LOCUS       NM_029254               1891 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus speedy/RINGO cell cycle regulator family, member A
            (Spdya), transcript variant 1, mRNA.
ACCESSION   NM_029254 XM_001480221 XM_001481181
VERSION     NM_029254.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Wang,D., Liang,W., Huo,D., Wang,H., Wang,Y., Cong,C., Zhang,C.,
            Yan,S., Gao,M., Su,X., Tan,X., Zhang,W., Han,L., Zhang,D. and
            Feng,H.
  TITLE     SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis
            by reducing lipid peroxidation through regulation of GCH1 and TFR1
  JOURNAL   Cell Death Differ 30 (2), 369-382 (2023)
   PUBMED   36443440
  REMARK    GeneRIF: SPY1 inhibits neuronal ferroptosis in amyotrophic lateral
            sclerosis by reducing lipid peroxidation through regulation of GCH1
            and TFR1.
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Chen,Y., Wang,Y., Chen,J., Zuo,W., Fan,Y., Huang,S., Liu,Y.,
            Chen,G., Li,Q., Li,J., Wu,J., Bian,Q., Huang,C. and Lei,M.
  TITLE     The SUN1-SPDYA interaction plays an essential role in meiosis
            prophase I
  JOURNAL   Nat Commun 12 (1), 3176 (2021)
   PUBMED   34039995
  REMARK    GeneRIF: The SUN1-SPDYA interaction plays an essential role in
            meiosis prophase I.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1891)
  AUTHORS   Palmer,N., Talib,S.Z.A., Singh,P., Goh,C.M.F., Liu,K.,
            Schimenti,J.C. and Kaldis,P.
  TITLE     A novel function for CDK2 activity at meiotic crossover sites
  JOURNAL   PLoS Biol 18 (10), e3000903 (2020)
   PUBMED   33075054
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1891)
  AUTHORS   Fifield,B.A., Qemo,I., Kirou,E., Cardiff,R.D. and Porter,L.A.
  TITLE     The atypical cyclin-like protein Spy1 overrides p53-mediated tumour
            suppression and promotes susceptibility to breast tumourigenesis
  JOURNAL   Breast Cancer Res 21 (1), 140 (2019)
   PUBMED   31829284
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1891)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   7  (bases 1 to 1891)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   8  (bases 1 to 1891)
  AUTHORS   Golipour,A., Myers,D., Seagroves,T., Murphy,D., Evan,G.I.,
            Donoghue,D.J., Moorehead,R.A. and Porter,L.A.
  TITLE     The Spy1/RINGO family represents a novel mechanism regulating
            mammary growth and tumorigenesis
  JOURNAL   Cancer Res 68 (10), 3591-3600 (2008)
   PUBMED   18483240
  REMARK    GeneRIF: the Spy1/RINGO family of proteins may play an essential
            role in regulating both normal and abnormal growth processes in the
            breast
REFERENCE   9  (bases 1 to 1891)
  AUTHORS   Cheng,A., Xiong,W., Ferrell,J.E. Jr. and Solomon,M.J.
  TITLE     Identification and comparative analysis of multiple mammalian
            Speedy/Ringo proteins
  JOURNAL   Cell Cycle 4 (1), 155-165 (2005)
   PUBMED   15611625
REFERENCE   10 (bases 1 to 1891)
  AUTHORS   Terret,M.E., Ferby,I., Nebreda,A.R. and Verlhac,M.H.
  TITLE     RINGO efficiently triggers meiosis resumption in mouse oocytes and
            induces cell cycle arrest in embryos
  JOURNAL   Biol Cell 93 (1-2), 89-97 (2001)
   PUBMED   11730327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077138.1 and CT010429.11.
            
            On or before Dec 14, 2008 this sequence version replaced
            XM_001480221.1, XM_001481181.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY820307.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849384, SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-940               AK077138.1         2-941
            941-1891            CT010429.11        120847-121797
FEATURES             Location/Qualifiers
     source          1..1891
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 41.87 cM"
     gene            1..1891
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /note="speedy/RINGO cell cycle regulator family, member A"
                     /db_xref="GeneID:70891"
                     /db_xref="MGI:MGI:1918141"
     exon            1..81
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..331
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1032
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     speedy protein A; speedy A; spy1; RINGO A; speedy-1;
                     mSpy/Ringo A; rapid inducer of G2/M progression in oocytes
                     A; protein expressed in male leptotene and zygotene
                     spermatocytes 465; speedy A1; speedy A2; speedy homolog 1;
                     spermatogenesis related protein Gs4; speedy homolog A"
                     /codon_start=1
                     /product="speedy protein A isoform 1"
                     /protein_id="NP_083530.1"
                     /db_xref="CCDS:CCDS50178.1"
                     /db_xref="GeneID:70891"
                     /db_xref="MGI:MGI:1918141"
                     /translation="MRHNQMYCETPPTVTIHVKSGSNRSHQTRKPISLKRPILKDSWE
                     ASENNAQNNKSKRPRGPCLIIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAM
                     TFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFL
                     KLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVHLPR
                     GPSATPVDCSLCGKKGRYVRLGLSSSSSSSSDTGELMEKDSQELHSAFSVDTAGDPPH
                     TYSQVANDHQSNKENETNFVKKNKSVEWFAESEE"
     exon            332..390
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..476
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..648
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..940
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1891
                     /gene="Spdya"
                     /gene_synonym="4921517J08Rik; 4930548B21Rik; GS4; MLZ-465;
                     Spdy1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacccag cacgcaaccg cctgaggtag atcgctgagg cggaggctgt ggggccgctc
       61 gctcttcgcc ggcctgcgca ggaatcttgg gaagctaaaa tgcggcataa tcagatgtat
      121 tgtgagacac cacctactgt cactattcat gtaaaatcag gctcaaatag gtcacatcaa
      181 accagaaaac ctattagtct gaaacgtcct attcttaaag atagttggga agcatctgaa
      241 aacaatgctc agaataacaa atctaagcgg cccagagggc cttgtctaat catacagcgc
      301 caggaaatga ctgctttctt taaattattt gatgatgatt taattcaaga tttcttgtgg
      361 atggactgct gctgcaagat tgcagacaag tatcttttgg ctatgacctt tgtttatttc
      421 aagagagcta aatttactat aaatgagcat accaggataa atttctttat tgctctgtat
      481 ctggctaata cggttgaaga agatgaagaa gaagccaagt atgaaatttt tccatgggct
      541 ttagggaaaa actggagaaa actgttccct aatttcttaa agttaaggga ccaactctgg
      601 gacagaattg actatagggc tattgtaagc aggcgatgct gtgaagaggt catggccatt
      661 gcgccaaccc attacatctg gcaacgagag cggtctgtgc atcacagtgg agctgttagg
      721 aactacaaca gagatgaggt tcacctgccc aggggaccta gtgccacacc agtggattgc
      781 tcactgtgtg gtaaaaaagg aagatacgtg agactgggac tgtcttcatc ctcatcttcc
      841 tccagtgaca caggagagct aatggaaaaa gattctcagg aactacacag tgcattctca
      901 gtggacacgg caggtgaccc tcctcatacc tattctcaag tagccaatga ccatcaatca
      961 aacaaagaaa atgaaactaa ttttgtgaag aaaaacaaat ccgtggaatg gtttgcagag
     1021 agtgaagaat gacaaggctc aactaaagca agctggagtc acagctacag aatggcaaac
     1081 caaatgcaag agaacgaaaa cgggactgtt acccagttgt acaatggcct ttagcttctg
     1141 ttacttttca aacacatgta aaagtcatac aaatcatagt aataactaaa cataccaaaa
     1201 taaggtaaaa agactttctg aagtagtgac taataatagt cagttctaat ttgatccttc
     1261 tttgtcttca gattcagtgc tgtcatctca ggtaccagtt caggtgtggt ctgaacttcc
     1321 tccaccagct taaaaggtta aactagaaga caaaagagct agtttaaaag agagaacagt
     1381 taaggtcata acactgaatt aatgaaaaaa aaaacaatta atatattctg aaaacagtac
     1441 tgacatgtgc gaccacttta ccagtgaata agtcaagcaa tgcagggaca tggtctgtgt
     1501 ggaaaatcag aatgtgactc ttctgtaaca gaaaatgcac actgtacaaa tgttttacag
     1561 tttgttcaca aaaagtgttg aaatgttaaa cactgtccct tttctgtaag ctttttctca
     1621 gaacttgttt tttaagcatt tttgagactg tttggctagt tactatcaga aacatttgtc
     1681 agtgattaca cagtaactct acagatgggc ttataaccaa acggagaagc ctgtttcata
     1741 aatcaatgta tcgaaaaccc atttcatggc ctaaataatg tgtacatatg agtacctaaa
     1801 cttgtttctt ggaagaactt cagcaatgtt gtaggagcta gaaaaacacc atatttcatt
     1861 ttctatacaa taaataaaaa ataaaaccct g
//
