LOCUS       NM_026911                713 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus signal peptidase complex subunit 1 homolog (S.
            cerevisiae) (Spcs1), mRNA.
ACCESSION   NM_026911
VERSION     NM_026911.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 713)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 713)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   3  (bases 1 to 713)
  AUTHORS   Kalies,K.U. and Hartmann,E.
  TITLE     Membrane topology of the 12- and the 25-kDa subunits of the
            mammalian signal peptidase complex
  JOURNAL   J Biol Chem 271 (7), 3925-3929 (1996)
   PUBMED   8632014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154727.2.
            
            On Jan 23, 2023 this sequence version replaced NM_026911.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034270.2, CB192786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC154727.2         111919-112087       c
            170-229             AC154727.2         111558-111617       c
            230-316             AC154727.2         111392-111478       c
            317-713             AC154727.2         110540-110936       c
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..713
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /note="signal peptidase complex subunit 1 homolog (S.
                     cerevisiae)"
                     /db_xref="GeneID:69019"
                     /db_xref="MGI:MGI:1916269"
     exon            1..169
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..442
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /note="SPase 12 kDa subunit; microsomal signal peptidase
                     12 kDa subunit"
                     /codon_start=1
                     /product="signal peptidase complex subunit 1"
                     /protein_id="NP_081187.3"
                     /db_xref="CCDS:CCDS26903.2"
                     /db_xref="GeneID:69019"
                     /db_xref="MGI:MGI:1916269"
                     /translation="MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQ
                     FGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQDLGTEDKKSGDRKIKRHAKNN
                     "
     exon            170..229
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            230..316
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            317..713
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      713
                     /gene="Spcs1"
                     /gene_synonym="1810004F21Rik"
                     /note="major polyA site"
ORIGIN      
        1 atccgcttcc ggggccacgg ccgaagtgaa acgctcggct ggtcggcctt gctctcgata
       61 tcgacccccg caaactttac tccttaataa tcggctacgt ccgtttcgtt gtcggtatcg
      121 gtcttcagca accatgctgg aacacctgag ttcgctgccc acccagatgg attacaaggg
      181 gcagaaacta gctgaacaga tgtttcaggg gatcattctt ttttctgcaa tagttgggtt
      241 tatctacggg tacgtggctg aacagtttgg gtggactgtc tacatagtta tggccggatt
      301 tgctttctcc tgtttgctga cacttcctcc atggcctatc taccgccgcc atcccctaaa
      361 gtggttacct gttcaagact taggcacaga agacaagaaa tcaggggaca gaaaaattaa
      421 gaggcatgct aaaaataact gattgggact ttcatgattc agcacctgct tttgtttcct
      481 gtgagatgag ctgaattgct ttcataagca aaacatgagc ttaaaccgcc tatgttctta
      541 tagcacagct gtgtcgagat ctaattgtca tggcttcatt tctaatccaa atgtatttta
      601 agttatgact attttatacc atctcttcat aagcttgtta tggagaacag gagatacaag
      661 tatgcaatgc ttctttcccg tgtgtataat gaataaacac ttcataactt gta
//
