LOCUS       NM_011445               8778 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus SRY (sex determining region Y)-box 6 (Sox6),
            transcript variant 1, mRNA.
ACCESSION   NM_011445
VERSION     NM_011445.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8778)
  AUTHORS   Cai,Y., Zhang,Y., Wang,S. and Changyong,E.
  TITLE     MiR-23b-3p alleviates Sjogren's syndrome by targeting SOX6 and
            inhibiting the NF-kappaB signaling
  JOURNAL   Mol Immunol 172, 68-75 (2024)
   PUBMED   38901181
  REMARK    GeneRIF: MiR-23b-3p alleviates Sjogren's syndrome by targeting SOX6
            and inhibiting the NF-kappaB signaling.
REFERENCE   2  (bases 1 to 8778)
  AUTHORS   Ichiyama-Kobayashi,S., Hata,K., Wakamori,K., Takahata,Y.,
            Murakami,T., Yamanaka,H., Takano,H., Yao,R., Uzawa,N. and
            Nishimura,R.
  TITLE     Chromatin profiling identifies chondrocyte-specific Sox9 enhancers
            important for skeletal development
  JOURNAL   JCI Insight 9 (11), e175486 (2024)
   PUBMED   38855864
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8778)
  AUTHORS   Zheng,B., Du,P., Zeng,Z., Cao,P., Ma,X. and Jiang,Y.
  TITLE     Propranolol inhibits EMT and metastasis in breast cancer through
            miR-499-5p-mediated Sox6
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 59 (2024)
   PUBMED   38294713
  REMARK    GeneRIF: Propranolol inhibits EMT and metastasis in breast cancer
            through miR-499-5p-mediated Sox6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8778)
  AUTHORS   Hagiwara,N.
  TITLE     Sox6, jack of all trades: a versatile regulatory protein in
            vertebrate development
  JOURNAL   Dev Dyn 240 (6), 1311-1321 (2011)
   PUBMED   21495113
  REMARK    Review article
REFERENCE   5  (bases 1 to 8778)
  AUTHORS   Ikeda,T., Saito,T., Ushita,M., Yano,F., Kan,A., Itaka,K., Moro,T.,
            Nakamura,K., Kawaguchi,H. and Chung,U.I.
  TITLE     Identification and characterization of the human SOX6 promoter
  JOURNAL   Biochem Biophys Res Commun 357 (2), 383-390 (2007)
   PUBMED   17433257
  REMARK    GeneRIF: Thus, we successfully identified the Sox6 promoter and its
            core enhancer and characterized the interactions with regulatory
            transcription factors.
REFERENCE   6  (bases 1 to 8778)
  AUTHORS   Lefebvre,V., Li,P. and de Crombrugghe,B.
  TITLE     A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in
            chondrogenesis and cooperatively activate the type II collagen gene
  JOURNAL   EMBO J 17 (19), 5718-5733 (1998)
   PUBMED   9755172
REFERENCE   7  (bases 1 to 8778)
  AUTHORS   Stock,D.W., Buchanan,A.V., Zhao,Z. and Weiss,K.M.
  TITLE     Numerous members of the Sox family of HMG box-containing genes are
            expressed in developing mouse teeth
  JOURNAL   Genomics 37 (2), 234-237 (1996)
   PUBMED   8921394
REFERENCE   8  (bases 1 to 8778)
  AUTHORS   Connor,F., Wright,E., Denny,P., Koopman,P. and Ashworth,A.
  TITLE     The Sry-related HMG box-containing gene Sox6 is expressed in the
            adult testis and developing nervous system of the mouse
  JOURNAL   Nucleic Acids Res 23 (17), 3365-3372 (1995)
   PUBMED   7567444
REFERENCE   9  (bases 1 to 8778)
  AUTHORS   Takamatsu,N., Kanda,H., Tsuchiya,I., Yamada,S., Ito,M., Kabeno,S.,
            Shiba,T. and Yamashita,S.
  TITLE     A gene that is related to SRY and is expressed in the testes
            encodes a leucine zipper-containing protein
  JOURNAL   Mol Cell Biol 15 (7), 3759-3766 (1995)
   PUBMED   7791783
REFERENCE   10 (bases 1 to 8778)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC102696.6, AC158579.7,
            AC111041.11, AC107371.17 and AC118676.6.
            
            On Mar 2, 2023 this sequence version replaced NM_011445.4.
            
            Summary: This gene encodes a member of a family of transcriptional
            regulators containing high mobility group (HMG) DNA-binding
            domains. Function of the encoded protein is important for proper
            cardiac and skeletal development. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Both variants 1 and 4 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U32614.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC102696.6         98310-98484         c
            176-244             AC102696.6         47213-47281         c
            245-485             AC158579.7         97018-97258         c
            486-693             AC158579.7         72700-72907         c
            694-783             AC111041.11        171301-171390       c
            784-956             AC111041.11        131877-132049       c
            957-1025            AC111041.11        129121-129189       c
            1026-1146           AC107371.17        197152-197272       c
            1147-1226           AC107371.17        180221-180300       c
            1227-1349           AC107371.17        178672-178794       c
            1350-1499           AC107371.17        149666-149815       c
            1500-1683           AC107371.17        144126-144309       c
            1684-1868           AC107371.17        141278-141462       c
            1869-1977           AC107371.17        112317-112425       c
            1978-2211           AC118676.6         147943-148176       c
            2212-2428           AC118676.6         144828-145044       c
            2429-8778           AC118676.6         129152-135501       c
FEATURES             Location/Qualifiers
     source          1..8778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 61.29 cM"
     gene            1..8778
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /note="SRY (sex determining region Y)-box 6"
                     /db_xref="GeneID:20679"
                     /db_xref="MGI:MGI:98368"
     exon            1..175
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            176..244
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            245..485
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..2732
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor SOX-6; SRY-box containing gene 6"
                     /codon_start=1
                     /product="transcription factor SOX-6 isoform 1"
                     /protein_id="NP_035575.1"
                     /db_xref="CCDS:CCDS40098.1"
                     /db_xref="GeneID:20679"
                     /db_xref="MGI:MGI:98368"
                     /translation="MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLH
                     PIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKP
                     DEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKD
                     WKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAAS
                     QIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQ
                     RTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQ
                     INPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPP
                     NSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPA
                     SKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMRE
                     QIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGV
                     IDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPM
                     NAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLE
                     KYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGV
                     VYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGED
                     EMEAYDDYEDDPKSDYSSENEAPEPVSAN"
     exon            486..693
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            694..783
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            784..956
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1025
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1146
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1226
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1349
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1499
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1683
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1868
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1977
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2211
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2428
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..8778
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8754..8759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /note="hexamer: ATTAAA"
     polyA_site      8778
                     /gene="Sox6"
                     /gene_synonym="SOX-LZ"
                     /note="major polyA site"
ORIGIN      
        1 agtacaatga tgatactttg atctgaaaag aagcaattct tgtgctacac gagacaggaa
       61 agatttccat ggctttgtaa gacctaacta tgataacatt aatgatagtg tttataacca
      121 ataagtaagg cagttgccaa tgtgacaatt tggaatcata aagatgaaat ttcaggtcac
      181 gttcatgaat tcaaaggcga tttaccagtg acttctgggt gctgggtgat cctcgtgtat
      241 aactaagaat gtcttccaag caagccacct ctccatttgc ctgtacagcg gatggagagg
      301 aagcaatgac ccaggacttg acctcaaggg aaaaggaaga gggcagtgat caacacccgg
      361 cctcccatct gcctctgcac cccataatgc acaacaaacc tcactctgag gagctgccta
      421 cacttgtcag taccattcaa caagatgctg actgggacag cgttctgtca tctcagcaaa
      481 gaatggagtc agagaataat aagttatgtt ccctatattc cttccgaaat acgtctacct
      541 caccacataa gcctgacgaa gggagtcggg agcgtgaaat aatgaacagt gttacttttg
      601 gaaccccgga acgccgcaaa gggagccttg ccgatgtggt ggatacgctg aagcagaaga
      661 agctggagga gatgactcgg acagaacaag aggattcctc ctgcatggaa aaactacttt
      721 caaaagattg gaaggaaaaa atggaaagac taaatacgag tgaacttctt ggagaaatca
      781 aaggtacacc tgagagcctt gcagagaaag aacggcaact ctccaccatg attacccagc
      841 tgatcagctt gcgggagcag ctcctggcag cccatgatga acagaaaaag ctggcagcat
      901 cgcagatcga gaaacagcgg cagcaaatgg accttgctcg ccaacagcaa gaacagatcg
      961 caagacaaca gcagcaactt ctacagcagc agcacaagat taatctcctg cagcaacaga
     1021 tccaggttca ggggcacatg cctccgctca tgatcccaat ttttccacat gaccagcgga
     1081 ccttggcagc agctgctgct gcccaacagg gattcctctt cccccctgga ataacataca
     1141 agccaggtga taactacccc gtacagttca ttccgtcaac aatggcagct gctgctgctt
     1201 ctggactcag ccctttacag cttcagaagg gtcatgtttc ccacccacaa attaacccaa
     1261 ggctaaaggg cataagtgac cgttttggca ggaatttgga cccctctgaa catggtggtg
     1321 gccactctta caaccacaga cagattgagc agctctatgc cgctcagctg gccagcatgc
     1381 aggtgtcacc tggagcaaag atgccatcaa ctccacagcc accaaactcg gcaggggcag
     1441 tctcacctac tgggataaaa aatgaaaaga gagggaccag ccctgtaact caagttaagg
     1501 atgaaacaac agcccagccg ctgaatctct catcccggcc taagacagca gagcctgtga
     1561 agtccccaac atctcccacc cagaacctct tcccagccag caaaaccagc cctgtcaacc
     1621 tgccaaacaa aagcagcatc cccagcccca ttggaggaag cctggggaga ggatcctctc
     1681 tagatatact atccagtctc aactctcctg ccctgtttgg ggaccaggac acagtgatga
     1741 aagccattca ggaggctcgg aagatgcgag aacagatcca gcgggagcaa caacagcagc
     1801 cacacggagt tgatgggaaa ctgtcctcca tgaacaacat ggggctgagc aactgcagga
     1861 ctgagaagga aagaacacgc tttgagaacc tgggtcccca attaacagga aagtcaagtg
     1921 aagatggaaa actgggcccg ggtgtcatcg atctcactcg gccagaggac gcagaaggaa
     1981 gcaaagcaat gaatggctct gcagctaaac tacagcagta ttattgttgg ccaacaggag
     2041 gcgccactgt ggctgaagcc cgtgtctaca gggatgcccg cggccgtgcc agcagcgaac
     2101 cccacatcaa gcgaccaatg aatgcgttca tggtttgggc aaaggacgaa aggaggaaaa
     2161 ttcttcaggc cttccctgac atgcataact ccaacattag caaaatctta ggatctcgct
     2221 ggaaatccat gtccaaccag gagaagcaac cttactatga agaacaggcc cggctaagca
     2281 aaatccacct agagaagtac ccaaactaca agtacaaacc ccggccgaag cgcacatgca
     2341 tcgtggatgg caagaagctc cggattgggg agtacaagca actgatgcgc tcgcgaaggc
     2401 aggagatgcg acagttcttc actgtggggc aacagcctca gatgcccatc accacaggaa
     2461 caggtgttgt gtatcctggt gctattacta tggcaacgac cacaccatca cctcagatga
     2521 catctgactg ctctagcacc tctgccagcc ccgagcccag cctccctgtc atccagagca
     2581 cgtatggtat gaagatggac ggcgcaagcc tggctgggaa cgacatgatt aatggagagg
     2641 atgaaatgga agcctatgac gactacgaag atgatcccaa atcagactat agcagcgaga
     2701 atgaggcccc agagcctgtc agtgccaact gaggagcttt tgtttgctga attaaaacac
     2761 tctgacattt cgctcccttt cccccaacaa caacaacaaa gttcttaaag agcccgcatg
     2821 catttgtggc tccacaatac atcagcagaa tggtcttaat tgcttcgtaa cgtgtgagac
     2881 agattacgtt ttcctgattt ttcataaact tgagtttttg tcgttaccgt tactgttgtt
     2941 gtttatttag gtgaagacgt attaaatatg agacaccggg acttggaaac ttatctctgc
     3001 ccatcgccgt cttatgagtc ttacatttct gtcttactat ttttcttttg gatgttgaca
     3061 aagggtttaa gttactgttt tagatggggt taaacattct cactcaggta tgctgtgccg
     3121 gctacaggtt gtgaatgtgt ttttattctg aattacttta gaaaacaact gaggatttcg
     3181 tattgtgaaa ccggacaagt ccacggcgtg agcggctgca tatagaacat gttcaaaagg
     3241 cctcggaatt ccatttgttt caatgtgtag aattcaactt tgaatgtgcc aaactttttt
     3301 cataactttt gaatcttaac tattttaaaa gtcttacagg agacactgca aagtcttaga
     3361 caatctttga catcttaaaa taaaacagca aaccacattt tttttccaga aaatggtgaa
     3421 gtactcagga atctggagac aagatattgt aaggaatgag caaggctgcc acagtgcgtg
     3481 aacccaattg tgtttgcctc ttgatgtgcc atcagtgtgt ggcgtgggat gacatagatc
     3541 agagcaatca ccacaccaga caccacacgg tggactcccc tgtctgagac cgcctctcac
     3601 tacatccatt cttaccttgc ctttgccctg acattcaacc ttaacacatt gttctcttaa
     3661 ataatttatt cattccagaa tgtcaagggt ccacttacta tttattttaa aaattattgg
     3721 tggcattaat ttaatatttt tttgccctcc ttgcccttta acctcttttt cctgctggat
     3781 acaaaagatg tacatagcaa tctcatgtcc ccagagcccc tggaaacatt tctgaagtga
     3841 tgctagtaca tgcatatatt gttgttttta aagacaagtg tgtagctggc tgcagggttg
     3901 tgcatctgcg tcaaggtatc ctacatttaa acatgtatgc ccccaggagt caccatgacc
     3961 ttgggtcttt gactagagtt tctccctcat tgagtttttc agtaaacagt agaacctgag
     4021 ttccattcag cagtgagagt cagcagtggt cactgccagt caaggagcct ctcacagcca
     4081 ctctgaagcc caaggaccat gggccacacg gggtctactt tggacccggc attctgtcac
     4141 ctttattgag ctacctggtc ccagctggca catccatgga gatctttgca aaactctaca
     4201 ggttgttaga caactccgag gaaatccagg aagaaaggaa accacaggca agggaagcaa
     4261 tggtgagctg ccagctccta gggacagatg ctagaggtac ccacagctcc cctgaagacc
     4321 tcgtttctca gtggctgctc gtgaacgctg ctgctgataa gctcttgcca ctgaaggtga
     4381 gctctggaga ctgagacatg ctgcagggct gagaggtgtc agggctccct ctctcatctc
     4441 ctaactacag gcagttctac tgttgtgagt ttgaccatcc tgaacccagg cctgttgttt
     4501 tcagggggcc ttactcagag cccttcagtg gggggtgtca gtgaacagta tagcctagca
     4561 tctaagcatc aggaaaagaa cagctccatc aaaaattgag ccattttgtc acttgggaaa
     4621 agtagtaaag cttcatattt atttaaagag tgctccaggc catagctaat agcaataaag
     4681 taggtctagc caagagatga ccagctgagt cattagctgt gagtgctctc cataagctgt
     4741 ttaaggtact gctagggatg tttgttctta agattaactg gggattggaa ttttgttctt
     4801 gtacattgat ttcatatgag gaggggtcac ttttcaaaaa caaaatgagt atttattatg
     4861 tcttactgat ttctcggatc tctcttcctc agtttctcct catgcttccc cacatgtctt
     4921 tggcttctgc tcccattggt atgtttgttt ttgtttttgt ttgtttgttc ttttttttaa
     4981 aaaagaaaac tgtgctgcat aggtagaatg ttgtatagct agcattgtat tgtatgtaat
     5041 taattttgca caaaggcaaa catttagcac agtagttaat tttgtttgtt tttatgacca
     5101 tgccaaaata atattctggg ctagtagaga acaaaggact gttctttagg attgaaactt
     5161 gattttgctt atagtaagaa aaagaaaaag aaaaaaaaaa tcccacacac tcacagatgt
     5221 cgtttcgtaa gtgttacaag cactggatat aaatggtatt tttatcactg actaatgtga
     5281 aactggtatg gaaactacat gaacaaaagt cacctgtttc gactcgtgtg ggcttgcctc
     5341 acagttgccg gatctgagtc atttttacgt cttgttattt catttattta tgcaaaatac
     5401 atgtgtgtag gaacgctctg tgtcagctcc agctcggcct cagcactggg ggccagtaac
     5461 ttctagccat attctcaagt gcaaaagctg tccgggaatg actgggtatg aatgcctctt
     5521 tcattggctc agacagtgat gctgtattca aatctaaatt ttgtgcatac acagtttatt
     5581 ctatttatta gccacacttg gctctaaata tccatgggaa tggagaatga caatcacaga
     5641 gatcacttac atcagtgggg cttaagcaaa gtttttatga cttcaccatc tcatttttag
     5701 agttttctaa ttgtgtaaat ataacataga aatagaattt atttttggtt catgaattcc
     5761 tagtgacata taagttatga atcttctttc tgttctctat tcatatgtgt tgctccgcac
     5821 taaaagctgg cccatcacat ttagcttcag tgaggcagtg tctaccctca gccaagacag
     5881 caggacccct acctgcttct cacacagtct ggaacccgct ggtcccccag ctcagactcc
     5941 ccctatttct aaataggaag ctgaggagtt gcacacactg agtttccagc agagttaaaa
     6001 gaaagtcagc ttgctttggg aatccatacc catctgtcca gatagttctg tggccccaga
     6061 atggcaagaa gcaggagttg tagttcagag gtaaagatct gcctgcaagg ttagtataaa
     6121 ccccacagca ccagtcaagg gcattctgaa atcaccttct tgcaatgttc cattccccag
     6181 tttacactag ctttaaatca gagcccaggt ttgtctccat caaagaactc acaggctcag
     6241 gtctttcttt gtcaactggg aacagcagca ttgatagaca gcctacttac taatgaacag
     6301 gttctatgga acaggaagga agggcagaga ggaaggaaca cagggacaca gaaaaaaaaa
     6361 aggttcttcc gtggacatga gaagcctagt tggcaatttc tcttcctcgc tggcaaattc
     6421 caggccatgt tgttttcgca aacactctct caacctttca ggtttgcatc atgagctatt
     6481 tgataccttc tagcctgtcc tcagcctgca ttcctcctcc aaggctgaca acagctccct
     6541 tctccaaggc ctgacactga ctcccaagcc agcttctaaa ttcaggtgtg ggctgccagt
     6601 gctgttccac ttgtcaaatg ctggcctcct ctggacattt gccctgtgtg agtgagccgg
     6661 aggagtgcta aaaaaaggtg tgatccctct agggctgaca ccaggctcct gcagagccag
     6721 gctacatctc tagtatacag tctctgagcc aggagctcag caatcaagga tgaccacctc
     6781 cttcagtaga aacatggcct ggtcatggct gatgccactg aggagggtgt tgctttccag
     6841 tctctcagtt ccaataagct gactttacca gctccttagg gaaaggcaac acacatcact
     6901 tcatagtttt gagccataga agtcctgtac caagtgccaa caacagcaaa gatctgtgtc
     6961 tagaagaatc agttgagatg atggccagcc aggtcttcct ctttactgag aaagcggcaa
     7021 ccaattggct gtgcccttgc ctggtgtgca catatcctct aaggatcagg ctgacccttg
     7081 agctcattct ccaagtgtaa caacagcggt ggcctggctt gtctcacttg ccctgccttt
     7141 ttttttaggc cctctatccc tgatgtggct tctttgtgag caggtattcc tcttgccaat
     7201 catgttgttt ctaatgctgc acatgatcgt gcatctgcac agcaaaagta gattgaaaat
     7261 catgacattg caagcatagt tctttgtccc catcctgacc tttccaaaca cctataaact
     7321 ggccctctcg agggcagagg aacagggatt ctgggaggga tggaaaagtc aaggcttcct
     7381 gcagattccc atctattgac aaagaagctg gtggaaggcg agtagatgat gtttcttgct
     7441 ggtcttattt ccacagaact gtaggtgtag agcggggctt tcatgtgtgg cactctggga
     7501 gtctggggga tgtgcgaaca tttaattgcc atcactatac gttgcaggtc tgctggtgtg
     7561 cgtcctccat tgtctttctt ggtcagagag catttactct gtctcctttt aaaacccagc
     7621 cttcattgta tcctcctcca gcttgtagca cattaggatg tttttagcac ttgtttttgc
     7681 tcattcttgt atttgccatg tacaattctg aattacccta tacaagcctc taagctgtta
     7741 ctacataact tatcttactg taaccctttt ctttgcctac attgtaattt gtttgtgatg
     7801 tatattgtga gattgtattc tatgttaatt taatcagcac aactcactga catgctggac
     7861 tgacatgctg gctgctgttt tgaagtataa agcttgtgta gggctgtccg gacaactaca
     7921 actctgttgc caaggtactg tgcattggtt cccatagcaa cactgtgggt gtgacccttg
     7981 aaactctagg gacattcggc acaccctcca gtaaatttta agtgcagatt ttctttgttg
     8041 aaactctatg aataccacag gtacctacgt ggcccatggc tggtaactat tttgggcaat
     8101 tagaaaaaca aacaagcatt aaaaaaacta gtgtctattg ctgctttgaa tatgtttgaa
     8161 agtctgaaaa tgtaaatagt ttatcaaaaa aaatcttgta cagtccagtg taaagttttt
     8221 aaatgacctg aagggttacc atcacagctt ttccacactc tcctctggat agtgataaag
     8281 agaagtttgc taaggactta aagaattggg aaaaaacaac agaatctctt caaacgcaaa
     8341 ggagtggatc actgccccta gctttgtcac atacacagac ctcttggatc ttattggaca
     8401 gtattggcat gagacaaact cagcatggaa caccctccag tgggacttgt ccagggcttt
     8461 ccagctctgc ctcacaatta agggacagga tgagatagaa aggcgtgccg tctttgtcta
     8521 tcctggaata ccttggcacc ttagctactt tccccctctt tgcacaaggt gctttcccga
     8581 tatgtgttag acacgccatc cttgggtgat aatgtatatg ccatgagagg gctcaggccc
     8641 gcgggggagt gtctatagga actgcctatt tatgctcatt tacctcaaga ctgtcctcta
     8701 ccctaaacta gttgtcatca ctccatcttt tgtactgctg ttgacactta ccaattaaag
     8761 ataaattttg ttttatga
//
