LOCUS       NM_001080964            3038 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus Sp2 transcription factor (Sp2), transcript variant 2,
            mRNA.
ACCESSION   NM_001080964
VERSION     NM_001080964.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3038)
  AUTHORS   Johnson,C.A. and Ghashghaei,H.T.
  TITLE     Sp2 regulates late neurogenic but not early expansive divisions of
            neural stem cells underlying population growth in the mouse cortex
  JOURNAL   Development 147 (4) (2020)
   PUBMED   32001437
  REMARK    GeneRIF: there is a stage-specific requirement for Sp2 in neural
            stem and progenitor cells in the mouse cortex
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3038)
  AUTHORS   Norrie,J.L., Lupo,M.S., Xu,B., Al Diri,I., Valentine,M., Putnam,D.,
            Griffiths,L., Zhang,J., Johnson,D., Easton,J., Shao,Y., Honnell,V.,
            Frase,S., Miller,S., Stewart,V., Zhou,X., Chen,X. and Dyer,M.A.
  TITLE     Nucleome Dynamics during Retinal Development
  JOURNAL   Neuron 104 (3), 512-528 (2019)
   PUBMED   31493975
REFERENCE   3  (bases 1 to 3038)
  AUTHORS   Volkel,S., Stielow,B., Finkernagel,F., Berger,D., Stiewe,T.,
            Nist,A. and Suske,G.
  TITLE     Transcription factor Sp2 potentiates binding of the TALE
            homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y
            to composite genomic sites
  JOURNAL   J Biol Chem 293 (50), 19250-19262 (2018)
   PUBMED   30337366
  REMARK    GeneRIF: a mechanism by which the DNA binding-independent activity
            of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to
            composite motifs present in many promoters of highly expressed
            genes
REFERENCE   4  (bases 1 to 3038)
  AUTHORS   Wegener,A., Kuspert,M., Sock,E., Philipsen,S., Suske,G. and
            Wegner,M.
  TITLE     Sp2 is the only glutamine-rich specificity protein with minor
            impact on development and differentiation in myelinating glia
  JOURNAL   J Neurochem 140 (2), 245-256 (2017)
   PUBMED   27889927
REFERENCE   5  (bases 1 to 3038)
  AUTHORS   Zschemisch,N.H., Brusch,I., Hambusch,A.S. and Bleich,A.
  TITLE     Transcription Factor SP2 Enhanced the Expression of Cd14 in
            Colitis-Susceptible C3H/HeJBir
  JOURNAL   PLoS One 11 (5), e0155821 (2016)
   PUBMED   27191968
  REMARK    GeneRIF: SP2 as important factor responsible for higher Cd14
            expression and reduced IBD susceptibility mediated by the C3Bir
            allele.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3038)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
REFERENCE   7  (bases 1 to 3038)
  AUTHORS   Moorefield,K.S., Fry,S.J. and Horowitz,J.M.
  TITLE     Sp2 DNA binding activity and trans-activation are negatively
            regulated in mammalian cells
  JOURNAL   J Biol Chem 279 (14), 13911-13924 (2004)
   PUBMED   14726517
REFERENCE   8  (bases 1 to 3038)
  AUTHORS   Hammer,F., Compagnone,N.A., Vigne,J.L., Bair,S.R. and Mellon,S.H.
  TITLE     Transcriptional regulation of P450scc gene expression in the
            embryonic rodent nervous system
  JOURNAL   Endocrinology 145 (2), 901-912 (2004)
   PUBMED   14576192
REFERENCE   9  (bases 1 to 3038)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3038)
  AUTHORS   Bakovic,M., Waite,K.A. and Vance,D.E.
  TITLE     Functional significance of Sp1, Sp2, and Sp3 transcription factors
            in regulation of the murine CTP:phosphocholine cytidylyltransferase
            alpha promoter
  JOURNAL   J Lipid Res 41 (4), 583-594 (2000)
   PUBMED   10744779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596384.17, BC086457.1, BP765918.1 and AA267604.1.
            
            On May 12, 2018 this sequence version replaced NM_001080964.1.
            
            Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF
            transcription factors. Sp family proteins are sequence-specific
            DNA-binding proteins characterized by an amino-terminal
            trans-activation domain and three carboxy-terminal zinc finger
            motifs. This protein contains the least conserved DNA-binding
            domain within the Sp subfamily of proteins, and its DNA sequence
            specificity differs from the other Sp proteins. The protein can act
            as a transcriptional activator or repressor, depending on the
            promoter and cell type. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172877.1, BC021759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL596384.17        196415-196445       c
            32-2898             BC086457.1         1-2867
            2899-2937           AL596384.17        172190-172228       c
            2938-3033           BP765918.1         45-140              c
            3034-3038           AA267604.1         2-6                 c
FEATURES             Location/Qualifiers
     source          1..3038
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.17 cM"
     gene            1..3038
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /note="Sp2 transcription factor"
                     /db_xref="GeneID:78912"
                     /db_xref="MGI:MGI:1926162"
     exon            1..68
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /inference="alignment:Splign:2.1.0"
     exon            69..145
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /inference="alignment:Splign:2.1.0"
     exon            146..1117
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1430
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1605
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1799
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..3038
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /note="hexamer: ATTAAA"
     polyA_site      2898
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /note="major polyA site"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /note="hexamer: AATAAA"
     polyA_site      3033
                     /gene="Sp2"
                     /gene_synonym="4930480I16Rik; mKIAA0048"
                     /note="major polyA site"
ORIGIN      
        1 gggcggtgtc aggctctcgg tggcggcgga ggcggcggag gccagggagg aagatgtcgt
       61 aatgagcgat ccacagatga gcatggccgc cactgctgct gtcagtccca gtgactacct
      121 gcagcctgct gctgctacta cccaggactc ccagccatct cccttggccc tgcttgctgc
      181 gacatgtagc aaaattggcc ccccagctgt tgaagctgca gtgacacctc ctgctccccc
      241 ccagcctacc ccaaggaaac tggtccctat caaacccgct cctctccctc tcagtccctg
      301 caagaatagc tttagcatct tatcatctaa aggaaatata cttcagattc agggctccca
      361 gctgagtacc tcctaccctg gagggcagtt tgtgtttgca atccagaacc ccaccctgat
      421 caacaaaggg agccgatcaa atgcaagtat ccagtaccaa gtccctcaga tccaagggaa
      481 cagttcccag accatccagg tgcagcccag tctcaccaac cagatccagg tcatcccagg
      541 caccaaccaa gccatcacca ccccgtcaac atctggtcat aagcctgtcc ccatcaagcc
      601 agctcctgtc cagaagtcaa gtacgactac cacccctgtg cagagcgggg ccaacgtggt
      661 gaagctgaca ggcgggggta gcaacatgac gctcaccctg ccgctcaaca acctggtgaa
      721 caccagcgat attgggggcc ctgctcagct cctcactgag agccccccca ccccactgtc
      781 taagactaac aagaaagcta ggaagaagag cctccctgtg tcacagccat ccgtagctgt
      841 ggctgagcag gtggagacgg tgctgataga gaccacggca gacaacatca tccaggcagg
      901 aaacaacctg ctgatcgtcc agagccctgg cgggggccag ccagctgtgg tccagcaagt
      961 ccaggtggtg ccacccaagg ctgagcagca gcaggtggtc cagatccccc agcaggcact
     1021 gcgggtggtg caagctgcct ctgccaccct ccccaccgtc ccccagaagc cctctcagaa
     1081 ctttcagatc cagacaactg aaccaacacc aacccaggtt tatatccgta caccttctgg
     1141 tgaggtacag acagtccttg tccaggacag ccccccagca acagctgcaa ccacatcaac
     1201 cgtcacctgt aacagccctg cactccgagc tccccatctg agtggcacca gcaaaaaaca
     1261 ttcagctgcc attctccgaa aagagcggcc cctgccaaag attgcacctg ctgggagcat
     1321 catcagcctg aacgccgcac agctggcagc agctgctcag gccatgcaga ccatcaacat
     1381 caatggtgtc caagtccagg gtgtgcctgt caccatcacc aacactggcg ggcagcagca
     1441 gctgaccgtg cagaacgttt ctggaaacaa cctgactatc agtgggctga gccccaccca
     1501 gatccagctg cagatggagc aggctctagc cggagaggcc cagcctgggg agaaacggcg
     1561 gcgcatggcc tgcacgtgtc ccaactgcaa ggatggggag aagaggtctg gggagcaggg
     1621 caagaagaag cacgtgtgcc acatcccgga ctgcgggaag actttccgga agacatcctt
     1681 gctccgggcc cacgtccgcc tgcacactgg cgagcggccc tttgtctgca actggttctt
     1741 ctgtggaaag agattcactc ggagcgatga actccagcga catgctcgaa cccacacagg
     1801 ggacaagcgc tttgagtgtg cccaatgtca gaagcgcttc atgaggagtg accacctcac
     1861 caagcattac aagacccacc taggcacgaa gggcttgtaa ggccaactga ggcaggaggc
     1921 cctgaagatg gaacacctcc catctgattg gccctgggtc catgatggac aggtgcccac
     1981 gactgccctg ggcagccctc accccactcc tgttctgtgg ctgtgtccct gcagagaggg
     2041 actctgttcc tgtgttctcc tccttccaaa ggctctgccc ctctcaccgt gagctcctgg
     2101 cctgcccagg ccatggacac tggccatgcc caatgagacg ttctaaccca ggacgcgtgg
     2161 ggacccttat ttccaaagga aaaacataca tttcactccg tcgaggagca aagtgagccc
     2221 ccatccccac cccatcccct tcctcaacac tgccggagtc ccattgtgcc atgccccctc
     2281 ccccaccgtg cctccttgtc cccctcaatt aagtcctcct gggccgctag ggacacccag
     2341 gggccctgta cccagcctcc cactgacacc ccccaccggg gaggtgggag gctgcctcca
     2401 ctccactgcc cagccctgcc acggctctcc tccaaacatt ccaacttcct atgaaaggtc
     2461 agacgccgag gacctgccct ccctcttttc tacggagaac gttgccttat actcacttca
     2521 gatgatgaca ctgtggacgt gtgtgcttta accacatttt atttaattgc tcccttcctc
     2581 tctttgctag acgcctcccc cttgcttgca ttcagtttag ggttttgggg gcaatgctga
     2641 gcataggagg gtcttttttt ttttgctatt ttttttctca ctttaacaat tcttttctaa
     2701 atgacacatt tcaactcaaa tctggactca cctgagaaca ccttccatcc tgaccccgcc
     2761 acgccctcat ctccccctgc ccaagctcca ctgtgtacag tgtatattgt ataatagact
     2821 attgtgtcta agacatgttt taaaaacata ttgcttgtta tttttgaggc ttttaaatta
     2881 aacagaaatc caactttatt ttcgttgtaa ctgcttgagg atgttttatt aattaagtga
     2941 agatttgtta tcctttatta acgatgtatt ttgttggtca gtactgggct gacaaaaagt
     3001 ttcttgctaa taaatttagt tgcccaaggc aaagtctg
//
