LOCUS       NM_001039593             755 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus spermatogenesis associated 46 (Spata46), mRNA.
ACCESSION   NM_001039593 XM_355274 XM_917508
VERSION     NM_001039593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 755)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 755)
  AUTHORS   Chen,J., Gu,Y., Zhang,Z., Zheng,W., Yang,L., Huang,W., Lin,S.,
            Li,Y., Guo,H., Luo,M., Ma,Q., Jiang,Z., Tang,A. and Gui,Y.
  TITLE     Deficiency of SPATA46, a Novel Nuclear Membrane Protein, Causes
            Subfertility in Male Mice
  JOURNAL   Biol Reprod 95 (3), 58 (2016)
   PUBMED   27488028
  REMARK    GeneRIF: In the present study, we demonstrated that deletion of
            Spata46, a gene encoding a novel protein of unknown function found
            in mouse testis, was responsible for male subfertility, and the
            cause of subfertility was characterized as abnormal sperm head
            shape and a failure of sperm-egg fusion.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119431.13.
            
            On Aug 22, 2018 this sequence version replaced NM_001039593.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099563.1, AK005990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC119431.13        146412-146577       c
            167-755             AC119431.13        143271-143859       c
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     gene            1..755
                     /gene="Spata46"
                     /gene_synonym="1700015E13Rik"
                     /note="spermatogenesis associated 46"
                     /db_xref="GeneID:76925"
                     /db_xref="MGI:MGI:1924175"
     exon            1..166
                     /gene="Spata46"
                     /gene_synonym="1700015E13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..678
                     /gene="Spata46"
                     /gene_synonym="1700015E13Rik"
                     /note="uncharacterized protein C1orf111 homolog"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 46"
                     /protein_id="NP_001034682.1"
                     /db_xref="CCDS:CCDS15471.1"
                     /db_xref="GeneID:76925"
                     /db_xref="MGI:MGI:1924175"
                     /translation="MDNYSLLSTPRPRISSSALSAFPDIMSSLATSLPDLGDTQNGEQ
                     LRRNCTIYRPWFSPYSYFVCTDKESHLEAYGFPEVDREEGRGDNCLLEDVAESVCSSS
                     SSQENTYPREANRKSKHGLDSITSQDILMASKWHPAQQNGYKCASCCRMYPTLHSLKS
                     HIKGGFKEGFSCKVYYRKLKTLWGKEQKARTGDRISLGSCQAFK"
     exon            167..755
                     /gene="Spata46"
                     /gene_synonym="1700015E13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaacccg gccaacctct caggagcggg cgtgtgacct ccgttcccct gtgtggtcag
       61 agcatggata actactcact cctcagcact cccagacctc gtatctcttc ctctgccctg
      121 agtgcttttc cggacataat gtcctcactt gccaccagct tgccagactt gggggacacc
      181 cagaatgggg agcagctgag acggaactgc accatctacc ggccctggtt ttccccttac
      241 agctacttcg tatgcacaga caaagagagc cacctggagg cctatgggtt cccagaggtg
      301 gaccgagaag agggcagagg ggataactgc cttcttgagg acgtggctga aagtgtctgc
      361 tcatcttctt cctcccaaga gaacacatac cccagggagg ccaacaggaa atccaagcat
      421 ggtttggatt ctatcacatc ccaggacatc ttaatggctt ccaagtggca cccagcccag
      481 cagaatggct acaagtgtgc atcctgttgt cgcatgtacc ccactctgca ctccctcaag
      541 agccacatca aggggggttt caaggagggt ttcagctgca aggtgtacta ccgaaagctc
      601 aaaaccctct ggggcaagga gcagaaggcc cggacaggag ataggatctc cttgggcagc
      661 tgccaggcct tcaagtagtc ctgctgacat ctcaggtaaa tagggatgaa gcctatttat
      721 gcctctagag gggtaacaat aaattgaaat tagtc
//
