
  JOURNAL   J Biol Chem 274 (15), 10259-10267 (1999)
   PUBMED   10187812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137522.1 and BC064038.1.
            
            On Jan 18, 2008 this sequence version replaced NM_011461.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064038.1, AK156892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1261              AK137522.1         4-1264
            1262-1266           BC064038.1         1223-1227
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.14 cM"
     gene            1..1266
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /note="Spi-C transcription factor (Spi-1/PU.1 related)"
                     /db_xref="GeneID:20728"
                     /db_xref="MGI:MGI:1341168"
     exon            1..49
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /inference="alignment:Splign:2.1.0"
     exon            50..145
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..871
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /note="pu.1-related factor"
                     /codon_start=1
                     /product="transcription factor Spi-C"
                     /protein_id="NP_035591.3"
                     /db_xref="CCDS:CCDS36023.1"
                     /db_xref="GeneID:20728"
                     /db_xref="MGI:MGI:1341168"
                     /translation="MTCCIDQDSLGQTFQDAIDILIQQSAGESQYSSENRNYMAIINP
                     YPHVRGNANYYGMSPTENPLYDWRGVTNGSADLYLEGGFHQSVQNIAESQLVQPPFFQ
                     QKGGRGRRKLRLFEYLFESLCNSEMVSCIQWVDKARGIFQFISKNKETLAELWGQRKG
                     NRKPMTYQKMARALRNYARTGEIIKIRRKLTYQFSEAVLQRLAPANYLGKDLFYPQYG
                     QPDQGYLSLNHWNANHYAHGSYQS"
     exon            146..242
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /inference="alignment:Splign:2.1.0"
     exon            243..355
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /inference="alignment:Splign:2.1.0"
     exon            356..464
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /inference="alignment:Splign:2.1.0"
     exon            465..1266
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1237..1242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /note="hexamer: AATAAA"
     polyA_site      1266
                     /gene="Spic"
                     /gene_synonym="Prf; Spi-C"
                     /note="major polyA site"
ORIGIN      
        1 gatagcgtcc ttgacatttc agtacagata tcgccacttg gttttcctga acgtgtattg
       61 aactcagagc ctgctgcaag ccagtgtgca cgcgcttact cgctgacatt tccgcaaccc
      121 aagactcttc aattcatgaa taatgacttg ttgtattgat caagacagtt tggggcaaac
      181 atttcaagac gccattgaca tattgatcca acaatcagct ggagaaagtc aatactcctc
      241 agaaaataga aattacatgg ctatcattaa cccttatcct cacgtcagag gcaacgctaa
      301 ctactatgga atgtcaccca cagagaaccc cctctatgac tggagaggtg taacaaatgg
      361 ttctgcagac ctgtatttgg aaggaggctt ccaccaatcc gtacagaaca tagctgaaag
      421 ccagctggta caacccccct tcttccagca aaagggagga agaggcagga gaaagcttcg
      481 gctgtttgaa taccttttcg aatccctgtg caattcagag atggtgtctt gtattcagtg
      541 ggttgacaaa gccagaggca tctttcagtt tatatcaaaa aacaaagaaa cactcgctga
      601 actctggggg cagagaaaag gcaaccggaa acccatgact taccagaaga tggccagagc
      661 cctgaggaat tatgccagaa ctggggagat cataaaaatc cggagaaagc tgacctacca
      721 gttcagcgag gctgttctcc aaagacttgc tccagctaac tacctgggaa aagacctctt
      781 ctaccctcag tatggccaac ctgatcaggg ctacctcagt ttaaaccact ggaatgcaaa
      841 tcactatgct cacggcagtt accagagctg accccagctt cttgcctcgc tagtgtctgt
      901 cagaaaagcc aagctctaga atgtctccaa agcacttttc aggttccaca ctaagaaggc
      961 aaaaacaaac aacaaacaac aaaacagaaa aatatgcaga gagacacaga acatgtttga
     1021 acttctgaga accttccagg cagtgtttac atattggtgt taaaagaaac ctagatgttt
     1081 cagaagggta cttacaattc cggcagacac tttgctattt ctaataaagt cttagtgtcc
     1141 atggattggg tatccaagaa catcctggag ccagaatgtc ttcagaaaaa tgtgggggag
     1201 accagcatag ggccacttag taattttata aattgaaata aacaattgca tttgaagcaa
     1261 ctgaaa
//
