LOCUS       NM_001199204            7399 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus sperm associated antigen 9 (Spag9), transcript variant
            6, mRNA.
ACCESSION   NM_001199204
VERSION     NM_001199204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7399)
  AUTHORS   Tian,M., Zhang,L., Zhang,M., Qiao,L., Xu,B., Li,C., Liu,S.,
            Song,Y., Wei,Z., Wang,Y. and Wang,H.
  TITLE     JLP/Foxk1/N-cadherin axis fosters a partial epithelial-mesenchymal
            transition state in epithelial tubular cells
  JOURNAL   iScience 26 (4), 106396 (2023)
   PUBMED   37013185
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7399)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7399)
  AUTHORS   Mohan,R.A., Bosada,F.M., van Weerd,J.H., van Duijvenboden,K.,
            Wang,J., Mommersteeg,M.T.M., Hooijkaas,I.B., Wakker,V., de Gier-de
            Vries,C., Coronel,R., Boink,G.J.J., Bakkers,J., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     T-box transcription factor 3 governs a transcriptional program for
            the function of the mouse atrioventricular conduction system
  JOURNAL   Proc Natl Acad Sci U S A 117 (31), 18617-18626 (2020)
   PUBMED   32675240
REFERENCE   4  (bases 1 to 7399)
  AUTHORS   Hanata,N., Shoda,H., Hatano,H., Nagafuchi,Y., Komai,T., Okamura,T.,
            Suzuki,A., Gunarta,I.K., Yoshioka,K., Yamamoto,K. and Fujio,K.
  TITLE     Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of
            Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice
  JOURNAL   Front Immunol 11, 1095 (2020)
   PUBMED   32655553
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7399)
  AUTHORS   Yan,Q., Zhu,K., Zhang,L., Fu,Q., Chen,Z., Liu,S., Fu,D.,
            Nakazato,R., Yoshioka,K., Diao,B., Ding,G., Li,X. and Wang,H.
  TITLE     A negative feedback loop between JNK-associated leucine zipper
            protein and TGF-beta1 regulates kidney fibrosis
  JOURNAL   Commun Biol 3 (1), 288 (2020)
   PUBMED   32504044
  REMARK    GeneRIF: A negative feedback loop between JNK-associated leucine
            zipper protein and TGF-beta1 regulates kidney fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7399)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 7399)
  AUTHORS   Kelkar,N., Delmotte,M.H., Weston,C.R., Barrett,T., Sheppard,B.J.,
            Flavell,R.A. and Davis,R.J.
  TITLE     Morphogenesis of the telencephalic commissure requires scaffold
            protein JNK-interacting protein 3 (JIP3)
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9843-9848 (2003)
   PUBMED   12897243
REFERENCE   8  (bases 1 to 7399)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7399)
  AUTHORS   Lee,C.M., Onesime,D., Reddy,C.D., Dhanasekaran,N. and Reddy,E.P.
  TITLE     JLP: A scaffolding protein that tethers JNK/p38MAPK signaling
            modules and transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14189-14194 (2002)
   PUBMED   12391307
  REMARK    GeneRIF: describe a protein, JLP, which acts as a scaffolding
            protein to bring mitogen-activated protein kinases and their target
            transcription factors together for the execution of specific
            signaling pathways
REFERENCE   10 (bases 1 to 7399)
  AUTHORS   Bowman,A.B., Kamal,A., Ritchings,B.W., Philp,A.V., McGrail,M.,
            Gindhart,J.G. and Goldstein,L.S.
  TITLE     Kinesin-dependent axonal transport is mediated by the sunday driver
            (SYD) protein
  JOURNAL   Cell 103 (4), 583-594 (2000)
   PUBMED   11106729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161623.1, FJ042496.1, AK147431.1 and CO044222.1.
            
            On May 10, 2018 this sequence version replaced NM_001199204.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.246350.1, FJ042496.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AK161623.1         2-129
            129-3587            FJ042496.1         6-3464
            3588-7389           AK147431.1         3196-6997
            7390-7399           CO044222.1         17-26               c
FEATURES             Location/Qualifiers
     source          1..7399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.9 cM"
     gene            1..7399
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /note="sperm associated antigen 9"
                     /db_xref="GeneID:70834"
                     /db_xref="MGI:MGI:1918084"
     exon            1..483
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..4143
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     JNK-interacting protein 4; C-jun-amino-terminal
                     kinase-interacting protein 4; JNK-interacting leucine
                     zipper; JNK/SAPK-associated protein 2; JNK-associated
                     leucine-zipper protein; mitogen-activated protein kinase
                     8-interacting protein 4"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     4 isoform 6"
                     /protein_id="NP_001186133.1"
                     /db_xref="GeneID:70834"
                     /db_xref="MGI:MGI:1918084"
                     /translation="MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDE
                     EVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEK
                     FIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALH
                     QRHTEMIHNYMEHLERTKLHQLSGSDQLEATAHSRIRKERPISLGIFPLPAGDGLLTP
                     DTQKGGETPGSEQWKFQELSQPRSHTSLKDELSDISQGGSKATTPASTANSDVSAIPP
                     DTPSKEDNEGFVKGTDTSNKSEISKHIEVQVAQETRNVSTESGENEEKSEVQAIIEST
                     PELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGM
                     GREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLED
                     KNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERL
                     MELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNATKKPEPPVNLKYNA
                     PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQK
                     EDGRVQAFGWSLPQKYKQVANGQGETKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLS
                     GGKTRDGGSVVGASVFYKDIAGLDTEGSKQRSASQSSLDKLDQELKEQQKEFKNQEEL
                     SSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEEL
                     SESGQVDKASLCGSMTSNSSAEMDSLLGGITVVGCSTEGLTGAATSPSTNGASPVIEK
                     PPEMETENSEVDENIPTAEEATEATEGNAGSTEDTVDISQPGVYTEHVFTDPLGVQIP
                     EDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSS
                     VAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLG
                     RPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGV
                     WVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWV
                     GTGNGVIISIPLTETVILHQGRLLGLRANKTSGTPGNRPGSVIRVYGDENSDKVTPGT
                     FIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSGGADLTADKAGSSAQEPSSQ
                     TPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
                     "
     exon            484..604
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..675
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..770
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..921
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1129
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1229
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1351
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1409
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1562
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1614
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1745
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1802
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1976
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2106
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2196
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2364
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2536
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2755
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2951
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3077
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3158
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3226
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3375
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3547
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3661
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3700
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3701..3877
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..4027
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..7399
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7371..7376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /note="hexamer: TATAAA"
     polyA_site      7393
                     /gene="Spag9"
                     /gene_synonym="3110018C07Rik; 4733401I23Rik;
                     4831406C20Rik; JIP-4; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4;
                     syd1"
                     /note="major polyA site"
ORIGIN      
        1 agttggtgca gcggcggttg gggcgagtgc gctcacccca cccctcccct ccttggccag
       61 ggctccggcc cccaccccgc ggggcccagc cccagcccca gcctccgccg ggcccgtccc
      121 gtgcgggccc gtgccacccc tcagccggcg acgcccgggg ccgcccgccc gcccgccacc
      181 atggagctgg aggacggtgt ggtataccag gaggagcccg gaggctccgg ggccgtgatg
      241 tcagagcggg tgtccggcct ggccggctcc atctaccgcg agttcgagcg gctcatcggg
      301 cgctacgatg aggaggtggt caaggagctg atgccactgg tggtggccgt gctggagaac
      361 ctggactcgg tgttcgcgca ggaccaggag caccaggtgg agctggagct gctgcgggac
      421 gacaacgagc agctcatcac ccagtacgag cgggagaagg cgctgcgcaa gcacgccgag
      481 gagaaattca ttgaatttga agactctcaa gaacaggaaa aaaaggattt acagacgcga
      541 gtggagtctc tagaatctca aacaagacaa cttgaactca aagcaaaaaa ctatgctgac
      601 cagatcagca gacttgaaga gagagaagca gaactgaaga aggaatataa tgcactgcat
      661 cagagacaca ctgagatgat ccataattat atggaacact tagaaagaac caaacttcat
      721 cagctctcag ggagtgatca actagaggct acagctcata gtagaattag aaaagaacgt
      781 cctatatcat tagggatttt ccctctacct gctggagatg gattgcttac acctgacact
      841 cagaaaggag gcgagacccc aggatcagag caatggaaat ttcaagaatt aagtcaacca
      901 cgttctcata ccagcctgaa ggatgaactt tctgatatta gtcaaggtgg atctaaagct
      961 accactccag cttcaacagc aaattcagac gtatcagcaa ttcctcctga tactccgtca
     1021 aaggaagata atgaaggatt tgtaaaaggc acagatacat caaataagtc agagataagc
     1081 aaacacatag aagtccaggt tgcccaagag actaggaatg tgtctacaga atctggtgaa
     1141 aatgaagaga aatcagaagt tcaagcaatc attgaatcca ctcctgaatt ggatatggac
     1201 aaagacctca gtggatataa aggttcaagc actcccacca aaggcataga gaacaaagct
     1261 tttgatcgca atacagaatc tctctttgaa gagctgtcct cagctggctc gggccttatt
     1321 ggagatgtgg atgaaggagc ggatttacta ggaatgggtc gtgaggtgga gaatctcata
     1381 ctggagaaca cacagctgct ggaaaccaaa aacgctctga atgtagtgaa gaatgactta
     1441 atagccaaag tggatgagct gacctgtgag aaggacgtgc tgcaggggga gctggaggct
     1501 gtgaagcaag ccaagctgaa gctggaggac aagaacagag agctggagga ggagctcagg
     1561 aaagctcgtg cagaagctga agatgcaagg caaaaagcaa aagacgatga tgatagtgac
     1621 attcccacag cccagaggaa gaggtttacc agagtagaaa tggcccgagt tctcatggag
     1681 agaaaccagt acaaagagag gctgatggag cttcaagaag ctgttcgatg gacggagatg
     1741 atccgggcct cacgagagaa cccagctatg caagaaaaga aaaggtcaag catctggcaa
     1801 tttttcagcc gactttttag ctcttcaagt aatgcaacaa agaagcctga accccctgtt
     1861 aacctgaagt acaacgcccc cacctctcac gtgactccct ccgtgaagaa aaggagcagc
     1921 actttatctc agctccctgg ggacaagtcc aaggcatttg atttcctcag tgaggaaact
     1981 gaggctagtt tagcctcccg cagagagcaa aagagagagc agtatcggca ggtgaaggct
     2041 cacgttcaga aggaagatgg ccgagtgcaa gctttcggct ggagtctgcc tcagaagtac
     2101 aaacaggtag ccaatggtca aggggaaact aagatgaaaa atttacctgt gcctgtctat
     2161 ctcagaccac tagacgaaaa agatgcgtct atgaagctgt ggtgtgctgt aggagtcaat
     2221 ttatctggtg gcaagacaag agatggcggg tctgttgttg gagcgagtgt attttacaag
     2281 gatattgctg gtttggacac tgaaggcagt aaacagcgga gtgcgtctca gagtagttta
     2341 gacaagttgg atcaagaact caaggaacag cagaaagaat ttaaaaatca agaagagttg
     2401 tccagtcagg tctggatctg taccagcacc cactcaacta caaaggttat catcattgat
     2461 gctgttcagc ctggcaacat cctagatagt ttcactgttt gcaattctca tgttctgtgc
     2521 attgccagtg tcccaggagc tcgggaaaca gactaccctg caggagaaga actttctgaa
     2581 tctggtcagg tagacaaagc gtcattgtgt ggaagcatga ccagtaacag ctccgcagag
     2641 atggacagct tgctgggagg catcacagtg gttgggtgct ccacagaagg actgacagga
     2701 gctgccactt ccccaagtac caacggtgct tctcctgtga ttgaaaagcc accagaaatg
     2761 gaaactgaaa atagcgaagt tgatgaaaat attccaacag cagaagaagc aactgaagcc
     2821 acagagggca atgcagggtc cactgaagac actgtggaca tctcccagcc tggcgtgtac
     2881 acagagcatg tgtttacaga tccactggga gttcagatcc cagaagacct ctccccagtg
     2941 tttcagtcaa gtaatgactc agatgtgtac aaagatcaaa tatcagtatt gccaaatgaa
     3001 caagaccttg cgagagaaga agctcagaaa atgagtagtc ttttaccaac catgtggctt
     3061 ggagctcaga atggctgttt gtatgtccac tcatctgtag cccagtggag gaaatgtctc
     3121 cattccatta agctcaaaga ctcaattctc agtattgtac atgtgaaagg aattgtacta
     3181 gtggccctgg cggatggcac ccttgcaatc ttccacagag gagttgatgg acaatgggat
     3241 ctgtcaaact atcacctttt agaccttgga cgtcctcatc attccatacg atgcatgact
     3301 gtggtacatg acaaagtctg gtgtggctat aggaacaaaa tctatgtggt tcaaccaaag
     3361 gctatgaaga tagagaaatc atttgatgca caccccagga aggagagcca agtacggcag
     3421 cttgcatggg tgggtgatgg tgtatgggtc tccattcgtt tggattccac gctccgcctc
     3481 tatcatgcac acacatacca acatctccag gatgtggata ttgagcctta tgtaagcaaa
     3541 atgttaggta ctggaaaact gggtttctct ttcgtgagga taacagctct tatggtgtct
     3601 tgcaatcgtt tgtgggtggg gactggaaat ggtgtcatta tctccatccc actgacagaa
     3661 accgtaatcc tccaccaggg acgtttactg gggctaaggg caaataaaac ctcagggact
     3721 ccaggtaacc gtcctggaag tgtaatccgt gtatatggtg atgagaacag tgataaagtg
     3781 actccaggga catttatacc ctactgttca atggcacatg cacagctttg tttccacggg
     3841 caccgggatg ctgtgaaatt ctttgtggca gtcccaggtc aggtcattag cccacaaagt
     3901 agcagtggtg gggcagatct tacagctgac aaggcagggt catctgcaca ggagcccagt
     3961 agccagacgc ccttgaagtc catgcttgtc atcagtggag gagagggcta cattgacttc
     4021 cggatgggtg atgaaggtgg agaatctgaa cttctgggag aggatcttcc actggaacct
     4081 tcagtcacca aagccgagag gagtcacctg atagtgtggc aagtgatgtg tggcaatgaa
     4141 tgagtctgtg agagacagac gaggatgagg aagttgcctc ttctgcatgg tttattttcc
     4201 ctttttcctt tatttaatgc tctttttgtg aaagacattt caccacataa taatgtgagc
     4261 attttcccct gttaccttta tattacacaa tctgttctat ggtaacaata cagaggagcg
     4321 agctagttta ctgcaccagt gttaatagga aatttcagta tatcatgaac aaatcgaaga
     4381 aggtttactt tctgtaaact gataaattac agaaagcaat ccagatgtgg tttgctctgc
     4441 cacagtctaa tgtcactcac ttaattgatg aggccatgtt ttacctgtca ctaataatgg
     4501 aactaatgga aaagacttaa taaatgaaat tgtaccatga agtacaatag agttttcccc
     4561 agtgtattat agaattgacg cactaataac agacggatta tcacgatttg tctgaatgtc
     4621 ccaagagcgc taagagctaa ctgtaaagta ctttaacttt cactttcaat tctgacaaat
     4681 cttgtttata tggtatataa aactttgttt tcatcagact cggggggttt tatattaaag
     4741 aaattaaggc tacactattt aaataaaatt tcttgttcct gtctcattag aactctaaag
     4801 tttacgaagc ctgcttctct gaatattctc atattttaga tgaatttcac ccattttcat
     4861 actgacattt aagaagtgta ttatctgacg tttaggaaat aacctgggaa gtgtggagga
     4921 cacttcaata ctggaaggat ggtctaaaag gaaattatgt tttgaattcc ttgtcctaga
     4981 gaatggtggt agtggattca gttttttcca tagaaaaaaa tgtacccatt agccacatgt
     5041 ccctaggctg ctcttaacct atcacggagg ggacactgtg gtggccgtgg attctgcctc
     5101 gtttgctgag tgcttaatga gtaggaaagg tgatttgttt tattctgtat aaaactacca
     5161 aacacctagt gcttgcttgg tataactact cttcagcatt tgttccctga taaaatgcca
     5221 tcttcaagga agtgcggtgg gaaagcaggc agagtctgca cctgtctcca ttcgtggcat
     5281 ccatctgaga aagtggggtc acatctagct ttaactggta accttaggag gtttcaaaaa
     5341 ccatgagcta caggcttgct ttcctctctc aagcttcctg aaagtaaatg atttaccatt
     5401 tcttacccac tgctgcaagc aaagttgaac ttaattttat gtgatctctt aaaaacatac
     5461 aggaaacagg tcttcgggtc attggaagga ccacctcata gaaaagaaat caaatacaga
     5521 tctctaattg tccaagtacg ggggatttcc cccggactgt catacaaaaa tatgtgtaaa
     5581 aaatatacca gggatttttt tcacatgtat atgattaggc tagatcctaa aatacatagg
     5641 acctagtgag catgggaggc ttttgtatca ttaagcacat tgggcacact ctaaaattgt
     5701 ggccctgtat gttttaaaag aaaaacacct gttttgataa agctgtataa aggataatca
     5761 atattttgtt tgatctactt attcattttt tttggtgcag accacttctt tagcttgtct
     5821 gctatgtctt tattttaaat ctgaatcatt tgtggcaaat acttttaaaa agcattatta
     5881 acatttattg gaaatgttgt ataaattcat aaggaaacac aaaagttttg gagagtttta
     5941 atcccaagaa gtgtccctgt cattgttcag aagtgctttt catgtttgtg tggtccagag
     6001 taactcaggg aatcagatgc taaagaagaa atattcaaat gtgttaccct ggttataatt
     6061 gtttctttga aatgtaacaa tgttgacttc acttgcagac tgtaggtgca tggtgatttt
     6121 agctaaagat ctcacattac tgtggccctg tgaactagct caaggacgag agaacgcaga
     6181 ggcacccgtg cggcttgttt taagggctgt gcttatattt gtaattctgc ttctcttcct
     6241 cttcccccat aacacaaata ttcttgtgat gtttattttg gtcaaggggg tgatctttgg
     6301 aagaaatacc aggataagct gattgcagac agtgacaggg tctaaaatgc cattgtcacc
     6361 acagggccaa gaaggcttac gtgcctctag gcagcctccc atgcaaaaac tgacttttaa
     6421 aggaagaagg cagggcactg agagttctcg ttttgttaca tccgggttat atgggttata
     6481 tatgaggcta aaccgtatga attgccagtg gacagccatt actggtctat agaaatagca
     6541 gtgctgtatg tttcaaccta acacgcgata ggaagtgcag gttaaatctc tgtgaggcaa
     6601 aaggaaggag actgctttct acaactcagg tttgagaata acttctctaa ctcatgtaga
     6661 tccaaatttg tctttcttac aagttgcagc ttgcagggag tttaaaacat ttcaacatag
     6721 agcgatgcgg cccatcacta ttgaggtgga atgtggttac tgtgggagga aaatccactc
     6781 tcagctggag catcgttcac tgcctgtgaa gttgagaaga gaccactaaa cgtgcagcct
     6841 ttggaacaaa acaaaatgcc tcatattaaa aatgtgtgtc ttgcaaatgc catgaaaatg
     6901 gatatttatt tcctaggaag tattatgact attaccaaag gactcgacca gactagggtt
     6961 cttcttaatt gatcatgttg gcaaagagac tgattgcatc ccactttata agatgggaag
     7021 agaaggaaac aaatgttgaa atcataaatg cttttctaac agggttatgc tattctgtaa
     7081 cactaattgt ctttctcttt aaaatgaagt tctattaata attttatcat atatttctca
     7141 atatttgaat atgttttaac tgtttgtatc ctaaatttgt tttcattcta gaaatccaga
     7201 actttacttg cctcataaat tgggttctag aattgtccca tttgctgtct ttagaggcca
     7261 cggcttcatt tctatgcgta aaaagctcat ttagcaatgt agttatttca gtatttattt
     7321 ctattatgga atccctgggg ttcggaatgt aactttgtac atgaaatata tataaatatg
     7381 tatatgaaac atgtgtgaa
//
