LOCUS       NP_001013839             534 aa            linear   ROD 16-JAN-2024
DEFINITION  SP140 nuclear body protein family member isoform 1 [Mus musculus].
ACCESSION   NP_001013839 XP_486317
VERSION     NP_001013839.1
DBSOURCE    REFSEQ: accession NM_001013817.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Kotov DI, Lee OV, Fattinger SA, Langner CA, Guillen JV, Peters JM,
            Moon A, Burd EM, Witt KC, Stetson DB, Jaye DL, Bryson BD and Vance
            RE.
  TITLE     Early cellular mechanisms of type I interferon-driven
            susceptibility to tuberculosis
  JOURNAL   Cell 186 (25), 5536-5553 (2023)
   PUBMED   38029747
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Fraschilla I, Amatullah H, Rahman RU and Jeffrey KL.
  TITLE     Immune chromatin reader SP140 regulates microbiota and risk for
            inflammatory bowel disease
  JOURNAL   Cell Host Microbe 30 (10), 1370-1381 (2022)
   PUBMED   36130593
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F,
            Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P,
            Sadreyev RI, Anthony RM, Rioux JD and Jeffrey KL.
  TITLE     Epigenetic reader SP140 loss of function drives Crohn's disease due
            to uncontrolled macrophage topoisomerases
  JOURNAL   Cell 185 (17), 3232-3247 (2022)
   PUBMED   35952671
  REMARK    GeneRIF: Epigenetic reader SP140 loss of function drives Crohn's
            disease due to uncontrolled macrophage topoisomerases.
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Matsushita K, Li X, Nakamura Y, Dong D, Mukai K, Tsai M, Montgomery
            SB and Galli SJ.
  TITLE     The role of Sp140 revealed in IgE and mast cell responses in
            Collaborative Cross mice
  JOURNAL   JCI Insight 6 (12), e146572 (2021)
   PUBMED   34156030
  REMARK    GeneRIF: The role of Sp140 revealed in IgE and mast cell responses
            in Collaborative Cross mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevee V, Chen KJ,
            Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I,
            Portnoy DA, Darwin KH and Vance RE.
  TITLE     Role of the transcriptional regulator SP140 in resistance to
            bacterial infections via repression of type I interferons
  JOURNAL   Elife 10, e67290 (2021)
   PUBMED   34151776
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147806.5.
            
            On Mar 31, 2005 this sequence version replaced XP_486317.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069971.1, SRR7345562.3519642.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.6 cM"
     Protein         1..534
                     /product="SP140 nuclear body protein family member isoform
                     1"
                     /note="SP140 nuclear body protein family member"
                     /calculated_mol_wt=62486
     Region          25..119
                     /region_name="HSR"
                     /note="HSR domain; pfam03172"
                     /db_xref="CDD:460835"
     Region          252..328
                     /region_name="SAND"
                     /note="SAND domain; pfam01342"
                     /db_xref="CDD:460167"
     Region          360..401
                     /region_name="PHD_SP110_140"
                     /note="PHD finger found in the Sp100/Sp140 family of
                     nuclear body components; cd15626"
                     /db_xref="CDD:277096"
     Site            order(360,365..366,369..374,381)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277096"
     Region          424..527
                     /region_name="Bromodomain"
                     /note="Bromodomains are found in many chromatin-associated
                     proteins and in nuclear histone acetyltransferases. They
                     interact specifically with acetylated lysine; cl02556"
                     /db_xref="CDD:445827"
     Site            order(450,455,458,497,501,506)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99933"
     CDS             1..534
                     /gene="Sp140"
                     /coded_by="NM_001013817.3:110..1714"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS35638.1"
                     /db_xref="GeneID:434484"
                     /db_xref="MGI:MGI:3702467"
ORIGIN      
        1 maggynelss rtipedqnee esddyqlmfk hfkenkveia saitkpfpfl mslrdrdfis
       61 eqkfqeyqet cknlvpverv vydilsnvqk kfsrdllkvi fskthlkayp dlketlkhff
      121 lnasktndeq aeemqcngge gsnsceqtrq trqepqddlp sslrqeagaq qptrekkcsc
      181 vicsptyvpe dlearmgssq gecvgtrrni parkpkkqrr kkkghnwskp rwrkpmsvqr
      241 krlrrrrken anfsaellpv tcgnlkgvlh kekfkqgisv ksiqcqngnw ftpsefemmg
      301 gygksknwkl slrchnwplk lliqrnflpn pprihrkrke qrtqnlhrsp adpsiqnsdk
      361 cevcrdggll fccdtcfraf hedchiptve aeitpwscif crmqslgsqp slpeseilqr
      421 emapqeqlkc eyvllrvycc sessffskmp yyyyfremtv svqepmwldi ikkklsdqay
      481 cqvedfvqdm rlifrnhkit fkdpkfgemg frleskfeks fkevfaiqet neks
//
