LOCUS       NM_001384193            2255 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus speedy/RINGO cell cycle regulator family, member E4B
            (Spdye4b), transcript variant 1, mRNA.
ACCESSION   NM_001384193 XM_006504713
VERSION     NM_001384193.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2255)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2255)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 2255)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123686.11.
            
            On Jun 5, 2020 this sequence version replaced XM_006504713.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.164469.1, BC115569.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               AC123686.11        155574-156195       c
            623-695             AC123686.11        144854-144926       c
            696-914             AC123686.11        142152-142370       c
            915-973             AC123686.11        141482-141540       c
            974-1059            AC123686.11        140839-140924       c
            1060-1228           AC123686.11        135026-135194       c
            1229-1331           AC123686.11        134762-134864       c
            1332-2255           AC123686.11        132136-133059       c
FEATURES             Location/Qualifiers
     source          1..2255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 81.99 cM"
     gene            1..2255
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /note="speedy/RINGO cell cycle regulator family, member
                     E4B"
                     /db_xref="GeneID:330228"
                     /db_xref="MGI:MGI:3612701"
     exon            1..622
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..1345
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="speedy/RINGO cell cycle regulator family, member
                     E4B isoform 1"
                     /protein_id="NP_001371122.1"
                     /db_xref="GeneID:330228"
                     /db_xref="MGI:MGI:3612701"
                     /translation="MVSGERVSSWMVMPWSSPLCTMPSKSAFFSQPRVEATPQPPSSI
                     QKRKRDESSDSEDDLAELFEPDPQPVWSVETPCGLRMTLQRQCVSTVRPEHHKVFTKL
                     LEDPVVKKFLTWDKMLRVSDKYLLSMVIAYFSRAGLFSWQYRPIHFFLALYLANDMEE
                     DNQAPKQDIFYFLYGKSYAQRPMFHKLRFQFIRSMGWRIWVSQEECEEIQAYDPELWV
                     WTRDRTKLTQNPRVMDTRGHPPAIDPCA"
     exon            623..695
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..914
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            915..973
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1059
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1228
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1331
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..2255
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2255
                     /gene="Spdye4b"
                     /gene_synonym="4933411G11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagcctggag aaacggcctg ctgcgtgaag tcccaagtct tgtccctggc tcaggactcc
       61 taaaataaga ggaagattgt gttagaagga aagaaaactg agtgtcattc tcgattaacc
      121 aaacttcctt gaagtactag gtacaagaaa taaccagctg tgctttacaa agaaggaggc
      181 acaaacacta atggtgggtt tctagaacat acgtctaatg cccagaaact ctaaaaaaca
      241 gaaccagaaa gagaacacag aaagaagaaa acacctacct gcaatgtgat ctctgaaagg
      301 tgatatttag ggccgggcga caatgacagt tttcaacgat ggttacatta tgatgaacgg
      361 ctcctcgatt tcttattgaa ttaatgcaac gacgttcttg gcctagttct tcataaagac
      421 gttggcgtca aaattaataa caaagcctgt caatagaaaa agttctctgc gccgatgcag
      481 agagtaacgt tttcatccca gaagcaccaa gcgccttgga gcgccaaccc taggtaataa
      541 actgctgagc aaccagcagg agacagaagc atcacgaatc cctctcagat gctgcagggc
      601 acacatggtc tcaggagaaa gggtaagctc gtggatggtc atgccctgga gctcgcctct
      661 gtgcaccatg ccgtctaaat ctgctttctt cagtcaacca agggtggaag ccactcccca
      721 gcctccatcc agcatccaaa agaggaagag ggacgagtca tcagattctg aggatgacct
      781 ggcagagcta tttgaacctg atccccagcc ggtgtggtca gtggagacgc cgtgtgggct
      841 caggatgacg ctgcagaggc aatgtgtgtc tacagtgagg cctgaacacc acaaggtctt
      901 caccaagttg ctcgaggatc ccgtggtgaa aaaattcctg acctgggaca agatgctgcg
      961 ggtgtcagac aagtacctcc tgtctatggt catagcttat ttcagccgcg ctgggctctt
     1021 ctcctggcag tacaggccca tccacttctt cctggctctc tacctggcca atgacatgga
     1081 ggaggacaac caggccccta agcaagacat tttttacttc ctctatggga agagctatgc
     1141 ccagcgcccc atgttccaca aactgcgctt ccagttcatt cggtccatgg gctggaggat
     1201 ctgggtgtcc caggaagagt gtgaagagat ccaggcttac gacccagagc tctgggtatg
     1261 gacacgggat cgtactaagc tgacccagaa ccctagggtc atggatactc gaggccatcc
     1321 gcctgccata gatccctgtg cctgagggag atgctctatg ccaacattag gactgctggg
     1381 ggaaaggaga gaggactgac tatcttccat gggaaaccta gaagaaccca gactcttcca
     1441 gaaggagtgg gatggaatca ccacactgcg ctcctgggag ctgggaccct tgtaggagtc
     1501 tctggagagg ccatgagaaa ccaggattcc tccaggctcc atgctttcca gaggcaccat
     1561 ctaaatgtta tcccgaatgt cctcggtccc cacctcccaa ccgtagcagc tgaaggccca
     1621 tggtttcctg taattggtct ccactgctca ggccatttga aggaggcacc tcagggctca
     1681 gatgtggagg gaactacctt caaagtatag cctttgagcc atatgtttgt aatagaaagc
     1741 tttaatatat ttcatgttta ttgaagactt tgaaagtttc tcatagaatt atttattatg
     1801 aacaggtttg aaatattgtg gatttgaaaa caggcagctc tcctgatttt gtgatggata
     1861 acattcatat atgtaaatat tttcactgga ggagaagatt tggggttttt aatccatttg
     1921 ttttggggtt ttgtttggtt ttttttgttt tggggcagag cctcactatg aagcccagcc
     1981 tggccccaga cttacagaga tccaccttcc tccaactcct cagtgctggg attaagggtg
     2041 gtgtgtgccc ctatgccttg tgagtttttt aaaaatctat tataatcgaa catagattct
     2101 acttaaagat atatgcttca tgtaagtgag aattgttgtt tgaagtttac tctttattat
     2161 tgagacgtga agaagcaaca cttgtgtctg ttgatttaaa ggtgagatgt attttgaaag
     2221 agcacgtgtt ttaataaata ctttgtcaac accca
//
