LOCUS       NM_026282               1374 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus SPC24, NDC80 kinetochore complex component, homolog
            (S. cerevisiae) (Spc24), transcript variant 1, mRNA.
ACCESSION   NM_026282 XM_979297 XM_979334 XM_979384 XM_979421
VERSION     NM_026282.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1374)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 1374)
  AUTHORS   Olthof,A.M., White,A.K., Mieruszynski,S., Doggett,K., Lee,M.F.,
            Chakroun,A., Abdel Aleem,A.K., Rousseau,J., Magnani,C.,
            Roifman,C.M., Campeau,P.M., Heath,J.K. and Kanadia,R.N.
  TITLE     Disruption of exon-bridging interactions between the minor and
            major spliceosomes results in alternative splicing around minor
            introns
  JOURNAL   Nucleic Acids Res 49 (6), 3524-3545 (2021)
   PUBMED   33660780
REFERENCE   4  (bases 1 to 1374)
  AUTHORS   Baumgartner,M., Olthof,A.M., Aquino,G.S., Hyatt,K.C., Lemoine,C.,
            Drake,K., Sturrock,N., Nguyen,N., Al Seesi,S. and Kanadia,R.N.
  TITLE     Minor spliceosome inactivation causes microcephaly, owing to cell
            cycle defects and death of self-amplifying radial glial cells
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30093551
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1374)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   6  (bases 1 to 1374)
  AUTHORS   Zhang,T., Zhou,Y., Wang,H.H., Meng,T.G., Guo,L., Ma,X.S., Shen,W.,
            Schatten,H. and Sun,Q.Y.
  TITLE     Spc24 is required for meiotic kinetochore-microtubule attachment
            and production of euploid eggs
  JOURNAL   Oncotarget 7 (44), 71987-71997 (2016)
   PUBMED   27713128
  REMARK    GeneRIF: Spc24 plays an important role in genomic stability
            maintenance during oocyte meiotic maturation.
REFERENCE   7  (bases 1 to 1374)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   8  (bases 1 to 1374)
  AUTHORS   Varma,D. and Salmon,E.D.
  TITLE     The KMN protein network--chief conductors of the kinetochore
            orchestra
  JOURNAL   J Cell Sci 125 (Pt 24), 5927-5936 (2012)
   PUBMED   23418356
  REMARK    Review article
REFERENCE   9  (bases 1 to 1374)
  AUTHORS   Ciferri,C., Pasqualato,S., Screpanti,E., Varetti,G., Santaguida,S.,
            Dos Reis,G., Maiolica,A., Polka,J., De Luca,J.G., De Wulf,P.,
            Salek,M., Rappsilber,J., Moores,C.A., Salmon,E.D. and Musacchio,A.
  TITLE     Implications for kinetochore-microtubule attachment from the
            structure of an engineered Ndc80 complex
  JOURNAL   Cell 133 (3), 427-439 (2008)
   PUBMED   18455984
REFERENCE   10 (bases 1 to 1374)
  AUTHORS   Ajioka,I., Maeda,T. and Nakajima,K.
  TITLE     Identification of ventricular-side-enriched molecules regulated in
            a stage-dependent manner during cerebral cortical development
  JOURNAL   Eur J Neurosci 23 (2), 296-308 (2006)
   PUBMED   16420439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011728.1 and AC161371.4.
            
            On Oct 25, 2017 this sequence version replaced NM_026282.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011728.1, AK075950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-814               AK011728.1         2-815
            815-1374            AC161371.4         52935-53494
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.88 cM"
     gene            1..1374
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /note="SPC24, NDC80 kinetochore complex component, homolog
                     (S. cerevisiae)"
                     /db_xref="GeneID:67629"
                     /db_xref="MGI:MGI:1914879"
     exon            1..185
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..631
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinetochore protein Spc24; spindle pole body component 24
                     homolog"
                     /codon_start=1
                     /product="kinetochore protein Spc24 isoform 1"
                     /protein_id="NP_080558.1"
                     /db_xref="CCDS:CCDS40554.1"
                     /db_xref="GeneID:67629"
                     /db_xref="MGI:MGI:1914879"
                     /translation="MAAFRDMVEVSNWLLSLLGANRAEAQQRRLLGSYEQMMERLLEM
                     QDGAYRQLRETLAVEEEVAQSLLELKECTRQGDTELQQLEVELQRTSKEDTCVQARLR
                     QLITELQELREMEEELQRQERDVDEDNTVTIPSAVYVAHLYHQISKIQWDYECEPGMI
                     KGIHHGPTVAQPIHLDSAQLSPKFISDYLWSLVDTTWEPEP"
     exon            186..330
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /inference="alignment:Splign:2.1.0"
     exon            331..435
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /inference="alignment:Splign:2.1.0"
     exon            436..512
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /inference="alignment:Splign:2.1.0"
     exon            513..1374
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      688..693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /note="hexamer: ATTAAA"
     polyA_site      706
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /note="major polyA site"
     regulatory      784..789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
                     /note="hexamer: ATTACA"
     polyA_site      802
                     /gene="Spc24"
                     /gene_synonym="2410030K01Rik; Spbc24"
ORIGIN      
        1 gggttcggac tcggcgcgat cagtcatggc ggctttccgc gacatggtgg aggtgagcaa
       61 ctggctactg agcctgctgg gggccaaccg cgccgaggcg cagcagcggc ggctgctcgg
      121 gagctacgag cagatgatgg agcggctgct ggagatgcag gacggcgcct accggcagct
      181 tcgggagact ctggctgtgg aggaggaagt ggctcagagc cttcttgaac tgaaagaatg
      241 tacgcgccag ggggacaccg agctgcagca gctggaggtg gagctccaga ggaccagcaa
      301 ggaggacacc tgtgtgcagg ctaggctacg tcagctcatc acagagctgc aggagctcag
      361 ggagatggag gaagagctcc agcgccagga gagggatgta gatgaggaca acaccgtcac
      421 catcccctct gcagtgtatg tggctcatct ctatcaccaa attagtaaaa tacagtggga
      481 ttatgaatgc gagccaggga tgatcaaggg catccaccac ggccccacag tggcccagcc
      541 catccacttg gacagtgcac agctctcgcc gaagttcatc agtgactacc tctggagcct
      601 ggtggacacc acgtgggagc cagagccttg acctcatacc ttgcacagaa ctggggttga
      661 gggagccaag gaggggatca ctctaaaatt aaatgtctgt atgtgagtgc gttcattgat
      721 ttatctactt gctttgagac agcatggagt ccaggctggc ctgcagcttc ttttttattt
      781 gtaattacat ttactgtatg aatgttttgt ctgcatgtgt gtctgttagc tgtgtattcc
      841 aggagaggtt agagagggct tcagaccccc tgaaactgga gttatgggtg gttctgagct
      901 gccatgtggc tactgggaat cgaacctgta ttctatagaa gagcagccag tgctcttaat
      961 tgttgagctg tctctccatc cccttaatta caattttaaa aaatgtgtgc ctagccgggc
     1021 gtggtggcgc acgcctttaa tcccagcact tgggaggcag aggcaggcgg atttctgagt
     1081 tcgaggccag cctggtctac agagtgagtt ccaggacagc cagggctata cagagaaacc
     1141 ctgtcttgaa aaaacaaaaa aaaaaaaaaa acaaacaaac aaaaaaacaa aaacaaaaat
     1201 gtgtgcagtt ggggctggag agatggctca gtggttaaga gcacactgat tgctcttcca
     1261 gaggttctgg gttcaattcc catctgtaat gggatccgat gccctcttct ggtgtgtctg
     1321 aagacagcca cagtgtactc acatacatta aataaatact ctttttaaaa aaaa
//
