LOCUS       NP_001268747            1058 aa            linear   ROD 27-APR-2025
DEFINITION  cytospin-B isoform 1 [Mus musculus].
ACCESSION   NP_001268747 XP_003945690
VERSION     NP_001268747.1
DBSOURCE    REFSEQ: accession NM_001281818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1058)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1058)
  AUTHORS   Chen,X., Wang,Y., Wang,J.N., Cao,Q.C., Sun,R.X., Zhu,H.J.,
            Zhang,Y.R., Ji,J.D. and Liu,Q.H.
  TITLE     m6A modification of circSPECC1 suppresses RPE oxidative damage and
            maintains retinal homeostasis
  JOURNAL   Cell Rep 41 (7), 111671 (2022)
   PUBMED   36384115
  REMARK    GeneRIF: m[6]A modification of circSPECC1 suppresses RPE oxidative
            damage and maintains retinal homeostasis.
REFERENCE   3  (residues 1 to 1058)
  AUTHORS   Lee,S. and Choi,I.
  TITLE     Expression patterns and biological function of Specc1 during mouse
            preimplantation development
  JOURNAL   Gene Expr Patterns 41, 119196 (2021)
   PUBMED   34166821
REFERENCE   4  (residues 1 to 1058)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1058)
  AUTHORS   Zheleznyakova,G.Y., Voisin,S., Kiselev,A.V., Sallman Almen,M.,
            Xavier,M.J., Maretina,M.A., Tishchenko,L.I., Fredriksson,R.,
            Baranov,V.S. and Schioth,H.B.
  TITLE     Genome-wide analysis shows association of epigenetic changes in
            regulators of Rab and Rho GTPases with spinal muscular atrophy
            severity
  JOURNAL   Eur J Hum Genet 21 (9), 988-993 (2013)
   PUBMED   23299920
REFERENCE   6  (residues 1 to 1058)
  AUTHORS   Maroteaux,G., Loos,M., van der Sluis,S., Koopmans,B., Aarts,E., van
            Gassen,K., Geurts,A., Largaespada,D.A., Spruijt,B.M., Stiedl,O.,
            Smit,A.B. and Verhage,M.
  CONSRTM   NeuroBSIK Mouse Phenomics Consortium
  TITLE     High-throughput phenotyping of avoidance learning in mice
            discriminates different genotypes and identifies a novel gene
  JOURNAL   Genes Brain Behav 11 (7), 772-784 (2012)
   PUBMED   22846151
  REMARK    GeneRIF: Specc1 mutant showes profound and specific delay in
            avoidance learning.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143663.1, AL592080.26 and AL596110.15.
            
            On Aug 8, 2013 this sequence version replaced XP_003945690.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3044193.1,
                                           SRR13422598.190187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1058
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     Protein         1..1058
                     /product="cytospin-B isoform 1"
                     /note="spectrin domain with coiled-coils 1; cytospin-B"
                     /calculated_mol_wt=116972
     Region          1..163
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            55
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            111
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            133
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Region          192..223
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Region          250..375
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Region          <358..726
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            360
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            368
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Region          <683..>783
                     /region_name="PRK00409"
                     /note="recombination and DNA strand exchange inhibitor
                     protein; Reviewed"
                     /db_xref="CDD:234750"
     Region          822..913
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            838
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            854
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            903
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Site            905
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5M775; propagated from
                     UniProtKB/Swiss-Prot (Q5SXY1.2)"
     Region          946..1057
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(958,1008,1010..1011,1014..1015,1017,1029..1033,1041,
                     1043..1044,1046..1047,1050..1051,1054)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     CDS             1..1058
                     /gene="Specc1"
                     /gene_synonym="2810012G08Rik; B230396K10Rik; Cytsb"
                     /coded_by="NM_001281818.1:151..3327"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS78965.1"
                     /db_xref="GeneID:432572"
                     /db_xref="MGI:MGI:2442356"
ORIGIN      
        1 mrsaakpwsp vakagshgpd rtrplpgtps gmksskssts lafesrlskl krassedtln
       61 kpgsassgva rlkktstsga iseltesrlr sntgtipttk rtgipaprel svtisrersv
      121 prgpssskkl gssptsscnp tptkhlrttp akpkqehega ekavlesqvr ellaeaktkd
      181 seinrlrsel kkckerwals tedanasdps aegtaspesd aqplirtlee knktfqkela
      241 dleeenralk ekltyleqsp nsegaashtg dsscptsith essfgspvgn elssetdeyr
      301 rtthgsalrt sgssssdvtk aslspdasdf ehitadtpsr plsatsnpfk sskgsptgss
      361 pnnaselsla sltekiqkme enqhstaeel qatlqelsdq qqmvqeltae neklvdekti
      421 letsfhqhre raeqlsqene klinllqerv kneepsaqgg kvleleqkct dileksrfer
      481 ekllniqqql tcslrkveee nqgaidmikh lkeeneklng flehercnns vmaktleecr
      541 vtleglkmen gslkallead kqkaieasst vgqtaenfev qemlkvarae kdqlqlscte
      601 lrqellkang eikhvsslla kmekdysylk evcdhqaeql srtslklqek asesdaeikd
      661 mketifeled qveqhravkl hnnqlisele gsvikleeqk sdlerqlktl tkqikeetee
      721 wrrfqadlqt avvvandikc eaqqelrtvk rrlleeeekn arlqkelgdi qghsrpvnee
      781 pepseadaag rwrgvyvnrt spapsdsatt vksliksfdl ghsggtgqsi svhktprspl
      841 sgipvrtapa aavspmqrhs tyssmkpask gtsqrldlpd lplsdllkgr aedrksdpyl
      901 rkspslesls rppslgfgnt rllsastggl kpsklsverr dplaalarey ggskrnallk
      961 wcqkktegya niditnfsss wsdglalcal lhtylpahip yqelnsqekk rnlllafeaa
     1021 qsvginpsle lsemlytdrp dwqsvmqyva qiykyfet
//
