LOCUS       NM_001013817            2417 bp    mRNA    linear   ROD 08-NOV-2022
DEFINITION  Mus musculus Sp140 nuclear body protein (Sp140), mRNA.
ACCESSION   NM_001013817 XM_486317
VERSION     NM_001013817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2417)
  AUTHORS   Fraschilla I, Amatullah H, Rahman RU and Jeffrey KL.
  TITLE     Immune chromatin reader SP140 regulates microbiota and risk for
            inflammatory bowel disease
  JOURNAL   Cell Host Microbe 30 (10), 1370-1381 (2022)
   PUBMED   36130593
REFERENCE   2  (bases 1 to 2417)
  AUTHORS   Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F,
            Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P,
            Sadreyev RI, Anthony RM, Rioux JD and Jeffrey KL.
  TITLE     Epigenetic reader SP140 loss of function drives Crohn's disease due
            to uncontrolled macrophage topoisomerases
  JOURNAL   Cell 185 (17), 3232-3247 (2022)
   PUBMED   35952671
  REMARK    GeneRIF: Epigenetic reader SP140 loss of function drives Crohn's
            disease due to uncontrolled macrophage topoisomerases.
REFERENCE   3  (bases 1 to 2417)
  AUTHORS   Matsushita K, Li X, Nakamura Y, Dong D, Mukai K, Tsai M, Montgomery
            SB and Galli SJ.
  TITLE     The role of Sp140 revealed in IgE and mast cell responses in
            Collaborative Cross mice
  JOURNAL   JCI Insight 6 (12), 146572 (2021)
   PUBMED   34156030
  REMARK    GeneRIF: The role of Sp140 revealed in IgE and mast cell responses
            in Collaborative Cross mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2417)
  AUTHORS   Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevee V, Chen KJ,
            Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I,
            Portnoy DA, Darwin KH and Vance RE.
  TITLE     Role of the transcriptional regulator SP140 in resistance to
            bacterial infections via repression of type I interferons
  JOURNAL   Elife 10, e67290 (2021)
   PUBMED   34151776
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147806.5.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_001013817.3.
            
            On Feb 27, 2007 this sequence version replaced NM_001013817.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069971.1, SRR7345562.3519642.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               AC147806.5         75113-75601         c
            490-652             AC147806.5         66448-66610         c
            653-824             AC147806.5         65394-65565         c
            825-875             AC147806.5         61450-61500         c
            876-959             AC147806.5         61033-61116         c
            960-1061            AC147806.5         56147-56248         c
            1062-1115           AC147806.5         54597-54650         c
            1116-1181           AC147806.5         50139-50204         c
            1182-1286           AC147806.5         45740-45844         c
            1287-1429           AC147806.5         43684-43826         c
            1430-1477           AC147806.5         40698-40745         c
            1478-1519           AC147806.5         38439-38480         c
            1520-1635           AC147806.5         34456-34571         c
            1636-1741           AC147806.5         33657-33762         c
            1742-1819           AC147806.5         33292-33369         c
            1820-1963           AC147806.5         32958-33101         c
            1964-2417           AC147806.5         31267-31720         c
FEATURES             Location/Qualifiers
     source          1..2417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2417
                     /gene="Sp140"
                     /note="Sp140 nuclear body protein"
                     /db_xref="GeneID:434484"
                     /db_xref="MGI:MGI:3702467"
     exon            1..489
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..2062
                     /gene="Sp140"
                     /codon_start=1
                     /product="SP140 nuclear body protein family member"
                     /protein_id="NP_001013839.1"
                     /db_xref="CCDS:CCDS35638.1"
                     /db_xref="GeneID:434484"
                     /db_xref="MGI:MGI:3702467"
                     /translation="MAGGYNELSSRTIPEDQNEEESDDYQLMFKHFKENKVEIASAIT
                     KPFPFLMSLRDRDFISEQKFQEYQETCKNLVPVERVVYDILSNVQKKFSRDLLKVIFS
                     KTHLKAYPDLKETLKHFFLNASKTNDEQAEEMQCNGGEGSNSCEQTRQTRQEPQDDLP
                     SSLRQEAGAQQPTREKKCSCVICSPTYVPEDLEARMGSSQGECVGTRRNIPARKPKKQ
                     RRKKKGHNWSKPRWRKPMSVQRKRLRRRRKENANFSAELLPVTCGNLKGVLHKEKFKQ
                     GISVKSIQCQNGNWFTPSEFEMMGGYGKSKNWKLSLRCHNWPLKLLIQRNFLPNPPRI
                     HRKRKEQRTQNLHRSPADPSIQNSDKCEVCRDGGLLFCCDTCFRAFHEDCHIPTVEAE
                     ITPWSCIFCRMQSLGSQPSLPESEILQREMAPQEQLKCEYVLLRVYCCSESSFFSKMP
                     YYYYFREMTVSVQEPMWLDIIKKKLSDQAYCQVEDFVQDMRLIFRNHKITFKDPKFGE
                     MGFRLESKFEKSFKEVFAIQETNEKS"
     exon            490..652
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            653..824
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            825..875
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            876..959
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1061
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1115
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1181
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1286
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1429
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1477
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1519
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1635
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1741
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1819
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1963
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2417
                     /gene="Sp140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctcaat tatcaggtcc cagcttctct ggttctgact tactagggtg ccaggacagt
       61 tccaagtctg agagactgca gacaatctaa ctcttcctgg tctttccagg caccgccccc
      121 gcttagggtt aagggaccac ttccttccta tcctaacagc cagctggcct tagacagctc
      181 tgagcccttc cctgaaacag acccttccac cttctttcct tagaaggcag caggcgtccc
      241 aggtttctgg ggacttgggc tgtctttgct cctcccctct ggggcagaga ctgggggtgg
      301 agggcagtgc cttagtgcag tgttgtcata gttaagcaat ttcactttcc tttttctcct
      361 ctttggaggc ccctgaagga gttctctctg ggcttcccag agactcagag ggggttcggt
      421 ctaccctgaa cagggtccct tggagtctgt gtaggggatg gcaggaggct acaatgaact
      481 cagcagcagg acaatcccag aggaccagaa tgaagaggag tcagatgact atcagctcat
      541 gttcaagcac ttcaaagaaa acaaggtgga gatcgcaagt gccatcacca agccgtttcc
      601 tttcctcatg agccttcgag accgagactt catctcggag cagaagtttc aggaatatca
      661 agaaacatgt aagaacctgg tcccagtgga gagagtcgtg tacgacatcc tcagcaatgt
      721 acagaagaag tttagccggg atcttctgaa agtgatattc agcaaaacac atctgaaggc
      781 ctaccccgac ttaaaggaga ctctaaaaca cttcttccta aatgcatcca aaacgaatga
      841 tgaacaagca gaggagatgc aatgcaatgg aggagaggga agtaattctt gtgaacaaac
      901 aagacaaaca agacaagagc cccaggatga cctgccctca tccctgagac aagaagcagg
      961 agcacagcaa cccacacgtg aaaagaagtg ttcctgtgtc atatgttccc caacatatgt
     1021 gccagaagac ctggaagcaa ggatgggaag cagccaagga gaatgtgtgg gcaccaggag
     1081 gaacattcct gcaagaaaac ccaagaagca gagaagaaaa aagaaaggcc acaactggtc
     1141 aaaaccaaga tggagaaagc caatgagtgt acagagaaaa cgtctaagaa gacgcagaaa
     1201 agaaaatgcc aattttagtg ctgagttgct tcccgtgacg tgtggtaact tgaagggagt
     1261 gttacacaag gaaaaattca aacaagggat atctgtgaag tccatacagt gtcagaatgg
     1321 aaactggttc acaccctcgg aatttgaaat gatgggaggc tatggaaagt caaagaactg
     1381 gaaactgagc ctgcgctgcc ataattggcc cctgaaactc ctgatccaga gaaattttct
     1441 acccaatcct ccacggatac atcgcaaaag aaaagagcag agaacacaga acttgcatcg
     1501 ttccccagct gaccctagta ttcagaactc agataaatgt gaggtgtgcc gggatggagg
     1561 attactcttc tgctgtgata cttgtttcag agccttccat gaggactgtc atatcccaac
     1621 agtggaagct gagataacac catggagttg catcttctgt aggatgcagt ccttaggaag
     1681 tcaaccgagt cttccagaat ctgagatact gcagagggag atggctcccc aggaacagtt
     1741 gaagtgtgag tatgttctct tgagagtcta ttgctgttct gagagctcct ttttttccaa
     1801 gatgccatat tattattatt ttagagagat gactgtgagt gtgcaagagc ctatgtggtt
     1861 ggacataatc aagaaaaagc tgagtgacca ggcttactgc caagtagaag actttgtgca
     1921 agacatgagg ctcatcttcc ggaatcacaa aatcacgttc aaggacccta agtttggcga
     1981 aatgggattt agactggagt ccaagtttga gaagagtttc aaggaagtgt ttgctattca
     2041 ggaaacaaat gaaaagagtt gactaaaatc agagacatgg ctggtgtcac ctggccatgt
     2101 ctgtctcacc tgcagcagca atgagtgttc tttatagact ctatcattcc cggatgatta
     2161 ctcttggtca tatggaaaca ggtgcagcta ggagttacac ctcctggcct gggggtccat
     2221 ccccctttct ccccatgaaa tcaagagtat ggtgcattgc tgctctctgg tcttcaaggg
     2281 tctaggctgg agcctgtctc cagctggctt tgctccacca ccacttcaac ccctcccccc
     2341 acatatatgt tgcttttctt gtctcttact ctcctgagaa caatccacaa taaaccataa
     2401 gcttccagga cttcaaa
//
