LOCUS       NM_145531               7661 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus SPG11, spatacsin vesicle trafficking associated
            (Spg11), mRNA.
ACCESSION   NM_145531 XM_904251
VERSION     NM_145531.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7661)
  AUTHORS   Fortier,M., Cauhape,M., Buono,S., Becker,J., Menuet,A., Branchu,J.,
            Ricca,I., Mero,S., Dorgham,K., El Hachimi,K.H., Dobrenis,K.,
            Colsch,B., Samaroo,D., Devaux,M., Durr,A., Stevanin,G.,
            Santorelli,F.M., Colombo,S., Cowling,B. and Darios,F.
  TITLE     Decreasing ganglioside synthesis delays motor and cognitive symptom
            onset in Spg11 knockout mice
  JOURNAL   Neurobiol Dis 199, 106564 (2024)
   PUBMED   38876323
  REMARK    GeneRIF: Decreasing ganglioside synthesis delays motor and
            cognitive symptom onset in Spg11 knockout mice.
REFERENCE   2  (bases 1 to 7661)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7661)
  AUTHORS   Horner,M., Popp,S., Branchu,J., Stevanin,G., Darios,F., Klebe,S.,
            Groh,J. and Martini,R.
  TITLE     Clinically approved immunomodulators ameliorate behavioral changes
            in a mouse model of hereditary spastic paraplegia type 11
  JOURNAL   Front Neurosci 18, 1299554 (2024)
   PUBMED   38435059
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7661)
  AUTHORS   Pierga,A., Matusiak,R., Cauhape,M., Branchu,J., Danglot,L.,
            Boutry,M. and Darios,F.
  TITLE     Spatacsin regulates directionality of lysosome trafficking by
            promoting the degradation of its partner AP5Z1
  JOURNAL   PLoS Biol 21 (10), e3002337 (2023)
   PUBMED   37871017
  REMARK    GeneRIF: Spatacsin regulates directionality of lysosome trafficking
            by promoting the degradation of its partner AP5Z1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7661)
  AUTHORS   Khundadze,M., Ribaudo,F., Hussain,A., Stahlberg,H.,
            Brocke-Ahmadinejad,N., Franzka,P., Varga,R.E., Zarkovic,M.,
            Pungsrinont,T., Kokal,M., Ganley,I.G., Beetz,C., Sylvester,M. and
            Hubner,C.A.
  TITLE     Mouse models for hereditary spastic paraplegia uncover a role of
            PI4K2A in autophagic lysosome reformation
  JOURNAL   Autophagy 17 (11), 3690-3706 (2021)
   PUBMED   33618608
REFERENCE   6  (bases 1 to 7661)
  AUTHORS   Chang,J., Lee,S. and Blackstone,C.
  TITLE     Spastic paraplegia proteins spastizin and spatacsin mediate
            autophagic lysosome reformation
  JOURNAL   J Clin Invest 124 (12), 5249-5262 (2014)
   PUBMED   25365221
REFERENCE   7  (bases 1 to 7661)
  AUTHORS   Perez-Branguli,F., Mishra,H.K., Prots,I., Havlicek,S., Kohl,Z.,
            Saul,D., Rummel,C., Dorca-Arevalo,J., Regensburger,M., Graef,D.,
            Sock,E., Blasi,J., Groemer,T.W., Schlotzer-Schrehardt,U.,
            Winkler,J. and Winner,B.
  TITLE     Dysfunction of spatacsin leads to axonal pathology in SPG11-linked
            hereditary spastic paraplegia
  JOURNAL   Hum Mol Genet 23 (18), 4859-4874 (2014)
   PUBMED   24794856
  REMARK    GeneRIF: Study provides evidence that SPG11 is implicated in axonal
            maintenance and cargo trafficking.
REFERENCE   8  (bases 1 to 7661)
  AUTHORS   Murmu,R.P., Martin,E., Rastetter,A., Esteves,T., Muriel,M.P., El
            Hachimi,K.H., Denora,P.S., Dauphin,A., Fernandez,J.C.,
            Duyckaerts,C., Brice,A., Darios,F. and Stevanin,G.
  TITLE     Cellular distribution and subcellular localization of spatacsin and
            spastizin, two proteins involved in hereditary spastic paraplegia
  JOURNAL   Mol Cell Neurosci 47 (3), 191-202 (2011)
   PUBMED   21545838
REFERENCE   9  (bases 1 to 7661)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 7661)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845457.16.
            
            On Jan 5, 2023 this sequence version replaced NM_145531.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147500.1, SRR10223970.4391.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AL845457.16        163847-164102       c
            257-438             AL845457.16        160334-160515       c
            439-663             AL845457.16        158741-158965       c
            664-856             AL845457.16        157442-157634       c
            857-994             AL845457.16        154419-154556       c
            995-1443            AL845457.16        153763-154211       c
            1444-1589           AL845457.16        149634-149779       c
            1590-1722           AL845457.16        147372-147504       c
            1723-1878           AL845457.16        143827-143982       c
            1879-2054           AL845457.16        142982-143157       c
            2055-2231           AL845457.16        141316-141492       c
            2232-2303           AL845457.16        140184-140255       c
            2304-2431           AL845457.16        139142-139269       c
            2432-2607           AL845457.16        138691-138866       c
            2608-2818           AL845457.16        137883-138093       c
            2819-3022           AL845457.16        133859-134062       c
            3023-3129           AL845457.16        132589-132695       c
            3130-3275           AL845457.16        130621-130766       c
            3276-3437           AL845457.16        129126-129287       c
            3438-3504           AL845457.16        127581-127647       c
            3505-3670           AL845457.16        125959-126124       c
            3671-3876           AL845457.16        121021-121226       c
            3877-3985           AL845457.16        120230-120338       c
            3986-4145           AL845457.16        118572-118731       c
            4146-4400           AL845457.16        117781-118035       c
            4401-4601           AL845457.16        116591-116791       c
            4602-4709           AL845457.16        115595-115702       c
            4710-4872           AL845457.16        114465-114627       c
            4873-5087           AL845457.16        111971-112185       c
            5088-5835           AL845457.16        110635-111382       c
            5836-5975           AL845457.16        106648-106787       c
            5976-6174           AL845457.16        105897-106095       c
            6175-6312           AL845457.16        105426-105563       c
            6313-6446           AL845457.16        105148-105281       c
            6447-6554           AL845457.16        104069-104176       c
            6555-6723           AL845457.16        101792-101960       c
            6724-6812           AL845457.16        101423-101511       c
            6813-6968           AL845457.16        101092-101247       c
            6969-7120           AL845457.16        100106-100257       c
            7121-7661           AL845457.16        99246-99786         c
FEATURES             Location/Qualifiers
     source          1..7661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.5 cM"
     gene            1..7661
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /note="SPG11, spatacsin vesicle trafficking associated"
                     /db_xref="GeneID:214585"
                     /db_xref="MGI:MGI:2444989"
     exon            1..256
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..7301
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /note="spastic paraplegia 11 protein homolog"
                     /codon_start=1
                     /product="spatacsin"
                     /protein_id="NP_663506.2"
                     /db_xref="CCDS:CCDS50687.1"
                     /db_xref="GeneID:214585"
                     /db_xref="MGI:MGI:2444989"
                     /translation="MAAQPGPGSAASPGCAGAMERVLPMLLVRIPAEETAQLGPRAQL
                     HRELEALGSLTAAGSLQVLSLAPGSRGGSSCCLPGPFRQFLWEESQNSTSRDRPKLLV
                     AREDYELLVYEFDLRDGRCDAALLHGCCGRTLQKLTEDQGVSISFKSLRILSFHNNTS
                     LLLINRCLILRVVFPGKEPGVPVLDCLSLPLPAQAADMIIDAQLCERFLFVLSTVGLI
                     YIFNTMDGTQVAQVDLALLREDSEQLEPASVSSFTSLRVSQDLDVLVLVSSASTAVAL
                     NLHLYFRQHPGHLLCEGTLEDLPIEGPPGIDEDDLVNSAHNMKLSKVSFQVDRSWRAQ
                     LLSLNESVRGSEPEVSCCAPWFQSALRLESLESADHTPTVPTHVFIPGDVPRGRCAFP
                     QKEHVKSSDPGRPWKTMHLSEHEQPTELTCLSVTGFTALFTWAVGATSCTIGLWDLET
                     QSMQCFSLSQKCTPVDIGGDQQLCLALTDDGLSLILFGLTQEEFLNRLMIHGSASTVD
                     SLCHLNGWGRCSIPIHALEAGIENRQLDTVDFFLKSKENLLTPSSQSPAPDQQHPFSS
                     HLYLRQVEEMSPALDLLCSAIRESDSETQSKHFAEQLLHLTLSFLNKQIRELCVHTEE
                     LDEHFQKGVAILTSYINELRTFMIKFPWKPGDAIDESDVNEGVVTVKEDRVWEELSFE
                     EVIADAILNNRIPEAQTFFRISGHSAQRLEELVRIGLDLAFDSLKKNNVEEASRLLRN
                     MGFSVEDELLKICFYTTDKNIRDFLVEILKEKECFSEKERRTVDFVHQLEALYSGHFQ
                     ENAQTQAFPRYWIKEQDCFKHKSVLDTFLKYDKKDEFHKQDHRIALNWAHRWDLQTQE
                     CILLRRLSPEEYKARSPEALWRHLTARHDCSSISLWMEEFQTQETESPQQSKWPPLSA
                     DIIEQGTCCHSHMRNEILDKLARSGIFLASELEDFERLLLRLSRIGGVMQDSLPVQSY
                     KSRAGCDFHSRFILYCLEHGLQHLLYTYLDYYKLSPGNCPFLEKKELHEAHPWLEFLV
                     QCRQVSSNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGHTLLALATTMYAPGGVS
                     QVIQNEDSENCLKKVDPQLLKVALTPYPKLKAALFPQYTAPSILPSDITLYHLIQSLP
                     PFDPSRLFVWQSANTLAIGDTGSQLPHFSSPDLVSKYAVLERLNYAYYLHHGRPSFAF
                     GTFLVQELIKSKTPKQLIQQVGKEAYTLGLSSFTNPSVGAACVCFLELLGLSSLKLRV
                     DLKMANVILGSKRRDEDARSSFIRESLAEKLSKLADGDRAATEELLVLLEEGVWDSIE
                     QQGFSRLSSESSSQWALVLQFCMLHDRKLSVSYLRECAKANDWLQFLVHSQLHNYHPA
                     EVESLLQYFSPVLQSHLKLASEKLSSGSISRDDSCLQELQKNKGETSNFFEILHRCSD
                     ESTSWSWLLAEAVRHRAPILSVLASCVQGASVVSCLCVWIVTSVEDKVAAEAMGHIQI
                     SVEDHHWSLKDLSIIWRTVLTRRKSHTLIRGFQLFIKDSPLLLIMEMYELCMFFKNYE
                     KAKVKLLEFQKSLETLDTVAARVLPIIPASWMKDQVCFLLKLMPQQCETQYELGKLLQ
                     LFVGTEQLFSDGPDVQKLCLLSQVLKDTPIAISPAVISSYSTENFQRECRSILEKLKA
                     DGQFAVARRVAELAALPVDSLLIEQLTQEMQTLTHTPQWSLKQERLGFWKKCHEIFKK
                     NSISKRAASSFFSSQAPEVSEHPAEQGSLEERHLLLTLAGHWLAQEEPVPVEELEGLE
                     KQIWICRVAQHTCGGAEEEAKPSLSQHKLAAAELSFDSLASELSFSKLAALNTSKYLG
                     LNDLPSKTTCENRLKHKEQESLNTLIGQLLDGGCVHEASRVCQYFRFYSQDLVLVLHC
                     RALASAEATMEDLHSEIRALLSSAAQPEDLESPSVPLRKAHSSSSLDSQSFVMVPPTD
                     EVAQNLHTLISKCLHGKNYCRQVLCLYELAKDLGCSYGDVAARDSEAMLRAILASQRP
                     DRCRQAQVFINTQGLEADTVAELVAEEVTRELLTPSEGTGEKQPFNPAEESQTFLQLT
                     ALCQDRTLVGMKLLDKIPSVPHGELSCTTELLILAHHCFTFTCHMEGITRVLQAARML
                     TDNHLAPNEEYGLVVRLLTGIGRYNEMTYIFDLLHQKHYFEVLMRKKLDPTGTLKTAL
                     LDYIKRCRPGDSEKHNMIALCFSMCREIGENHEAAACIQLKLIESQPWEESLKDGAQL
                     KQLLLKALTLMLDAAESYAKDSCVRQALHCNRLTKLITLQIHFLNSGQNTMLINLGHQ
                     KLMDCIMTLPRFYQASIVAEAYDFVPDWAEVLYQQVILKGDFSYLEEFKQQKLLRPNI
                     FEDISKKYKQHQPTDRVTENLKKLLSYCEDIYLYYKLAYEHKFFEIVNMLLKDPQTGC
                     CLKDMLAG"
     exon            257..438
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            439..663
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            664..856
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            857..994
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1443
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1589
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1722
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1878
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2054
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2231
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2303
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2431
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2607
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2818
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..3022
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3129
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3275
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3437
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3504
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3670
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3876
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3985
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3986..4145
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4400
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4601
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4602..4709
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4872
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..5087
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5835
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..5975
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5976..6174
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6175..6312
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6313..6446
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6447..6554
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6555..6723
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6724..6812
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6813..6968
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6969..7120
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7121..7661
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7365..7370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7387
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /note="major polyA site"
     regulatory      7635..7640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7661
                     /gene="Spg11"
                     /gene_synonym="6030465E24Rik; A330015I11; C530005A01Rik"
ORIGIN      
        1 aggccaagat ggctgcccag ccagggcccg gaagtgctgc ctcccccggc tgtgccgggg
       61 ccatggagcg ggtcctgccc atgctgctgg tgcggatccc agctgaggag acggcgcagc
      121 tgggaccgcg ggcgcagctg caccgagagc tggaggccct ggggagcctg acggctgcgg
      181 gcagtctcca agtgctttcc ttggcgccgg gcagcagggg tgggagcagc tgctgcctcc
      241 caggaccctt taggcagttc ctatgggagg agtctcagaa cagcacatca agagacaggc
      301 ccaagctgct tgttgccaga gaagattatg agctgctcgt atatgaattt gacttgagag
      361 atggaagatg tgacgcagcc ttattacacg gctgttgtgg gaggacactg cagaagctca
      421 ctgaagatca aggtgtcagt atttccttca agtctttgag aattctgtca tttcacaaca
      481 acacgtcatt actgctcatc aacagatgtc tcatcctacg cgttgtgttt ccggggaaag
      541 aacctggggt cccagtgctg gactgcctct cactgcccct gcctgcacag gcagcggaca
      601 tgatcattga tgcacagctc tgtgagagat ttctttttgt tctgagcaca gtgggcttga
      661 tctatatttt taacactatg gatggcacgc aggtagcgca agtggacctg gctcttctca
      721 gagaagattc tgagcagctg gagcccgcca gtgtctcttc ctttacatcg ctgagagtgt
      781 ctcaggactt ggatgttctg gtgctggtca gctcagccag tactgcagtt gctcttaacc
      841 tacatttgta tttcaggcaa catccgggac acctactgtg tgaaggaaca ctggaagacc
      901 ttcctattga agggcctcca gggatagatg aagacgacct ggttaactct gcccacaaca
      961 tgaaactgag caaggtgtcc tttcaagttg ataggtcctg gagagcccag ctgttgtcac
     1021 tgaatgaatc agtgaggggc tcggaaccag aggtttcctg ctgtgctccg tggttccaga
     1081 gtgctttgcg tttggagtcc ctggaatctg ctgaccacac ccccactgtg ccaacccacg
     1141 ttttcattcc cggggatgtc ccacgtggcc ggtgtgcttt tcctcagaag gagcacgtga
     1201 agagcagtga tccaggaagg ccgtggaaga caatgcacct gagtgaacat gagcagccca
     1261 cggagctcac gtgcctgtct gtgacgggat ttactgcact gtttacctgg gcagtaggag
     1321 cgaccagctg caccatcggc ctctgggact tggagaccca gagcatgcag tgtttttctc
     1381 tcagccagaa gtgtactcct gtagacattg gcggagacca gcagctgtgc cttgctttga
     1441 cagatgatgg tctgtctctg attttgtttg gtttaaccca agaggagttt ttgaacagac
     1501 taatgatcca cggcagcgcc agcactgtgg actccctttg tcatctcaac ggttggggac
     1561 ggtgctcaat ccctatccac gctctagagg ctggcataga aaatcgtcag ctggacacag
     1621 tagatttctt cttgaagagc aaggaaaatc ttcttactcc gtcttcacaa tctcctgctc
     1681 ctgatcagca gcatcccttt tcatcccatc tgtacctaag acaggtagaa gagatgagcc
     1741 cagccctgga tttactatgc tcagcaatta gagaaagtga ctcggaaacc caaagcaaac
     1801 actttgctga gcagctgctt cacctcacac tgtccttcct taacaaacag ataagggagc
     1861 tttgtgttca cactgaagag ctagatgagc attttcagaa aggagtggcc attttgacca
     1921 gctacatcaa tgagcttcgg acttttatga taaagtttcc ttggaaacca ggagatgcca
     1981 tagatgaatc tgatgtaaat gaaggtgtcg tcacagtgaa ggaggaccgg gtttgggagg
     2041 aactcagctt tgaggaagtt attgctgatg ccattttaaa taacagaata ccagaggcac
     2101 aaactttctt taggattagt ggtcattccg ctcaacgact ggaggaactg gttaggatcg
     2161 gcctagatct ggcatttgac agtttaaaaa agaacaacgt ggaggaggcc tcgaggctcc
     2221 tgaggaacat gggcttcagt gtggaagatg agttgcttaa gatatgcttt tatacaactg
     2281 ataaaaatat acgggacttt ttggttgaaa ttttaaaaga aaaggaatgt ttttctgaaa
     2341 aagaaagaag aactgtagac tttgttcatc aacttgaagc actttattct ggacacttcc
     2401 aggaaaatgc acagacgcag gctttcccca ggtattggat aaaggaacag gactgtttca
     2461 aacacaaatc tgtcttggac acattcctca aatatgataa aaaagatgag tttcacaaac
     2521 aggaccatag aattgcattg aattgggctc accggtggga tctccaaaca caggaatgta
     2581 tccttctccg cagactaagt ccagaagaat acaaagcgcg ctccccggaa gccctgtgga
     2641 gacacctcac ggctcgccat gactgctcaa gcatcagctt gtggatggaa gaatttcaga
     2701 cccaggaaac cgagtcacct cagcagagca agtggccccc tctgagtgct gacatcattg
     2761 agcagggcac ttgctgccac agtcacatga ggaatgagat tttagacaag ctggccagaa
     2821 gtggcatttt tcttgcatct gagctggaag actttgaacg tctcctcctg aggctgagcc
     2881 ggattggggg cgtaatgcag gacagcctcc ccgtgcagag ctacaaatcc cgtgcagggt
     2941 gtgactttca ttcccggttc atcctctact gtttagagca cggcctacag catcttctct
     3001 acacctatct tgactattac aaacttagtc ctggaaattg tccttttttg gaaaagaaag
     3061 aactacatga agctcaccct tggcttgaat ttttggttca atgtcggcaa gtctccagta
     3121 acttgacaga tcccaaactc atctttcagg ctagccttgc aaatgctcag attttgattc
     3181 ccaccaatca ggccagtgtg agcagtatgc tgttggaagg acacaccctc ctggcccttg
     3241 ctaccaccat gtatgctcca gggggtgtca gccaggtcat tcagaatgaa gacagcgaga
     3301 actgtttgaa gaaagtggac ccccagctac tgaaggtggc tttaacacct tacccaaagc
     3361 tcaaagctgc gctcttccca cagtacactg ctcctagtat tctgccctct gatattacac
     3421 tctaccacct catccagtcc ttgccgccct ttgatcctag ccggctgttc gtctggcagt
     3481 ctgccaacac actagctata ggagacacag gcagtcagct cccacacttt tccagccctg
     3541 acctggtgag taaatacgct gtgctggaac ggctgaacta cgcgtattat ctacatcacg
     3601 gacgcccgtc gtttgccttt ggcacctttc tggtccagga gttgatcaag agtaagactc
     3661 ccaaacaact gatccagcaa gtaggcaagg aggcctatac cttagggctc tcttccttca
     3721 ccaacccttc ggtaggggct gcctgtgtct gcttcttaga attgcttggc ctcagcagcc
     3781 tcaagctcag agttgacctg aaaatggcaa atgtaatttt gggctccaag cgtagagatg
     3841 aagatgctcg ttccagcttc atcagagagt ctctggctga gaagctgtct aagcttgctg
     3901 acggtgacag agcagccaca gaagagctgc ttgttctctt ggaggaaggc gtgtgggaca
     3961 gcattgagca gcagggcttt agcaggttgt ccagtgagtc cagcagccag tgggcattag
     4021 tgcttcagtt ctgcatgctc catgacagga agctgagcgt gtcctacctt agagaatgtg
     4081 ccaaagccaa tgactggctg cagttcctgg tccacagcca gctgcataac taccacccag
     4141 cagaggtgga atctcttctt cagtatttca gtcctgtcct tcagagccac ttgaagctgg
     4201 cttctgagaa actgtcatca gggtccatct ctagggatga cagctgcctc caggaactcc
     4261 agaaaaacaa aggagaaacg agtaatttct ttgaaattct ccaccggtgc tcagatgagt
     4321 ccacctcttg gagctggctc ctggctgagg cagtgagaca tcgggctccc atcctcagtg
     4381 tcctggcctc gtgtgtgcag ggtgccagtg ttgtctcctg tctctgtgtt tggattgtca
     4441 cctccgtgga ggacaaggtt gcagctgaag caatgggaca cattcagatc tctgtagagg
     4501 accatcactg gagcctgaag gacctgtcca tcatctggag aactgtattg acaagacgca
     4561 agagccacac tctcatccga ggtttccagc tctttattaa ggattcccca cttctattga
     4621 ttatggagat gtatgaactg tgtatgttct tcaagaatta cgagaaagcc aaagttaaac
     4681 ttttggagtt ccagaaaagc cttgaaacac ttgacacagt ggccgcaagg gtccttccta
     4741 tcatacctgc ctcgtggatg aaagaccagg tttgtttcct tttgaaactt atgccgcagc
     4801 agtgtgagac gcagtatgag ctggggaaac tcctccaact gtttgttggc actgagcagc
     4861 tcttctctga cgggccagac gtgcagaagc tgtgtctcct cagccaagtg ctgaaggaca
     4921 cacctatcgc cattagccct gcagtcattt ccagctacag cactgagaac tttcagcggg
     4981 aatgtagatc tattttggag aagctaaaag cagatgggca gtttgctgtg gctaggagag
     5041 tggccgagtt agcagccctg cctgtggaca gcttgctgat tgaacagtta actcaggaaa
     5101 tgcaaacact aacacacact ccgcagtggt ccctgaaaca agaaagactt ggcttctgga
     5161 aaaaatgcca tgaaattttt aagaaaaact ctatttcaaa gagagcagcc tcttccttct
     5221 tctctagcca agcccccgag gtgagtgagc accctgctga acagggcagc cttgaggagc
     5281 gccatctgct gctcactctg gctggccact ggcttgccca agaagagccg gttcccgtgg
     5341 aggaactgga ggggctggag aaacagattt ggatctgccg cgtcgcccag cacacatgtg
     5401 gaggggctga agaggaagcc aagcccagcc tctctcaaca caagttggct gctgctgaac
     5461 tttcttttga tagcttagcc agtgagctgt ccttctccaa gctcgctgct ttgaacacat
     5521 ccaaatactt aggccttaat gatcttccat ccaagacgac gtgtgagaac agactgaaac
     5581 acaaagagca ggagtcactg aacactttga tcgggcagct gctggatggt ggctgtgtgc
     5641 atgaagcaag cagagtgtgc cagtatttcc gtttctatag ccaggatcta gtgctggtgt
     5701 tgcactgcag agccttggcc tccgcagaag ccaccatgga agacttgcac tcagagatcc
     5761 gtgccctcct ctcaagtgcc gcacagcctg aggacctgga gagcccgagt gtccctcttc
     5821 ggaaagccca tagctcttca agtttggaca gtcagtcatt tgtgatggta ccacccactg
     5881 atgaggtagc ccagaacctc cacactctca taagcaagtg cctccatggg aagaactact
     5941 gccggcaggt cctctgtctg tatgaacttg ccaaggattt gggctgttcc tatggagatg
     6001 ttgctgctag ggacagtgaa gccatgctcc gagcaatctt ggcttctcag cggcctgacc
     6061 gatgtagaca agcccaggtc ttcatcaaca cccagggcct tgaagcagac actgtggctg
     6121 aactagtggc tgaagaggtg acacgggagc tactgactcc atcagaggga acaggagaaa
     6181 agcaaccttt caacccagca gaggaaagcc agacatttct tcagctaact gctttgtgtc
     6241 aagaccgtac attggtaggc atgaagttgt tggacaagat tccctctgtc ccccacgggg
     6301 agctgtcttg caccacagag ctcctgatcc tggcccacca ctgctttacc ttcacgtgcc
     6361 acatggaagg catcaccaga gtcctgcaag ccgcccgcat gctcacagat aaccacttgg
     6421 ctcccaatga ggagtacgga ttagtggtcc gcctcctcac tggcatcggg cgctacaatg
     6481 agatgacgta catatttgac ttgctgcatc aaaagcatta tttcgaagtt ctgatgagaa
     6541 agaagctaga cccaaccggc accctgaaga cagccctact agactacatc aaacgttgcc
     6601 gccctggaga cagcgaaaag cacaatatga ttgccctgtg cttcagtatg tgccgggaga
     6661 taggagagaa tcacgaggca gcagcctgca tccaactgaa gctgattgag tctcagccct
     6721 gggaggaaag cctcaaggat ggagcccaac taaaacagct cctgcttaaa gccctgactc
     6781 tgatgttgga tgcagcagag agttacgcca aggactcctg tgttcgacag gccctgcact
     6841 gtaaccggct caccaagttg ataacactac agattcactt tctcaacagt ggccagaata
     6901 caatgcttat caacttgggc catcagaagc taatggactg tatcatgacc ctacctcggt
     6961 tctaccaggc ttctattgta gctgaggcct atgactttgt tcctgactgg gctgaagtac
     7021 tctaccaaca agtgattctt aaaggagact ttagttattt ggaagaattt aagcagcaga
     7081 agttactaag acccaatata tttgaagaca tttccaaaaa atataaacaa caccagccta
     7141 ccgacagggt cacagaaaac ctgaagaagt tactttcata ttgtgaagat atctacctgt
     7201 attacaagtt ggcatatgaa cacaaatttt ttgaaattgt aaatatgctt ctgaaggacc
     7261 ctcagacggg atgctgcctt aaagatatgc tcgcaggtta gaagattgga aaggcgcctg
     7321 attgcttgtt tgtacctata cagctctaag ggatgttcaa tcctaataaa gtatttggag
     7381 atctttaccc ccatttgagt tgaaaagccc agaaatatac catactgcac tagtcgtttg
     7441 tggctgtagg gaacggagga aaaattagta ttgagatcag aagtgttttg ttagagtggc
     7501 ttctacatca gagaaacaat agtggttaaa gaacgcctgt acctgcaggt tccagtttca
     7561 aagcaattta atcttattta cacagttaag gaacacgtga tacattttca tgagttagaa
     7621 actgaacttt ctataataaa atagttttta tttcagtgtc a
//
