LOCUS       NM_001033272            7541 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus spermatogenesis associated 13 (Spata13), transcript
            variant 1, mRNA.
ACCESSION   NM_001033272 XM_901902 XM_923227
VERSION     NM_001033272.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7541)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7541)
  AUTHORS   Najas,S., Pijuan,I., Esteve-Codina,A., Usieto,S., Martinez,J.D.,
            Zwijsen,A., Arbones,M.L., Marti,E. and Le Dreau,G.
  TITLE     A SMAD1/5-YAP signalling module drives radial glia
            self-amplification and growth of the developing cerebral cortex
  JOURNAL   Development 147 (13) (2020)
   PUBMED   32541003
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7541)
  AUTHORS   Bourbia,N., Chandler,P., Codner,G., Banks,G. and Nolan,P.M.
  TITLE     The guanine nucleotide exchange factor, Spata13, influences social
            behaviour and nocturnal activity
  JOURNAL   Mamm Genome 30 (3-4), 54-62 (2019)
   PUBMED   31020388
  REMARK    GeneRIF: Spata13 modulates social hierarchy in both male and female
            mice in addition to affecting voluntary activity in females.
REFERENCE   5  (bases 1 to 7541)
  AUTHORS   Chaboub,L.S., Manalo,J.M., Lee,H.K., Glasgow,S.M., Chen,F.,
            Kawasaki,Y., Akiyama,T., Kuo,C.T., Creighton,C.J., Mohila,C.A. and
            Deneen,B.
  TITLE     Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles
            for Asef during Development and after Injury
  JOURNAL   J Neurosci 36 (47), 11904-11917 (2016)
   PUBMED   27881777
REFERENCE   6  (bases 1 to 7541)
  AUTHORS   Kawasaki,Y., Tsuji,S., Muroya,K., Furukawa,S., Shibata,Y.,
            Okuno,M., Ohwada,S. and Akiyama,T.
  TITLE     The adenomatous polyposis coli-associated exchange factors Asef and
            Asef2 are required for adenoma formation in Apc(Min/+)mice
  JOURNAL   EMBO Rep 10 (12), 1355-1362 (2009)
   PUBMED   19893577
  REMARK    GeneRIF: Asef and Asef2 are required for adenoma formation in
            Apc(Min/+)mice. [Asef2, mouse]
REFERENCE   7  (bases 1 to 7541)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   8  (bases 1 to 7541)
  AUTHORS   Yoshizawa,M., Sone,M., Matsuo,N., Nagase,T., Ohara,O., Nabeshima,Y.
            and Hoshino,M.
  TITLE     Dynamic and coordinated expression profile of dbl-family guanine
            nucleotide exchange factors in the developing mouse brain
  JOURNAL   Gene Expr Patterns 3 (3), 375-381 (2003)
   PUBMED   12799088
REFERENCE   9  (bases 1 to 7541)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 7541)
  AUTHORS   Tchernev,V.T., Barbosa,M.D., Detter,J.C., Patel,T.D., Achey,K.,
            Wakeland,E.K., Gueorguieva,R.V., Yang,M.C., Gossler,A. and
            Kingsmore,S.F.
  TITLE     Genetic mapping of 20 novel expressed sequence tags from
            midgestation mouse embryos suggests chromosomal clustering
  JOURNAL   Genomics 40 (1), 170-174 (1997)
   PUBMED   9070936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114000.5 and AC151835.4.
            
            On Apr 15, 2022 this sequence version replaced NM_001033272.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.5281828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC114000.5         125650-125809       c
            161-1855            AC114000.5         67966-69660         c
            1856-2221           AC114000.5         53435-53800         c
            2222-2366           AC114000.5         50945-51089         c
            2367-2503           AC114000.5         14733-14869         c
            2504-2683           AC114000.5         13621-13800         c
            2684-2869           AC114000.5         12888-13073         c
            2870-3049           AC114000.5         10372-10551         c
            3050-3282           AC114000.5         8647-8879           c
            3283-3412           AC114000.5         6604-6733           c
            3413-3785           AC114000.5         3930-4302           c
            3786-3860           AC114000.5         857-931             c
            3861-7541           AC151835.4         115859-119539       c
FEATURES             Location/Qualifiers
     source          1..7541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 31.77 cM"
     gene            1..7541
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /note="spermatogenesis associated 13"
                     /db_xref="GeneID:219140"
                     /db_xref="MGI:MGI:104838"
     exon            1..160
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1855
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..4036
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spermatogenesis-associated protein 13; APC-stimulated
                     guanine nucleotide exchange factor 2"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 13 isoform 1"
                     /protein_id="NP_001028444.1"
                     /db_xref="CCDS:CCDS49516.1"
                     /db_xref="GeneID:219140"
                     /db_xref="MGI:MGI:104838"
                     /translation="MTTAQDGHGQGATATCSASNPKAPKMVTSSACQNGGCKSSPSSD
                     PEAGETRLSPSKLVRLFSGSRKRMNSNSERPRSVVLVGNSSTWNALASFRKMGSFKRL
                     KSSVLQGIQNREGAEVSKEEPTGDPGRAAPNGTVAILGKGLGRCTSLGPVGDGAGSDC
                     SDPEDTEDAFQRSTHRSRSIRRAYGLGRISLLDLGRQPVPEPAVCEIQVRDPEPSRAV
                     PLPRRSKSIDSLSVLKSSFKRKSASNLTELQGDRQVPSRTLSSFFTDPEKPGGSERRT
                     RRWRSPIRAKDFDRVLRLVSNVKDAAWKREAPRSAAPGPGPGLGDENPLLAPRSKLHD
                     DYSRRTSSSVEPDARRGGSPCIPAPCTTAPYAAPEPHLDVDTAVFPLETKSAQPLGND
                     GPRASSPSPIPTDPEGLSQGSSEAHTGSQHPFNPVQLPTPLRPTTPKPQSPQSPGSTK
                     CPSSLSVLSLSSADSEERTEDASHRQPGPVSLQDTVLNAAGDVGGESGDSYFPENLDG
                     ATHPEEKKEEVLVTEDDWPQGSALEEEQNEAPRISRRRWGSGRRTRPRPLSDYGQLAG
                     RSLSIPEDAIAADPPDEDHVDRMHPASVTTTSQDPCAPSGSCRGGRRRRPISVIGGVS
                     FYGNTQVEDVENLLVQPAARPPVPAHQVPPYKAVSARLRPFTFSQSTPIGLDRVGRRR
                     QMKTSNVSSDGGAESSALVDDNGSEEDFSYEELCQANPRYLQPGGEQLAINELISDGS
                     VVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRNEDKEAWFPASFVRLRVN
                     QEELPENCSSSHGEEQDEDTSKARHKHPESQQQMRTNVIQEIMNTERVYIKHLKDICE
                     GYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFL
                     EHQEGFAIYSEYCNNHPGACVELSNLMKHSKYRHFFEACRLLQQMIDIALDGFLLTPV
                     QKICKYPLQLAELLKYTTQEHGDYNNIKAAYEAMKNVACLINERKRKLESIDKIARWQ
                     VSIVGWEGLDILDRSSELIHSGELTKITRQGKSQQRIFFLFDHQLVSCKKDLLRRDML
                     YYKGRMDMDEVELVDVEDGRDKDWSLSLRNAFKLVSKATDEVHLFCARKQEDKARWLQ
                     AYADERRRVQEDQQMGMEIPENQKKLAMLNAQKAGHGKSKGYNSCPVAPPHQSLPPLH
                     QRHITVPTSIPQQQVFALAEPKRKPSIFWHTFHKLTPFRK"
     exon            1856..2221
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2366
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2503
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2683
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2869
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3049
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3282
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3412
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3785
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3860
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..7541
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7518..7523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /note="hexamer: ATTAAA"
     polyA_site      7533
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
     polyA_site      7536
                     /gene="Spata13"
                     /gene_synonym="asef2; ESTM11; mFLJ00298"
                     /note="major polyA site"
ORIGIN      
        1 ggctgagcgc gggagggcgg aatcagcgct gctctttctt ggaggccacg gcgcgcagag
       61 cctggcgagc tcgcggctgc atccctgctg gagccggctg ggcagcagga cctcttggac
      121 acgctggctt tggagcttcg gtggagtggg gaccgtcgag gcagtagctg tgactacgga
      181 tccagatgca cacagcagat gtgaaagcca ggctgctgtc cttggagatg aaggtctgga
      241 gcagggaccc ccagttaccg gcgtgaatgg gggtttgagc caggctgccc accccaagaa
      301 catgacaaca gcccaggatg gccatgggca aggtgccaca gccacttgtt cagcctccaa
      361 cccaaaggcc ccgaaaatgg tgacatcctc agcatgtcag aatggaggct gcaaaagcag
      421 ccccagcagt gatcccgaag ccggggaaac caggctcagc ccatcgaagc tggtacgtct
      481 cttctctggt agtcggaaga ggatgaattc gaactctgag agacctcgct cagtcgtcct
      541 tgtggggaat tcctccacgt ggaatgccct ggcctccttc cgtaaaatgg gctcctttaa
      601 aagactaaaa tcttctgtcc ttcaaggaat tcagaaccgg gagggggcag aagtttccaa
      661 ggaggagcct acaggagacc caggaagggc tgctcccaat ggcaccgttg ccatcctggg
      721 aaagggcctg ggcaggtgta catccttggg ccctgtagga gatggcgccg ggtctgactg
      781 ctcagacccc gaggacacgg aggacgcctt ccagaggagc acacaccgtt ctcgcagcat
      841 ccgcagggcc tatggcctgg gccgcatcag cctgctggac ctggggcggc agccagtgcc
      901 ggagcccgcc gtgtgtgaga tccaagttcg agaccctgaa cccagcaggg ctgtgcctct
      961 gccacgcaga agcaagagca tcgacagctt gagcgtcctg aagagctcct tcaagcgcaa
     1021 gtctgcatcc aacctcacgg aactgcaggg tgacaggcag gttccctcca gaaccttgag
     1081 cagcttcttc acagacccgg agaagccggg tggctcagag agaagaacca gacgctggag
     1141 gagccccatc cgggccaagg acttcgacag agtcctgaga ctggtgagca atgtcaagga
     1201 tgcggcttgg aagagggagg cccccaggag tgcagcccct ggccctggtc ccggtctcgg
     1261 ggatgagaac ccactacttg cgccacgaag caagctacac gatgactact cgcgtcgtac
     1321 tagcagcagc gtggagccag atgccaggcg tggcggctca ccctgtatcc ctgcaccatg
     1381 caccactgcg ccctacgcag ctccagagcc ccacttagat gtggatactg cagtattccc
     1441 cctggaaact aaaagtgctc agccactggg aaatgatgga cctcgtgcca gcagtccctc
     1501 accaatcccc acggacccag aagggttgag ccaaggctcc agtgaggcac atactggcag
     1561 ccaacatcct tttaatcccg tgcagcttcc cactcctctg agacctacca cacccaagcc
     1621 ccaaagccct cagagcccag ggagtactaa gtgccccagt agtctgagtg tgctgtccct
     1681 cagttcagcg gacagtgaag agcggactga ggatgcttcg cacaggcaac cgggacccgt
     1741 gtccctccag gatactgtcc ttaacgctgc tggtgatgtg gggggagaaa gcggtgacag
     1801 ctattttccc gagaatctcg atggagccac ccatccagaa gagaagaagg aagaggtcct
     1861 ggtgactgag gatgactggc cgcagggctc agccctggag gaggagcaga atgaggcgcc
     1921 tcgaatctcc aggaggaggt ggggctcggg acgccgcacc cggccacgac cactgtctga
     1981 ctatggccag ctggccggca gaagcttgtc cattcctgaa gatgccattg ctgcagaccc
     2041 tccagatgag gaccacgtgg acaggatgca cccagcaagt gtgactacca ccagccagga
     2101 tccatgcgcc ccctcaggct cttgcagggg aggccggaga aggcgaccta tatctgtgat
     2161 tggaggggtc agcttctatg gcaacaccca ggtagaggat gtggagaacc tcttggtcca
     2221 accagcagcc aggcctcctg tgcctgcaca ccaagttcca ccctacaagg ctgtgtctgc
     2281 ccgcctccgg cccttcacct tctctcagag cactcccatc gggctggacc gcgtggggcg
     2341 gcgacggcag atgaaaacat ccaatgtctc ttcagatgga ggtgcggagt cttcggcctt
     2401 agtggatgat aatggtagtg aggaagactt cagctatgag gagctctgcc aggccaaccc
     2461 tcggtacctg cagccaggag gggaacagct ggccatcaat gagctcatca gcgatggcag
     2521 cgtggtctgt gcagaagcac tgtgggacca tgtgaccatg gacgaccagg agctgggctt
     2581 caaggctggg gatgtcatcc aagttctgga agcttctaac aaggactggt ggtggggccg
     2641 gaatgaagac aaagaggcct ggttccctgc aagctttgtt aggcttcgag tcaatcagga
     2701 ggagctgccc gagaactgca gcagctccca tggggaagag caggatgagg acaccagcaa
     2761 agcccgccac aagcacccag agagccagca gcagatgcgg accaacgtca tccaggagat
     2821 aatgaacacc gagcgagtgt atatcaagca cctgaaggac atctgcgagg gctatatccg
     2881 acagtgtcgt aagcacacgg gaatgttcac cgttgcgcag ctagccacta tttttggaaa
     2941 cattgaagac atttacaaat tccaaagaaa gtttctgaaa gaccttgaga aacagtacaa
     3001 caaagaggaa cctcacttga gtgaaatagg atcctgcttt cttgagcacc aagagggctt
     3061 cgccatctac tctgagtact gcaacaacca cccaggcgcc tgtgtggagc tgtccaacct
     3121 catgaaacac agcaagtacc ggcacttctt cgaggcctgc cgcctgctcc agcagatgat
     3181 cgacatcgcc ctggacggct tcctcctcac gcctgtgcag aagatctgca aatacccgct
     3241 gcagctggct gagctgctca agtacaccac acaggagcac ggcgattaca acaatataaa
     3301 ggcagcctat gaagccatga agaacgtggc ctgcttgatc aatgaacgca agcgcaagct
     3361 ggagagcatc gacaagatcg cccgctggca ggtgtccatc gtaggctggg agggcctgga
     3421 cattctagac cgaagctctg agttgattca ttccggagag ctgaccaaaa tcaccaggca
     3481 gggcaagagc cagcaacgca tcttcttcct tttcgaccac cagctggtgt cctgcaagaa
     3541 ggacctgctg cgcagggaca tgctatacta caagggccgc atggacatgg acgaggtaga
     3601 gcttgtggac gtggaggatg ggcgggacaa agactggagc ctcagcctgc ggaatgcctt
     3661 caagctggtc agcaaagcca cggacgaggt ccatctgttc tgcgccagaa agcaagaaga
     3721 caaggccagg tggctgcagg cctatgcgga cgagaggcgg cgggtgcagg aggaccagca
     3781 gatgggtatg gaaatcccag aaaatcagaa gaaactcgcc atgttgaacg ctcagaaggc
     3841 aggacatggg aaatctaaag gctacaacag ctgtcccgtg gccccacccc accagagcct
     3901 gccgcccctt caccagcgcc acatcactgt gcccaccagc atcccgcagc agcaggtctt
     3961 tgccttggct gagcccaaga ggaagccatc gatattctgg cacactttcc acaaactcac
     4021 ccccttccgg aaatgagcct tacccagggc gtgcctctga ggtactgtgg ggaggaagac
     4081 cagctttgtc acttcagcgt gatgtccggg gatggcttct tgctcagtgc tgaacacttc
     4141 atttggggat cgatgaaggg gagaagaagt tggactcagc tttgaccttg aaaggcccca
     4201 gcacccttgt cgaaggaagg aaccatgaag cactgttctg tcccacactg gaagccacac
     4261 tctccggtgg ccatgatata aggaccaggg cttctctgta tggagactgc tgactcagtt
     4321 tcccactgac ggtcacactc ctccagttcc gaacagtatc aggagccttt cagttcctca
     4381 ggagcaacta cattgaggac agcttctgtg tttgatctta aaggagactc attgacagga
     4441 gttggtagga tgttggcagc catgggatga cctgggtctg gtcaggccct gaagagacca
     4501 tgaaggaact agagccaatg gagcaggtgc ccatagttct ccaaggtgtc acagatgcca
     4561 agctagagtg taggtctcat cctgcaaggt tccttactct caagagaatc gggaggcacc
     4621 tgctgccctg gcagtgccgg ggatgatagc atcctcaggg cagtgccact ttccagacag
     4681 gtgggaaggc tgctgccacc tgacttgtcc cttcaaacag cggtcacgcc ttgctcaccc
     4741 ctcacaacct aagaacctgc catccgcaga agtacgggtg atgtgaaacg tgtaactttg
     4801 ataatgtgac actgcatctt cagcggccct ttgtatcact ggtgggatga agaaggcaca
     4861 tccacagaga aaaccagggc aaaaccatcc tgcttcctgg ggaaatggac acgcctctgt
     4921 cacgtgaccc tgaaacagta gtaaatcgag aatggtcttg atggctcctt agctctgaga
     4981 gagctgactc ttaatgaggg ccacaggagc tgacacccac agagagcaac ctttctctgt
     5041 tgacactgtg tttgttagtt gatgaaaatg ccttttaact cgacctaagg gagactggtt
     5101 ctgcatttga atctgcacag cgggctggcc aggaggggtc ctgccgtgtg gctagtgtgt
     5161 tcctttggac gtgatcttgt atgcgggttt tgtgcaaggt tctcgcctct catcagctct
     5221 cgcttgagga taagcaagtc cgcagtgtca gagatgaagg tattggtccg tcagcacagt
     5281 tcaccgtgtc tccacatcta tgcctgaaac aagtcacatc acagctaata accttgaccc
     5341 tgggcctggg atcaacctca accctgctgt gcaccttggc atggtcactt ataggcagca
     5401 ctgctgagga ctgtagtcag tgccccccat cccccgcagg tgtgtctgtg tgctatgaag
     5461 tggttcaggt gtacagagca tgcgccgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5521 gtgtgtgtgt gtaagagggt ggcagggagg gagacggagg cctcaacttc actgcattta
     5581 tataactgac aggtttggtt ggttggttgg tttcttgttt gttttctaat agaatgtcag
     5641 gatatatttt tagaaaccat actttgggta cttttctgtg ctccagtgtg tgtgtgcagc
     5701 aattctcaca gttgtattgt taatatgaaa attgctttaa agaagtgaat agtctttggt
     5761 cctgttcatt ttcactgcgg attcctcttg agtcagaccc gctgcaggct ccatttgctg
     5821 ttacagctga cgacagtgaa gaaggctatg tttgtgaccg gtcctaatag aattcccagc
     5881 tgccctaact tccagttccc accacctcca cagagccccc taacaatccc ggatatcagg
     5941 acgtgtttat attgagtcac attcaagacc tgggctggcc ccgggtgatt ttatacagcc
     6001 tgagaagtgc ttgatcaaat aaagtctgac ccaggtgact tacttgggat ttctgggtga
     6061 ttttgaaaac taatgtgttt ttaaaagatg taatagcctt tgactttgta aaactctgta
     6121 tgtcagtatg cattttatta ccaaatacag aatgtggagg acctttagta gtttttattt
     6181 tcagttcgcc aaacttcctt tttgatgtaa ggcatgtgct ctactttgga aggaaataga
     6241 aacaacaaag aacctcctgc ccagacggct cacgaacatc ccctccctct ccctcaatgg
     6301 gccaaataat attggtgatt taaaatgttg atgaattcat ttgttctatt tttagcgtat
     6361 ttttagcatt ccagaatttg ccagctctgt tcacgtgata gagaaggcct ccctggctta
     6421 gattgtacct ataacgtgta ggcgtcgtgt ggtaggtaaa aagtgatcac aacacttgaa
     6481 ggtgtagaga aagaaagaac attccagcag ctgattgggc ttgtgtgagc gtttgatgcc
     6541 ggcccctagc tcctgtcacc tgctctggtc ttccttgcct ctcgcgcgtg gtagatccac
     6601 ccctgcaggt gagagccacc accgccactg tttctaacta ctgtgccttt tactgtccaa
     6661 tctattgaag actgattcct catcctgcgt cgctgttatt acatgcaaag cataaagtgt
     6721 atttaatttg aaacctggtt caaagcgcaa gtcttttttt tttttttttt aagcaccagc
     6781 gctccagcat tgtgtgcttg tggggatctg taactggatt gctgatgttt ctcaggacaa
     6841 attagtcctt ttttccagcc agagtttcct ggagccaggg catggtttct gcattacggc
     6901 ttcatcacag ataggaaaag cagaagtgtc ctcaggccag tgccaagaaa tataagtcag
     6961 tgcctttcag ctgacaggca ggatgctggg cacattgtgc ccacagattg ttccttctca
     7021 ggacccgggg aaaggggcgc ttgaaagatt taggacaaag taagtggaaa cctctagcca
     7081 gtcttagaga ggggaaagaa acatcagctt atataatgta tgtaaatttg ctaagccacc
     7141 ccatgtacct accacattat tgcctttact gttctcctgg gcattgccaa ttgtatttag
     7201 aaagtacttt gagccaattc tataatttaa ttggtcctct tttggggtac atattggtgc
     7261 ccactgtgca tgacttgccg atcttggcta tgcttttgat gataacaaat ccaggctgcg
     7321 gtgctgtggt ctgtaagagt caagctgctg agctggtggg ctgcctttga ccctgaaata
     7381 ggacccgcgt gctagacgtg catcttggct gaatgaaggg tttattggtt tttagtgtct
     7441 ttttgttctt aaaaaaatac tgttatttga tttcttgtaa atgctgtgaa tctctatttg
     7501 tcattttgta tttgtatatt aaaattaatt tgccaagctg g
//
