LOCUS       NM_001348108            1625 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus small regulatory polypeptide of amino acid response
            (Spaar), mRNA.
ACCESSION   NM_001348108 NR_033355
VERSION     NM_001348108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Spiroski,A.M., Sanders,R., Meloni,M., McCracken,I.R., Thomson,A.,
            Brittan,M., Gray,G.A. and Baker,A.H.
  TITLE     The Influence of the LINC00961/SPAAR Locus Loss on Murine
            Development, Myocardial Dynamics, and Cardiac Response to
            Myocardial Infarction
  JOURNAL   Int J Mol Sci 22 (2), 969 (2021)
   PUBMED   33478078
  REMARK    GeneRIF: The Influence of the LINC00961/SPAAR Locus Loss on Murine
            Development, Myocardial Dynamics, and Cardiac Response to
            Myocardial Infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Spencer,H.L., Sanders,R., Boulberdaa,M., Meloni,M., Cochrane,A.,
            Spiroski,A.M., Mountford,J., Emanueli,C., Caporali,A., Brittan,M.,
            Rodor,J. and Baker,A.H.
  TITLE     The LINC00961 transcript and its encoded micropeptide, small
            regulatory polypeptide of amino acid response, regulate endothelial
            cell function
  JOURNAL   Cardiovasc Res 116 (12), 1981-1994 (2020)
   PUBMED   31990292
  REMARK    GeneRIF: The LINC00961 transcript and its encoded micropeptide,
            small regulatory polypeptide of amino acid response, regulate
            endothelial cell function.
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Matsumoto,A., Pasut,A., Matsumoto,M., Yamashita,R., Fung,J.,
            Monteleone,E., Saghatelian,A., Nakayama,K.I., Clohessy,J.G. and
            Pandolfi,P.P.
  TITLE     mTORC1 and muscle regeneration are regulated by the
            LINC00961-encoded SPAR polypeptide
  JOURNAL   Nature 541 (7636), 228-232 (2017)
   PUBMED   28024296
  REMARK    GeneRIF: data provide a mechanism by which mTORC1 activation may be
            finely regulated in a tissue-specific manner in response to injury,
            and a paradigm by which lncRNAs encoding small polypeptides like
            SPAR can modulate general biological pathways and processes to
            facilitate tissue-specific requirements, consistent with their
            restricted and highly regulated expression profile
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL824712.8.
            
            On Jan 24, 2023 this sequence version replaced NM_001348108.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030334.1, AK017317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL824712.8         17926-18045
            121-1625            AL824712.8         18461-19965
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..1625
                     /gene="Spaar"
                     /gene_synonym="5430416O09Rik; Spar"
                     /note="small regulatory polypeptide of amino acid
                     response"
                     /db_xref="GeneID:71406"
                     /db_xref="MGI:MGI:1918656"
     exon            1..120
                     /gene="Spaar"
                     /gene_synonym="5430416O09Rik; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            121..1625
                     /gene="Spaar"
                     /gene_synonym="5430416O09Rik; Spar"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..733
                     /gene="Spaar"
                     /gene_synonym="5430416O09Rik; Spar"
                     /codon_start=1
                     /product="small regulatory polypeptide of amino acid
                     response"
                     /protein_id="NP_001335037.1"
                     /db_xref="CCDS:CCDS89739.1"
                     /db_xref="GeneID:71406"
                     /db_xref="MGI:MGI:1918656"
                     /translation="METAVIGMVAVLFVITMAITCILCYFSYDSHTQDPERSSRRSFT
                     VATFHQEASLFTGPALQSRPLPRPQNFWTVV"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spaar"
                     /gene_synonym="5430416O09Rik; Spar"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="Spaar"
                     /gene_synonym="5430416O09Rik; Spar"
                     /note="major polyA site"
ORIGIN      
        1 agcaccaaca aaaacactgc aggcttggga gggagaagca tggccacctg gggtggtcac
       61 cagacagggg gtcaccagct ccagatacag tcaggataca tggcactatt ggagtccaag
      121 taactcttga agtcctgagg cgttgctcgt gggcctggct tccgtcttag caacatctct
      181 gctcctcctt cccttgcccc ttccatgtcg agggactcat ttgcttacag ctttcctgat
      241 agtgcttctt agcagctgcc agtagagccg accacagctc ttggaggtct gacctgaggt
      301 taaaactaga ccgaagatca tctgactcca gcagaaggat ttggtggcct acggtggcac
      361 agttcaaggc ctcagagccg agtcttagaa ggaggcatag gagaagccgc ttgcttgtcc
      421 tggccaacag ccccagcttc tgttgggaca ctaagactca gagaccaccc accgtgttcg
      481 gtgtgacaag tgccactcag aaatcatgga gaccgcggtg attgggatgg tggcagtgct
      541 ttttgtcatc accatggcca ttacctgcat cctctgctac ttcagctatg actcacacac
      601 ccaagaccca gagcgcagct ccagacgtag cttcaccgtg gccacgtttc accaggaggc
      661 gtcgctcttc acggggccgg ctctccaatc ccggccactg ccgcggcccc agaacttctg
      721 gactgttgtg tgaggttggc aattccctcg acatttattc tgctagtggg tcagacccat
      781 ctgccccttc aataagcagt gtctggtgtc tcactcctcc cagctctcca tccgtatcct
      841 tctacgtttc acaaacttct tgcctccctc cattctggct cgctcttccc tctctccctg
      901 gggagctgag gtgtcaggac caggtgtgag ttacctctga gctgaacgat cagctaggct
      961 ctactcacaa tggggctgag gagtctgagg agatgtggaa ggatgctgtg tggtatccta
     1021 atggtggggt agctccagac agctatggaa cctcaccgga agttagcacc ctgtcagcgg
     1081 ggtgctgtga cagaagtcta tttgccaccc agggaaccag agccctcgag cggacgattt
     1141 gaagaactaa gtgtttgtta gtatttttgg atgctgcacc gtgcccaacc ctcaggcttg
     1201 ctcctgttgc ctgaaatcag ccctgaaatt ctgaaaacaa agagctgttt tctgggaaca
     1261 agtgacttat tttataattg aggacgtata tccttttatg gatctttcca aatctgctct
     1321 ggaaaaccac aaaaggaagc aggagagaaa aagagagcca cagagagcac aaggtgtttc
     1381 attaacagga aggccaccaa gaagacttta aaacacgttt tgaacaagac ttgctttatt
     1441 gctatagtcc gacagactgt gtctattctt agcaaatgtg agtgatttgc gtcacttagg
     1501 aatgatagaa aaatcgtgaa ctgaaagata attccaaaaa agtcaaaatg ttgttacatt
     1561 tcagcgcatg tggagctgtt gattttaaca caaataaagg gacatttgtt tttattaata
     1621 gaaaa
//
