LOCUS       NM_011443               2480 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus SRY (sex determining region Y)-box 2 (Sox2), mRNA.
ACCESSION   NM_011443 XM_985079
VERSION     NM_011443.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Hoffmann,J., Schutze,T.M., Kolodziejczyk,A., Kuster,K., Krankel,A.,
            Reinhardt,S., Derihaci,R.P., Birdir,C., Wimberger,P., Koseki,H. and
            Albert,M.
  TITLE     Canonical and non-canonical PRC1 differentially contribute to
            regulation of neural stem cell fate
  JOURNAL   Life Sci Alliance 8 (4), e202403006 (2025)
   PUBMED   39933923
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Yuan,H., Corbi,N., Basilico,C. and Dailey,L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   7  (bases 1 to 2480)
  AUTHORS   Holmberg,M., Leonardsson,G. and Ny,T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
REFERENCE   8  (bases 1 to 2480)
  AUTHORS   Gubbay,J., Collignon,J., Koopman,P., Capel,B., Economou,A.,
            Munsterberg,A., Vivian,N., Goodfellow,P. and Lovell-Badge,R.
  TITLE     A gene mapping to the sex-determining region of the mouse Y
            chromosome is a member of a novel family of embryonically expressed
            genes
  JOURNAL   Nature 346 (6281), 245-250 (1990)
   PUBMED   2374589
REFERENCE   9  (bases 1 to 2480)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
REFERENCE   10 (bases 1 to 2480)
  AUTHORS   Lyon,M.F., Phillips,R.J. and Fisher,G.
  TITLE     Dose-response curves for radiation-induced gene mutations in mouse
            oocytes and their interpretation
  JOURNAL   Mutat Res 63 (1), 161-173 (1979)
   PUBMED   522864
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY713734.1, AW494059.1,
            CD354017.1, CF164429.1, AL606746.17, CX205480.1 and BM938133.1.
            
            On Sep 17, 2015 this sequence version replaced NM_011443.3.
            
            Summary: This intronless gene encodes a member of the SRY-related
            HMG-box (SOX) family of transcription factors involved in the
            regulation of embryonic development and in the determination of
            cell fate. The product of this gene is required for stem-cell
            maintenance in the central nervous system, and also regulates gene
            expression in the stomach. Mutations in a similar gene in human
            have been associated with optic nerve hypoplasia and with syndromic
            microphthalmia, a severe form of structural eye malformation. This
            gene lies within an intron of another gene called SOX2 overlapping
            transcript (Sox2ot). [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7652917.7095.1, SRR14777534.971406.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY713734.1         1-75
            76-76               AW494059.1         317-317             c
            77-403              BY713734.1         77-403
            404-410             CD354017.1         381-387
            411-705             CD354017.1         390-684
            706-994             CF164429.1         190-478
            995-1017            AL606746.17        73541-73563
            1018-1480           CX205480.1         1-463
            1481-1818           AL606746.17        74027-74364
            1819-2480           BM938133.1         1-662               c
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 16.93 cM"
     gene            1..2480
                     /gene="Sox2"
                     /gene_synonym="lcc; Sox-2; ysb"
                     /note="SRY (sex determining region Y)-box 2"
                     /db_xref="GeneID:20674"
                     /db_xref="MGI:MGI:98364"
     exon            1..2467
                     /gene="Sox2"
                     /gene_synonym="lcc; Sox-2; ysb"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1381
                     /gene="Sox2"
                     /gene_synonym="lcc; Sox-2; ysb"
                     /note="SRY-box containing gene 2"
                     /codon_start=1
                     /product="transcription factor SOX-2"
                     /protein_id="NP_035573.3"
                     /db_xref="CCDS:CCDS38413.1"
                     /db_xref="GeneID:20674"
                     /db_xref="MGI:MGI:98364"
                     /translation="MYNMMETELKPPGPQQASGGGGGGGNATAAATGGNQKNSPDRVK
                     RPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRAL
                     HMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMD
                     SYAHMNGWSNGSYSMMQEQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTY
                     MNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMI
                     SMYLPGAEVPEPAAPSRLHMAQHYQSGPVPGTAINGTLPLSHM"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox2"
                     /gene_synonym="lcc; Sox-2; ysb"
                     /note="hexamer: AATAAA"
     polyA_site      2467
                     /gene="Sox2"
                     /gene_synonym="lcc; Sox-2; ysb"
                     /note="major polyA site"
ORIGIN      
        1 ggatggttgt ctattaactt gttcaaaaaa gtatcaggag ttgtcaaggc agagaagaga
       61 gtgtttgcaa aaagggaaaa gtactttgct gcctctttaa gactagggct gggagaaaga
      121 agaggagaga gaaagaaagg agagaagttt ggagcccgag gcttaagcct ttccaaaaac
      181 taatcacaac aatcgcggcg gcccgaggag gagagcgcct gttttttcat cccaattgca
      241 cttcgcccgt ctcgagctcc gcttcccccc aactattctc cgccagatct ccgcgcaggg
      301 ccgtgcacgc cgaggccccc gcccgcggcc cctgcatccc ggcccccgag cgcggccccc
      361 acagtcccgg ccgggccgag ggttggcggc cgccggcggg ccgcgcccgc ccagcgcccg
      421 catgtataac atgatggaga cggagctgaa gccgccgggc ccgcagcaag cttcgggggg
      481 cggcggcgga ggaggcaacg ccacggcggc ggcgaccggc ggcaaccaga agaacagccc
      541 ggaccgcgtc aagaggccca tgaacgcctt catggtatgg tcccgggggc agcggcgtaa
      601 gatggcccag gagaacccca agatgcacaa ctcggagatc agcaagcgcc tgggcgcgga
      661 gtggaaactt ttgtccgaga ccgagaagcg gccgttcatc gacgaggcca agcggctgcg
      721 cgctctgcac atgaaggagc acccggatta taaataccgg ccgcggcgga aaaccaagac
      781 gctcatgaag aaggataagt acacgcttcc cggaggcttg ctggcccccg gcgggaacag
      841 catggcgagc ggggttgggg tgggcgccgg cctgggtgcg ggcgtgaacc agcgcatgga
      901 cagctacgcg cacatgaacg gctggagcaa cggcagctac agcatgatgc aggagcagct
      961 gggctacccg cagcacccgg gcctcaacgc tcacggcgcg gcacagatgc aaccgatgca
     1021 ccgctacgac gtcagcgccc tgcagtacaa ctccatgacc agctcgcaga cctacatgaa
     1081 cggctcgccc acctacagca tgtcctactc gcagcagggc acccccggta tggcgctggg
     1141 ctccatgggc tctgtggtca agtccgaggc cagctccagc ccccccgtgg ttacctcttc
     1201 ctcccactcc agggcgccct gccaggccgg ggacctccgg gacatgatca gcatgtacct
     1261 ccccggcgcc gaggtgccgg agcccgctgc gcccagtaga ctgcacatgg cccagcacta
     1321 ccagagcggc ccggtgcccg gcacggccat taacggcaca ctgcccctgt cgcacatgtg
     1381 agggctggac tgcgaactgg agaaggggag agattttcaa agagatacaa gggaattggg
     1441 aggggtgcaa aaagaggaga gtaggaaaaa tctgataatg ctcaaaagga aaaaaaatct
     1501 ccgcagcgaa acgacagctg cggaaaaaaa ccaccaatcc catccaaatt aacgcaaaaa
     1561 ccgtgatgcc gactagaaaa cttttatgag agatcttggg acttcttttt gggggactat
     1621 ttttgtacag agaaaacctg agggcggcgg ggagggcggg ggaatcggac catgtataga
     1681 tctggaggaa aaaaactacg caaaactttt ttttaaagtt ctagtggtac gttaggcgct
     1741 tcgcagggag ttcgcaaaag tctttaccag taatatttag agctagactc cgggcgatga
     1801 aaaaaaagtt ttaatatttg caagcaactt ttgtacagta tttatcgaga taaacatggc
     1861 aatcaaatgt ccattgttta taagctgaga atttgccaat atttttcgag gaaagggttc
     1921 ttgctgggtt ttgattctgc agcttaaatt taggaccgtt acaaacaagg aaggagttta
     1981 ttcggatttg aacattttag ttttaaaatt gtacaaaagg aaaacatgag agcaagtact
     2041 ggcaagaccg ttttcgtggt cttgtttaag gcaaacgttc tagattgtac taaattttta
     2101 acttactgtt aaaggcaaaa aaaaaatgtc catgcaggtt gatatcgttg gtaatttata
     2161 atagcttttg ttcaatccta ccctttcatt ttgttcacat aaaaaatatg gaattactgt
     2221 gtttgaaata ttttcttatg gtttgtaata tttctgtaaa ttgtgatatt ttaaggtttt
     2281 tccccccttt tattttccgt agttgtattt taaaagattc ggctctgtta ttggaatcag
     2341 gctgccgaga atccatgtat atatttgaac taataccatc cttataacag ctacattttc
     2401 aacttaagtt tttactccat tatgcacagt ttgagataaa taaatttttg aaatatggac
     2461 actgaaaaaa aaaaaaaaaa
//
