LOCUS       NM_001045531            1274 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus spermatogenesis associated 22 (Spata22), mRNA.
ACCESSION   NM_001045531
VERSION     NM_001045531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1274)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1274)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
REFERENCE   3  (bases 1 to 1274)
  AUTHORS   Felipe-Medina,N., Caburet,S., Sanchez-Saez,F., Condezo,Y.B., de
            Rooij,D.G., Gomez-H,L., Garcia-Valiente,R., Todeschini,A.L.,
            Duque,P., Sanchez-Martin,M.A., Shalev,S.A., Llano,E., Veitia,R.A.
            and Pendas,A.M.
  TITLE     A missense in HSF2BP causing primary ovarian insufficiency affects
            meiotic recombination by its novel interactor C19ORF57/BRME1
  JOURNAL   Elife 9, e56996 (2020)
   PUBMED   32845237
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1274)
  AUTHORS   Petrillo,C., Barroca,V., Ribeiro,J., Lailler,N., Livera,G.,
            Keeney,S., Martini,E. and Jain,D.
  TITLE     shani mutation in mouse affects splicing of Spata22 and leads to
            impaired meiotic recombination
  JOURNAL   Chromosoma 129 (2), 161-179 (2020)
   PUBMED   32388826
  REMARK    GeneRIF: shani mutation in mouse affects splicing of Spata22 and
            leads to impaired meiotic recombination.
REFERENCE   5  (bases 1 to 1274)
  AUTHORS   Zhang,J., Gurusaran,M., Fujiwara,Y., Zhang,K., Echbarthi,M.,
            Vorontsov,E., Guo,R., Pendlebury,D.F., Alam,I., Livera,G.,
            Emmanuelle,M., Wang,P.J., Nandakumar,J., Davies,O.R. and Shibuya,H.
  TITLE     The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and
            impairs the mitotic BRCA2-RAD51 function in cancer cells
  JOURNAL   Nat Commun 11 (1), 2055 (2020)
   PUBMED   32345962
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1274)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 1274)
  AUTHORS   Abby,E., Tourpin,S., Ribeiro,J., Daniel,K., Messiaen,S., Moison,D.,
            Guerquin,J., Gaillard,J.C., Armengaud,J., Langa,F., Toth,A.,
            Martini,E. and Livera,G.
  TITLE     Implementation of meiosis prophase I programme requires a conserved
            retinoid-independent stabilizer of meiotic transcripts
  JOURNAL   Nat Commun 7, 10324 (2016)
   PUBMED   26742488
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1274)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1274)
  AUTHORS   Luo,M., Yang,F., Leu,N.A., Landaiche,J., Handel,M.A., Benavente,R.,
            La Salle,S. and Wang,P.J.
  TITLE     MEIOB exhibits single-stranded DNA-binding and exonuclease
            activities and is essential for meiotic recombination
  JOURNAL   Nat Commun 4, 2788 (2013)
   PUBMED   24240703
REFERENCE   10 (bases 1 to 1274)
  AUTHORS   La Salle,S., Palmer,K., O'Brien,M., Schimenti,J.C., Eppig,J. and
            Handel,M.A.
  TITLE     Spata22, a novel vertebrate-specific gene, is required for meiotic
            progress in mouse germ cells
  JOURNAL   Biol Reprod 86 (2), 45 (2012)
   PUBMED   22011390
  REMARK    GeneRIF: Spata22, a novel vertebrate-specific gene, is required for
            meiotic progress in mouse germ cells.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645739.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL645739.9         62830-62864
            36-142              AL645739.9         64177-64283
            143-271             AL645739.9         66387-66515
            272-332             AL645739.9         69099-69159
            333-428             AL645739.9         69284-69379
            429-762             AL645739.9         73340-73673
            763-886             AL645739.9         76826-76949
            887-984             AL645739.9         77735-77832
            985-1274            AL645739.9         78844-79133
FEATURES             Location/Qualifiers
     source          1..1274
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.29 cM"
     gene            1..1274
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /note="spermatogenesis associated 22"
                     /db_xref="GeneID:380709"
                     /db_xref="MGI:MGI:2685728"
     exon            1..35
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     exon            36..142
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1176
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 22"
                     /protein_id="NP_001038996.1"
                     /db_xref="CCDS:CCDS36219.1"
                     /db_xref="GeneID:380709"
                     /db_xref="MGI:MGI:2685728"
                     /translation="MKRNLNESSARSTAGCLPVPLFNQKKRNRQPLTSNPLQNDPGVS
                     TVSDSYGSPSFPTDWAWEAVNPEVAPLKKTVNTGQIPASASYPWRSQDSVSKSIQSNA
                     ERSQSAWGYRGNNRNTSLRTWDFRPQHKTVSPAANSEFSSCPVNLGAQQQKQFQTPEF
                     PNLPGHKEAEVPRQTCLSKLPGSTMKGPDRASALQAFKPSFQQNPFKKTVLGDIPREN
                     SLKEGTLHQLKEKDNSLRIISAVIESMKYWRAHVQKTVLLFEILAVLDSAVTSGPHYS
                     KTFLMRDGKNILPCVFYEIDRELPRLIRGRVHRCVGHYDPDKNIFKCVSVRPASASEQ
                     KTFQAFVTIADAEMKYHTKVTNEM"
     exon            143..271
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     exon            272..332
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     exon            333..428
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     exon            429..762
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     exon            763..886
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     exon            887..984
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1274
                     /gene="Spata22"
                     /gene_synonym="Gm882"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttccgc gtggctgcct gctgaaggag gcgaggttta gttaacttca tcctgtaaat
       61 gtcaagtgct aaatacaaaa agctttgaca cagaagaaaa tgaagagaaa tctaaatgaa
      121 agttcagccc gaagtacagc aggctgtttg cctgtgccat tgttcaatca gaaaaagagg
      181 aacagacagc cattaacttc taatccactt cagaatgatc caggtgtcag tactgtttct
      241 gacagttacg gttccccttc ttttccaaca gattgggcgt gggaagctgt gaatccagag
      301 gtggctcctt taaagaaaac agtgaataca gggcaaatac cagcttctgc ttcttatccc
      361 tggagaagtc aagattctgt gtctaaatct attcaatcaa atgctgaaag aagccaaagt
      421 gcctggggct acagaggcaa caacagaaat actagcttga gaacttggga ttttcgacct
      481 cagcataaaa ctgtaagccc tgcggcaaac agtgagttca gttcttgtcc agtgaatttg
      541 ggagctcaac aacaaaaaca gttccaaaca cctgaatttc ctaacttacc tggacataaa
      601 gaagctgaag taccccgaca aacatgttta tcaaaactgc ctggctctac aatgaaaggc
      661 ccagacagag ccagtgcact gcaggcattt aaaccaagtt ttcaacaaaa tccatttaag
      721 aaaacagtgt tgggagatat tccaagagaa aattctctga aggaaggtac tttgcatcag
      781 ttaaaggaaa aagataattc tttaagaatt atttctgcag ttattgaaag tatgaagtat
      841 tggcgagcac atgtgcagaa aactgtactt ctttttgaaa tattggctgt cctggattca
      901 gctgtcacat ctggcccaca ttattcaaag acttttctta tgagagatgg gaaaaatatt
      961 cttccatgtg tattttatga aattgatcgt gaacttccaa gactgattag aggccgagtt
     1021 cacaggtgtg ttggacacta cgacccagac aagaacattt tcaagtgtgt ttctgtcaga
     1081 ccagcatctg cttctgaaca aaagactttc caagcatttg ttacaattgc agatgctgag
     1141 atgaagtatc atactaaagt aacgaatgaa atgtaaatag tgacaaaggg aattacacag
     1201 tatgagcagg agcttttgct gtcactgctt taccacttgc atggtttaat cactcttgtt
     1261 tttgtatttc actt
//
