LOCUS       NM_027411               2526 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus spindle apparatus coiled-coil protein 1 (Spdl1), mRNA.
ACCESSION   NM_027411
VERSION     NM_027411.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Taliani,V., Buonaiuto,G., Desideri,F., Setti,A., Santini,T.,
            Galfre,S., Schirone,L., Mariani,D., Frati,G., Valenti,V.,
            Sciarretta,S., Perlas,E., Nicoletti,C., Musaro,A. and Ballarino,M.
  TITLE     The long noncoding RNA Charme supervises cardiomyocyte maturation
            by controlling cell differentiation programs in the developing
            heart
  JOURNAL   Elife 12, e81360 (2023)
   PUBMED   36877136
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2526)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2526)
  AUTHORS   Kodama,T., Marian,T.A., Lee,H., Kodama,M., Li,J., Parmacek,M.S.,
            Jenkins,N.A., Copeland,N.G. and Wei,Z.
  TITLE     MRTFB suppresses colorectal cancer development through regulating
            SPDL1 and MCAM
  JOURNAL   Proc Natl Acad Sci U S A 116 (47), 23625-23635 (2019)
   PUBMED   31690663
  REMARK    GeneRIF: Spdl1 expression is significantly down-regulated in Mrtfb
            knockout mouse intestine.
REFERENCE   4  (bases 1 to 2526)
  AUTHORS   Zhou,L., Dai,H., Wu,J., Zhou,M., Yuan,H., Du,J., Yang,L., Wu,X.,
            Xu,H., Hua,Y., Xu,J., Zheng,L. and Shen,B.
  TITLE     Role of FEN1 S187 phosphorylation in counteracting oxygen-induced
            stress and regulating postnatal heart development
  JOURNAL   FASEB J 31 (1), 132-147 (2017)
   PUBMED   27694478
REFERENCE   5  (bases 1 to 2526)
  AUTHORS   Zhang,Q.H., Wei,L., Tong,J.S., Qi,S.T., Li,S., Ou,X.H.,
            Ouyang,Y.C., Hou,Y., An,L.G., Schatten,H., Schatten,H. and Sun,Q.Y.
  TITLE     Localization and function of mSpindly during mouse oocyte meiotic
            maturation
  JOURNAL   Cell Cycle 9 (11), 2230-2236 (2010)
   PUBMED   20505367
  REMARK    GeneRIF: Overexpression of mSpindly failed to enhance inactivation
            of SAC and acceleration of the meiotic process.
REFERENCE   6  (bases 1 to 2526)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY712013.1, AK139553.1, AK160143.1 and DV663229.1.
            
            On Nov 15, 2007 this sequence version replaced NM_027411.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006674.1, AK139553.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BY712013.1         2-127
            127-2399            AK139553.1         3-2275
            2400-2493           AK160143.1         1063-1156
            2494-2526           DV663229.1         700-732
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.9 cM"
     gene            1..2526
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /note="spindle apparatus coiled-coil protein 1"
                     /db_xref="GeneID:70385"
                     /db_xref="MGI:MGI:1917635"
     exon            1..154
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            155..329
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2000
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /note="coiled-coil domain-containing protein 99;
                     coiled-coil domain containing 99; spindle apparatus
                     coiled-coil domain-containing protein 1"
                     /codon_start=1
                     /product="protein Spindly"
                     /protein_id="NP_081687.2"
                     /db_xref="CCDS:CCDS24541.1"
                     /db_xref="GeneID:70385"
                     /db_xref="MGI:MGI:1917635"
                     /translation="MEADITNLRNKLKECEDERLKAAHYGLQLLERQTELQSQLDKCH
                     EEMMITAEKYNQEKHALQREVELKSRMLDSLSCECEALKQQQKAQLEQLEVQLHRSHR
                     QEVSDLKNKLENLKVELDEARLGEKQLKQKLDLQGELLAHKSEELRLLSEQRVLSSMS
                     SELLALETELTAAEGVKNALKEEVNELQYKQEQLECLNTSLLHQVDRLKEEKEERERE
                     AVSYYNALEKARVENQDLQVQLGHALQQAADPNSKGNSLFAEVEDRRVAMERQLNLMK
                     DKYQSLKKQNAFTRDQMNKMKLQISTLLRMRGSQTEFEQQERLFAMIEQKNGEIKHLL
                     GEINKLEKFKNLYESMESRPSTSDTACVLEDSTYYSDLLQLKLDKLNKENESTKDELS
                     IQRMKALFESQRALDIERKLFTNERHLQLSESENMKLRAKLDELKLKYEPEERIEVPV
                     LKRRREVLPLNITTPEETEETAAASATEDGVSRLPPHREEESCLNSLKDNTVQWKQPA
                     SSCVQPASLSPHKNLHLDTQPKKEKKCVKLVDSPANIEVLHEQSGNTPNSPRLTAESK
                     LPTEVKERIETTSKLGKGACKKSHNIIYVSSKSAPETQCSQQ"
     exon            330..506
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            507..704
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            705..854
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            855..953
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1064
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1205
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1315
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1503
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1852
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2510
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2486..2491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /note="hexamer: AATAAA"
     polyA_site      2510
                     /gene="Spdl1"
                     /gene_synonym="1700018I02Rik; 2600001J17Rik;
                     2810049B11Rik; Ccdc99"
                     /note="major polyA site"
ORIGIN      
        1 attcaaaaat ccccggcgct tacttagcag tgctgctgcc gagtgaagag ggagttattt
       61 ctgtgctgag gtggagttag tgtcacgaat ctgggagtcc agtgctctcc ggacaggcct
      121 ccggttgcag cagccaggaa gcgtgaggag agagtaggtt gagaacagac atcatggagg
      181 cagatatcac aaatcttcgg aacaaactca aagagtgtga agacgagcga ctgaaagctg
      241 cacactatgg cctacagctc ttggagaggc agacggaact gcagagccaa ctggataaat
      301 gtcatgaaga aatgatgatc acagcagaga aatacaacca agagaagcat gcccttcaaa
      361 gagaagtgga gctcaagagt cggatgttag acagcctgag ctgtgagtgt gaagctctga
      421 aacagcagca gaaggcgcag ctggagcagc tagaggtgca gctacatagg agccaccggc
      481 aggaagtgag cgacctgaag aacaagttag aaaatctgaa agtggaattg gatgaagcaa
      541 ggcttggcga gaagcagctg aagcagaagc tggatctgca gggggaactt ctcgctcaca
      601 agtcagaaga gctccggctc ctgtctgagc agagagtgct cagtagcatg tcttcggagc
      661 tgctggctct tgagactgag ctgacggcag cggaaggtgt gaagaatgcc ctcaaagaag
      721 aggtgaatga actgcagtac aaacaagagc agctagaatg tctcaatact tccttactgc
      781 accaggtaga caggcttaaa gaagaaaaag aggagcgtga gagagaagcg gtctcttact
      841 ataatgcctt ggagaaagct cgtgtagaga accaggatct tcaggtacag ctgggtcacg
      901 cactccagca ggcggcggac cccaatagca aagggaactc gctgttcgca gaggtggagg
      961 atcgaagggt ggcaatggaa cgccagctca acttgatgaa agacaaatac cagtcactga
     1021 agaagcaaaa tgcgttcacc agagatcaga tgaacaagat gaagttacaa atctccacat
     1081 tgctgaggat gaggggctcg cagactgagt ttgaacagca ggagcggttg tttgccatga
     1141 tagaacagaa gaatggtgaa ataaaacacc ttttagggga aattaataaa ctggagaaat
     1201 ttaagaactt atatgaaagt atggaatcga ggccttccac atcagacacc gcttgtgtgc
     1261 tagaagacag cacctattac tcagatctac ttcagctgaa gcttgataag ctaaacaaag
     1321 aaaatgaaag cacaaaggac gagctgtcca tccagaggat gaaggcttta tttgagagcc
     1381 agcgggccct ggatattgag cggaaactgt ttacaaatga aagacacctg cagctctcag
     1441 aaagtgaaaa catgaaactg agagcgaagc tagatgaact caagctgaag tatgaaccgg
     1501 aagagagaat tgaagtacct gtactcaaaa ggaggcgcga ggtgctgcca ttgaatataa
     1561 ccacgccaga agaaacagaa gaaacagctg ctgccagtgc cactgaggat ggagtttcta
     1621 gactcccacc tcacagggag gaggaatcct gtcttaatag cttaaaagat aacactgtgc
     1681 agtggaaaca gccagcctct tcatgtgtgc agccagccag cctctctcct cataagaacc
     1741 tgcatctgga tacacagccg aagaaggaga agaagtgtgt gaagcttgtg gatagtccgg
     1801 ccaacattga ggtcttacat gaacaaagtg ggaatacccc caattctccc aggttaactg
     1861 cagaatcaaa gcttccaaca gaagtgaagg aaaggataga aactacaagc aaattgggaa
     1921 aaggagcttg taagaaatca cacaacatca tatatgtgtc ctcaaagtca gccccagaaa
     1981 cgcagtgctc acagcagtag tgaggcctgc gcgctgggcc acgctaacca tcgctcctat
     2041 gcgtgggaca cccttgtgga gctttgcata ggtcagtgct gaagcctggc gtgctcgcac
     2101 cgctgtgacc aagacttccg atgtggctgt gattctgacc cataagtcct taactgatga
     2161 tccttctcag aactgtgggt cacagggaac agaccagatc agaagagaat gggagaattt
     2221 aaacctactt gctgtgttgg atgtggagtt tgaacatggt taaataatct gtcataagaa
     2281 ccaaaaatta gaaaatggaa cacttaaaat tatttataat tttctttgta catcgttttg
     2341 cacttagatt ttccttgtct tgtaaaaata atgaaattgg cttgaaaata tatattacta
     2401 caaaatgttt taaagtgtga agtacctata ttcatatgtg taatttagat tttatgactc
     2461 aaacatcaat aattttgaaa tttaaaataa aattgcagta atttcttcta aaaaaaaaaa
     2521 aaaaaa
//
