LOCUS       NM_019866               2786 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Spi-B transcription factor (Spi-1/PU.1 related)
            (Spib), mRNA.
ACCESSION   NM_019866 XM_620488
VERSION     NM_019866.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2786)
  AUTHORS   Sasaki,T., Ota,Y., Takikawa,Y., Terrooatea,T., Kanaya,T.,
            Takahashi,M., Taguchi-Atarashi,N., Tachibana,N., Yabukami,H.,
            Surh,C.D., Minoda,A., Kim,K.S. and Ohno,H.
  TITLE     Food antigens suppress small intestinal tumorigenesis
  JOURNAL   Front Immunol 15, 1373766 (2024)
   PUBMED   39359724
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2786)
  AUTHORS   Kim,N., Ju,I.G., Jeon,S.H., Lee,Y., Jung,M.J., Gee,M.S., Cho,J.S.,
            Inn,K.S., Garrett-Sinha,L.A., Oh,M.S. and Lee,J.K.
  TITLE     Inhibition of microfold cells ameliorates early pathological
            phenotypes by modulating microglial functions in Alzheimer's
            disease mouse model
  JOURNAL   J Neuroinflammation 20 (1), 282 (2023)
   PUBMED   38012646
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2786)
  AUTHORS   Horiuchi,S., Koike,T., Takebuchi,H., Hoshino,K., Sasaki,I.,
            Fukuda-Ohta,Y., Kaisho,T. and Kitamura,D.
  TITLE     SpiB regulates the expression of B-cell-related genes and increases
            the longevity of memory B cells
  JOURNAL   Front Immunol 14, 1250719 (2023)
   PUBMED   37965309
  REMARK    GeneRIF: SpiB regulates the expression of B-cell-related genes and
            increases the longevity of memory B cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2786)
  AUTHORS   Michelson,D.A., Zuo,C., Verzi,M., Benoist,C. and Mathis,D.
  TITLE     Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver
            development within the thymus
  JOURNAL   J Exp Med 220 (10) (2023)
   PUBMED   37399024
REFERENCE   5  (bases 1 to 2786)
  AUTHORS   Givony,T., Leshkowitz,D., Del Castillo,D., Nevo,S., Kadouri,N.,
            Dassa,B., Gruper,Y., Khalaila,R., Ben-Nun,O., Gome,T., Dobes,J.,
            Ben-Dor,S., Kedmi,M., Keren-Shaul,H., Heffner-Krausz,R., Porat,Z.,
            Golani,O., Addadi,Y., Brenner,O., Lo,D.D., Goldfarb,Y. and
            Abramson,J.
  TITLE     Thymic mimetic cells function beyond self-tolerance
  JOURNAL   Nature 622 (7981), 164-172 (2023)
   PUBMED   37674082
  REMARK    Erratum:[Nature. 2023 Dec;624(7991):E4. doi:
            10.1038/s41586-023-06881-0.. PMID: 38036683]
REFERENCE   6  (bases 1 to 2786)
  AUTHORS   Chen,H.M., Gonzalez,D.A., Radomska,H.S., Voso,M.T., Sun,Z.,
            Zhang,P., Zhang,D.E. and Tenen,D.G.
  TITLE     Two promoters direct expression of the murine Spi-B gene, an Ets
            family transcription factor
  JOURNAL   Gene 207 (2), 209-218 (1998)
   PUBMED   9511763
REFERENCE   7  (bases 1 to 2786)
  AUTHORS   Su,G.H., Chen,H.M., Muthusamy,N., Garrett-Sinha,L.A., Baunoch,D.,
            Tenen,D.G. and Simon,M.C.
  TITLE     Defective B cell receptor-mediated responses in mice lacking the
            Ets protein, Spi-B
  JOURNAL   EMBO J 16 (23), 7118-7129 (1997)
   PUBMED   9384589
REFERENCE   8  (bases 1 to 2786)
  AUTHORS   Peters,L.L., Ciciotte,S.L., Su,G.H. and Simon,M.C.
  TITLE     The gene encoding the transcription factor Spi-B maps to mouse
            chromosome 7
  JOURNAL   Mamm Genome 8 (6), 452-453 (1997)
   PUBMED   9166596
REFERENCE   9  (bases 1 to 2786)
  AUTHORS   Su,G.H., Ip,H.S., Cobb,B.S., Lu,M.M., Chen,H.M. and Simon,M.C.
  TITLE     The Ets protein Spi-B is expressed exclusively in B cells and T
            cells during development
  JOURNAL   J Exp Med 184 (1), 203-214 (1996)
   PUBMED   8691135
REFERENCE   10 (bases 1 to 2786)
  AUTHORS   Ray,D., Bosselut,R., Ghysdael,J., Mattei,M.G., Tavitian,A. and
            Moreau-Gachelin,F.
  TITLE     Characterization of Spi-B, a transcription factor related to the
            putative oncoprotein Spi-1/PU.1
  JOURNAL   Mol Cell Biol 12 (10), 4297-4304 (1992)
   PUBMED   1406622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAAA01070168.1.
            
            On May 25, 2005 this sequence version replaced XM_620488.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141118.1, SRR4048177.49025.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CAAA01070168.1     17771-17811
            42-69               CAAA01070168.1     18596-18623
            70-142              CAAA01070168.1     19917-19989
            143-372             CAAA01070168.1     20238-20467
            373-523             CAAA01070168.1     20859-21009
            524-2786            CAAA01070168.1     21589-23851
FEATURES             Location/Qualifiers
     source          1..2786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.83 cM"
     gene            1..2786
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /note="Spi-B transcription factor (Spi-1/PU.1 related)"
                     /db_xref="GeneID:272382"
                     /db_xref="MGI:MGI:892986"
     exon            1..41
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..822
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /note="Spi-1/PU.1 related; Ets transcription factor Spi-B"
                     /codon_start=1
                     /product="transcription factor Spi-B"
                     /protein_id="NP_063919.1"
                     /db_xref="CCDS:CCDS21209.1"
                     /db_xref="GeneID:272382"
                     /db_xref="MGI:MGI:892986"
                     /translation="MLALEAAQLDGPHLSCLYPEGVFYDLDSCKPFSYPDSDGGLDST
                     WGWTEAPPAPAIAPYEAFDPATAAFSHSQTVQLCYSHGPNPSTYSPMGTLDPAPSLEA
                     PGPGLQVYPPEDFTSQTLGSLAYAPYPSPVLSEEEDIMLDSPALEVSDSESDEALLAG
                     SEGRGSEAGARKKLRLYQFLLGLLLRGDMRECVWWVEPGAGVFQFSSKHKELLARRWG
                     QQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPASRHV"
     exon            42..69
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /inference="alignment:Splign:2.1.0"
     exon            70..142
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /inference="alignment:Splign:2.1.0"
     exon            143..372
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /inference="alignment:Splign:2.1.0"
     exon            373..523
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /inference="alignment:Splign:2.1.0"
     exon            524..2786
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2762..2767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /note="hexamer: AATAAA"
     polyA_site      2779
                     /gene="Spib"
                     /gene_synonym="Spi-B"
                     /note="major polyA site"
ORIGIN      
        1 agcctgctct gaaccaccat gcttgctctg gaggctgcac agctggatgg cccacactta
       61 agctgtttgt acccagaagg agtcttctac gacctggaca gctgcaagcc cttcagttac
      121 ccagattcag atgggggcct tgactctaca tggggctgga cagaggcccc gcctgctcct
      181 gccatcgctc cctatgaagc cttcgatcct gctactgctg cctttagcca ctcccaaact
      241 gttcagctct gttatagcca tggtcctaac ccctccacct atagccccat ggggaccctc
      301 gacccagccc ccagcttgga ggccccaggg cctggcctcc aggtgtaccc cccagaggac
      361 ttcaccagcc agaccctggg ctccttggct tatgctccgt accccagccc tgtgctatca
      421 gaggaagaag acattatgct ggacagcccc gccctggagg tctcggacag tgagtcagac
      481 gaggccctct tggctggctc cgaggggagg ggatctgagg caggtgcacg caagaagctg
      541 cgcctgtacc agttcttgct ggggttgctc ctacgcgggg acatgcgcga gtgcgtgtgg
      601 tgggtggagc caggtgccgg cgtcttccag ttctcctcca agcacaagga gttgttggct
      661 cgccgctggg gccagcagaa gggcaaccgc aagcgcatga cgtatcagaa gctggcccga
      721 gcgctgcgca actatgccaa gacaggcgaa atccgcaagg tcaaacgcaa actcacctac
      781 cagtttgaca gcgcgctgct gccagcctcc cggcatgtct gagcactccg ctaaggaccc
      841 ctttctggcc cctaagtccc atggagcccc atatgagggc agtcagggtt ctcagctctc
      901 cctagagcct ccccagagtt tcctgtgccg tgtataggat tccaatctag gatggtcgtg
      961 tttgagggag cactggccat tctacacggt ttcagaatgg caggtttctc gggggggggg
     1021 gggatggggg agccctgatg tcgtctacgg ttccagaaac cgcagttctt gcgagtcctg
     1081 tgagctcaca tgacatctca ccagcaggtg gcgctgtcta cagccccccc caaacccttg
     1141 ttttgttggc cagataggtc ggtccctctg tactccccct gaagcccttg ttagatctga
     1201 ggtctagtta tgtttggagc tctctgagaa ccctgtgcca cctgtgtgtg acttttctct
     1261 gcgtccgttt atgacttttg tttgtttgag acagggtctc attatgtagc tcaggctggc
     1321 cccccaactt ttaacaatcg tcctgcctcg gcctcctgag tgctgggatg acaagggtgc
     1381 accatcacac caggtttttt ccttttttga gagattttac tatgtaaccc gggctgggct
     1441 attctcaagc tagtggcagt cctcttgcct caggctcctc ttgcctcagg caccccttgg
     1501 gaccctctgg gacctatgtc cgagatgaat ggctgggtaa ggtagggtgg gaggttcagt
     1561 gaaccttata ggttgggccc ttccttctgg gatcccttga tcatatggga agttctctag
     1621 gctctcagca gccctgcatt cacacactga ctgaggcgcg acctgtatgt tgtgtttgag
     1681 ggggatgtgt ggcagaggta tggctgtggc aaggccggtg ccttttattc ttgagattga
     1741 gtcttatgta gctcaggctg gtcttgaact cactctcact gtgtagctag ggaagacctt
     1801 gagcccttgc ctcagccaga atgctcagat gtcaggcagc gcaccacgtg actgtttctt
     1861 tccattgtct tgtctttttg ttgttgttgt tttcgagaca gggtttctct gtgtagccct
     1921 ggccgttctg gaactcactc tgtagaccag gctggcctta aactcagaaa tccacctgcc
     1981 tctgcctctc aaatgctggg attaaaggcg tgcaccacca cgcccttttt cctttttctt
     2041 aagtcaaggt ctatttgtgt agcccaggct ggcttcaagc tcatgacact cttcctgcct
     2101 ctgcgtctgg aactatgaac ataccttact actctgtgct tacccacgcc atgggtagac
     2161 agacttctag acttggtcaa cccccaccca caaggcaggc aaattaagtc cctgcaggtg
     2221 ctttctttgg aggaaagccc gctttcatag tgatctgtca agctagaaag cactcccgcc
     2281 acccagatat ctaagtgtga atctttggac aactggtgac ttctggccag cttttctggg
     2341 gccggcctct gtccaggtgt ctgcccagga ccctgctcag tgcctgtctg tctcacacca
     2401 gtgacttcct cacacccgcc tgttcaggcc cagtcttttc cgttcaagtg ctacaggcca
     2461 agtaggctca aactgtgggt ttgtcttggg catccacagc agaatcagaa cccagagctt
     2521 tgaagcctga gtgaggggag gggggcactc aggcttccgt ctctctgaga aacagacgat
     2581 gaagaggccc ttaaaactct ttgcaacccc atgagcctcc ccaatgagcc tgtgacacac
     2641 cggaactcac ctctgtgggt ggccgggagg gggaacaggg tcatggaaga tccagatgtc
     2701 catgtggtca aggctaaact gtactaaata aaattatttc tcatcaccac tatacatgca
     2761 taataaataa agtgtacatc aaaatt
//
