LOCUS       NM_009239               9017 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus trans-acting transcription factor 4 (Sp4), transcript
            variant 1, mRNA.
ACCESSION   NM_009239
VERSION     NM_009239.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9017)
  AUTHORS   Gu,Y., Zhou,Y., Ju,S., Liu,X., Zhang,Z., Guo,J., Gao,J., Zang,J.,
            Sun,H., Chen,Q., Wang,J., Xu,J., Xu,Y., Chen,Y., Guo,Y., Dai,J.,
            Ma,H., Wang,C., Jin,G., Li,C., Xia,Y., Shen,H., Yang,Y., Guo,X. and
            Hu,Z.
  TITLE     Multi-omics profiling visualizes dynamics of cardiac development
            and functions
  JOURNAL   Cell Rep 41 (13), 111891 (2022)
   PUBMED   36577384
REFERENCE   2  (bases 1 to 9017)
  AUTHORS   Sheehan,K., Lee,J., Chong,J., Zavala,K., Sharma,M., Philipsen,S.,
            Maruyama,T., Xu,Z., Guan,Z., Eilers,H., Kawamata,T. and
            Schumacher,M.
  TITLE     Transcription factor Sp4 is required for hyperalgesic state
            persistence
  JOURNAL   PLoS One 14 (2), e0211349 (2019)
   PUBMED   30811405
  REMARK    GeneRIF: Although our studies initially focused on the relationship
            between Sp4, TRPV1 and thermal hyperalgesia, our results more
            broadly suggest that a larger Sp4-dependent gene network or
            nociceptive transcriptome exists inclusive of TRPV1, TRPA1 and
            TRPM8.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9017)
  AUTHORS   Hirata,Y., Toyono,T., Kokabu,S., Obikane,Y., Kataoka,S.,
            Nakatomi,M., Masaki,C., Hosokawa,R. and Seta,Y.
  TITLE     Kruppel-like factor 5 (Klf5) regulates expression of mouse T1R1
            amino acid receptor gene (Tas1r1) in C2C12 myoblast cells
  JOURNAL   Biomed Res 40 (2), 67-78 (2019)
   PUBMED   30982802
  REMARK    GeneRIF: RNAi-mediated depletion of Sp4 and Klf5 decreased Tas1r1
            expression, while overexpression of Klf5, but not Sp4,
            significantly increased Tas1r1 expression in the myoblast cells.
REFERENCE   4  (bases 1 to 9017)
  AUTHORS   Wang,X., Pinto-Duarte,A., Behrens,M.M., Zhou,X. and Sejnowski,T.J.
  TITLE     Ketamine independently modulated power and phase-coupling of theta
            oscillations in Sp4 hypomorphic mice
  JOURNAL   PLoS One 13 (3), e0193446 (2018)
   PUBMED   29513708
  REMARK    GeneRIF: Sp4 hypomorphic mice had markedly elevated theta power
            localized frontally and parietally, a more pronounced theta phase
            progression along the neuraxis, and a stronger frontal-parietal
            theta coupling. Acute subanesthetic ketamine did not affect theta
            power in wildtype animals but significantly reduced it in Sp4
            hypomorphic mice, nearly completely neutralizing their excessive
            frontal/parietal theta power.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9017)
  AUTHORS   Wegener,A., Kuspert,M., Sock,E., Philipsen,S., Suske,G. and
            Wegner,M.
  TITLE     Sp2 is the only glutamine-rich specificity protein with minor
            impact on development and differentiation in myelinating glia
  JOURNAL   J Neurochem 140 (2), 245-256 (2017)
   PUBMED   27889927
REFERENCE   6  (bases 1 to 9017)
  AUTHORS   Jin,P., Sun,Y. and Grabowski,G.A.
  TITLE     In vivo roles of RORalpha and Sp4 in the regulation of murine
            prosaposin gene
  JOURNAL   DNA Cell Biol 20 (12), 781-789 (2001)
   PUBMED   11879571
  REMARK    GeneRIF: SP4 regulates prosaposin which is involved in
            glycosphingolipid catabolism
REFERENCE   7  (bases 1 to 9017)
  AUTHORS   Gollner,H., Bouwman,P., Mangold,M., Karis,A., Braun,H., Rohner,I.,
            Del Rey,A., Besedovsky,H.O., Meinhardt,A., van den Broek,M.,
            Cutforth,T., Grosveld,F., Philipsen,S. and Suske,G.
  TITLE     Complex phenotype of mice homozygous for a null mutation in the Sp4
            transcription factor gene
  JOURNAL   Genes Cells 6 (8), 689-697 (2001)
   PUBMED   11532028
REFERENCE   8  (bases 1 to 9017)
  AUTHORS   Song,J., Mangold,M., Suske,G., Geltinger,C., Kanazawa,I., Sun,K.
            and Yokoyama,K.K.
  TITLE     Characterization and promoter analysis of the mouse gene for
            transcription factor Sp4
  JOURNAL   Gene 264 (1), 19-27 (2001)
   PUBMED   11245974
REFERENCE   9  (bases 1 to 9017)
  AUTHORS   Nguyen-Tran,V.T., Kubalak,S.W., Minamisawa,S., Fiset,C.,
            Wollert,K.C., Brown,A.B., Ruiz-Lozano,P., Barrere-Lemaire,S.,
            Kondo,R., Norman,L.W., Gourdie,R.G., Rahme,M.M., Feld,G.K.,
            Clark,R.B., Giles,W.R. and Chien,K.R.
  TITLE     A novel genetic pathway for sudden cardiac death via defects in the
            transition between ventricular and conduction system cell lineages
  JOURNAL   Cell 102 (5), 671-682 (2000)
   PUBMED   11007485
REFERENCE   10 (bases 1 to 9017)
  AUTHORS   Supp,D.M., Witte,D.P., Branford,W.W., Smith,E.P. and Potter,S.S.
  TITLE     Sp4, a member of the Sp1-family of zinc finger transcription
            factors, is required for normal murine growth, viability, and male
            fertility
  JOURNAL   Dev Biol 176 (2), 284-299 (1996)
   PUBMED   8660867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY070406.1, AC163034.5, BC076630.1 and AC163032.5.
            
            On Dec 17, 2013 this sequence version replaced NM_009239.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62522.1, SRR10223969.12262.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY070406.1         2-63
            63-70               AC163034.5         87649-87656
            71-791              BC076630.1         1-721
            792-792             AC163034.5         89302-89302
            793-2108            BC076630.1         723-2038
            2109-2114           AC163032.5         25162-25167
            2115-5488           BC076630.1         2039-5412
            5489-9017           AC163032.5         44557-48085
FEATURES             Location/Qualifiers
     source          1..9017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 63.48 cM"
     gene            1..9017
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /note="trans-acting transcription factor 4"
                     /db_xref="GeneID:20688"
                     /db_xref="MGI:MGI:107595"
     exon            1..214
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2556
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor Sp4"
                     /codon_start=1
                     /product="transcription factor Sp4 isoform 1"
                     /protein_id="NP_033265.4"
                     /db_xref="CCDS:CCDS36579.1"
                     /db_xref="GeneID:20688"
                     /db_xref="MGI:MGI:107595"
                     /translation="MSDQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPS
                     PLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQL
                     VASTPPASKENNVSQPASSSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGS
                     VQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNIL
                     AQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVTAGG
                     GTGQVGQPTTTTDSGTSNGNQLVSTPTTSTAPASTMPESPSSSTTCTTTASTTLTSSD
                     TLVSSADTGQYASTSASSSERTIEEPQTPAATESEAQSSSQLQSNGIQNAQDQSNSLQ
                     QVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPT
                     QVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQI
                     APVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGV
                     KVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVACS
                     CPNCREGEGRGSSEPGKKKQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFC
                     GKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIV
                     TSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF"
     exon            215..324
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /inference="alignment:Splign:2.1.0"
     exon            325..1879
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2108
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2308
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..9017
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5694..5699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /note="hexamer: ATTAAA"
     polyA_site      5715
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /note="major polyA site"
     regulatory      5751..5756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /note="hexamer: AATAAA"
     polyA_site      5772
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
     regulatory      8285..8290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /note="hexamer: AATAAA"
     polyA_site      8312
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
     regulatory      8993..8998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
                     /note="hexamer: ATTAAA"
     polyA_site      9012
                     /gene="Sp4"
                     /gene_synonym="5730497N03Rik; HF-1b; HF1-b"
ORIGIN      
        1 gagtcagccg ggctcgggcg gagagaggag ctgctacgcc acagcccagc ggcggccatt
       61 cgcggaaaaa gaggcagagc ctgtgccagc tacagcctcc tccgagccac cgcgggcggg
      121 cgggaccggc ctctcctccc gcctcgcccc cacccccacc cacctctatc ccagtgtctc
      181 tgagagggtt tgtcctgtta atgcgggatg agcgatcaga agaaggagga ggaggaggag
      241 gcggcagcgg cgatggctac agaaggaggg aaaacctctg agccagagaa taacaataaa
      301 aaacccaaaa cctcaggctc ccaggactct cagccctctc ctctggcttt actggcagct
      361 acttgcagca aaatagggac tcctggtgaa aatcaagcaa ctggacaaca gcagattatt
      421 atagatccaa gccaaggatt ggtgcaactt cagaatcagc cacagcagct agaactggtg
      481 acgacgcagc ttgctggaaa cgcttggcaa cttgttgcct ccactcctcc tgcttcaaaa
      541 gaaaataacg tttctcagcc agcttctagt tcatctagtt cttccagcag taataacggg
      601 agttcctctc ctacaaaaac taaatcaggt aatccttcca cccctaatca atttcaagtc
      661 atacaagtac aaaacccaag cggtagtgta cagtaccaag tgatccccca acttcagacg
      721 gtggaaggcc agcaaattca aatcaaccca actagtagtt catctctaca ggatttgcag
      781 ggtcaaattc agctcatttc tgcaggtaat aatcaagcta tcctcacggc tgctaacagg
      841 acagcttctg ggaatatcct tgctcaaaac ctggcaaatc agacagttcc agtacaaatt
      901 agacctggcg tttcaatacc attgcaattg cagacccttc ctggtactca ggctcaagtt
      961 gtaacaaccc taccaattaa cattggagga gtgactttag ctttgccagt aataaataac
     1021 gtgactgctg gaggagggac tggacaagtc ggccagccta ctactactac tgacagtggg
     1081 acttccaatg ggaatcagtt agtttctacg cccaccacca gcactgctcc cgccagtact
     1141 atgcctgaat cgccctcctc ctctactacc tgcacaacca ccgcatcaac aactctgacg
     1201 agcagtgaca cattagtgag ctcagcagat acaggccagt atgcaagcac atcagccagt
     1261 agttctgaac gcaccattga agaaccacag acacctgctg ctactgagtc tgaagcccag
     1321 agctccagcc agcttcagtc caacggaatt cagaatgcac aagaccagtc aaattccctt
     1381 caacaagtac agattgtagg ccagcctatc ctgcagcaaa tccagatcca gcagcctcag
     1441 cagcagatta ttcaagctat cccaccacag tcatttcagc tccagtcagg gcagacaatt
     1501 cagaccatcc agcagcagcc tttgcagaat gttcaacttc aagcagtaaa cccgactcag
     1561 gtacttatca gggctccaac tttaacacct tcagggcaaa tcagctggca aactgtccag
     1621 gtccagaata ttcaaagtct ttcaaatttg caagttcaga atgctgggtt atcccagcag
     1681 ttaaccatca ccccagtgtc ttcaagtggt ggcacaactc ttgctcagat tgctcctgtg
     1741 gctgttgctg gtgccccaat aactttgaat actgcccagc ttgcatcagt gcctaacctt
     1801 cagacagtga gcgttgccaa cctgggtgct gcgggtgttc aagttcaggg agttccagta
     1861 acaatcacta gtgttgcagg tcaacagcaa ggacaggatg gagtgaaagt ccaacaagct
     1921 actatagctc ctgtaacggt ggcagttgga gggattgcta atgcgacaat aggtgctgtt
     1981 agtcctgacc aactcacaca agtgcatttg cagcaaggcc agcagacctc tgatgcagag
     2041 gtgcaacctg gcaagaggct ccgaagagtt gcctgctcct gtcctaactg tagggaagga
     2101 gaaggaaggg gcagcagtga accaggaaag aagaagcagc atgtttgcca cattgaaggg
     2161 tgtgggaaag tatatggcaa gacctctcac ctccgagcac atctccgatg gcacactgga
     2221 gaaagaccgt tcatatgcaa ctggatgttt tgtggcaaaa gattcacaag gagcgatgag
     2281 cttcagagac acagaaggac ccacacaggt gaaaagagat ttgaatgtcc agagtgttct
     2341 aaaaggttta tgcggagtga tcacctatcc aagcatgtca aaactcacca gaataagaaa
     2401 ggaggtggga cagctcttgc cattgttacc tccggagaac tggactcatc tgttacagag
     2461 gtgcttggct ctccacggat tgtcacggtt gccgccattt cccaagattc gaatccagca
     2521 actcccaatg tttcaacaaa catggaagaa ttctgaaacg ttatttataa caaagacctc
     2581 tagtgctgca cttaagttta cacacctttg aaaatctgga aatgggctgg tcaagtggat
     2641 tacagagtag gaaatcacgt ttgtatcctt ggcatcttta agtattccag ggattttggt
     2701 tcaacacaga aagtgttgaa ttttttaaaa aattgaaaaa gaaaaccaat atactggaaa
     2761 cagaaaagta tttcttccat ggtataagtt gctgtagttt tttggaaata catcacataa
     2821 cctttaaaca gaatcttccc tcctttaaca tcctgtgttg ttgacatgtc taaagagaca
     2881 gaccacacta atttgtaggc tgggccttaa ttggactttc tctgtttgga agaactttgt
     2941 taaaatttta gtcagtaata atatacatac atttcttcta ctgtctagca cagaaaacag
     3001 attgctacct gacaataggg ataatactgt ttctttggct tggtttttgg aaaaaaatct
     3061 attcaaaata gttttggccg tcttttctaa atatcaaaaa ttcttcaaaa gttgaattag
     3121 gatatgttgt tccaaaatgg taatctgagc cgtgtctcag atctttatta cactacatta
     3181 tagtagtgtg tgtgcagaca atcagtgaaa cccaattatt ttctccattt tggagacaca
     3241 agaggacctt agagctaaat cttaggttaa attttagatt gaaaccttag gaaaatgctg
     3301 ggggaaaatt tgttaggaca gaattgatga tagcctcaga aaggcaagac gaagcagttt
     3361 aacaatattt taaagtcagg gttgactgtg tgcctaaccc tgtgttcaag agtgaaattt
     3421 cattttaagt gttcatattg gaaatacttg catagattat agatctatgt aatttcatat
     3481 tctgtaaata tgagttacgt tgacaatatg caggattctt tatgctttgg tagccaaaga
     3541 aagaattatc ataattttca aggccagcag gaaattattt ttaattacat tataatcctt
     3601 ttttccttta ctaaaaattg gcaaatccta ctttatttct agtactgtgt ttggctaatt
     3661 aggaacatat atcacagtga tatctttatg ttataccaat aacagaattt tccctaaagg
     3721 tctagacagc ttaacaaatg tataatagat atgatattat gaagcaaaat tatttttgga
     3781 aatccagaat acttttcagt caaatactga ctgaaaatat atttcattgt ttgtgcaagg
     3841 gtcttagaga acagtgtctt attaggaaag atggccaaaa gtttcatatg gaaagcaatt
     3901 ggattattct aatagattaa acattagtaa gacacttcat gtttttagaa cgtatttaca
     3961 cagaatcata actattgaaa cagaccattt ggaaactaaa gtttttacct acttcctttt
     4021 ttaaccatca ttagtttgaa tataataggt atatgttttc ttgtgcattc tttattattt
     4081 caggaaaagt actactcatg agaattctct tcccaaatcg tgatgtttca tgtatttttg
     4141 atgaaggaga aatactgtaa tgatcactgt ttacactatg tacactctag gccagccctt
     4201 tgtagcgtta tataaaactg aaggcctttt gtgctttcgg tttgtataaa aaagctttga
     4261 gattaaagga aaaaaatttt tacactgtgg ttataaattt caagtttctt aaagcttttg
     4321 tagacttgta acaaagtctt taaattttag ttggattttg taaattgttt tgtatatttt
     4381 atttaatgta ctcttaacag ctgatggatc tggctttaaa atatcagaat cagtttgttg
     4441 ttttgtctgg tacggaggag catttggtaa tgttaatttt aattttatta tataggagct
     4501 gaaacatcaa atatatttta tctatcatgc tacacaatca gtgctatcaa ttttttttat
     4561 gcaaagagac tttcttaatg ttttaatcat gttttctccc agtgatactt tttgttgttt
     4621 gcaccaagtt tgagcgctgt gcatcactgt tccacaatcc agttttatgc aacccatata
     4681 cgctcatcag aagtgcaagt tttcctcatc aacaatgagg tctgttatac atgtatcaga
     4741 ctgaatctgg ataaccttat agcatataaa atgacctgtc agcaggcaca tttgaccacc
     4801 gaatcagacc tcttttggca gtctgttctg cataccattc tgagtccacc ttcctttctg
     4861 tctacagcag ttgtaggttt cactgtcccg tgtttgactc ggtgggatgt agctgtggta
     4921 gggcacagat actcagtaca gtcttgtgaa gggcatttca ctgctcactc cccttgccac
     4981 cattatgaag cttttctttg taaaattatc agtgcaaagc tctgtattta ccatggtaga
     5041 actcagtgtt agaatagttt tctcttacag tatacttcct ttggttaggt ttgtgtgtgt
     5101 gctgctgatt acattagaag ttgatgttaa aaagtcatta tttatcacac tcatgagagc
     5161 agtaatacaa gtgtgtaatc taggagaaaa acttaatttg tcaaacttag ataagcatga
     5221 tgtttaggtc ctatttttca attttataac tgttttattg caacaatatt tgtacttaag
     5281 tctccatttt aatgccttgt ggtgtttttt tatgcatgtc actaagttgt catcccacat
     5341 aaattgatgt gcagcatagg gtattaaatc tacataatga ttttaaaaca gatatagttg
     5401 atggtaaaat gtaaatgttt tgcaaaaatt ccttataaaa agtttcgtag taacatttca
     5461 cttgtaaatt ttttgtaaaa aagaaaatgg aaaaaaaaaa agatgaatcc aggaaaaaaa
     5521 aaaaaaacct gttttcccat attctagaat ttagacaatt attctgccag caaagcctct
     5581 ggggctgtaa ttgacatttt tacagtgctg atttgtataa aatttgtttt ttgtggattt
     5641 ggaaataaaa tcatgtacaa gttgttgcct gcagtaacaa ttgcaagtaa cctattaaag
     5701 tccccttggg ttgaacatgc ctcatttaat tatgtatact atagagcagc aataaagtgt
     5761 ttaaactacc aaccttctca tcacggtgaa cactgaaaat ttaaatacct ctcactagaa
     5821 catgtattgg caactcttct taatcccggt tttaagatct gatcaacaaa cctctgaaaa
     5881 taccgccaaa gaacaccagt ttaaattgca tgttaatttg tgaccattgc tataggcatt
     5941 tgtgaaaatt aaattttgat ttagagacac tatttaaata attttaatca ataaatgtta
     6001 ggaaataggt ggtctaaaaa tgaaaaacaa aattaaaata atatttaagt tcagagcaat
     6061 aatatttaag ttcacttaga aacagtgtag gccacatagt tgtggaaaag tctgtaagga
     6121 agaattgtcc ttctgggaga gacttgcatg tctcacaaaa accttactgc taacgagaat
     6181 ccattacagt atgacttgaa tggacatact tctaagagtg cagagacagc agagctgtag
     6241 gggagacctg cgggatgtta ggcagaggga agtgagctgc ccacaagctt ccaactaata
     6301 tttaaacatg gagtaggtag ggtggtatac tgtctgggca catagcttgt atagcataga
     6361 gtaagggcat ggttacatca catacataac agtgatcaaa acaagaggca gttacattta
     6421 tgctcctcta ccaagtaaca actttgtcga aagctttcat gtcaaaagta aaggtaccca
     6481 tcgtgaccag gattgcttaa ctatgcctga ttcttattcc cctgagttct tattcttaag
     6541 cccaaagctc atattgctac cccaaagata aacttggagt agggagtggg aggtggcgac
     6601 tttacctctt taactattcc tcttaccagt gagcaccaat tacatttctc ctttttaatc
     6661 cttcttaaaa acacgtatgt gtttcaattt cctgaaagat taacatatgt acttatcagg
     6721 ataacactgc atgaaaagat aatgaaattt aaaacctgaa actttctcgt taagtccagt
     6781 aacggtccgg tttctaagct agagattcaa ccacatgaaa aagactgaaa agtaaagtag
     6841 gatcggtcac aatcagactg ctgacatgaa accgtttagt gtggagctaa agcagtggtt
     6901 agagccactg ttgtaatagc tgtagttgac agtgtcttgt taaagatgac cttgaagtca
     6961 gaaaactcac atatgacaca gcttttctat atttaaagtt taggtgtaag ttataggggt
     7021 actgagactt cagatgccag taagaagtgt gggattcttt gattcctctg atggttgtct
     7081 gtgctgtgat gtgtataata tgtaattgtg ttgcaggatt ttaaaggcat tttctaagat
     7141 ttgctggttg gcatagcctt gggttttgct tctcttagtt gcaggttgca gtgaaattat
     7201 ttattttcag atacctgagc aagatctcag gtggaaggaa gcaaggaaag aagggggaaa
     7261 ggaaagagca caaaggactg ttggtaatgc agaattatct ttccatggtg atagtacttg
     7321 gaaaaaagga gctggtgttc agttacctcc tgatttagtt gttgctgaac tattaaatct
     7381 tactgcattg tgtccttatt tgcacagttg tggttgacat tgtagtaagt gcacccagca
     7441 cctggtaagc agaagcattc acagtagcta acccagaaag ggttacttta ttcatgatac
     7501 tgtgtcagca taagctggat ggcttataga cacaataggc ataagcccaa agtcacagtt
     7561 cagtgtcccc tgacaacaca tgttcccttc acatagtagg aggatgagat ggctttctga
     7621 gagccttttt ttcttggaat actaatacca tttcaagagg atgccatttt tatgatctta
     7681 ccacttctta gaggccccac ctcctctgct gtgttggtaa ttggatttca acgtggggat
     7741 ctggagagac aaaccatcag acccagcagg aggcattgag tagttcccaa agagcttaat
     7801 ggaaatgcat ggaaggctca tcacgttgca aagctggctc tctacattac atcaaaggaa
     7861 cttcagtgag aatttcccat ctcaagcatg ttttggtcaa gctgagctag tctgaggtat
     7921 ggtacctcag aattacacaa tagcaccctc tccctctgga gtggcaggac tcactgggaa
     7981 caagactgaa gatactaaag cacatggaga ttgtgcctcc tgggaagagc taaagcaggg
     8041 caagtaagga tgcccaggtt tcaagacagc cgagaaagct catccggttg cagtgatcag
     8101 acaccagcaa gggatgggag acacaaagag ataaacctgc acaggtgcct caagcaacag
     8161 ttcatctttg catcctacct ttctaggtag ttggcttgat ttaaagtgtg ttatttattg
     8221 tcctgctatg aaatgcagtc taataaatat tttatttata gtatttttgt gatgtggaag
     8281 ctataataaa gttatatttt ctgctgataa aattgtttct agcttgtata attttatgtc
     8341 ggaattaaag gtatgagtaa ttcgtggtac tatgtaaatg gcatcatgat ttctaattat
     8401 ttgatcacct aacaagttca aaaaccacta ctgaggaaaa taccataaaa gtaagcaagc
     8461 taacaaaaga aaaaaaaata gcaattcaat aaccaggtta tacctttaga gtaaccatat
     8521 tataccttta cagtagcttt tgctttgtgt atgtgtttgg tggagtgtta tatctctaat
     8581 gatgctcttt aagactggtg tttataagtt actgtattcc tttctaattt catggacagg
     8641 aaaatattgt tgaaaaatca aactgatttt gatggtcata tattagttta tctaaagaac
     8701 ctgaggtggt ggttgtgttc gttgttcatg ttgtttattt gtctttgttt ttcataatgt
     8761 agatggcagt tggtattaaa aggctatgta aattggtcca caacttctgt aagtaactgg
     8821 aagtactttc cgtttacatc ccatttgtga acaaaacgta tttaagaaaa agtgaaaaaa
     8881 taagcaaacc taccagattt cttggagtta atcattttgc agacttgggc atttttttct
     8941 gtatttttag gaaaagaatt atcttcctga taaaagtgaa ttttaaatat taattaaact
     9001 tatttgaatc tatgatc
//
