LOCUS       NM_030194               1921 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus Sp110 nuclear body protein (Sp110), transcript variant
            2, mRNA.
ACCESSION   NM_030194
VERSION     NM_030194.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   Shi,F., Xu,Y., Zhang,S., Fu,Z., Yu,Q., Zhang,S., Sun,M., Zhao,X.
            and Feng,X.
  TITLE     Decabromodiphenyl ethane affects embryonic development by
            interfering with nuclear F-actin in zygotes and leads to cognitive
            and social disorders in offspring mice
  JOURNAL   FASEB J 36 (8), e22445 (2022)
   PUBMED   35816173
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Ji,D.X., Witt,K.C., Kotov,D.I., Margolis,S.R., Louie,A., Chevee,V.,
            Chen,K.J., Gaidt,M.M., Dhaliwal,H.S., Lee,A.Y., Nishimura,S.L.,
            Zamboni,D.S., Kramnik,I., Portnoy,D.A., Darwin,K.H. and Vance,R.E.
  TITLE     Role of the transcriptional regulator SP140 in resistance to
            bacterial infections via repression of type I interferons
  JOURNAL   Elife 10, e67290 (2021)
   PUBMED   34151776
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   De Iaco,A., Verp,S., Offner,S., Grun,D. and Trono,D.
  TITLE     DUX is a non-essential synchronizer of zygotic genome activation
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31806660
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Leu,J.S., Chen,M.L., Chang,S.Y., Yu,S.L., Lin,C.W., Wang,H.,
            Chen,W.C., Chang,C.H., Wang,J.Y., Lee,L.N., Yu,C.J., Kramnik,I. and
            Yan,B.S.
  TITLE     SP110b Controls Host Immunity and Susceptibility to Tuberculosis
  JOURNAL   Am J Respir Crit Care Med 195 (3), 369-382 (2017)
   PUBMED   27858493
  REMARK    GeneRIF: Using mouse models and genetic characteristics of human
            patients the role of SP110b was studied to determine its role in
            controlling host immunity and susceptibility to TB by modulating
            nuclear factor-kappaB (NF-kappaB) activity resulting in down
            regulation of TNF-alpha production and upregulation of
            NF-kappaB-induced antipoptotic gene expression suppressing
            IFN-gamma-mediated monocyte and/or macrophage cell death.
REFERENCE   6  (bases 1 to 1921)
  AUTHORS   He,X.N., Su,F., Lou,Z.Z., Jia,W.Z., Song,Y.L., Chang,H.Y., Wu,Y.H.,
            Lan,J., He,X.Y. and Zhang,Y.
  TITLE     Ipr1 gene mediates RAW 264.7 macrophage cell line resistance to
            Mycobacterium bovis
  JOURNAL   Scand J Immunol 74 (5), 438-444 (2011)
   PUBMED   21790702
  REMARK    GeneRIF: mediates RAW 264.7 macrophage cell line resistance to
            Mycobacterium bovis
REFERENCE   7  (bases 1 to 1921)
  AUTHORS   Cai,L., Pan,H., Trzcinski,K., Thompson,C.M., Wu,Q. and Kramnik,I.
  TITLE     MYBBP1A: a new Ipr1's binding protein in mice
  JOURNAL   Mol Biol Rep 37 (8), 3863-3868 (2010)
   PUBMED   20221700
  REMARK    GeneRIF: Ipr1 might be involved in apoptosis pathway via MYBBP1A.
REFERENCE   8  (bases 1 to 1921)
  AUTHORS   Pan,H., Yan,B.S., Rojas,M., Shebzukhov,Y.V., Zhou,H., Kobzik,L.,
            Higgins,D.E., Daly,M.J., Bloom,B.R. and Kramnik,I.
  TITLE     Ipr1 gene mediates innate immunity to tuberculosis
  JOURNAL   Nature 434 (7034), 767-772 (2005)
   PUBMED   15815631
  REMARK    GeneRIF: data indicate that the Ipr1 gene product might have a
            previously undocumented function in integrating signals generated
            by intracellular pathogens with mechanisms controlling innate
            immunity, cell death and pathogenesis
REFERENCE   9  (bases 1 to 1921)
  AUTHORS   Traut,W., Rahn,I.M., Winking,H., Kunze,B. and Weichehan,D.
  TITLE     Evolution of a 6-200 Mb long-range repeat cluster in the genus Mus
  JOURNAL   Chromosoma 110 (4), 247-252 (2001)
   PUBMED   11534816
REFERENCE   10 (bases 1 to 1921)
  AUTHORS   Weichenhan,D., Kunze,B., Winking,H., van Geel,M., Osoegawa,K., de
            Jong,P.J. and Traut,W.
  TITLE     Source and component genes of a 6-200 Mb gene cluster in the house
            mouse
  JOURNAL   Mamm Genome 12 (8), 590-594 (2001)
   PUBMED   11471051
  REMARK    GeneRIF: identification and analysis of the genes Sp100, Csprs, and
            Ifi75 in two members of the genus Mus, M. musculus and M. caroli
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY234698.1, AK077800.1, AK019873.1 and BF662066.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094500.1, AK150373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY234698.1         1-60
            61-67               AK077800.1         16-22
            68-80               AK077800.1         24-36
            81-1793             AK077800.1         38-1750
            1794-1910           AK019873.1         2178-2294
            1911-1921           BF662066.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.6 cM"
     gene            1..1921
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /note="Sp110 nuclear body protein"
                     /db_xref="GeneID:109032"
                     /db_xref="MGI:MGI:1923364"
     exon            1..182
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..330
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1521
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /note="interferon-induced protein 75, 52kD; intracellular
                     pathogen resistance protein 1; intracellular pathogen
                     resistance 1"
                     /codon_start=1
                     /product="sp110 nuclear body protein"
                     /protein_id="NP_084470.1"
                     /db_xref="CCDS:CCDS35637.1"
                     /db_xref="GeneID:109032"
                     /db_xref="MGI:MGI:1923364"
                     /translation="MFTLTKALEKALLQHFIYMKVNIAYAINKPFPFFEALRDNSFIT
                     ERMYKESLEACQNLVPLSKVVHNILTSLEQTFHPSVLLTLFSKVNLREYPSLVAIFRS
                     FRNVGYTYEEKNRPPLTLLEDLANPAEGCSLQTLLPPPRPQISLPSHLSSAPRVCDPR
                     ATAQPIIEILDEQPSPSPRAVPLLGCIQEGKTTPVSSRDHQRKDKEDSREMPHSPSGP
                     ESVVKDDSPAANDLEMAREVPCTPANKKARRKKRPNWSNSKRRRQKKKPRQDEMMGVA
                     SPGHGVQEKLKAVSRRTLWKDDSSTNVKEVTKTQRTRMRRAQTSNSQEISKEASKTSG
                     RKRPSTARRTTQVPEKTKNDAVDFSPTLPVTCGKAKGTLFQEKLKQGASKKCIQNEAG
                     DWLTVKEFLNEGGRATSKDWKGVIRCNGETLRHLEQKGLLFFTSKSKPQKKGA"
     exon            331..499
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..766
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..844
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..922
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1003
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1153
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1222
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1324
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1467
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1914
                     /gene="Sp110"
                     /gene_synonym="5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75;
                     Ipr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagatcact ttcatttttc ttttcttgaa gcctgactcc ccgcgggact tccaaggcag
       61 cataacttcg ggtccagact gggctgtcag gcttttccag gaaggatcca ggaacccctt
      121 aactaatcca ggcagtgacc tgggagaact cgggagaacc cgtggcagcc ctcagcatcc
      181 aggatgttca ctctgaccaa agccttggaa aaggctcttc tccagcattt catatacatg
      241 aaggtgaaca tcgcctatgc catcaacaag ccattcccct tcttcgaagc gctccgggac
      301 aattccttca tcactgagag aatgtacaag gaatctctgg aagcctgtca aaatctggtc
      361 cctctgtcca aagtggtgca caatattctc accagtctgg agcagacttt ccacccgtca
      421 gtgctgctga cgttgttcag caaggtcaac ctccgggaat accccagcct ggtggcaatt
      481 ttcagaagct tcagaaacgt tggttatacc tacgaagaga aaaacagacc cccactgacc
      541 ctgcttgaag acctggccaa cccagcagaa gggtgctccc ttcagacact gctgccacca
      601 ccccgacccc agatatcgct gccaagtcat ctgtcctcag caccgagagt ctgtgacccc
      661 agagcaaccg cacagccaat cattgagatc ctggatgagc agcccagtcc ttctccccga
      721 gctgtgcctc tccttggctg cattcaggaa ggaaaaacca ctccagtgtc ctccagagat
      781 caccagagaa aagataagga agactctcga gagatgcccc acagtccctc aggacccgag
      841 tcagtggtaa aagatgactc tccagcagca aatgacctgg aaatggccag ggaagtaccc
      901 tgcacacctg caaacaagaa agcaagaaga aaaaaacgtc cgaactggtc aaattccaaa
      961 agaagacggc agaaaaaaaa gccccgtcaa gatgagatga tgggagtggc ctcacctgga
     1021 catggagttc aagagaagct caaggcagtg agcaggagga ctttgtggaa agatgactca
     1081 tctacgaacg tgaaggaggt gaccaagaca cagagaacaa ggatgaggcg tgcccagaca
     1141 tccaattcac aagagatcag caaagaggca tcaaaaacaa gtggtagaaa gaggcccagc
     1201 acagcacgaa gaaccacaca agttccagag aagaccaaga atgacgctgt ggatttctct
     1261 cccacactcc ctgtgacctg tggtaaggcc aaagggactt tgttccaaga gaaactgaag
     1321 caaggagcct caaaaaagtg cattcagaat gaggcaggag attggctcac tgtaaaggaa
     1381 tttttaaatg aagggggaag ggccacatca aaagactgga agggcgttat acgttgtaac
     1441 ggggagacat taagacatct ggagcagaaa ggacttttgt tctttacctc caagagtaaa
     1501 cctcaaaaga agggtgccta gcagatgaac tcctgacctg atatgtgctc agctcctgtg
     1561 ctcgctcgca ctctgtctct gtctctctgt ctctctctgt ctctctctat ctctgtctct
     1621 ctctctctct ctctctctct ctctctctct ctctctgtgt gtgtgtgtgt gtgtgtgtgt
     1681 gtgtgtgtgt gtctgaactt tgcctttgag cctctgagtg tcccagctct gaggtccttc
     1741 gtagttgtgg tcctcatcac aactgaccca gcactgtggt acacgctcac gatgtccttg
     1801 ttcacagctg acttacaatg gcaaagtgca tgaatactag acagtaaaaa taaagctgtt
     1861 ggtgtctctg tgcgtttgaa aactatcttg atattaaaat ggatataaac taaaaaaaaa
     1921 a
//
