LOCUS       NP_975009                617 aa            linear   ROD 12-NOV-2024
DEFINITION  sphingosine kinase 2 [Mus musculus].
ACCESSION   NP_975009
VERSION     NP_975009.1
DBSOURCE    REFSEQ: accession NM_203280.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 617)
  AUTHORS   Yokoyama,S., Koo,I., Aibara,D., Tian,Y., Murray,I.A., Collins,S.L.,
            Coslo,D.M., Kono,M., Peters,J.M., Proia,R.L., Gonzalez,F.J.,
            Perdew,G.H. and Patterson,A.D.
  TITLE     Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear
            Translocation and Target Gene Activation
  JOURNAL   Adv Sci (Weinh) 11 (40), e2400794 (2024)
   PUBMED   39207053
  REMARK    GeneRIF: Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor
            Nuclear Translocation and Target Gene Activation.
REFERENCE   2  (residues 1 to 617)
  AUTHORS   Diaz Escarcega,R., Murambadoro,K., Valencia,R.,
            Moruno-Manchon,J.F., Furr Stimming,E.E., Jung,S.Y. and
            Tsvetkov,A.S.
  TITLE     Sphingosine kinase 2 regulates protein ubiquitination networks in
            neurons
  JOURNAL   Mol Cell Neurosci 130, 103948 (2024)
   PUBMED   38909878
  REMARK    GeneRIF: Sphingosine kinase 2 regulates protein ubiquitination
            networks in neurons.
REFERENCE   3  (residues 1 to 617)
  AUTHORS   Green,C.D., Brown,R.D.R., Uranbileg,B., Weigel,C., Saha,S.,
            Kurano,M., Yatomi,Y. and Spiegel,S.
  TITLE     Sphingosine kinase 2 and p62 regulation are determinants of sexual
            dimorphism in hepatocellular carcinoma
  JOURNAL   Mol Metab 86, 101971 (2024)
   PUBMED   38925249
  REMARK    GeneRIF: Sphingosine kinase 2 and p62 regulation are determinants
            of sexual dimorphism in hepatocellular carcinoma.
REFERENCE   4  (residues 1 to 617)
  AUTHORS   Muller,T., Krieg,N., Lange-Polovinkin,A.I., Wissuwa,B.,
            Graler,M.H., Dennhardt,S. and Coldewey,S.M.
  TITLE     Deletion of Sphingosine Kinase 2 Attenuates Acute Kidney Injury in
            Mice with Hemolytic-Uremic Syndrome
  JOURNAL   Int J Mol Sci 25 (14), 7683 (2024)
   PUBMED   39062926
  REMARK    GeneRIF: Deletion of Sphingosine Kinase 2 Attenuates Acute Kidney
            Injury in Mice with Hemolytic-Uremic Syndrome.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 617)
  AUTHORS   Weigel,C., Maczis,M.A., Palladino,E.N.D., Green,C.D., Maceyka,M.,
            Guo,C., Wang,X.Y., Dozmorov,M.G., Milstien,S. and Spiegel,S.
  TITLE     Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable
            Tumor Microenvironment in Breast Cancer
  JOURNAL   Cancer Res 83 (4), 553-567 (2023)
   PUBMED   36541910
  REMARK    GeneRIF: Sphingosine Kinase 2 in Stromal Fibroblasts Creates a
            Hospitable Tumor Microenvironment in Breast Cancer.
REFERENCE   6  (residues 1 to 617)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   7  (residues 1 to 617)
  AUTHORS   Igarashi,N., Okada,T., Hayashi,S., Fujita,T., Jahangeer,S. and
            Nakamura,S.
  TITLE     Sphingosine kinase 2 is a nuclear protein and inhibits DNA
            synthesis
  JOURNAL   J Biol Chem 278 (47), 46832-46839 (2003)
   PUBMED   12954646
  REMARK    GeneRIF: a functional nuclear localization signal is mapped to the
            N-terminal region of SPHK2
REFERENCE   8  (residues 1 to 617)
  AUTHORS   Liu,H., Toman,R.E., Goparaju,S.K., Maceyka,M., Nava,V.E.,
            Sankala,H., Payne,S.G., Bektas,M., Ishii,I., Chun,J., Milstien,S.
            and Spiegel,S.
  TITLE     Sphingosine kinase type 2 is a putative BH3-only protein that
            induces apoptosis
  JOURNAL   J Biol Chem 278 (41), 40330-40336 (2003)
   PUBMED   12835323
  REMARK    GeneRIF: the apoptotic effect of SphK2 might be because of its
            putative BH3 domain
REFERENCE   9  (residues 1 to 617)
  AUTHORS   Yoshimoto,T., Furuhata,M., Kamiya,S., Hisada,M., Miyaji,H.,
            Magami,Y., Yamamoto,K., Fujiwara,H. and Mizuguchi,J.
  TITLE     Positive modulation of IL-12 signaling by sphingosine kinase 2
            associating with the IL-12 receptor beta 1 cytoplasmic region
  JOURNAL   J Immunol 171 (3), 1352-1359 (2003)
   PUBMED   12874225
  REMARK    GeneRIF: SPHK2 associates with the interleukin (IL)-12 receptor
            beta 1 cytoplasmic region and appears to be involved in the
            positive modulation of IL-12 signaling, especially IL-12-induced
            interferon-gamma production.
REFERENCE   10 (residues 1 to 617)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY256088.1, AK151990.1 and
            AC167242.4.
            
            Summary: This gene encodes a kinase that phosphorylates sphingosine
            into sphingosine-1-phosphate, which is involved in cell
            differentiation, motility, and apoptosis. The encoded protein plays
            a role in maintaining cellular levels of sphingosine-1-phosphate.
            The gene product also enhances apoptosis in different cell types
            and suppresses cellular proliferation. In mast cells, the encoded
            protein is necessary for influx of calcium, protein kinase C
            activation, and cytokine production and degranulation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) encodes the same protein as
            variants 2 and 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053737.1, AK151990.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.45 cM"
     Protein         1..617
                     /product="sphingosine kinase 2"
                     /EC_number="2.7.1.91"
                     /calculated_mol_wt=65487
     Region          1..140
                     /region_name="Required for binding to sulfatide and
                     phosphoinositides and for membrane localization.
                     /evidence=ECO:0000250|UniProtKB:Q9NRA0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Region          87..95
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000269|PubMed:12954646"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Region          <142..608
                     /region_name="PLN02958"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase"
                     /db_xref="CDD:215517"
     Site            358
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Site            364
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Region          371..472
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Site            377
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Region          381..390
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:Q9NRA0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NRA0; propagated from
                     UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Site            386
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NRA0; propagated from
                     UniProtKB/Swiss-Prot (Q9JIA7.2)"
     Site            578
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NRA0; propagated from
                     UniProtKB/Swiss-Prot (Q9JIA7.2)"
     CDS             1..617
                     /gene="Sphk2"
                     /gene_synonym="Sk2; Spk2"
                     /coded_by="NM_203280.3:437..2290"
                     /db_xref="CCDS:CCDS21261.1"
                     /db_xref="GeneID:56632"
                     /db_xref="MGI:MGI:1861380"
ORIGIN      
        1 mapppllpva astpilhgef gsypangprf altlttqalh iqrlrpkpea rprdglvsld
       61 evsgcgtlqs rspedtaayf ciytyprgrr ggrrratrtf radgattyee nraeaqrwat
      121 altcllrgvp lsgdqeitpe llprkprlli lvnpfggrgl awqrcmdhvv pmiseaglsf
      181 nliqterqnh arelvqglsl sewegivtvs gdgllyevln glldrpdwed avrmpigvlp
      241 cgsgnalaga vnhhggfeqv vgvdlllncs lllcrggshp ldllsvtlas gsrcfsflsv
      301 awgflsdvdi hserfralgs arftlgavlg laslhtyrgr lsylpattep alpipghslp
      361 rakselvlap apapaathsp lhrsvsdlpl plpqpalvsp gspeplpdls lngggpeltg
      421 dwggagdapl spdpllpssp nalktaqlsp iaegppempa ssgflppths apeastwgpv
      481 dhllpplgsp lpqdwvtieg efvlmlgilp shlcadlmaa pharfddgvv hlcwvrsgis
      541 raallrilla mehgnhfslg cphlgyaaar afrlepltpr glltvdgelv eygpiqaqvh
      601 pglatlltgp agqkpqa
//
