LOCUS       NM_130458               2920 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant
            1, mRNA.
ACCESSION   NM_130458 NM_178770
VERSION     NM_130458.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Bobzin,L., Nickle,A., Ko,S., Ince,M., Huang,A., Bhojwani,A.,
            Roberts,R. and Merrill,A.E.
  TITLE     FGFR2 directs inhibition of WNT signaling to regulate anterior
            fontanelle closure during skull development
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39775862
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Komaki,M., Asakura,A., Rudnicki,M.A., Sodek,J. and Cheifetz,S.
  TITLE     MyoD enhances BMP7-induced osteogenic differentiation of myogenic
            cell cultures
  JOURNAL   J Cell Sci 117 (Pt 8), 1457-1468 (2004)
   PUBMED   15020674
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Mori-Akiyama,Y., Akiyama,H., Rowitch,D.H. and de Crombrugghe,B.
  TITLE     Sox9 is required for determination of the chondrogenic cell lineage
            in the cranial neural crest
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9360-9365 (2003)
   PUBMED   12878728
REFERENCE   8  (bases 1 to 2920)
  AUTHORS   Nakashima,K. and de Crombrugghe,B.
  TITLE     Transcriptional mechanisms in osteoblast differentiation and bone
            formation
  JOURNAL   Trends Genet 19 (8), 458-466 (2003)
   PUBMED   12902164
REFERENCE   9  (bases 1 to 2920)
  AUTHORS   Yagi,K., Tsuji,K., Nifuji,A., Shinomiya,K., Nakashima,K.,
            DeCrombrugghe,B. and Noda,M.
  TITLE     Bone morphogenetic protein-2 enhances osterix gene expression in
            chondrocytes
  JOURNAL   J Cell Biochem 88 (6), 1077-1083 (2003)
   PUBMED   12647290
  REMARK    GeneRIF: osterix gene was expressed in rib cartilage-derived
            chondrocytes and BMP-2 treatment enhanced this expression
REFERENCE   10 (bases 1 to 2920)
  AUTHORS   Nakashima,K., Zhou,X., Kunkel,G., Zhang,Z., Deng,J.M.,
            Behringer,R.R. and de Crombrugghe,B.
  TITLE     The novel zinc finger-containing transcription factor osterix is
            required for osteoblast differentiation and bone formation
  JOURNAL   Cell 108 (1), 17-29 (2002)
   PUBMED   11792318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076229.1, AK032521.1 and BB375475.1.
            
            On Feb 8, 2017 this sequence version replaced NM_130458.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AK076229.1         2-9
            9-2854              AK032521.1         2-2847
            2855-2920           BB375475.1         224-289
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.51 cM"
     gene            1..2920
                     /gene="Sp7"
                     /gene_synonym="6430578P22Rik; C22; Osx"
                     /note="Sp7 transcription factor 7"
                     /db_xref="GeneID:170574"
                     /db_xref="MGI:MGI:2153568"
     exon            1..120
                     /gene="Sp7"
                     /gene_synonym="6430578P22Rik; C22; Osx"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1386
                     /gene="Sp7"
                     /gene_synonym="6430578P22Rik; C22; Osx"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor Sp7; zinc finger protein osterix"
                     /codon_start=1
                     /product="transcription factor Sp7 isoform 1"
                     /protein_id="NP_569725.1"
                     /db_xref="CCDS:CCDS37228.1"
                     /db_xref="GeneID:170574"
                     /db_xref="MGI:MGI:2153568"
                     /translation="MASSLLEEEAHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKGGT
                     KKPYADLSAPKTMGDAYPAPFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGA
                     QDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHP
                     GGNWLGGGQGQGDGLQGTLSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQ
                     HVLPQDVYKPKAVGNSGQLEGSGAAKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELE
                     RLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTR
                     SDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGR
                     SVGEEEANQPPRSSTSPAPPEKAHGGSPEQSNLLEI"
     exon            121..2920
                     /gene="Sp7"
                     /gene_synonym="6430578P22Rik; C22; Osx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp7"
                     /gene_synonym="6430578P22Rik; C22; Osx"
                     /note="hexamer: AATAAA"
     polyA_site      2917
                     /gene="Sp7"
                     /gene_synonym="6430578P22Rik; C22; Osx"
                     /note="major polyA site"
ORIGIN      
        1 attctcccat tctccctccc tctcccttct ccctctccca ctggctcctc ggttctctcc
       61 atctgcctga ctccttggga cccggtcccc agctcgagga tggcgtcctc tctgcttgag
      121 gaagaagctc actatggctc cagtcccctg gccatgctga ctgcagcctg cagcaaattt
      181 ggcggctcta gccctctgcg ggactcaaca accctgggga aaggaggcac aaagaagcca
      241 tacgctgacc tttcagcccc caaaaccatg ggggacgcct acccagctcc cttctcaagc
      301 accaatggac tcctctctcc tgcaggcagt cctccggccc cagcctctgg ctatgcaaat
      361 gactacccac ccttccctca ctcatttcct gggcccaccg gtgcccaaga ccctgggctc
      421 ctagtgccta aggggcacag ctcgtctgac tgcctgccta gtgtctacac ttccctggat
      481 atgactcatc cctatggctc gtggtacaag gcaggcatcc acgcaggcat ctcaccaggt
      541 ccaggcaaca cacctactcc ttggtgggac atgcaccctg ggggcaactg gctaggtggt
      601 ggtcagggcc agggtgatgg gctgcaaggg acactgtcca caggccctgc ccagcctcca
      661 ctgaaccccc agctgcctac ttacccatct gactttgctc cccttaaccc agctccctac
      721 ccagcgcccc acctcttgca accagggccc cagcatgtcc taccccaaga tgtctataag
      781 cccaaggcgg ttggcaatag tgggcaactg gaggggagtg gtgcagccaa accccctcgg
      841 ggtgctggca cagggggcag cggtggatat gcgggcagtg gggcagggcg ttctacctgc
      901 gactgcccca actgtcagga gctagagcgg ctcggggcag cagcggctgg gctgaggaag
      961 aagcccattc acagctgcca catccctggg tgcggcaagg tgtacggcaa ggcttcgcat
     1021 ctgaaagccc acttgcgctg gcacactggc gagaggcctt tcgtctgcaa ctggcttttc
     1081 tgcggcaaga ggttcactcg ctctgacgag ctggagcgcc acgtgcgcac tcacacccgg
     1141 gagaagaagt tcacctgcct gctctgttcc aagcgcttta ccagaagcga ccacttgagc
     1201 aaacatcagc gcacccacgg ggagccaggc ccgggaccgc ccccaagtgg ccctaaggag
     1261 ctgggggagg gtcgcagcgt cggggaagaa gaagccaatc agccgccccg atcttccact
     1321 tcgcctgcac ccccagaaaa agcccacgga ggcagcccag agcagagcaa cctgctagag
     1381 atctgagctg ggtagaggaa ggtctccagc tccagggtcc tcttgccagg ctctcttggc
     1441 gcggtggacc cattggttgc ccctcgctct ctcctattgc atgctatact ctgggggctc
     1501 tctctgttcc cctaggttat ctccttgcat gtctcctcag ttcttctctc tttgtcaaga
     1561 gtcttagcca aactcctctc aggcctttgc cagtgcctag ttcctatgct ccgacctcct
     1621 caactttttc ttctctgccc ctgttcttca cagcttccat ctggcctcac atcattttct
     1681 cattaactcg ttgccatcta atctttctgc ttcccaatcc tatttgccgt tttcccgaag
     1741 cttccaggct gtcgcctcga ttccccctga gctttgtgtt ttcttttttt aaacaaacac
     1801 gatgatgatg atgatgatga tgataattta ttgccccctg gtgttcttca ttaggaacca
     1861 gagttaagga gattggtgtt agtaacctgg ccgggagcag agtgccaaga agggggaagt
     1921 ccaatgggga tctgatccca aagatggggt gaccccaggg tcagggaggc tgcccccagc
     1981 cttgagtact taacccctat gcgccaggag taaagaatag taatagtaat aataataata
     2041 attctattta tctaagttat gatgacgggt caggtacagt gagctggaga gggaaaggga
     2101 ttctccccgc ccccaaggaa attctagtca aatgcatctc tgtatagaca aatgatagtg
     2161 gagaccttgc tcgtagattt ctatcctcga ggtctccgag agtttctttt tcagttgagt
     2221 tttgggttgt tcggcctctt ttagagtttc tgtgggtgtc tctctgttag gcagtcacta
     2281 agatccccag ccccagccag aaagctgtga aacttcaagt cctatggcgg ggaggactgg
     2341 aatgtacccc agtcctctcg acccgactgc agatcaggtt cctcccctga tcctcttctc
     2401 ataccctgtg acctcaccag gttatcccct tgtcgtcatg gttacagaga gcttgcagct
     2461 gccatcttaa acgtgctctt tgggggagag cccacctaac aggaggattt tggtttggag
     2521 gtgcccctcc tgaaaaagta ggtgggcaaa ggctttctct gggatcaaat tcaaataaat
     2581 caagtattta ttgaatgctt aatatgtgca aggcctggtg cctagaagcc acgagaaaga
     2641 atttataaca ggacagaagt ccctaaacta aacatccaca ggcccccaat ctaggaggtt
     2701 tcactccatt ccagtgactt ttaaagccgc tttgtgcctt tgaaatgcct ttcctgagat
     2761 ttttggatct tcctgttctg tcccctgctc cttctaggcc ccaagataaa gggtaaagcc
     2821 atggagtctg ggaagagcat aacgtcgttg acgggatcgt ccctttgtgg aatctttctt
     2881 ttttttttaa tttaataaat aaaagttcga tttgaaattg
//
