LOCUS       NM_177753               3798 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus SRY (sex determining region Y)-box 21 (Sox21), mRNA.
ACCESSION   NM_177753 NM_145464 XM_979432
VERSION     NM_177753.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3798)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3798)
  AUTHORS   Erjavec,E., Angee,C., Hadjadj,D., Passet,B., David,P., Kostic,C.,
            Dode,E., Zanlonghi,X., Cagnard,N., Nedelec,B., Crippa,S.V.,
            Bole-Feysot,C., Zarhrate,M., Creuzet,S., Castille,J., Vilotte,J.L.,
            Calvas,P., Plaisancie,J., Chassaing,N., Kaplan,J., Rozet,J.M. and
            Fares Taie,L.
  TITLE     Congenital microcoria deletion in mouse links Sox21 dysregulation
            to disease and suggests a role for TGFB2 in glaucoma and myopia
  JOURNAL   Am J Hum Genet 111 (10), 2265-2282 (2024)
   PUBMED   39293448
REFERENCE   3  (bases 1 to 3798)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3798)
  AUTHORS   Eenjes,E., Benthem,F., Boerema-de Munck,A., Buscop-van Kempen,M.,
            Tibboel,D. and Rottier,R.J.
  TITLE     Distinct roles for SOX2 and SOX21 in differentiation, distribution
            and maturation of pulmonary neuroendocrine cells
  JOURNAL   Cell Mol Life Sci 80 (3), 79 (2023)
   PUBMED   36867267
  REMARK    GeneRIF: Distinct roles for SOX2 and SOX21 in differentiation,
            distribution and maturation of pulmonary neuroendocrine cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3798)
  AUTHORS   Allegre,N., Chauveau,S., Dennis,C., Renaud,Y., Meistermann,D.,
            Estrella,L.V., Pouchin,P., Cohen-Tannoudji,M., David,L. and
            Chazaud,C.
  TITLE     NANOG initiates epiblast fate through the coordination of
            pluripotency genes expression
  JOURNAL   Nat Commun 13 (1), 3550 (2022)
   PUBMED   35729116
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3798)
  AUTHORS   Jukkola,T., Lahti,L., Naserke,T., Wurst,W. and Partanen,J.
  TITLE     FGF regulated gene-expression and neuronal differentiation in the
            developing midbrain-hindbrain region
  JOURNAL   Dev Biol 297 (1), 141-157 (2006)
   PUBMED   16782087
REFERENCE   7  (bases 1 to 3798)
  AUTHORS   Wilson,M.E., Yang,K.Y., Kalousova,A., Lau,J., Kosaka,Y., Lynn,F.C.,
            Wang,J., Mrejen,C., Episkopou,V., Clevers,H.C. and German,M.S.
  TITLE     The HMG box transcription factor Sox4 contributes to the
            development of the endocrine pancreas
  JOURNAL   Diabetes 54 (12), 3402-3409 (2005)
   PUBMED   16306355
REFERENCE   8  (bases 1 to 3798)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   9  (bases 1 to 3798)
  AUTHORS   Ohba,H., Chiyoda,T., Endo,E., Yano,M., Hayakawa,Y., Sakaguchi,M.,
            Darnell,R.B., Okano,H.J. and Okano,H.
  TITLE     Sox21 is a repressor of neuronal differentiation and is antagonized
            by YB-1
  JOURNAL   Neurosci Lett 358 (3), 157-160 (2004)
   PUBMED   15039105
  REMARK    GeneRIF: Overexpression of Sox21 results in a substantial
            repression of NGF-induced neurite outgrowth in PC12 cells.  Y-box
            binding protein 1 not only binds to Sox21 but also partially
            restores NGF-induced neurite outgrowth of PC12 cells inhibited by
            Sox21.
REFERENCE   10 (bases 1 to 3798)
  AUTHORS   Hwang,C.K., Wu,X., Wang,G., Kim,C.S. and Loh,H.H.
  TITLE     Mouse mu opioid receptor distal promoter transcriptional regulation
            by SOX proteins
  JOURNAL   J Biol Chem 278 (6), 3742-3750 (2003)
   PUBMED   12446692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025686.7.
            
            On or before Mar 24, 2009 this sequence version replaced
            NM_145464.1, NM_177753.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY142959.1, AY069926.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3798              CT025686.7         107953-111750
FEATURES             Location/Qualifiers
     source          1..3798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 61.92 cM"
     gene            1..3798
                     /gene="Sox21"
                     /gene_synonym="Sox25"
                     /note="SRY (sex determining region Y)-box 21"
                     /db_xref="GeneID:223227"
                     /db_xref="MGI:MGI:2654070"
     exon            1..3798
                     /gene="Sox21"
                     /gene_synonym="Sox25"
                     /inference="alignment:Splign:2.1.0"
     CDS             1396..2226
                     /gene="Sox21"
                     /gene_synonym="Sox25"
                     /note="HMG-box protein SOX21; DNA-binding protein SOX21;
                     SRY-box containing gene 21"
                     /codon_start=1
                     /product="transcription factor SOX-21"
                     /protein_id="NP_808421.1"
                     /db_xref="CCDS:CCDS27334.1"
                     /db_xref="GeneID:223227"
                     /db_xref="MGI:MGI:2654070"
                     /translation="MSKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHNSEISKRLGA
                     EWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPVPYGLGS
                     VADAEHPALKAGAGLHAGAGGGLVPESLLANPEKAAAAAAAAAARVFFPQSAAAAAAA
                     AAAAAAGSPYSLLDLGSKMAEISSSSSGLPYASSLGYPTAGAGAFHGAAAAAAAAAAA
                     AGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYILLPGMGKPQLDPYPAAYAAAL
                     "
ORIGIN      
        1 acacacacac tcacacacgg ccgcggctgg acatgcacac ccagcgcccg ctgccggcgc
       61 caacactcgc aggtggcgac actcacctga gccgggctgc agtcgcctcg gaagcggcgg
      121 agcgaaagcc tgggcccgga gctgggaaag caggagcagc cccagagcag acctgcgatc
      181 tgaggtgata tagcacgttt tctttaatcc ccgtcctcct ccaggacctg gatccctgca
      241 tccttccagc ctgcggcgcc cggagtagcc gggacccagg ggctcgcggg cgcggcaccc
      301 acgcgggcgc acgctcggag gcgcgctcac cgagaggggc gcggctgagc ccgggccgga
      361 aacttgggag aagttagttg caagtgtctg gctgctgcga ccggagctgg gagaaggcgc
      421 ccgggcctgg ccggccgcgc cgcaccgagc agccctccgc ttctggagtg ctccgggagc
      481 ccgagacctt cagtgcgccc ggggaagctg ggagccagcg gagcaagcat ggccccgggg
      541 acagcctgca gcagcgagtc ggagaacccg gacagtctcc actgaggccc ggcgactcag
      601 gctaactcaa aacctcagcc cgcctccttc ctctcctctc ctgtgccaaa gcccggcagc
      661 aagattctcc aggcaggtgc ccggggacag cgtcagccct cagcagaact acaggattgg
      721 gggttccatc agcgcgccct gaccccgaca cagaagacgg gccgctgcag tgtttgtgtt
      781 tctgtccgcc gccctgctct gcgcgccccg accctacccc tcctcttcct cttcgcggcc
      841 acccctcccc cactcccatc tgcttctgtc aaatgagaaa gtcaccgggg agaacccaaa
      901 cactccagcc gccgagagcc ccctttggca cttggcagca cgcggcggcg ggcttctcgg
      961 ctcaacttgg tggatcctcc gccgctcaac tttcggggct gcttggcttt taaggcgctg
     1021 aagacagagg agaggggaga gcagaaccag gcagcggcca cctgcaggga gttggcgagc
     1081 caaagcaacg ggacagagga caaaaaagca gagggcagag tgacaccgcg gagtggggac
     1141 accgaggaga agtttcaggg tcccggagag gattttttct tagagctcga ccagacagac
     1201 caaagcggtc cgggacgcag cgccccgacc cagggctggt cgtctggtcc tctcttcccg
     1261 cgcgggaacg acgcggggac gcacggccgc ccgctgagcc ggttccctct ggcagccaac
     1321 attgatttcc tccgggcgga ggccgagggc cccggtggcg gcggcggcgg gctgcagccg
     1381 cggcacggcg acagcatgtc caagcctgtg gaccacgtca agcggcccat gaacgccttc
     1441 atggtgtggt cgcgggctca gcggcggaag atggcccagg agaaccctaa gatgcacaac
     1501 tcggagatca gcaagcgcct gggcgccgag tggaagctgc tcaccgagtc ggagaagcgg
     1561 ccgttcatcg acgaggcgaa gcgcctgcga gccatgcaca tgaaggagca tcccgactac
     1621 aagtaccggc cgcggcgcaa gcccaagacg ctgctcaaaa aggacaagtt cgccttcccc
     1681 gtgccctacg gcctgggcag cgtggcggac gccgagcacc cggcgctcaa ggcgggagcc
     1741 gggctgcacg cgggcgcggg cggcggcctg gtccccgagt ctctgctcgc gaaccccgag
     1801 aaggcggccg ccgcagctgc cgccgccgcc gcgcgcgtct tcttcccgca gtctgcggcc
     1861 gctgccgccg ccgccgctgc cgccgccgcc gctggcagcc cctactcact gctcgacctg
     1921 ggctccaaga tggcagagat ctcgtcgtcg tcgtccggcc tgccgtacgc gtcgtcgctg
     1981 gggtacccca cggcgggtgc gggcgccttc cacggggcgg ccgcggcggc tgctgcggcc
     2041 gcggcggccg ccggagggca cacgcactcg caccccagtc ccggcaaccc cggctacatg
     2101 atcccgtgca actgcagcgc gtggcccagc ccggggctgc agccgccgct cgcctacatc
     2161 ctgctgccag gcatgggcaa gcctcagctg gacccctacc ccgcggccta cgctgccgcg
     2221 ctatgacccc gcggggacct gtgcacacac gtgtacatat gtataggttc gagactcgcg
     2281 gccttccgct gcgccctcgg gcgacagggg gcccggtttg tatgtacata gatgtatagg
     2341 tgtcaggcag aggcggagat gccagtccgg gcttgaaagg ccgagccttc gagggcgcgg
     2401 gcgagagagc gtgtggattt cgcagcatca ttccccagcc gccgcacttc tgcagccaac
     2461 tttaaaggag agcggttgtt agcgccagca gttggtgttt gctttgcact tcggaacctg
     2521 ttgcgttttg acccacagag ggggaggggc ggtgctttac gatacgttgg gctttccagt
     2581 tttgttggtt ggattttgct ttttgcgtct catccttcct ccctcccggt cccacttggt
     2641 ccgtgttgca tgagctcggt tctgatgttc ggtctgaaat agctggccaa ggggagagcc
     2701 ggtgactcgt gtctttagct ttttagagta gggtggctct gggcagcctt actctgattg
     2761 tactgttgaa ttctgtaggc ctctgcagaa cacagcccgg atctcttctt gaccagtgaa
     2821 tgaccagctc gaatccggcc tgtatatgag agatgaccgc cgttcctttt gtttcatccc
     2881 atgtgcaaat caaagcaaga ccttttttgg tttttcttct acttctttcc caagaacaag
     2941 aaatgcaaag aaatacatgt gaggtggaag ttgtcagttc gatattctac ccctgaaata
     3001 tcagctagaa gtctctgagt ccgctggctt ggacttgtga cacagtttac gaacgcgtgg
     3061 aaagtacaca agctgtttcc cctcaaggct gagttcacct taagattgta aatgtgtgta
     3121 tgtcagtgaa aacgttgagt cttgggaaat gtgttatttt cgttgcccta aatttgagtc
     3181 ggtttgagac tcaatacatg ttgagcaaat gtcaaagtta acttttaaga attgcggaac
     3241 tttcagaatc gcaattttat ctaatattaa atcagacttt tttgtctggg ccgtaattat
     3301 atatttatta cttagcaaaa ctggggaaaa aaaggacaga aagaaagcac agaattgttt
     3361 ttgaaagatg cctctcacca actagtactc ctcccaagct gaactgtttt ggcctgtttt
     3421 tcagagctcc cttcccattt agcttatttt ctagacagcc tgcaattcac ttgcaaatta
     3481 taaaacacat tttagaaaaa aaaaaaacct tcctgaaatt atagcttttt gttccctttt
     3541 aaatgtatat attttgacta atgtttgtga atgaagttgc taacatgtat tcagtttcgt
     3601 tttggcttta tgtaagataa agttttaaaa gtttaaatat tggttttaac ttttatgtgt
     3661 aaatggtttt cttgtgcgat cttctaattt aatattagat gcgtctaagc tatatctgta
     3721 aattagaacc ctactatcac tccgttcatt ttttttgaac aaagagttaa ataaagcctg
     3781 aaccagggaa aagagaaa
//
