LOCUS       NM_001363230            3620 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus trans-acting transcription factor 6 (Sp6), transcript
            variant 2, mRNA.
ACCESSION   NM_001363230 XM_006534531
VERSION     NM_001363230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3620)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3620)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   3  (bases 1 to 3620)
  AUTHORS   Rhodes,C.S., Yoshitomi,Y., Burbelo,P.D., Freese,N.H., Nakamura,T.,
            Chiba,Y. and Yamada,Y.
  CONSRTM   NIDCD/NIDCR Genomics and Computational Biology Core
  TITLE     Sp6/Epiprofin is a master regulator in the developing tooth
  JOURNAL   Biochem Biophys Res Commun 581, 89-95 (2021)
   PUBMED   34662808
  REMARK    GeneRIF: Sp6/Epiprofin is a master regulator in the developing
            tooth.
REFERENCE   4  (bases 1 to 3620)
  AUTHORS   Zhang,P., Ishikawa,M., Doyle,A., Nakamura,T., He,B. and Yamada,Y.
  TITLE     Pannexin 3 regulates skin development via Epiprofin
  JOURNAL   Sci Rep 11 (1), 1779 (2021)
   PUBMED   33469169
  REMARK    GeneRIF: Pannexin 3 regulates skin development via Epiprofin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3620)
  AUTHORS   Ruspita,I., Das,P., Xia,Y., Kelangi,S., Miyoshi,K., Noma,T.,
            Snead,M.L., D'Souza,R.N. and Bei,M.
  TITLE     An Msx2-Sp6-Follistatin Pathway Operates During Late Stages of
            Tooth Development to Control Amelogenesis
  JOURNAL   Front Physiol 11, 582610 (2020)
   PUBMED   33192593
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3620)
  AUTHORS   Gritli-Linde,A., Hallberg,K., Harfe,B.D., Reyahi,A.,
            Kannius-Janson,M., Nilsson,J., Cobourne,M.T., Sharpe,P.T.,
            McMahon,A.P. and Linde,A.
  TITLE     Abnormal hair development and apparent follicular transformation to
            mammary gland in the absence of hedgehog signaling
  JOURNAL   Dev Cell 12 (1), 99-112 (2007)
   PUBMED   17199044
REFERENCE   7  (bases 1 to 3620)
  AUTHORS   Jarvinen,E., Salazar-Ciudad,I., Birchmeier,W., Taketo,M.M.,
            Jernvall,J. and Thesleff,I.
  TITLE     Continuous tooth generation in mouse is induced by activated
            epithelial Wnt/beta-catenin signaling
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18627-18632 (2006)
   PUBMED   17121988
REFERENCE   8  (bases 1 to 3620)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   9  (bases 1 to 3620)
  AUTHORS   Nakamura,T., Unda,F., de-Vega,S., Vilaxa,A., Fukumoto,S.,
            Yamada,K.M. and Yamada,Y.
  TITLE     The Kruppel-like factor epiprofin is expressed by epithelium of
            developing teeth, hair follicles, and limb buds and promotes cell
            proliferation
  JOURNAL   J Biol Chem 279 (1), 626-634 (2004)
   PUBMED   14551215
  REMARK    GeneRIF: Epiprofin is a highly cell- and tissue-specific nuclear
            protein expressed primarily by proliferating epithelial cells of
            teeth, hair follicles, and limbs that may function in the
            development of these tissues by regulating cell growth
REFERENCE   10 (bases 1 to 3620)
  AUTHORS   Scohy,S., Gabant,P., Van Reeth,T., Hertveldt,V., Dreze,P.L., Van
            Vooren,P., Riviere,M., Szpirer,J. and Szpirer,C.
  TITLE     Identification of KLF13 and KLF14 (SP6), novel members of the
            SP/XKLF transcription factor family
  JOURNAL   Genomics 70 (1), 93-101 (2000)
   PUBMED   11087666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606664.17 and AK137686.1.
            
            On May 12, 2018 this sequence version replaced XM_006534531.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM295492.1, AK137686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL606664.17        19804-19824
            22-788              AK137686.1         2-768
            789-790             AL606664.17        22970-22971
            791-3619            AK137686.1         770-3598
            3620-3620           AL606664.17        25801-25801
FEATURES             Location/Qualifiers
     source          1..3620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.51 cM"
     gene            1..3620
                     /gene="Sp6"
                     /gene_synonym="1110025J03Rik; Epfn; Klf14"
                     /note="trans-acting transcription factor 6"
                     /db_xref="GeneID:83395"
                     /db_xref="MGI:MGI:1932575"
     exon            1..286
                     /gene="Sp6"
                     /gene_synonym="1110025J03Rik; Epfn; Klf14"
                     /inference="alignment:Splign:2.1.0"
     exon            287..3620
                     /gene="Sp6"
                     /gene_synonym="1110025J03Rik; Epfn; Klf14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3598..3603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp6"
                     /gene_synonym="1110025J03Rik; Epfn; Klf14"
                     /note="hexamer: AATAAA"
     polyA_site      3620
                     /gene="Sp6"
                     /gene_synonym="1110025J03Rik; Epfn; Klf14"
                     /note="major polyA site"
ORIGIN      
        1 tgcaggggag aggatgaagg cagagagtgc ggtgagtcac gggcggagct ggcctcgctc
       61 gctcgctcgc tcgctcgctt actcgctcac cggcgcccgc ccgccctccg ccctcccgcc
      121 ggctctcact gcctccaccg tcgcggatca cccagcccgg tcgcagcccc ggcttgccct
      181 cggctcctgt cccacgccgc tgagagccgg ccagcgcgca gggcccatga gcgcccgtct
      241 gtagcgcgcc agcctgcggt gccccaagcc cgagcgcagc cgccaggttc catctgaggt
      301 acccttgacc gtccctgcct tcattccatc ccggatcccg gcaatgctaa ccgctgtctg
      361 tggctctctg ggcagccagc acaccgacgc gcctcacgct tcaccgccgc gcctcgacct
      421 gcaacctctc cagacatacc agggtcacac gagcccggag gctggggact acccctcccc
      481 gctgcagcct ggagagctgc agagcctccc gctgggcccg gaggtagact tttcacaggg
      541 ctatgagttg ccaggggcct cctcgcgggt aacctgcgag gacctggaaa gtgacagtcc
      601 cttggcaccg ggaccctttt ccaagctcct gcagccggac atgtcacacc actatgaatc
      661 gtggttccgg ccgactcacc caggcacaga ggatggctcg tggtgggacc ttcatcccgg
      721 caccagctgg atggacctcc cccatactca gggagcgctg acctcacctg gccatccggg
      781 ggcgcttcag cctgctttgg gaggatacgt cggagaccat cagctctgtg ctccgccgcc
      841 ccacccgcac ccgcaccacc tcctcccagc cgctggtggg cagcaccttc tggggccacc
      901 cgacggggct aaggccttgg aagcggccgc acaagagtcc caagggctgg attccagtct
      961 ggatgcagcg tcccgaccca aaggctcccg gcgatcagtt ccccgcagct cagggcagac
     1021 cgtgtgtcgc tgccccaact gcctggaggc ggagcgactc ggggctccgt gcgggcccga
     1081 tgggggcaag aagaagcatt tgcacaactg ccacatccca ggctgcggca aggcatacgc
     1141 taagacgtcg catctgaagg cgcacctgcg gtggcacagc ggtgaccgac ccttcgtgtg
     1201 caactggctt ttctgcggca agcgcttcac gcgctccgac gagctgcagc gccaccttca
     1261 gacccacacc gggaccaaga agttcccctg tgcggtctgc agccgagtct tcatgcgcag
     1321 cgaccacctg gccaaacaca tgaaaaccca cgaaggcgcc aaagaggagg cggcggcggc
     1381 ggcccaaggc gagggcaagg ccggtggcgt ggtggaacca cccgggggca aaggcaaacg
     1441 tgaggccgaa ggcagctcgg cgtcctccaa ctgagcccca tggatgtcac atacctgccg
     1501 ttctttattt gggggggcgg ggggaatggg gcggcctgag taagaggaag gtggttattt
     1561 attggtgatg aggggacagg gaaagggacg ctaggggttt ttagtctcgg gggctacatg
     1621 ggaggctgct tgaatattta ggctgccagg agctgaacac gcccctcgct tcttcccttt
     1681 ctcactattt caccctcccc tgagttgctg aagagttggg atggagcgcc cctaccatgt
     1741 ggaggggttc gcatagtaga gagatggcat gtcccagaag ctgagggaac tcgagattgg
     1801 gtcggggcgt tgggggaagc tgtctggaca cgtctttagt tcctgggaac ccggacataa
     1861 aagcaccttg gagccgccct tcggcctagg tctctttcat cccctcttct agtgctgctc
     1921 cctctaaaat ttccggagag aaagcagaga tgaggtgtgt gtgtggggaa gcctggggtg
     1981 gttcccctta aggggctgtc tacctagctt ggagggttat tagtatagaa agaactccct
     2041 tcagtgaatt tcttctaaac ccttctggat ggtagagcca ggaagagcag ctcagctctg
     2101 cagccagggc tctgagctgg aggtcagagc tggatggcat agaggaggga tccagcagaa
     2161 aaatcctctt acaaagtgga agagctagcc gctcctttca actcgaattc aatccttaac
     2221 tcttagacct tgtaaaagaa agcaaactca gcagtcgaca ttccccatct attcccctag
     2281 gtagtttcct aaagtcagct gccagcactt gctccagagt tgacaaaaca acccccaccc
     2341 cactcccagg tccccatccc ttgctttcct gttgggggtg gaagggagag aggttgtcct
     2401 agcagaggga ttacagcaga aaaccctgcc tggactcccc gtccctctct ttcttagctt
     2461 gacccttccg tgttccctcc attgttatag agtcctcccc agtagaaaat ctccttccat
     2521 gtgaagaaat attgttcccc cactggaagg aattctggga agctgtctct ctgtcccctt
     2581 ctttagagtc tagagataca tttgggtttt gatcatagga tgagagggta gacttctgcc
     2641 tggcagactg caggaccctg gggctggggg cactctcagg tttgaggtag aggccttgag
     2701 accctctgac cccactcttg ctctcttctc tccacccaga accttctgca gggaatagct
     2761 gtgtgttgat ttttaagtta taagcaaagg gtattttatt taataattag ggtgtgagtg
     2821 tgtgtatgcg tgtgttgtct gcacctgtat gtgtgcatgt atgtgtttct ctactgagcc
     2881 tggggtctcc tgagacccca tcttgttcac cccgtccaag acctggggac aagaacctca
     2941 gcatcttcct ccctggggga tgctggagcc cagtccaagg actgggacct gtatgggaag
     3001 taggggctgg gatctgggta ggaatatatg tttgtgtaga aaggcctcct ccttgaaggg
     3061 acagggtgac tccctgtggg acttaggggc ctgagatagt ttaagttctt tctgtgttct
     3121 ccctctttcc ccacctcctg tgaacctagc cagaggttcc ctttcttaca aagaaggctg
     3181 caggcaagag cgaagttggc catgcctgca ggttgcctag ctaggtgcag aggggcctaa
     3241 aggagggcac cgtgggtgtg ggatgccttc ttctccaccc atcaaaacca gccacctctc
     3301 actgcgctac caagacaacc ttttttcagt gaccatgctt agggggaact cctacatgga
     3361 gtattagggg gcacggagat gctccccctt atagaggcct tgaaccctaa gatctgcagg
     3421 tggggctcgg ataggttttt gtctggcctg ctctttatca aatctaggtt tctcagctgc
     3481 ctgtccttcc aggcagcccc tctagaggaa aatgtaggat tttttttttt ctttaactgc
     3541 tgtgaaccca cttgggggcg aggaggaggc agaaacagcc tgtgtttttt atgcaacaat
     3601 aaagtcatca accaaccaca
//
