LOCUS       NP_780577                503 aa            linear   ROD 27-APR-2025
DEFINITION  uncharacterized protein SPEM2 [Mus musculus].
ACCESSION   NP_780577
VERSION     NP_780577.1
DBSOURCE    REFSEQ: accession NM_175368.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Li,C., Shen,C., Xiong,W., Ge,H., Shen,Y., Chi,J., Zhang,H.,
            Tang,L., Lu,S., Wang,J., Fei,J. and Wang,Z.
  TITLE     Spem2, a novel testis-enriched gene, is required for spermiogenesis
            and fertilization in mice
  JOURNAL   Cell Mol Life Sci 81 (1), 108 (2024)
   PUBMED   38421455
  REMARK    GeneRIF: Spem2, a novel testis-enriched gene, is required for
            spermiogenesis and fertilization in mice.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077090.1, BC137961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.89 cM"
     Protein         1..503
                     /product="uncharacterized protein SPEM2"
                     /note="uncharacterized protein C17orf74 homolog"
                     /calculated_mol_wt=56803
     Region          1..261
                     /region_name="Spem1"
                     /note="Spermatid maturation protein 1; pfam15670"
                     /db_xref="CDD:464793"
     Site            26..46
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5U4.1)"
     Region          155..176
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5U4.1)"
     Region          311..381
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5U4.1)"
     Region          436..456
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5U4.1)"
     Region          472..503
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5U4.1)"
     CDS             1..503
                     /gene="Spem2"
                     /gene_synonym="4933402P03Rik"
                     /coded_by="NM_175368.2:67..1578"
                     /db_xref="CCDS:CCDS24912.1"
                     /db_xref="GeneID:108803"
                     /db_xref="MGI:MGI:1918293"
ORIGIN      
        1 menqlwqntl rcceqyqesp qdaenilfll lgliilvnis invatamwqg lqnaidkmif
       61 wmnqktevvq vtecppkepq panvqdvhih cildpvqvkm aqptqcssss shyfckrsnd
      121 rrsrrrygyq qgnlqihqss qqqgclshqq rlrnrplsrg yppfrkqpqg hkmsqmrpmp
      181 ffdmedrdsl peghscphak qprrgwgslc kpvrlasnvg lwgrqggila slplpslyls
      241 pelrrlpkrv eakselrlqg fgphysqsri wgtveaeqwa sspppprrll pnpswvtvgy
      301 ssfpsgghip ydardqwrrg tegcepppaf vprnprevqg yrdhnsqahr qnfsshthsq
      361 pnhsppqsmg hvgyssresh evrrrapdwi evfpsrhplt tstsltalge asyqrappas
      421 sglmiphssq rlaevqisdp tpppttfvpl srnpggnaty qvydslelkr qvqenrgras
      481 slpppstsas rpslhrsrtg kln
//
