LOCUS       NM_009236               1619 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SRY (sex determining region Y)-box 18 (Sox18), mRNA.
ACCESSION   NM_009236
VERSION     NM_009236.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Chen,J., Feng,W., Sun,M., Huang,W., Wang,G., Chen,X., Yin,Y.,
            Chen,X., Zhang,B., Nie,Y., Fan,D., Wu,K. and Xia,L.
  TITLE     TGF-beta1-Induced SOX18 Elevation Promotes Hepatocellular Carcinoma
            Progression and Metastasis Through Transcriptionally Upregulating
            PD-L1 and CXCL12
  JOURNAL   Gastroenterology 167 (2), 264-280 (2024)
   PUBMED   38417530
  REMARK    GeneRIF: TGF-beta1-Induced SOX18 Elevation Promotes Hepatocellular
            Carcinoma Progression and Metastasis Through Transcriptionally
            Upregulating PD-L1 and CXCL12.
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1619)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1619)
  AUTHORS   Abbott,C.M., Evans,E.P., Burtenshaw,M., Ball,S.T., Skidmore,C.J.,
            Jones,J. and Peters,J.
  TITLE     Adenosine deaminase, Ada, is in mouse chromosome 2H3, and is not
            allelic with wasted, wst
  JOURNAL   Biochem Genet 29 (11-12), 537-544 (1991)
   PUBMED   1820019
REFERENCE   7  (bases 1 to 1619)
  AUTHORS   Davisson,M.T. and Cattanach,B.M.
  TITLE     The mouse mutation ulnaless on chromosome 2
  JOURNAL   J Hered 81 (2), 151-153 (1990)
   PUBMED   2338491
REFERENCE   8  (bases 1 to 1619)
  AUTHORS   Wallace,M.E.
  TITLE     Analysis of genetic control of chylous ascites in ragged mice
  JOURNAL   Heredity (Edinb) 43 (1), 9-18 (1979)
   PUBMED   291594
REFERENCE   9  (bases 1 to 1619)
  AUTHORS   Wallace,M.E.
  TITLE     Mapping with mimic genes in the mouse
  JOURNAL   J Hered 70 (3), 216 (1979)
   PUBMED   489949
REFERENCE   10 (bases 1 to 1619)
  AUTHORS   Green,M.C., Sweet,H.O. and Bunker,L.E.
  TITLE     Tight-skin, a new mutation of the mouse causing excessive growth of
            connective tissue and skeleton
  JOURNAL   Am J Pathol 82 (3), 493-512 (1976)
   PUBMED   176891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144281.1, BY141110.1 and AV167860.1.
            
            On Jan 26, 2007 this sequence version replaced NM_009236.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144281.1, BC006612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AK144281.1         2-160
            160-160             BY141110.1         156-156
            161-1611            AK144281.1         162-1612
            1612-1619           AV167860.1         343-350
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.71 cM"
     gene            1..1619
                     /gene="Sox18"
                     /gene_synonym="Ra; Ragl"
                     /note="SRY (sex determining region Y)-box 18"
                     /db_xref="GeneID:20672"
                     /db_xref="MGI:MGI:103559"
     exon            1..459
                     /gene="Sox18"
                     /gene_synonym="Ra; Ragl"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1253
                     /gene="Sox18"
                     /gene_synonym="Ra; Ragl"
                     /note="ragged; Sry-related HMG-box gene 18; SRY-box
                     containing gene 18"
                     /codon_start=1
                     /product="transcription factor SOX-18"
                     /protein_id="NP_033262.2"
                     /db_xref="CCDS:CCDS17218.1"
                     /db_xref="GeneID:20672"
                     /db_xref="MGI:MGI:103559"
                     /translation="MQRSPPGYGAQDDPPSRRDCAWAPGIGAAAEARGLPVTNVSPTS
                     PASPSSLPRSPPRSPESGRYGFGRGERQTADELRIRRPMNAFMVWAKDERKRLAQQNP
                     DLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKVR
                     RLEPGLLLPGLVQPSAPPEAFAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLE
                     PGEASFFPPPLAPEDCALRAFRAPYAPELARDPSFCYGAPLAEALRTAPPAAPLAGLY
                     YGTLGTPGPFPNPLSPPPESPSLEGTEQLEPTADLWADVDLTEFDQYLNCSRTRPDAT
                     TLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG"
     exon            460..1619
                     /gene="Sox18"
                     /gene_synonym="Ra; Ragl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox18"
                     /gene_synonym="Ra; Ragl"
                     /note="hexamer: ATTAAA"
     polyA_site      1618
                     /gene="Sox18"
                     /gene_synonym="Ra; Ragl"
                     /note="major polyA site"
ORIGIN      
        1 taccacgtcc ccagtgtctc cacccgacgt ccatcagacc tccgtacttg gctttgcagt
       61 gcccgccact gtctcctgcg ctcccgcgcc gcgttccgcc caggccttgc ccagctggaa
      121 tgcagagatc gccgcccggc tacggcgcac aggacgaccc gccctcccgc cgcgactgtg
      181 catgggcccc tggaatcggg gccgctgctg aggcgcgcgg cctccctgtc accaacgtct
      241 cgcccacctc gcccgcctcc ccgtccagcc ttccgcggag cccaccgcgc agccccgaat
      301 cagggcgcta tggctttggc cgcggagagc gccaaactgc cgacgagttg cgcattcggc
      361 ggcccatgaa cgccttcatg gtgtgggcga aggacgagcg caagcgactg gcgcaacaaa
      421 atccggatct gcacaacgca gtactgagca agatgctggg caaagcgtgg aaggagctga
      481 acacggcgga gaagcggccc ttcgtggaag aggccgaacg gctgcgtgtg cagcacttgc
      541 gcgaccatcc caactacaag taccggcctc gccgcaaaaa acaggcgcgc aaggtccgga
      601 ggctggagcc gggcctcttg ctcccgggcc tcgtgcagcc gtctgcgccg cccgaggcct
      661 tcgctgcagc gtcagggtca gctcgctcct tccgcgagct acccactctg ggtgcggagt
      721 tcgatggctt ggggctaccc acgcccgagc gctcgcctct ggacggcctg gagcctggcg
      781 aggcctcctt cttcccaccg cctttggcgc ccgaggactg cgctctgcgg gctttccggg
      841 caccctatgc ccctgagctg gcacgggacc cgagcttctg ctacggggcg cccctggctg
      901 aagcgctcag gacagcgccg cctgccgcgc cactcgcagg tctctactat ggcaccctgg
      961 gcactccggg cccgtttccc aatcctctgt caccaccacc tgagtccccg tctcttgagg
     1021 gcacagagca actggagcct accgccgacc tttgggccga tgtggacctc accgaatttg
     1081 accagtatct caattgcagc cggactcgac cggatgccac tacactcccc taccacgtgg
     1141 cactggccaa actaggtccg cgcgccatgt cctgtccaga agagagcagc ctcatttctg
     1201 cgctgtctga tgctagcagc gcggtctatt acagtgcttg catctcaggc tagacactgt
     1261 ccttgccctc caccgcttct gcatgtggcc aagtggcaga gttgcctgct cccttccttt
     1321 cgcatatgta tgttagggta tgcaacagcc tttagagctg gtggcctaaa gatgccattt
     1381 ctgtcgcctc ctcatttaca cacctccttc tgggggttcc tgtgctttgg gccttcccta
     1441 ggaacctcag gccctggacg tgctagctgc ctctgccagg gttgtttttg aatcatctaa
     1501 ttcttttctg ctatgtattt tctagaatga gactgtgttt tttactttgc ctttatatat
     1561 atatacatat ataatacaat atatttaatt tttaattaaa cttttttctt taaaagggt
//
