LOCUS       NM_010097               3132 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus SPARC-like 1 (Sparcl1), transcript variant 3, mRNA.
ACCESSION   NM_010097
VERSION     NM_010097.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3132)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 3132)
  AUTHORS   Coren,L., Zaffryar-Eilot,S., Odeh,A., Kaganovsky,A. and Hasson,P.
  TITLE     Fibroblast diversification is an embryonic process dependent on
            muscle contraction
  JOURNAL   Cell Rep 43 (12), 115034 (2024)
   PUBMED   39636726
REFERENCE   3  (bases 1 to 3132)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 3132)
  AUTHORS   Zhao,G., Gentile,M.E., Xue,L., Cosgriff,C.V., Weiner,A.I.,
            Adams-Tzivelekidis,S., Wong,J., Li,X., Kass-Gergi,S., Holcomb,N.P.,
            Basal,M.C., Stewart,K.M., Planer,J.D., Cantu,E., Christie,J.D.,
            Crespo,M.M., Mitchell,M.J., Meyer,N.J. and Vaughan,A.E.
  TITLE     Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia
            through pro-inflammatory macrophage activation
  JOURNAL   Nat Commun 15 (1), 4235 (2024)
   PUBMED   38762489
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3132)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3132)
  AUTHORS   Oritani,K., Kanakura,Y., Aoyama,K., Yokota,T., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Tomiyama,Y., Matsuzawa,Y. and
            Kincade,P.W.
  TITLE     Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis
  JOURNAL   Blood 90 (9), 3404-3413 (1997)
   PUBMED   9345023
REFERENCE   7  (bases 1 to 3132)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 3132)
  AUTHORS   Soderling,J.A., Reed,M.J., Corsa,A. and Sage,E.H.
  TITLE     Cloning and expression of murine SC1, a gene product homologous to
            SPARC
  JOURNAL   J Histochem Cytochem 45 (6), 823-835 (1997)
   PUBMED   9199668
REFERENCE   9  (bases 1 to 3132)
  AUTHORS   McKinnon,P.J., Kapsetaki,M. and Margolskee,R.F.
  TITLE     The exon structure of the mouse Sc1 gene is very similar to the
            mouse Sparc gene
  JOURNAL   Genome Res 6 (11), 1077-1083 (1996)
   PUBMED   8938431
REFERENCE   10 (bases 1 to 3132)
  AUTHORS   Oritani,K. and Kincade,P.W.
  TITLE     Identification of stromal cell products that interact with pre-B
            cells
  JOURNAL   J Cell Biol 134 (3), 771-782 (1996)
   PUBMED   8707854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY277497.1, AK134608.1, AK158725.1 and CD742522.1.
            
            On Apr 22, 2009 this sequence version replaced NM_010097.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003759.1, SRR1660821.159286.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               BY277497.1         2-361
            361-1858            AK134608.1         2-1499
            1859-3114           AK158725.1         1366-2621
            3115-3132           CD742522.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.55 cM"
     gene            1..3132
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /note="SPARC-like 1"
                     /db_xref="GeneID:13602"
                     /db_xref="MGI:MGI:108110"
     exon            1..712
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..777
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             724..2676
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /note="SPARC-like protein 1; matrix glycoprotein Sc1;
                     SPARC-like 1 (mast9, hevin); extracellular matrix protein
                     2"
                     /codon_start=1
                     /product="SPARC-like protein 1 precursor"
                     /protein_id="NP_034227.3"
                     /db_xref="CCDS:CCDS19483.1"
                     /db_xref="GeneID:13602"
                     /db_xref="MGI:MGI:108110"
                     /translation="MKAVLLLLCALGTAVAIPTSTRFLSDHSNPTTATLVTPEDATVP
                     IAGVEATADIENHPSDKAEKPSALNSEEETHEQSTEQDKTYSFEVDLKDEEDGDGDLS
                     VDPTEGTLTLDLQEGTSEPQQKSLPENGDFPATVSTSYVDPNQRANITKGKESQEQPV
                     SDSHQQPNESSKQTQDLKAEESQTQDPDIPNEEEEEEEDEEEEEEEEPEDIGAPSDNQ
                     EEGKEPLEEQPTSKWEGNREQSDDTLEESSQPTQISKTEKHQSEQGNQGQESDSEAEG
                     EDKAAGSKEHIPHTEQQDQEGKAGLEAIGNQKDTDEKAVSTEPTDAAVVPRSHGGAGD
                     NGGGDDSKHGAGDDYFIPSQEFLEAERMHSLSYYLKYGGGEETTTGESENRREAADNQ
                     EAKKAESSPNAEPSDEGNSREHSAGSCTNFQCKRGHICKTDPQGKPHCVCQDPETCPP
                     AKILDQACGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPACTDFEVAQ
                     FPLRMRDWLKNILMQLYEPNPKHGGYLNEKQRSKVKKIYLDEKRLLAGDHPIELLLRD
                     FKKNYHMYVYPVHWQFNELDQHPADRILTHSELAPLRASLVPMEHCITRFFEECDPNK
                     DKHITLKEWGHCFGIKEEDIDENLLF"
     exon            778..906
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1902
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1972
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2091
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2212
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2349
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2498
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2647
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..3117
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3093..3098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /note="hexamer: AATAAA"
     polyA_site      3117
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; hevin; mast9; Sc1"
                     /note="major polyA site"
ORIGIN      
        1 attttccaga gctgcttacg agtaggacgg ttaaagcagc cggaacggtt ctctgttaac
       61 gttcagactg cggtcatgag gacagcttcc aatcgagcaa tataaaaacg catctgctgc
      121 agtgatcctt ctgtcctttc accctggctt tgcagtcgcc ctaggaataa acaagagtgt
      181 gaagcctctc tgcagtgtct cagagtcaca agccccaagg gatcccaatc atacgatctc
      241 tcagagttgt ttgaaaaaaa aaaattgcat gaagagccaa atgcttacac tctggccaag
      301 ttaggagcct atgaggagga gaggctaggg gagggccgtt cactccatgc atgctgcaga
      361 attagctctc tccctctggg tctgctctgc tgcaaagctc agcagcacgg agggagcgag
      421 atccaggaat ctgcaacaga aaccatgaca gcctgaaaca ccctgtggtg ccaacctcca
      481 aattctcatc tgtcacttca gaccctgact ggctgacaga gcagcagaat ttcaactcca
      541 ataaacgtga atgtgcttct aggcaaagca gccaagctga cgagggaggg gggtggaaga
      601 gctagctcct cttgggcatt tgtcaaactt ttacctcctg gctgtgtgca aggaggggac
      661 tcaacttcgg cttcaagcta ccaaggctct ggatccagcc acctctccgc agatctagcc
      721 agcatgaagg ctgtgcttct cctcctgtgc gccttgggaa ccgctgtggc aatcccgaca
      781 agtacaaggt ttctctctga ccactccaac ccaactactg caacactggt gacaccggaa
      841 gacgctacag tccccattgc cggggttgaa gctacagcag acatagaaaa ccatcccagt
      901 gacaaggctg aaaaaccttc agcacttaat tcagaagagg aaactcatga acagtcaaca
      961 gagcaggaca aaacctacag cttcgaggtg gacctgaagg atgaggagga tggagatggg
     1021 gatttaagtg tagatccaac ggaaggaaca ctaacactgg atctacaaga aggtacaagt
     1081 gagcctcaac agaaaagtct cccggagaac ggcgatttcc ccgcgaccgt gtccacttcc
     1141 tatgtggatc ctaaccaacg cgcaaacatc acaaagggaa aggagagtca ggagcaacct
     1201 gtaagtgact cacaccagca accgaatgaa agcagcaagc aaacccaaga cttaaaggct
     1261 gaagaaagcc agacacaaga tccagacatt cccaatgaag aagaggaaga agaagaggac
     1321 gaagaagagg aagaagagga agagccggaa gacattggtg cccccagtga taaccaagag
     1381 gagggaaaag aacctctgga ggagcagcct accagcaagt gggaaggaaa cagagagcaa
     1441 tctgatgaca ccttagaaga gtccagtcag cccactcaga taagcaagac agagaagcat
     1501 caatctgagc aaggaaacca agggcaggag agtgactctg aggcagaagg agaggacaag
     1561 gctgcaggca gcaaggaaca cattccacat acagagcagc aggaccaaga agggaaagct
     1621 ggccttgaag ctattggcaa ccagaaggac actgatgaga aggccgtttc cacagaacct
     1681 accgatgctg ccgtggtgcc taggagtcac ggaggagctg gtgataacgg gggcggggat
     1741 gactctaagc atggtgcagg cgatgactac ttcatcccca gccaggaatt cctagaggcc
     1801 gaaaggatgc attccctctc ctattacctc aaatatggcg gcggcgagga gacaacgact
     1861 ggcgagagtg agaaccggag ggaggctgca gacaaccaag aggccaagaa agctgagagc
     1921 tcaccaaatg ctgaaccttc agatgagggc aactcaaggg agcacagtgc tggttcttgc
     1981 acgaacttcc aatgtaaaag gggacacatt tgcaaaaccg atccacaagg gaaacctcac
     2041 tgtgtttgcc aagatccaga gacttgtccc cctgcaaaaa tcctagatca ggcttgtggc
     2101 actgacaacc aaacctacgc cagctcctgt cacctgtttg ctaccaagtg caggctggag
     2161 gggaccaaaa agggacacca actgcagctg gattacttcg gagcttgcaa atctattcct
     2221 gcttgtacgg actttgaagt ggctcagttt cccctgcgga tgagagactg gctcaaaaac
     2281 atcctcatgc agctttatga accaaatccc aaacatggcg gctatctcaa tgaaaagcaa
     2341 agaagcaaag tcaaaaaaat ttacctggat gagaagagac tcttggctgg agaccatccc
     2401 attgaacttc tcttgaggga ctttaagaaa aactaccaca tgtatgtgta tcctgtgcac
     2461 tggcagttta atgaactgga ccagcatcct gcagacagga tcttgacaca ctctgaactt
     2521 gctcctctgc gagcttccct ggtgcccatg gaacactgca taactcgctt ctttgaggag
     2581 tgtgacccca acaaggataa gcacatcacc ttgaaggaat ggggccactg ctttggaatt
     2641 aaagaggagg atatagatga aaacctcctc ttttgaatta agatttgaga gaatcggaac
     2701 tttccatcca cctcacctgc tttaaccgct tcagaaatac gagcagccat gacactatac
     2761 attcatatgt agcaaaacat ttgtttgcat gtgagagaag acaatggtag taattacttc
     2821 ttggtgatat atatatgagc caggcactta atattaactt aggaaatgaa actttaaaat
     2881 taagtagagt caatgtctat aaaagactgt cctgtctggg gacagttagc caccatggca
     2941 atgtcactct gtgcatctgc gtttataatt gataattata aactattaaa aaaacaatgt
     3001 tcatattgtc cataatacct tatgcatgct gaggaagtga gatactgctc ttttgagata
     3061 aatatgcctc cttttcagtg tcttgatgtc ctaataaaaa atctataaaa cctcaaaaaa
     3121 aaaaaaaaaa aa
//
