LOCUS       NP_001396513             509 aa            linear   ROD 02-MAY-2024
DEFINITION  sperm-associated antigen 6 isoform 1 [Mus musculus].
ACCESSION   NP_001396513 XP_006497565
VERSION     NP_001396513.1
DBSOURCE    REFSEQ: accession NM_001409584.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Man,Y., Li,W., Yap,Y.T., Kearney,A., Yee,S.P., Strauss,J.F. 3rd,
            Harding,P., Song,S., Zhang,L. and Zhang,Z.
  TITLE     Generation of floxed Spag6l mice and disruption of the gene by
            crossing to a Hprt-Cre line
  JOURNAL   Genesis 61 (3-4), e23512 (2023)
   PUBMED   37058328
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Yap,Y.T., Li,W., Zhou,Q., Haj-Diab,S., Chowdhury,D.D., Vaishnav,A.,
            Harding,P., Williams,D.C. Jr., Edwards,B.F., Strauss,J.F. 3rd and
            Zhang,Z.
  TITLE     The Ancient and Evolved Mouse Sperm-Associated Antigen 6 Genes Have
            Different Biologic Functions In Vivo
  JOURNAL   Cells 11 (3), 336 (2022)
   PUBMED   35159146
  REMARK    GeneRIF: The Ancient and Evolved Mouse Sperm-Associated Antigen 6
            Genes Have Different Biologic Functions In Vivo.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Li,X., Zhang,D., Xu,L., Liu,W., Zhang,N., Strauss,J.F. 3rd,
            Zhang,Z. and Wang,H.
  TITLE     Sperm-associated antigen 6 (Spag6) mutation leads to vestibular
            dysfunction in mice
  JOURNAL   J Pharmacol Sci 147 (4), 325-330 (2021)
   PUBMED   34663514
  REMARK    GeneRIF: Sperm-associated antigen 6 (Spag6) mutation leads to
            vestibular dysfunction in mice.
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Luo,J., Mu,J., Zhang,M., Zhao,B. and Liu,L.
  TITLE     SPAG6-silencing enhances decitabine-induced apoptosis and
            demethylation of PTEN in SKM-1 cells and in a xenograft mouse model
  JOURNAL   Leuk Lymphoma 62 (9), 2242-2252 (2021)
   PUBMED   33843428
  REMARK    GeneRIF: SPAG6-silencing enhances decitabine-induced apoptosis and
            demethylation of PTEN in SKM-1 cells and in a xenograft mouse
            model.
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Alciaturi,J., Anesetti,G., Irigoin,F., Skowronek,F. and Sapiro,R.
  TITLE     Distribution of sperm antigen 6 (SPAG6) and 16 (SPAG16) in mouse
            ciliated and non-ciliated tissues
  JOURNAL   J Mol Histol 50 (3), 189-202 (2019)
   PUBMED   30911868
  REMARK    GeneRIF: In this work, we performed a quantitative analysis of the
            expression of Spag6 and Spag16 genes in parallel with the
            immune-localization of the proteins in several tissues of adult
            mice.
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Hu,X., Yan,R., Cheng,X., Song,L., Zhang,W., Li,K. and Zhao,S.
  TITLE     The function of sperm-associated antigen 6 in neuronal
            proliferation and differentiation
  JOURNAL   J Mol Histol 47 (6), 531-540 (2016)
   PUBMED   27566703
  REMARK    GeneRIF: our data indicate that Spag6 plays an essential role in
            the process of neuronal proliferation and differentiation.
REFERENCE   8  (residues 1 to 509)
  AUTHORS   Yan,R., Hu,X., Zhang,Q., Song,L., Zhang,M., Zhang,Y. and Zhao,S.
  TITLE     Spag6 Negatively Regulates Neuronal Migration During Mouse Brain
            Development
  JOURNAL   J Mol Neurosci 57 (4), 463-469 (2015)
   PUBMED   26130477
  REMARK    GeneRIF: Spag6 was continuously expressed in the developing
            cerebral cortex.  Overexpression of Spag6 caused a significant
            decrease in neurite number and length of cortical neurons.
REFERENCE   9  (residues 1 to 509)
  AUTHORS   Li,W., Mukherjee,A., Wu,J., Zhang,L., Teves,M.E., Li,H.,
            Nambiar,S., Henderson,S.C., Horwitz,A.R., Strauss,J.F. III, Fang,X.
            and Zhang,Z.
  TITLE     Sperm Associated Antigen 6 (SPAG6) Regulates Fibroblast Cell
            Growth, Morphology, Migration and Ciliogenesis
  JOURNAL   Sci Rep 5, 16506 (2015)
   PUBMED   26585507
  REMARK    GeneRIF: Data show reduced motility of sperm associated antigen 6
            (Spag6)-deficient mouse embryonic fibroblasts (MEFs).
            Publication Status: Online-Only
REFERENCE   10 (residues 1 to 509)
  AUTHORS   Qiu,H., Golas,A., Grzmil,P. and Wojnowski,L.
  TITLE     Lineage-specific duplications of Muroidea Faim and Spag6 genes and
            atypical accelerated evolution of the parental Spag6 gene
  JOURNAL   J Mol Evol 77 (3), 119-129 (2013)
   PUBMED   24071998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928680.5.
            
            On Jul 20, 2022 this sequence version replaced XP_006497565.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.3062936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 12.9 cM"
     Protein         1..509
                     /product="sperm-associated antigen 6 isoform 1"
                     /note="sperm associated antigen 6 like"
                     /calculated_mol_wt=55275
     Region          34..70
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          76..108
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          127..152
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          <161..>423
                     /region_name="SRP1"
                     /note="Karyopherin (importin) alpha [Intracellular
                     trafficking and secretion]; COG5064"
                     /db_xref="CDD:227396"
     Region          162..194
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(185,189,193,227,231,235,269,273,277)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          202..238
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          244..278
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          335..369
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..406
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..509
                     /gene="Spag6"
                     /gene_synonym="Spag6l"
                     /coded_by="NM_001409584.1:985..2514"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="GeneID:381350"
                     /db_xref="MGI:MGI:3040687"
ORIGIN      
        1 msqrqvlqvf elyqnartrf vqmvaeqatk pqnietlqna gimsllrpll ldvvptiqqt
       61 aalalgrlan ynddlaeavv kgdilpqlvy slaeqncvyk kaaafvlrav gkhspqlaqa
      121 tvdcgaldsl vicledfdpg vkeaaawala yiarhnaels qavvdagavp llvlciqepe
      181 talkriaasa lsdiskhspe laqtvvdvga iahlaqmiln pdeklkqqvl salshiakhs
      241 vdlaemvvea eifpvvltcl kdkddfvkkn actlireiak htpelsqliv naggvaavid
      301 cigsckgnir lpgimmlgym aahsenlama viiskgvpql sdclseeped hikaaaawal
      361 gqvgrhtpeh aravaitntl pvllalymsp essedlqvks kkaikniiqk ctylpalepf
      421 lydappnilk yvagqfskvl phdskarrlf vtsgglkkiq eikaepgsil qeyinninsc
      481 ypeeivryys pgysdillqr idsyqplin
//
