LOCUS       NP_001398324             515 aa            linear   ROD 14-FEB-2025
DEFINITION  spermatogenesis-associated protein 2 isoform 1 [Mus musculus].
ACCESSION   NP_001398324 XP_017174138
VERSION     NP_001398324.1
DBSOURCE    REFSEQ: accession NM_001411395.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 515)
  AUTHORS   Griewahn,L., Muller-Foxworth,M., Peintner,L., Wissler,M., Weiss,M.,
            Brauns-Schubert,P., Massoumi,R., Borner,C., Gross,O., Yabal,M.,
            Charvet,C. and Maurer,U.
  TITLE     SPATA2 restricts OTULIN-dependent LUBAC activity independently of
            CYLD
  JOURNAL   Cell Rep 42 (1), 111961 (2023)
   PUBMED   36640323
  REMARK    GeneRIF: SPATA2 restricts OTULIN-dependent LUBAC activity
            independently of CYLD.
REFERENCE   3  (residues 1 to 515)
  AUTHORS   Yang,X.D., Li,W., Zhang,S., Wu,D., Jiang,X., Tan,R., Niu,X.,
            Wang,Q., Wu,X., Liu,Z., Chen,L.F., Qin,J. and Su,B.
  TITLE     PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3
            inflammasome activation at the centrosome
  JOURNAL   EMBO J 39 (2), e102201 (2020)
   PUBMED   31762063
REFERENCE   4  (residues 1 to 515)
  AUTHORS   Zhao,J., Zhao,J., Xu,G., Wang,Z., Gao,J., Cui,S. and Liu,J.
  TITLE     Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha
            expression and attenuated fertility in male mice
  JOURNAL   Biol Reprod 97 (3), 497-513 (2017)
   PUBMED   29025062
  REMARK    GeneRIF: Our data revealed the impact of SPATA2 on male fertility
            and suggested that SPATA2 ensures the normal secretory function of
            Sertoli cells
REFERENCE   5  (residues 1 to 515)
  AUTHORS   Wei,R., Xu,L.W., Liu,J., Li,Y., Zhang,P., Shan,B., Lu,X., Qian,L.,
            Wu,Z., Dong,K., Zhu,H., Pan,L., Yuan,J. and Pan,H.
  TITLE     SPATA2 regulates the activation of RIPK1 by modulating linear
            ubiquitination
  JOURNAL   Genes Dev 31 (11), 1162-1176 (2017)
   PUBMED   28701375
  REMARK    GeneRIF: Spata2 can regulate inflammatory response and cell death
            in both RIPK1-dependent and RIPK1-independent manners
            Erratum:[Genes Dev. 2018 Dec 1;32(23-24):1591. doi:
            10.1101/gad.321075.118.. PMID: 30509949]
REFERENCE   6  (residues 1 to 515)
  AUTHORS   Schlicher,L., Wissler,M., Preiss,F., Brauns-Schubert,P., Jakob,C.,
            Dumit,V., Borner,C., Dengjel,J. and Maurer,U.
  TITLE     SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB
            signaling and cell death
  JOURNAL   EMBO Rep 17 (10), 1485-1497 (2016)
   PUBMED   27458237
  REMARK    GeneRIF: this study identifies SPATA2 as an important factor in the
            TNF signaling pathway with a substantial role for the effects
            mediated by the cytokine.
REFERENCE   7  (residues 1 to 515)
  AUTHORS   Kupka,S., De Miguel,D., Draber,P., Martino,L., Surinova,S.,
            Rittinger,K. and Walczak,H.
  TITLE     SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to
            Signaling Complexes
  JOURNAL   Cell Rep 16 (9), 2271-2280 (2016)
   PUBMED   27545878
  REMARK    GeneRIF: SPATA2 has been described as a previously unrecognized
            factor in the linear ubiquitin chain assembly complex-dependent
            signaling pathways that serves as an adaptor between HOIP and CYLD,
            thereby enabling recruitment of CYLD to signaling complexes.
REFERENCE   8  (residues 1 to 515)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589870.30.
            
            On Aug 25, 2022 this sequence version replaced XP_017174138.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.75384.1,
                                           SRR14995048.2251162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.23 cM"
     Protein         1..515
                     /product="spermatogenesis-associated protein 2 isoform 1"
                     /note="spermatogenesis-associated protein 2"
                     /calculated_mol_wt=57681
     Region          321..338
                     /region_name="PIM motif.
                     /evidence=ECO:0000250|UniProtKB:Q9UM82"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K004.1)"
     Region          429..452
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K004.1)"
     Region          455..498
                     /region_name="Bbox1"
                     /note="B-box-type 1 zinc finger (Bbox1); cd19757"
                     /db_xref="CDD:380815"
     CDS             1..515
                     /gene="Spata2"
                     /gene_synonym="mKIAA0757"
                     /coded_by="NM_001411395.1:496..2043"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="GeneID:263876"
                     /db_xref="MGI:MGI:2146885"
ORIGIN      
        1 mdtkykddlf rkyvqfhegk vdttpgnqqp gsdeylrvaa atllslhkvd plyrfrliqf
       61 yevvesslrs lsssslsalh cafsmletma inlflfpwkk efrsiktytg pfvyyvkstl
      121 lekdirailr fmgyepelgt vyklkelves lqvkmvsfel flakveceqm lgihsqvkdk
      181 gyseldvvae rkgstedarg csdalrrrae srehlttsma rvalqksase raakdyykpr
      241 vtkpsrsvda ydsywesrkp pskaslslrk eplamdvged lkdeiirpsp sllamsssph
      301 gspddlssis singlgllrs tyfstqddvd lytdseprat yrrqdalrpd vwlvkndthp
      361 iyhkrspptk esalskcqnc glscssslcq rcdsvlvcps askpsafpsk asvhdslahg
      421 apmrekyvgh qtqgldrlap vhskpkpstt atsrcgfcnr agatntctqc skvscdaclg
      481 ayhydpccrk selhkflpns qlnyksapfs qlvyr
//
