LOCUS       NM_001018042            4191 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus trans-acting transcription factor 3 (Sp3), transcript
            variant 1, mRNA.
ACCESSION   NM_001018042
VERSION     NM_001018042.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4191)
  AUTHORS   Zhao,H., Wong,R.J. and Stevenson,D.K.
  TITLE     The placental vasculature is affected by changes in gene expression
            and glycogen-rich cells in a diet-induced obesity mouse model
  JOURNAL   PLoS One 18 (11), e0294185 (2023)
   PUBMED   37948457
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4191)
  AUTHORS   Lu,H., Jiang,X., He,L., Ji,X., Li,X., Liu,S., Sun,Y., Qin,X.,
            Xiong,X., Philipsen,S., Xi,B., Zhang,M., Yang,J., Zhang,C.,
            Zhang,Y. and Zhang,W.
  TITLE     Endothelial Sp1/Sp3 are essential to the effect of captopril on
            blood pressure in male mice
  JOURNAL   Nat Commun 14 (1), 5891 (2023)
   PUBMED   37735515
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4191)
  AUTHORS   McCoy,A.M., Lakhdari,O., Shome,S., Caoili,K., Hernandez,G.E.,
            Aghaeepour,N., Butcher,L.D., Fisch,K. and Prince,L.S.
  TITLE     Sp3 is essential for normal lung morphogenesis and cell cycle
            progression during mouse embryonic development
  JOURNAL   Development 150 (5) (2023)
   PUBMED   36762637
  REMARK    GeneRIF: Sp3 is essential for normal lung morphogenesis and cell
            cycle progression during mouse embryonic development.
REFERENCE   4  (bases 1 to 4191)
  AUTHORS   Lu,H., Yuan,P., Ma,X., Jiang,X., Liu,S., Ma,C., Philipsen,S.,
            Zhang,Q., Yang,J., Xu,F., Zhang,C., Zhang,Y. and Zhang,W.
  TITLE     Angiotensin-converting enzyme inhibitor promotes angiogenesis
            through Sp1/Sp3-mediated inhibition of notch signaling in male mice
  JOURNAL   Nat Commun 14 (1), 731 (2023)
   PUBMED   36759621
  REMARK    GeneRIF: Angiotensin-converting enzyme inhibitor promotes
            angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling
            in male mice.
            Erratum:[Nat Commun. 2023 Apr 25;14(1):2371. doi:
            10.1038/s41467-023-38092-6.. PMID: 37185975]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4191)
  AUTHORS   Gao,P., Chen,C., Howell,E.D., Li,Y., Tober,J., Uzun,Y., He,B.,
            Gao,L., Zhu,Q., Siekmann,A.F., Speck,N.A. and Tan,K.
  TITLE     Transcriptional regulatory network controlling the ontogeny of
            hematopoietic stem cells
  JOURNAL   Genes Dev 34 (13-14), 950-964 (2020)
   PUBMED   32499402
REFERENCE   6  (bases 1 to 4191)
  AUTHORS   Gollner,H., Dani,C., Phillips,B., Philipsen,S. and Suske,G.
  TITLE     Impaired ossification in mice lacking the transcription factor Sp3
  JOURNAL   Mech Dev 106 (1-2), 77-83 (2001)
   PUBMED   11472836
  REMARK    GeneRIF: Sp3 is an essential transcription factor for late bone
            development.
REFERENCE   7  (bases 1 to 4191)
  AUTHORS   Bouwman,P., Gollner,H., Elsasser,H.P., Eckhoff,G., Karis,A.,
            Grosveld,F., Philipsen,S. and Suske,G.
  TITLE     Transcription factor Sp3 is essential for post-natal survival and
            late tooth development
  JOURNAL   EMBO J 19 (4), 655-661 (2000)
   PUBMED   10675334
REFERENCE   8  (bases 1 to 4191)
  AUTHORS   Jensen,J., Heller,R.S., Funder-Nielsen,T., Pedersen,E.E.,
            Lindsell,C., Weinmaster,G., Madsen,O.D. and Serup,P.
  TITLE     Independent development of pancreatic alpha- and beta-cells from
            neurogenin3-expressing precursors: a role for the notch pathway in
            repression of premature differentiation
  JOURNAL   Diabetes 49 (2), 163-176 (2000)
   PUBMED   10868931
REFERENCE   9  (bases 1 to 4191)
  AUTHORS   Yajima,S., Lee,S.H., Minowa,T. and Mouradian,M.M.
  TITLE     Sp family transcription factors regulate expression of rat D2
            dopamine receptor gene
  JOURNAL   DNA Cell Biol 17 (5), 471-479 (1998)
   PUBMED   9628590
REFERENCE   10 (bases 1 to 4191)
  AUTHORS   Sack,M.N., Disch,D.L., Rockman,H.A. and Kelly,D.P.
  TITLE     A role for Sp and nuclear receptor transcription factors in a
            cardiac hypertrophic growth program
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6438-6443 (1997)
   PUBMED   9177236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC079874.1.
            
            On Jun 1, 2007 this sequence version replaced NM_001018042.2.
            
            Summary: This gene product belongs to a family of Sp1 related
            transcription factors, which regulate transcription by binding to
            consensus GC- and GT-box regulatory elements in target genes. This
            protein contains a zinc finger DNA-binding domain and several
            transactivation domains, and has been reported to function as a
            bifunctional transcription factor that either stimulates or
            represses transcription of numerous genes. Alternative splicing
            results in transcript variants encoding different isoforms, and one
            variant initiates translation from a non-AUG (AUA) codon. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079874.1, SRR13861859.1561832.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3430              BC079874.1         1-3430
            3431-4191           BC079874.1         3432-4192
FEATURES             Location/Qualifiers
     source          1..4191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.35 cM"
     gene            1..4191
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="trans-acting transcription factor 3"
                     /db_xref="GeneID:20687"
                     /db_xref="MGI:MGI:1277166"
     exon            1..197
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2542
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor Sp3"
                     /codon_start=1
                     /product="transcription factor Sp3 isoform 1"
                     /protein_id="NP_001018052.1"
                     /db_xref="CCDS:CCDS16122.1"
                     /db_xref="GeneID:20687"
                     /db_xref="MGI:MGI:1277166"
                     /translation="MTAPEKPVKQEEMAALDVDGGGGGGGHGEYLQQQQQQQQQHGNG
                     AAAAAAQDTQPSPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASA
                     QLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGS
                     DSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQENSQIQIIPGSNQTLLA
                     SGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDL
                     DSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVP
                     TSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVST
                     AQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTF
                     LIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAL
                     TSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSG
                     DSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHI
                     CHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKK
                     FVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILA
                     NIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME"
     exon            198..343
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            344..475
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1835
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2028
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2225
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..4178
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3762..3767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="hexamer: ATTACA"
     polyA_site      3782
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="major polyA site"
     regulatory      3934..3939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3962
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="major polyA site"
     regulatory      4086..4091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="hexamer: AATATA"
     polyA_site      4105
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="major polyA site"
     regulatory      4156..4161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="hexamer: AATATA"
     polyA_site      4178
                     /gene="Sp3"
                     /gene_synonym="D130027J01Rik"
                     /note="major polyA site"
ORIGIN      
        1 cccttttggg ctggaggctc caccttttgt gtttcccgca cagtcaatca aaataggaaa
       61 aaaaaaattc cccggaccgc tccggccgtg tccgccgccg cttcccgcat cctctcccgc
      121 cgccgccgcc ttcgcttctc accatgtgta aggcggcggg gagccccgcc tgagctgtcc
      181 taaacacact atgaccgctc ccgaaaagcc cgtgaaacaa gaggaaatgg ctgccttgga
      241 cgtggacggc ggcggaggcg gcggcggcca cggcgagtat ctacagcagc agcagcagca
      301 acagcagcag cacggaaacg gcgcggcggc ggcggcggcc caggacactc agccgtcacc
      361 gctcgctctg ctggccgcta cctgcagcaa gatagggccg ccatcgccgg gcgacgacga
      421 cgaggaggcg gccgttgccg ccgccgccgg ggtccccgcc gccgccgccg gagcgacagg
      481 tgatttggct tctgcacagt taggaggagc accaaaccga tgggaggttt tgtcagctac
      541 acctacaact ataaaagatg aagctggtaa tctagtacag attccaggtg ctgctacttc
      601 aagtgggcag tatgtccttc cccttcagaa tttgcagaat caacaaatat tttcagttgc
      661 accaggatca gattcatcaa atggcacagt gtccaatgtt cagtatcaag taataccaca
      721 aattcagtca acagacgctc agcaggttca gattggcttc acaggctcct cagataatgg
      781 gggcataaat caagaaaaca gccaaattca gatcattcct ggctctaatc aaaccttact
      841 cgcctctgga acacctcctg ctaatatcca gaatctcata ccacagactg gtcaagtcca
      901 ggttcaggga gttgcaattg gtggctcatc atttcctggc caaactcaag tagtcgctaa
      961 tgtgcctctt ggtctgccag gaaatattac ctttgtacca atcaatagtg tcgatctaga
     1021 ttctttggga ctctcgggaa gttctcagac aatgactgca ggcattaatg ccgatggaca
     1081 tttgataaac acaggacaag ctatggatag ttcagacaat tcagaaagga ctggtgagcg
     1141 ggtttctcct gatgttaatg aaactaatgc tgatacagat ttatttgtgc caacatcctc
     1201 ttcatcacag ttgcctgtta caatagatag tacaggtata ttacagcaaa acacaaatag
     1261 cttgactact actagtgggc aagtccattc ttcagatctt cagggaaatt atatccagtc
     1321 gcctgtttct gaagagacac aggctcagaa tattcaggtt tctacagcac agcctgttgt
     1381 acaacatcta caacttcaag attctcagca gccaaccagt caagcccaaa ttgtgcaagg
     1441 tattacacca cagacaatcc atggcgtgca agccagtggt caaaatatat cacaacaggc
     1501 tttgcaaaac cttcagttgc agctgaatcc tggaaccttt ttaattcagg cacagacagt
     1561 gaccccttct ggacagataa cttggcaaac atttcaagta caaggggtcc agaacttaca
     1621 gaatttgcaa atacaaaata ctgctgccca acaaattact ttgacgcctg ttcagacact
     1681 cacgcttggt caagtcgcag caggtggagc cttgacttca actccagtca gtctaagcac
     1741 tggtcagttg ccaaatctac agacagttac agtaaattct atagattcta ctggcataca
     1801 gctacatcca ggagagaatg ccgacagtcc tgcagatatt aggatcaagg aagaggaacc
     1861 tgaccctgaa gaatggcagc tcagtggtga ctctacactg aacaccaatg acctaacaca
     1921 tttacgagta caagtggtag atgaagaagg ggaccaacaa catcaagaag gaaaaagact
     1981 tcggagggta gcttgcacct gtcccaactg taaagaaggt ggtgggagag gtaccaatct
     2041 tgggaaaaag aagcaacaca tttgtcatat accgggatgt ggtaaagtct atgggaagac
     2101 ctcacatctg agagcacacc tgcgttggca ttcgggggag cgccctttta tttgtaactg
     2161 gatgttctgt ggtaaaagat ttacacgaag tgatgaatta cagaggcaca gaagaacaca
     2221 tacaggtgag aagaagtttg tttgtccaga atgttcaaaa cgctttatga gaagtgacca
     2281 ccttgccaaa catattaaaa cacatcaaaa taaaaaagtc attcactcta gcagtacagt
     2341 gctcgcatct gtggaagctg gaagagatga tgccttgatt actgcaggag gaacaacact
     2401 tatccttgca aatattcaac aggggtctgt gtcagggata ggaactgtca atacttctgc
     2461 caccagcaat caagacatcc ttaccaacac tgaaatacct ttacagcttg tcacagtttc
     2521 tggaaatgag acaatggagt aaatattaca caaatactta ttcattgtgg ttatttttat
     2581 acagtagtga gaagaatatt gttcctaagt tcttagatat ctttttattg atgtgcaaaa
     2641 atttttggat tgacagtaac ttggttatac atgacactga aatgccttac tttgtatgat
     2701 attccatagt atattaaaaa tggtaaaatt tgcatggatt ttgtaggtac ttttggaatc
     2761 tagaagaaat gaaattttac caagttatat aaagagaaaa ttgaatttaa caatgcgaat
     2821 ggtagtctaa ccaaatgcat caatcctgtg tggtttagtg taaaaatgag aaactgttgg
     2881 tatttatcta ttgtaagata aaaaaagttg gtgggtgaaa gaaatcatgt tataaatttt
     2941 tgtaattttc ttgatgactg gaatttttat tatgcataac tgacaaatca agtttccaag
     3001 caaatgttac atagtgtagg ctttacttag cttatcaatt tgtcattttg aagctaatta
     3061 ttttaattag gttaactgta caatatttta agcattactc ttgtaagatt ttgaaaacta
     3121 cattttaaca tggaccttta gggatagtca ccttttaaat cctgttgaaa agccatgttt
     3181 aagatttaat ttgccaaaat aatgtcttgt taatattctt tcaataatga agttgggcaa
     3241 tataaccgat gtttttaaaa agtttaaaat gtgtaggttg aagcatttgg gtggtaaaat
     3301 gttctagtga attacccctt ttcctgaagt ttggaggacc aaaaaataat aataaggtgt
     3361 attgcgtctt agcagagaat tttttttttt ttttttaaat tcaatcttgg ttccaaaaaa
     3421 aaaaaaaaaa tatgtctgcc agggccttaa aagccatcgt tgtaaattac caataaagta
     3481 taacatatgc aaacataaca aaatcacttc cacagtgacg atactccaac catatggata
     3541 ttagtcatag aaactagagg ctttatgata tttttttaag tttttttaat ctaggtagtc
     3601 tgcacttaaa tatcaaccat tttccttttt ttgcttcttc ccttaaaatt tatatgtatc
     3661 caatacattt aattgagaaa tgtatgtttt ttattatgct gtattttctt tttatttttt
     3721 aattattgtt tatattttca attaaaaatg tacaaaataa aattacattg ctggtcttgt
     3781 aagagctcta cacttttcct acatgtacct acaactacag cagttcatct atttcaggaa
     3841 gttgaattct gttcatttgt tctctttaag accacctcag ataaaaggct accttattgt
     3901 acgtttaaag tgtattataa cagtgtggta gttaataaaa cactattttt tttttctttt
     3961 gagtttgttg tagtccgatg catctaaaat actgcaatgg tatggataag aaagcctggc
     4021 ttatttttct ttactttaga cttttatttt tagattcttg atttcagatg ctgggattgt
     4081 aaataaatat atttacttaa aaagaggtgt atagaggtgc tggcaattaa tttttcactt
     4141 aaaatgaatt tattaaatat aacttgaaac ttgaaaaaaa aaaaaaaaaa a
//
