LOCUS       NM_001379379            4309 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus trans-acting transcription factor 8 (Sp8), transcript
            variant 1, mRNA.
ACCESSION   NM_001379379 XM_006515982
VERSION     NM_001379379.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Liang,X.G., Hoang,K., Meyerink,B.L., Kc,P., Paraiso,K., Wang,L.,
            Jones,I.R., Zhang,Y., Katzman,S., Finn,T.S., Tsyporin,J., Qu,F.,
            Chen,Z., Visel,A., Kriegstein,A., Shen,Y., Pilaz,L.J. and Chen,B.
  TITLE     A conserved molecular logic for neurogenesis to gliogenesis switch
            in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 121 (20), e2321711121 (2024)
   PUBMED   38713624
REFERENCE   2  (bases 1 to 4309)
  AUTHORS   Sun,M., Gao,Y., Li,Z., Yang,L., Liu,G., Xu,Z., Guo,R., You,Y. and
            Yang,Z.
  TITLE     ERK signaling expands mammalian cortical radial glial cells and
            extends the neurogenic period
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2314802121 (2024)
   PUBMED   38498715
REFERENCE   3  (bases 1 to 4309)
  AUTHORS   Alderman,P.J., Saxon,D., Torrijos-Saiz,L.I., Sharief,M., Page,C.E.,
            Baroudi,J.K., Biagiotti,S.W., Butyrkin,V.A., Melamed,A., Kuo,C.T.,
            Vicini,S., Garcia-Verdugo,J.M., Herranz-Perez,V., Corbin,J.G. and
            Sorrells,S.F.
  TITLE     Delayed maturation and migration of excitatory neurons in the
            juvenile mouse paralaminar amygdala
  JOURNAL   Neuron 112 (4), 574-592 (2024)
   PUBMED   38086370
REFERENCE   4  (bases 1 to 4309)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   5  (bases 1 to 4309)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   6  (bases 1 to 4309)
  AUTHORS   Kroll,T.T. and O'Leary,D.D.
  TITLE     Ventralized dorsal telencephalic progenitors in Pax6 mutant mice
            generate GABA interneurons of a lateral ganglionic eminence fate
  JOURNAL   Proc Natl Acad Sci U S A 102 (20), 7374-7379 (2005)
   PUBMED   15878992
REFERENCE   7  (bases 1 to 4309)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   8  (bases 1 to 4309)
  AUTHORS   Kawakami,Y., Esteban,C.R., Matsui,T., Rodriguez-Leon,J., Kato,S.
            and Izpisua Belmonte,J.C.
  TITLE     Sp8 and Sp9, two closely related buttonhead-like transcription
            factors, regulate Fgf8 expression and limb outgrowth in vertebrate
            embryos
  JOURNAL   Development 131 (19), 4763-4774 (2004)
   PUBMED   15358670
  REMARK    GeneRIF: Sp8 and Sp9, via Fgf8, are involved in mediating the
            actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate
            limb outgrowth.
REFERENCE   9  (bases 1 to 4309)
  AUTHORS   Treichel,D., Schock,F., Jackle,H., Gruss,P. and Mansouri,A.
  TITLE     mBtd is required to maintain signaling during murine limb
            development
  JOURNAL   Genes Dev 17 (21), 2630-2635 (2003)
   PUBMED   14597661
REFERENCE   10 (bases 1 to 4309)
  AUTHORS   Bell,S.M., Schreiner,C.M., Waclaw,R.R., Campbell,K., Potter,S.S.
            and Scott,W.J.
  TITLE     Sp8 is crucial for limb outgrowth and neuropore closure
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12195-12200 (2003)
   PUBMED   14526104
  REMARK    GeneRIF: observations indicate that Sp8 functions downstream of
            Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates
            apical ectodermal ridge formation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN527217.1 and AC131717.3.
            
            On Apr 1, 2020 this sequence version replaced XM_006515982.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN527217.1, SRR10662774.4249644.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CN527217.1         43-68
            27-232              CN527217.1         72-277
            233-233             AC131717.3         159730-159730
            234-542             CN527217.1         279-587
            543-4309            AC131717.3         160040-163806
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 63.48 cM"
     gene            1..4309
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
                     /note="trans-acting transcription factor 8"
                     /db_xref="GeneID:320145"
                     /db_xref="MGI:MGI:2443471"
     exon            1..109
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1603
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor Sp8"
                     /codon_start=1
                     /product="transcription factor Sp8 isoform 1"
                     /protein_id="NP_001366308.1"
                     /db_xref="GeneID:320145"
                     /db_xref="MGI:MGI:2443471"
                     /translation="MATSLLGEEPRLGSTPLAMLAATCNKIGSPSPSPSSLSDSSSSF
                     GKGFHPWKRSSSSSSGSCNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVS
                     DSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGG
                     GGGGGSGAHSQDSSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKPSHPGLGAAA
                     DVGSAGASSWWDVGAGWIDVQNPNGAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGL
                     SHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGSSMLSAGPAAQLG
                     GSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLK
                     AHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLS
                     KHVKTHSGGGGSAGSGGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE"
     exon            110..4309
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3207..3212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
                     /note="hexamer: AATAAA"
     polyA_site      3231
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
     regulatory      4281..4286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
                     /note="hexamer: AATAAA"
     polyA_site      4309
                     /gene="Sp8"
                     /gene_synonym="D930049B17Rik; mBtd"
                     /note="major polyA site"
ORIGIN      
        1 attgtattgc acacctctaa aaaaaacact gcctctgatt tatcaatata aaaaagatcc
       61 tctgagagga ggagggcgct tctgtgtgat ggcaacttca cttctagggg aagaaccgag
      121 gttgggatcc actcctctgg ccatgcttgc tgctacctgt aataagatcg gcagccccag
      181 cccgtctccc tcctccctgt cggacagctc ttcttccttc ggtaaaggct tccacccttg
      241 gaaacgctcc tcgtcttcct cctccggcag ctgcaacgta gtgggttcca gtctctctag
      301 cttcggtgtg tcgggggcct cccggaacgg cggctcctcc tcagccgcag cggcggcagc
      361 ggcggcagca gcggcggccg cagccctggt gtccgactct tttagctgcg gaggctcgcc
      421 cggctccagc gccttctctc tcacctccag cagcgccgcc gcagcggcag cagctgcggc
      481 ggctgccgct tccagctcgc cctttgccaa cgactactct gtgttccagg ctccgggcgt
      541 ctcggggggc agcggcggcg gcggcggggg aggcggcggc ggttccggag cgcactcgca
      601 ggatagctcc catcagccag tgtttatctc caaggtgcac acgtcggtgg acggactgca
      661 gggtatctac ccgcgcgtgg gaatggcgca cccgtatgag tcctggttca agccttcgca
      721 cccgggcctt ggcgccgcgg ccgacgtggg ctccgcgggc gcctccagct ggtgggatgt
      781 gggcgcgggc tggatcgacg tgcagaaccc caatggggcg gcagcgctgc ccggctcgct
      841 gcacccggcg gccgggggcc ttcagacgtc gctgcattca ccgctgggag gctacaactc
      901 ggattattcc ggcctgagcc actccgcatt cagtagcggt gcctcgtcgc acctgctcag
      961 ccctgcagga cagcacctca tggacggttt caagccggta ttgcccggct cttaccccga
     1021 ttccgccccg tcgccgctgg ccggcgcggg cagctccatg ctgagcgcgg ggcccgcggc
     1081 gcagttaggg gggtccccac gctcgtccgc tcgccgctac tccggccgcg ccacttgcga
     1141 ctgccccaac tgccaggagg ctgagcggct gggcccagcg ggagcgagcc tgcgtcgcaa
     1201 agggctgcat agctgccaca tcccgggctg cggcaaggtg tacggcaaga cgtcgcacct
     1261 gaaggcgcac ctgcgttggc acaccggcga gcggccgttc gtgtgcaatt ggctgttctg
     1321 cggtaagcgc tttacgcgct ccgacgagct gcagcggcac ctgcggaccc acacgggcga
     1381 gaagcgcttc gcctgcccgg tgtgcaacaa acgcttcatg cgcagcgacc acctgagcaa
     1441 gcacgtgaag acacacagtg gtggcggcgg ctcggcgggc tccggcggcg gcaagaaagg
     1501 cagcgacacc gacagcgagc acagcgcggc gggaagccct ccttgccact cccctgagct
     1561 gttgcagcct ccagagccgg gccaccgcaa cggcctggag tgactgtcgc gatgcctccc
     1621 acctgaatcc cgtcgggctt gtgtacctag actgggctcc agtctaggct agctgtgcgt
     1681 tctttccccc aacttctcat tctctctctc accggttttc tgctcttaac ttttaggatg
     1741 tggacagtaa gtagcacaca tcggtggctg aatccttggc tcccttctgc acagtgacag
     1801 ccatgcgggg cgcagtggaa acccgctcct ccagcactgg gctggcggaa ctttgaagag
     1861 gctgtggcct ctggggttag gacgggatga atgggttgtc tggtagaaca gtggcttttg
     1921 tggccttgga aagaacagtg ttcaacccgc ttgagccgca gctgtaggga gagggatgta
     1981 ggagtcctgc caaggaatcc cctcctggac ccccgagtgc tccccttgga ctgtcctgtg
     2041 ctgagcatta cactcgtggg aggactgctg caacccagac cgggttagca gagtttagat
     2101 ctccccattc agctctggct aggtctttgt gccctgcggg tgaaccgatg agagttctgc
     2161 gaacgggaat caatgcctcc ccctcctttc ttctttgtaa ctttttattt tttaactgaa
     2221 aaactgagag gaaaaaaata aacaagcaat cttcctctta gcttctcgtt tagatagttt
     2281 tcctctgctt gcgagcacgt ttctctccaa actgcaaata ttgatcccaa agttattttg
     2341 gtcgccgtaa tttatggggt gggggcggga gtgagggtag gtgtcttttc ttatgcaaaa
     2401 ataccccctt tccggtgaga ccagattaag tatcttcgtg tttgtctttt tctacctcgg
     2461 ttttttcacc atccccaagc atattcttcc aacttcccac atcaccacca cttttgggtt
     2521 agtctaggaa tcaatttatc tactgatttc tgtaaattat tgcaagtcat tgattaattt
     2581 tagggttaaa ctttttcttt gtgatttaaa cttaagtgaa gaagctatcg tttatttcag
     2641 atgaggctgt agtttaaatg ccaaaagagg gaaacgggga aacaattttt aaaaattctt
     2701 tgtaaaatat atctgaacct aatggtttgt acaactggaa aatcgttcta gattagtttc
     2761 ccattaaact tgactccgcc gctgtgaggt gtgagacgat tttgtatagt atttttcttg
     2821 tacattactt ccggtaaata tttgaaaata tattgaagta aacttgattt tttttctttt
     2881 tcgtcagaag gaattattaa gagttattgc tgaggttcta atgagctgca ggtgtttttt
     2941 tttttttttt ttttttcctt tttctttttt ccttgaactc aattctggag gtgcagagcc
     3001 acacacgcac tttccgggcc tagttttgct cgaatatgaa tttagatagg tatcaagctg
     3061 taactaagac actatttgat aaatgttgga tgacatttaa tttaatggcg catgtactta
     3121 tttgcatttg ctggcagttc aggtatagtt aaagtgagag ttctcctata cttcataata
     3181 acggggtctg ccaaacccat gtattaaata aattgtccaa gtgatactcg actaactttg
     3241 gcctttgtgt atttcctgaa ggtgatattg ttaactgttg acaaatactc ctgacactac
     3301 atttaagtgt tgtttgcaga gtctgcaaac taactattca ttgtcatgtt gaaataattt
     3361 ggatatttca cattgaaatg aaaagccttt ctctggaaca ttagacttgc attttaaatg
     3421 catgaaatgt aattgattta tttgtaatat tttaaatggt attaataaac tcaaaaaaga
     3481 ctaggtcagt taatttggtg tttttccccc ccttttaaaa ctacgggcat ttgcatttta
     3541 tcttccgttt taatgtctaa tttaaacaaa atatgaccct gttttttgtg gcaatattta
     3601 attatttgcc tttaagatat tatgtagatg gaagatctat ttggcaaagc tgtttctttg
     3661 tttaccaaga taaagattat agtgtctaag atatgtaatt aattatttac cattagattt
     3721 agctcagcac caggatttat tgacctctta aaacttgtag taattcacaa acaattcaaa
     3781 gaaattccat gttgctgctt ccttctcagt cttcagaagg agtcaggttg ttggcctttg
     3841 atcgagttta gtgtttgaaa ggccaagact tagatgaaag atcaatacat ctaaaataaa
     3901 agcatcattt ggggatacct tctgttagga gacagagggg gtcaagctaa caaaagcttg
     3961 ttttctggca ctctatgtct tagctaaaca ttctgcagag gtaaatatca gtagattcct
     4021 gttgaaatga gttatctgtt ctttaaaagt ctctaaacag ccaccaaaga aaagaaaggt
     4081 taaaccttaa tctatctacg aggctattgt tcaaaggtgt caatgatgcc aataaaaaaa
     4141 cattgtcttg ttatgtctaa gtgcatttaa gcaatgggtg ttccttgagc catactttga
     4201 aacatagtat actttaaatg ttgattgatg ttatatcaaa ctatttcact attagattaa
     4261 tattattttg aatcaaactt aataaaaagt tagtgtgttg agattctaa
//
