LOCUS       NM_011447               2999 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus SRY (sex determining region Y)-box 8 (Sox8), mRNA.
ACCESSION   NM_011447
VERSION     NM_011447.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2999)
  AUTHORS   Jorg,L.M., Schlotzer-Schrehardt,U., Lefebvre,V., Sock,E. and
            Wegner,M.
  TITLE     Transcription Factors Sox8 and Sox10 Contribute with Different
            Importance to the Maintenance of Mature Oligodendrocytes
  JOURNAL   Int J Mol Sci 25 (16), 8754 (2024)
   PUBMED   39201442
  REMARK    GeneRIF: Transcription Factors Sox8 and Sox10 Contribute with
            Different Importance to the Maintenance of Mature Oligodendrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2999)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (bases 1 to 2999)
  AUTHORS   Molin,A.N., Contentin,R., Angelozzi,M., Karvande,A., Kc,R.,
            Haseeb,A., Voskamp,C., de Charleroy,C. and Lefebvre,V.
  TITLE     Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in
            promoting reserve chondrocyte commitment to columnar proliferation
  JOURNAL   Proc Natl Acad Sci U S A 121 (8), e2316969121 (2024)
   PUBMED   38346197
REFERENCE   4  (bases 1 to 2999)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   5  (bases 1 to 2999)
  AUTHORS   Freudenstein,D., Lippert,M., Popp,J.S., Aprato,J., Wegner,M.,
            Sock,E., Haase,S., Linker,R.A. and Gonzalez Alvarado,M.N.
  TITLE     Endogenous Sox8 is a critical factor for timely remyelination and
            oligodendroglial cell repletion in the cuprizone model
  JOURNAL   Sci Rep 13 (1), 22272 (2023)
   PUBMED   38097655
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2999)
  AUTHORS   Schepers,G.E., Bullejos,M., Hosking,B.M. and Koopman,P.
  TITLE     Cloning and characterisation of the Sry-related transcription
            factor gene Sox8
  JOURNAL   Nucleic Acids Res 28 (6), 1473-1480 (2000)
   PUBMED   10684944
REFERENCE   7  (bases 1 to 2999)
  AUTHORS   Pfeifer,D., Poulat,F., Holinski-Feder,E., Kooy,F. and Scherer,G.
  TITLE     The SOX8 gene is located within 700 kb of the tip of chromosome 16p
            and is deleted in a patient with ATR-16 syndrome
  JOURNAL   Genomics 63 (1), 108-116 (2000)
   PUBMED   10662550
REFERENCE   8  (bases 1 to 2999)
  AUTHORS   Stock,D.W., Buchanan,A.V., Zhao,Z. and Weiss,K.M.
  TITLE     Numerous members of the Sox family of HMG box-containing genes are
            expressed in developing mouse teeth
  JOURNAL   Genomics 37 (2), 234-237 (1996)
   PUBMED   8921394
REFERENCE   9  (bases 1 to 2999)
  AUTHORS   Yuan,H., Corbi,N., Basilico,C. and Dailey,L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   10 (bases 1 to 2999)
  AUTHORS   Wright,E.M., Snopek,B. and Koopman,P.
  TITLE     Seven new members of the Sox gene family expressed during mouse
            development
  JOURNAL   Nucleic Acids Res 21 (3), 744 (1993)
   PUBMED   8441686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053716.1 and BC085619.1.
            
            On Apr 18, 2009 this sequence version replaced NM_011447.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053716.1, AK033460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2870              AK053716.1         2-2871
            2871-2995           BC085619.1         2847-2971
            2996-2999           AK053716.1         3000-3003
FEATURES             Location/Qualifiers
     source          1..2999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.69 cM"
     gene            1..2999
                     /gene="Sox8"
                     /note="SRY (sex determining region Y)-box 8"
                     /db_xref="GeneID:20681"
                     /db_xref="MGI:MGI:98370"
     exon            1..577
                     /gene="Sox8"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1559
                     /gene="Sox8"
                     /note="SRY-box containing gene 8"
                     /codon_start=1
                     /product="transcription factor SOX-8"
                     /protein_id="NP_035577.1"
                     /db_xref="CCDS:CCDS28521.1"
                     /db_xref="GeneID:20681"
                     /db_xref="MGI:MGI:98370"
                     /translation="MLDMSEARAQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGR
                     AGGGGRGDTAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGTLKAKPHVKRP
                     MNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHK
                     KDHPDYKYQPRRRKSVKTGRSDSDSGTELGHHPGGPMYKADAVLGEAHHHSDHHTGQT
                     HGPPTPPTTPKTDLHQASNGSKQELRLEGRRLVDSGRQNIDFSNVDISELSSEVISNM
                     DTFDVHEFDQYLPLNGHSALPTEPSQATASGSYGGASYSHSGATGIGASPVWAHKGAP
                     SASASPTEAGPLRPQIKTEQLSPSHYNDQSHGSPGRADYGSYSAQASVTTAASATAAS
                     SFASAQCDYTDLQASNYYSPYPGYPPSLYQYPYFHSSRRPYASPLLNGLSMPPAHSPS
                     SNWDQPVYTTLTRP"
     exon            578..810
                     /gene="Sox8"
                     /inference="alignment:Splign:2.1.0"
     exon            811..2999
                     /gene="Sox8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagactgagc tactgcggcg gaggagctgc tgctgggccc ctgcggtgag gacaaagatt
       61 gggtcctgcg tggcaacctt ggattctaga gtgtccttcc acagagtgac cgggcgcgac
      121 ccctgcgtcc atccccactg agtgcccctc cgcgcgtggc cccgatgctg gacatgagtg
      181 aggcccgcgc ccagcctccc tgcagcccgt ctggcaccgc tagctccatg tcacacgtgg
      241 aggattcgga ctccgacgcg ccaccgtcgc ccgcgggatc agagggcctg ggccgcgcgg
      301 ggggcggcgg ccgaggggat actgctgagg cagcagacga acgcttccca gcctgcatcc
      361 gtgatgccgt gtcgcaggtg cttaagggtt atgactggag tctggtgcct atgcctgtgc
      421 gcggcggcgg tggcggcacg ctcaaggcca agccacacgt gaagcggccc atgaatgcct
      481 tcatggtgtg ggcacaggcg gcgcgccgca agctggcgga ccagtacccg catctccata
      541 acgcagagct cagcaagacc ctaggcaagc tgtggcgctt gctgagtgaa agcgagaaga
      601 ggccgtttgt ggaggaggcc gagaggctcc gtgtgcagca caagaaagac cacccagatt
      661 acaaatacca gccaaggcga aggaagagtg tgaagactgg ccggagcgac tcagactctg
      721 gtactgaact gggccaccac cctggtggtc ccatgtacaa agctgatgca gtgctcggcg
      781 aggcacacca tcacagtgac caccacacag gccagaccca tgggccaccc accccaccca
      841 ctacccccaa gacggacctg caccaggcga gcaatggaag caagcaagag ctaaggctgg
      901 aagggcgccg cctagtggac agcgggcgcc agaacatcga cttcagcaat gtggacatct
      961 ccgagctcag cagcgaggtt atcagtaaca tggatacctt cgatgtccat gaatttgacc
     1021 agtacttgcc cctcaatggc cactcagccc tgcccacaga gcccagccag gccactgcct
     1081 ctggctccta tggaggcgct tcctactcgc actccggggc aaccggcata ggggcatccc
     1141 ctgtgtgggc ccacaaggga gctccctcgg cttcagcttc gcccacagag gcaggacccc
     1201 ttcggccaca gatcaagacg gagcagctga gtcctagcca ctacaacgac cagtcacatg
     1261 gctcacctgg ccgtgctgac tatggctctt acagtgccca ggccagcgtc accacagctg
     1321 cctctgccac ggctgccagc tccttcgcca gcgcacagtg tgattacact gacctgcagg
     1381 cttccaacta ctacagcccc taccctggct accctcccag cctctaccaa tacccttact
     1441 tccattcatc ccgtcggccc tatgcctcgc cactgctcaa tgggctctct atgccacccg
     1501 cacacagccc cagcagcaac tgggaccagc ctgtgtacac caccctgacc cgaccctgag
     1561 gctgctgcat ccaggaagtc tagccagatc tttgagttct tccggagtgt actcggtaga
     1621 ggttggaggc agccagcacg gccttactcc gtcaagtgcc tgctgaatgt gcaggaagcc
     1681 aggctttgtc atcctgtgtc cctttgcttc tggatatcca aacttctgcc aggggacaga
     1741 gctctctttt ccccctcttc tttctctgag gtgactggtg gtttccaaaa caggcattcc
     1801 gttgctctcc ggtttggata agtgtacacc agctcccgag ttttgcatct cagtagataa
     1861 gaagatagtt atgcctaagg acaaaggaga gaatgggctt catgtcctta tcagcctacc
     1921 caagacctcc ctgggaccaa tggatgctgt tcccacggtg aaagcatgaa aggacatctg
     1981 tggatgctcg aggatacatc caacccgggg actctcttgg gaccaatgtg agattgaggg
     2041 gtttctcatt accaccgttc ttcccagcaa ggcttggctg agatgaacac tttctgtgtc
     2101 tatttttatt ttttgttatt ttttatttta aggcttaaac atgtttgttt ttttgaaagg
     2161 tgttgaagac gtatttatgt tctgttgtta ttttatcttt aattaatgaa gtaatttgtg
     2221 cagagagtag aatttaagac aaaattaaag tggggaagct tgctctgtaa agggcaggag
     2281 ggaggtggct cagaatccct aagcatctct ttgcttggcc ttcggatgtc cctggaggcc
     2341 tccaccaggc acaggaggaa gtgatcaacc tcttagggtc tagttagaac aagaagcccg
     2401 gcaccatcat tgggccaggc attgaaaggc aggagtagca tctctgcctt catggtgcca
     2461 agcggtagaa gacggaattt cctgcaagct gggcagctgc agaaccacga taatcttggc
     2521 tctttggcac caggcgctac ttaccaagct gtgaaaggag agcctcccca actaacctgc
     2581 ttaggttcct agttagagag taacatcagc ttccctgcct gcgtcgctgt gtcgagtgta
     2641 taaaccggct acgtcacgga aacttgtgcc ttgaacactt tgtatatttg ctcacatttg
     2701 agaagtttcg cttcttttta atttttctac ttttcctacc tttttttaga ggggaaaaaa
     2761 aaatccagcc ttttttttct ttcttcagct tatctccttc cgggggccga ggtgggaacc
     2821 acagcaaact catttttatg cagtcttttt tttttttttt tttttttttt ggtgttgaat
     2881 tcagaaagac atttgctgtc ctttactcgc tgtgtttcgt tcctttctga ccaggcaatg
     2941 ctaacttttg tacagataaa tttgataaaa tttaaaaaaa aaaatgtttt ctctacttg
//
