LOCUS       NM_009238               4808 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus SRY (sex determining region Y)-box 4 (Sox4), mRNA.
ACCESSION   NM_009238
VERSION     NM_009238.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4808)
  AUTHORS   Wang,Y., Yang,J., Wu,C., Guo,Y., Ding,Y. and Zou,X.
  TITLE     LncRNA SNHG14 silencing attenuates the progression of diabetic
            nephropathy via the miR-30e-5p/SOX4 axis
  JOURNAL   J Diabetes 16 (6), e13565 (2024)
   PUBMED   38751373
  REMARK    GeneRIF: LncRNA SNHG14 silencing attenuates the progression of
            diabetic nephropathy via the miR-30e-5p/SOX4 axis.
REFERENCE   2  (bases 1 to 4808)
  AUTHORS   Zhou,M., Wang,F., Dai,Q., Dou,J., Wu,Y. and Zhu,Y.
  TITLE     Identification of a novel de novo mutation in SOX4 for syndromic
            tooth agenesis
  JOURNAL   Clin Oral Investig 28 (5), 287 (2024)
   PUBMED   38684576
  REMARK    GeneRIF: Identification of a novel de novo mutation in SOX4 for
            syndromic tooth agenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4808)
  AUTHORS   Khader,N., Shchuka,V.M., Dorogin,A., Shynlova,O. and Mitchell,J.A.
  TITLE     SOX4 exerts contrasting regulatory effects on labor-associated gene
            promoters in myometrial cells
  JOURNAL   PLoS One 19 (4), e0297847 (2024)
   PUBMED   38635533
  REMARK    GeneRIF: SOX4 exerts contrasting regulatory effects on
            labor-associated gene promoters in myometrial cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4808)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4808)
  AUTHORS   Katsuda,T., Sussman,J.H., Ito,K., Katznelson,A., Yuan,S.,
            Takenaka,N., Li,J., Merrell,A.J., Cure,H., Li,Q., Rasool,R.U.,
            Asangani,I.A., Zaret,K.S. and Stanger,B.Z.
  TITLE     Cellular reprogramming in vivo initiated by SOX4 pioneer factor
            activity
  JOURNAL   Nat Commun 15 (1), 1761 (2024)
   PUBMED   38409161
  REMARK    GeneRIF: Cellular reprogramming in vivo initiated by SOX4 pioneer
            factor activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4808)
  AUTHORS   Yuan,H., Corbi,N., Basilico,C. and Dailey,L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   7  (bases 1 to 4808)
  AUTHORS   Rex,M., Uwanogho,D., Cartwright,E., Pearl,G., Sharpe,P.T. and
            Scotting,P.J.
  TITLE     Sox gene expression during neuronal development
  JOURNAL   Biochem Soc Trans 22 (3), 252S (1994)
   PUBMED   7821514
REFERENCE   8  (bases 1 to 4808)
  AUTHORS   Behlke,M.A., Bogan,J.S., Beer-Romero,P. and Page,D.C.
  TITLE     Evidence that the SRY protein is encoded by a single exon on the
            human Y chromosome
  JOURNAL   Genomics 17 (3), 736-739 (1993)
   PUBMED   8244390
REFERENCE   9  (bases 1 to 4808)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
REFERENCE   10 (bases 1 to 4808)
  AUTHORS   Gubbay,J., Collignon,J., Koopman,P., Capel,B., Economou,A.,
            Munsterberg,A., Vivian,N., Goodfellow,P. and Lovell-Badge,R.
  TITLE     A gene mapping to the sex-determining region of the mouse Y
            chromosome is a member of a novel family of embryonically expressed
            genes
  JOURNAL   Nature 346 (6281), 245-250 (1990)
   PUBMED   2374589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB570163.1, BC052736.1, AK153771.1, BB678274.1 and EH106705.1.
            
            On Apr 13, 2018 this sequence version replaced NM_009238.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BB570163.1         2-18
            18-2984             BC052736.1         1-2967
            2985-4633           AK153771.1         967-2615
            4634-4766           BB678274.1         279-411
            4767-4808           EH106705.1         6-47                c
FEATURES             Location/Qualifiers
     source          1..4808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 12.87 cM"
     gene            1..4808
                     /gene="Sox4"
                     /gene_synonym="Sox-4"
                     /note="SRY (sex determining region Y)-box 4"
                     /db_xref="GeneID:20677"
                     /db_xref="MGI:MGI:98366"
     exon            1..4781
                     /gene="Sox4"
                     /gene_synonym="Sox-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             679..2001
                     /gene="Sox4"
                     /gene_synonym="Sox-4"
                     /note="SRY-box containing gene 4"
                     /codon_start=1
                     /product="transcription factor SOX-4"
                     /protein_id="NP_033264.2"
                     /db_xref="CCDS:CCDS26411.1"
                     /db_xref="GeneID:20677"
                     /db_xref="MGI:MGI:98366"
                     /translation="MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGG
                     KADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKD
                     SDKIPFIQEAERLRLKHMADYPDYKYRPRKKVKSGNAGAGSAATAKPGEKGDKVAGSS
                     GHAGSSHAGGGAGGSSKPAPKKSCGPKVAGSSVGKPHAKLVPAGGSKAAASFSPEQAA
                     LLPLGEPTAVYKVRTPSAATPAASSSPSSALATPAKHPADKKVKRVYLFGSLGASASP
                     VGGLGASADPSDPLGLYEDGGPGCSPDGRSLSGRSSAASSPAASRSPADHRGYASLRA
                     ASPAPSSAPSHASSSLSSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSS
                     ALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY"
     regulatory      4753..4758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox4"
                     /gene_synonym="Sox-4"
                     /note="hexamer: AATAAA"
     polyA_site      4781
                     /gene="Sox4"
                     /gene_synonym="Sox-4"
                     /note="major polyA site"
ORIGIN      
        1 ctgctctaag ctgcagccag agaaacagag tgaggggaag agggccgtct ccctcccggt
       61 ttccagttct tgcacgctgt ttcttagaga gtctgcagtg ggggaactct gccggtaacc
      121 agctcccctt cttgcaggag ggagggagaa acatacattt attcatgccg gtctgttgca
      181 tgcaagcttc ttggcttcct accttgcaac aaaataattg caccaactcc tcagcgccga
      241 ttccgcccac agagagtccc ggagccagag tcgctttggc tttgcactgc aggaaaggga
      301 cttaggcgct agagacgatg tcgctttcct gagctaccgc gagctctcgt gaactgcaat
      361 cgactgcttc agggaaaggg gtgggggaaa gacttgcccc ggaggcggcg agaaacttgc
      421 gtttggaaga tactccggct accaacgttt ggagaaactc ctcgccgcgg ccgactccag
      481 cctcggtgcc cgcagggagc acttcagcgg tgagggagga cggagggcct cggggactct
      541 aggttggcgg cgggaggcgg ccgcccctgg cccgcgcgcc gctcagggga ccctggtctc
      601 cgccccgggg agcccgcagg gcccggcgac cgcgccgcga gcgtgtgagc gcgcgtgggc
      661 gcccggcaag ccggggccat ggtacaacag accaacaacg cggagaacac tgaggctctg
      721 ctggccgggg agagctcgga ctcgggcgcc ggcctggagc tgggcatcgc gtcctccccg
      781 acgcctggct ccaccgcgtc gacgggcggc aaggcggacg accccagctg gtgcaagacg
      841 cccagtggcc acatcaagcg gcccatgaac gcctttatgg tgtggtcgca gatcgagcgg
      901 cgcaagatca tggagcagtc gcccgacatg cacaacgccg agatctccaa gcggctaggc
      961 aaacgctgga agctgctcaa ggacagcgac aagattccgt tcatccagga ggcggagcgg
     1021 ctgcgcctca agcacatggc tgactaccct gactacaagt accggccgcg aaagaaggtg
     1081 aagtcgggca acgcgggcgc gggatcggcg gccacagcca agccagggga gaagggcgac
     1141 aaggtcgcgg gcagcagcgg ccacgcggga agcagccacg cggggggtgg cgcgggcggc
     1201 agctccaagc ccgcgcccaa gaagagctgt ggccccaagg tggcgggcag ctcggtcggc
     1261 aagccccacg ctaagctggt cccggcgggc ggcagcaagg cggctgcatc gttctctcca
     1321 gagcaagctg ccctgctgcc cctgggggag cccacggccg tctacaaggt gcggactccc
     1381 agtgcggcca ctccggccgc ctcctcctcg ccgtccagtg cgctggccac cccagccaaa
     1441 caccctgccg acaagaaagt gaagcgcgtc tacctgtttg gaagcctggg cgcttcggcg
     1501 tctcccgtcg ggggcctggg agcgagcgcc gaccccagtg atccactggg gttgtacgaa
     1561 gatggaggcc cgggatgctc gcccgatggc cggagtctga gcggccgcag cagcgcagca
     1621 tcatcgccag ccgccagccg atcgcccgct gaccaccgcg gctacgccag cctacgcgca
     1681 gcctcgcccg ccccgtccag cgcgccctcg cacgcgtcct cctcgctctc ctcgtcctct
     1741 tcctcctcct cgggctcttc gtcgtccgac gacgagttcg aagacgacct gctcgacctg
     1801 aaccccagct caaactttga gagcatgtcc ctgggcagtt tcagctcctc atcggcgctc
     1861 gatcgggacc tggattttaa cttcgaaccc ggctcaggct cccacttcga attcccggac
     1921 tattgcacgc ccgaggtgag cgagatgatc tcgggagatt ggctggagtc cagcatctct
     1981 aacctggtct tcacctactg aagggagcgc gggccgggga gaaggtgggc caagaggcag
     2041 gagaggagag agggaaaaaa gaaaacaaaa aacaaacaaa caaaaaaaca aacaaaaaaa
     2101 tgttaaaaag aagaagaaag aaagaaacag aaaaaaaatg agttaaaaag aatagatgga
     2161 gagtagaagg agaaagggga aaagaaaagg aagaaaaagt gcatagagct ggcctggaac
     2221 acgtcccgcc gttggagaag gagcgcgggg gcgttagtgg acccgcgctc ccatccccca
     2281 ctctcagggc tggggactcg aaggaggcgg agagtagacg ggggcgacct ttttttgttg
     2341 ttgttattga tgttggtggt ggctaaaaaa gctacttcga gtttcctccc caattttgct
     2401 tgaagagact cccccccacc ccacccttcc aacgagcttc cggacttggt tgcaccccca
     2461 gcaagaaaag aagccaagca aagcttctaa agaccgaagg aatctttccc tcacccccac
     2521 cccctcgcct tggtgatttc ttgtttgatt ttgcctcatg gtcaagaaag gagggggaaa
     2581 atccagcgtg ccccatctcc tacccacccc ctctttgtat tctctttgta tttttcccct
     2641 tcttaaaatt tctttttctg caatgaagac agaaagaagg ctctggggtg atgcgtttgg
     2701 catttgtgtt gagcttaggg gagcattggc atggagaaac tccacgctgg cgaagtcccg
     2761 ggctgggctt tctcctcctc cccccacctt ttttcccctt gtccttgcag ctggagatgt
     2821 gctgggagta gcaggccagc ctcggaaatg gacatgggga cctcgtggaa gccacagcaa
     2881 cctggttggg gatgcagaag gacccggagc acagagggcg ttggggttcc cgggcctccg
     2941 cctggggtct gtgcaaaaat aaagaattaa aaaaaaaaaa aaaatcagag aggtgaggct
     3001 acccagagcc ggcgggagga caggagactg tgggatgtgg tccaggggcc gcggagtggt
     3061 ttggggggga aaagagattt ttttcttctc ttaatgggaa tcgtgatggt gttgagttat
     3121 ttcactggtg gggttaatat agcatgttat cctgtctatc ttttgaagat ttctgtataa
     3181 gactgttgag cagtttttaa aatagtgtag gataatataa aaagcggata gatggcgcta
     3241 tgtttgattc ctacaacgaa ccgatcacca gctccttttc atttttaact ctttaaaagg
     3301 attcaaacgc aactcaaatc tgtgctggac ttttgaaaaa ccacaattca ggaccaaatt
     3361 ttttctccgt gtgtgtttat tccttatagg tgtaattgag aagacccgtt tatttttacc
     3421 ccctcacgga ctctccatct ttgtattttt ttttcccttg taaatgtaat cagatgccat
     3481 tttatatgtg gacgtattta tactggccaa acagttttct tattttgtcc cccctttttt
     3541 tcccttttca tttgctttct tgtcttttaa cctcgtttct ttatcttctt ttttattttc
     3601 tttctttttc ttcgtttttt ttttttttct agtgttgtta cccacgccat tttacgtctc
     3661 cttcactgaa gggctagagt tttaactttt aattttttat atttaaatgt agacttttga
     3721 cacttttaaa aaacaaaaaa tgacaagaga gatgaaaacg tttgattatt ttctcagtgt
     3781 atttttgtaa aaaatatata aagggggtgt taatcggtgt aaatcgctgt ttggatttcc
     3841 tgattttata atagggtggc tggttaatat ctcacacagt ttgaaaaatc agcccctggt
     3901 ttctccatgt ttacacttca atctgcaggc ttcttaaagt gacagtatcc cttaacctgc
     3961 caccggtttc cacctttcaa ccccctggtc ttataagggg aggagagttc agcccagcac
     4021 cataatgctt taaaaaaaaa aatttttttt ttttaacgaa ttgctgttct gtccagaggt
     4081 ttttaaaact ggtgcattca cagcaaaaag ggattctgta gctttaactt gtaaaccaca
     4141 tcttttttgc actttttttt ataaagcaaa aacgtgccgt ttaaaccact ggatctatct
     4201 aaatgccgat ttgagttcgc gacacaatgt actgcgtttt cattcttgta tttgactatt
     4261 taatcctttc tacttgtcgc taaatataat tgtttcagtc ctatggcatg gtgatagcat
     4321 atgtgttcag gtttatagct gttgtgttta aagattgaaa aaagtggaaa acatctttgt
     4381 acatttaagt ctgtattata ataagcaaaa agattgtgtg tatgtatgtt taatataaca
     4441 tgacaggcac gaggacgcct gccttttaag aggcagttcc gttaagggtt tttgttttaa
     4501 aactcttttt tttcctttct ttttttattt cttttttttt aaccatccat cctgtgcaat
     4561 atgccgtgta gaatatttgt cttaaaattc aaggccacaa aaaaaagcaa aaaaaaaaaa
     4621 acaaaaaaaa aaacaaaaaa caatatttgg gggaagagaa aaagaaaaaa aatcatgcca
     4681 gctaatcctg tccgtcactg cctgtcaggt tgttcctata taccttctgt aaataacttt
     4741 ttttgagaag gaaataaaat cagctggaac tgaaccctaa aaaaaaaaaa aaaaaaaaaa
     4801 aaaaaaaa
//
