LOCUS       NM_022435               2097 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus trans-acting transcription factor 5 (Sp5), mRNA.
ACCESSION   NM_022435
VERSION     NM_022435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Zhao,R., Moore,E.L., Gogol,M.M., Unruh,J.R., Yu,Z., Scott,A.R.,
            Wang,Y., Rajendran,N.K. and Trainor,P.A.
  TITLE     Identification and characterization of intermediate states in
            mammalian neural crest cell epithelial to mesenchymal transition
            and delamination
  JOURNAL   Elife 13, 92844 (2024)
   PUBMED   38873887
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   4  (bases 1 to 2097)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   5  (bases 1 to 2097)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   6  (bases 1 to 2097)
  AUTHORS   Zhang,D., Stumpo,D.J., Graves,J.P., DeGraff,L.M., Grissom,S.F.,
            Collins,J.B., Li,L., Zeldin,D.C. and Blackshear,P.J.
  TITLE     Identification of potential target genes for RFX4_v3, a
            transcription factor critical for brain development
  JOURNAL   J Neurochem 98 (3), 860-875 (2006)
   PUBMED   16893423
REFERENCE   7  (bases 1 to 2097)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 2097)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   9  (bases 1 to 2097)
  AUTHORS   Treichel,D., Becker,M.B. and Gruss,P.
  TITLE     The novel transcription factor gene Sp5 exhibits a dynamic and
            highly restricted expression pattern during mouse embryogenesis
  JOURNAL   Mech Dev 101 (1-2), 175-179 (2001)
   PUBMED   11231070
REFERENCE   10 (bases 1 to 2097)
  AUTHORS   Harrison,S.M., Houzelstein,D., Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Sp5, a new member of the Sp1 family, is dynamically expressed
            during development and genetically interacts with Brachyury
  JOURNAL   Dev Biol 227 (2), 358-372 (2000)
   PUBMED   11071760
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK036234.1.
            
            On Jun 19, 2003 this sequence version replaced NM_022435.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036234.1, AF279479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 41.49 cM"
     gene            1..2097
                     /gene="Sp5"
                     /note="trans-acting transcription factor 5"
                     /db_xref="GeneID:64406"
                     /db_xref="MGI:MGI:1927715"
     exon            1..394
                     /gene="Sp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1540
                     /gene="Sp5"
                     /codon_start=1
                     /product="transcription factor Sp5"
                     /protein_id="NP_071880.1"
                     /db_xref="CCDS:CCDS16106.1"
                     /db_xref="GeneID:64406"
                     /db_xref="MGI:MGI:1927715"
                     /translation="MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIG
                     QPGAAAAPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQ
                     PSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYS
                     NLLPPPPPPPPPPTCRQLSPAPAPDDLPWWSIPQSGAGPGSSGVPGTSLSSACAGPPH
                     APRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRC
                     PNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCG
                     KSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKR
                     ENPRDL"
     exon            395..2097
                     /gene="Sp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcagttct tttatccaga ccaacaaaca caccatagga gctttgtgga ttcaaaggat
       61 ttgctttcgc ttctgaaaga gccgctattc tttgatgatt gggtagcggc aaacttcaaa
      121 gccataaatc tttcctctga ctggctggcg gcccagcaaa gcccttatca aattcttgga
      181 ggtgatcctg aagcgctcag accgcgagcc gggcgagcaa gcggggcgcg ggaggggagg
      241 actcggaggc acgctgggcg gccgttcgtc ctcgccttcg ggtgtccatg cctcggcggc
      301 ggccgcgtcc tgctccacag cgagcggcct tcaagcagta gccatggccg ctgtggccgt
      361 cctccggaac gactcactgc aggccttcct ccaggaccgc acccccagcg cctccccgga
      421 cctgggcaag cactcgcccc tggcgctgct ggccgccacc tgtagccgga tcggccagcc
      481 cggcgctgcg gcggcacccg acttccttca ggtgccctat gacccagcgc tgggttcacc
      541 ctccagactt ttccaccctt ggactgccga catgcccgcg cactcgccag gcgccctgcc
      601 gcccccacac cccagcctgg ggctgacgcc gcagaaaaca cacctgcagc cgtccttcgg
      661 ggcagcccac gagctcccgc tcacgccccc cgcggatccg tcgtaccctt acgagttctc
      721 gccggtcaag atgctgccct cgagcatggc tgctctgcct gccagctgcg cgcccgccta
      781 cgtgccctac gccgcgcagg ccgcgttgcc cccgggctac tccaacctgc tgcccccgcc
      841 gccgccaccg cctccaccgc ccacctgccg ccagttatcc cccgccccgg ctccggacga
      901 cctcccctgg tggagcatcc cgcaatcggg cgcggggccg gggagctccg gggttccagg
      961 gaccagcctc tccagcgcct gtgccggacc tccccacgct ccccgcttcc ctgcctcagc
     1021 cgccgctgct gcagcggcgg ctgctgccct gcaacggggt ctagtgttgg gcccgtcgga
     1081 ctttgcacag taccagagcc agatcgccgc gctgctgcag accaaggccc ccctggcggc
     1141 cacggccagg aggtgccgcc gctgccgctg ccccaactgc caggcggctg gcggtgcccc
     1201 cgaggcggaa ccgggcaaaa agaagcaaca cgtgtgccac gtgccaggct gtggcaaggt
     1261 gtacggcaaa acgtcgcacc tgaaggcgca cctgcgctgg cacacgggcg agcggccctt
     1321 cgtgtgcaac tggctcttct gcggcaagag cttcacgcgc tcggacgagc tgcagcggca
     1381 cctgcggact cacacgggcg agaagcgctt cgcttgtccc gagtgcggca aacgcttcat
     1441 gcgaagcgat cacctcgcca agcacgtgaa gacgcaccaa aataagaagc tcaaagtcgc
     1501 tgaggccggg gtgaagcggg agaatccgcg ggacctatga gcgcaccggg acactttcga
     1561 ggccactcct gcccaagaca tctttcccag cacctttgct ggcacaccag ggtacttgcc
     1621 atcgaggtag ctgacaaaga gtaacttttt aaatgaactt tttattctcc tccgcccgaa
     1681 gtcttgctgt ccagcccaag agcagagggc agggcaggca ggacaggaaa ctgggtcgta
     1741 gttgagttac cccaggagga ttccaaagtc cgagccatcg cctgcctggg agacttacat
     1801 tttacccagg gctggccttg cttgtgggag tcgctgctga aaaaaaattt taaaaagaag
     1861 gctcttggga gatttaaaaa caaggcctaa gtttttgcta ggcccgattc ggactttgta
     1921 caggttattt aataatagct ttgttaaaga gtaattatga ttataacgtt aataaatgtt
     1981 tctgttgttc tcagctccac gcagagctac agcatggtac gtttctgtaa agcgaacagc
     2041 agttggcagc gtgaaaataa atacttcatt ccagggtctc ctcgggaaga cccccac
//
