LOCUS       NM_011441               4071 bp    mRNA    linear   ROD 20-APR-2023
DEFINITION  Mus musculus SRY (sex determining region Y)-box 17 (Sox17),
            transcript variant 1, mRNA.
ACCESSION   NM_011441
VERSION     NM_011441.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4071)
  AUTHORS   Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu Q, Shi Y, Cook
            T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz
            KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ,
            Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H,
            Nichols WC, Black SM and Desai AA.
  TITLE     SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads
            of Sex, Metabolism, and Genetics
  JOURNAL   Am J Respir Crit Care Med 207 (8), 1055-1069 (2023)
   PUBMED   36913491
  REMARK    GeneRIF: SOX17 Deficiency Mediates Pulmonary Hypertension: At the
            Crossroads of Sex, Metabolism, and Genetics.
REFERENCE   2  (bases 1 to 4071)
  AUTHORS   Chiang IKN, Graus MS, Kirschnick N, Davidson T, Luu W, Harwood R,
            Jiang K, Li B, Wong YY, Moustaqil M, Lesieur E, Skoczylas R,
            Kouskoff V, Kazenwadel J, Arriola-Martinez L, Sierecki E, Gambin Y,
            Alitalo K, Kiefer F, Harvey NL and Francois M.
  TITLE     The blood vasculature instructs lymphatic patterning in a
            SOX7-dependent manner
  JOURNAL   EMBO J 42 (5), e109032 (2023)
   PUBMED   36715213
REFERENCE   3  (bases 1 to 4071)
  AUTHORS   Uchida A, Imaimatsu K, Suzuki H, Han X, Ushioda H, Uemura M,
            Imura-Kishi K, Hiramatsu R, Takase HM, Hirate Y, Ogura A,
            Kanai-Azuma M, Kudo A and Kanai Y.
  TITLE     SOX17-positive rete testis epithelium is required for Sertoli valve
            formation and normal spermiogenesis in the male mouse
  JOURNAL   Nat Commun 13 (1), 7860 (2022)
   PUBMED   36543770
  REMARK    GeneRIF: SOX17-positive rete testis epithelium is required for
            Sertoli valve formation and normal spermiogenesis in the male
            mouse.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4071)
  AUTHORS   Hsieh CH, Kuan WH, Chang WL, Kuo IY, Liu H, Shieh DB, Liu H, Tan B
            and Wang YC.
  TITLE     Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy
            resistance and emerges as a novel therapeutic target in esophageal
            squamous cell carcinoma
  JOURNAL   J Biomed Sci 29 (1), 90 (2022)
   PUBMED   36310172
  REMARK    GeneRIF: Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy
            resistance and emerges as a novel therapeutic target in esophageal
            squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4071)
  AUTHORS   Park CS, Kim SH, Yang HY, Kim JH, Schermuly RT, Cho YS, Kang H,
            Park JH, Lee E, Park H, Yang JM, Noh TW, Lee SP, Bae SS, Han J, Ju
            YS, Park JB and Kim I.
  TITLE     Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via
            HGF/c-Met Signaling
  JOURNAL   Circ Res 131 (10), 792-806 (2022)
   PUBMED   36205124
  REMARK    GeneRIF: Sox17 Deficiency Promotes Pulmonary Arterial Hypertension
            via HGF/c-Met Signaling.
REFERENCE   6  (bases 1 to 4071)
  AUTHORS   Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, Kurohmaru M,
            Sanai Y, Yonekawa H, Yazaki K, Tam PP and Hayashi Y.
  TITLE     Depletion of definitive gut endoderm in Sox17-null mutant mice
  JOURNAL   Development 129 (10), 2367-2379 (2002)
   PUBMED   11973269
  REMARK    GeneRIF: important role of Sox17 in endoderm development in the
            mouse
REFERENCE   7  (bases 1 to 4071)
  AUTHORS   Dickmeis T, Mourrain P, Saint-Etienne L, Fischer N, Aanstad P,
            Clark M, Strahle U and Rosa F.
  TITLE     A crucial component of the endoderm formation pathway, CASANOVA, is
            encoded by a novel sox-related gene
  JOURNAL   Genes Dev 15 (12), 1487-1492 (2001)
   PUBMED   11410529
REFERENCE   8  (bases 1 to 4071)
  AUTHORS   Kinder SJ, Tsang TE, Ang SL, Behringer RR and Tam PP.
  TITLE     Defects of the body plan of mutant embryos lacking Lim1, Otx2 or
            Hnf3beta activity
  JOURNAL   Int J Dev Biol 45 (1), 347-355 (2001)
   PUBMED   11291865
REFERENCE   9  (bases 1 to 4071)
  AUTHORS   Stock DW, Buchanan AV, Zhao Z and Weiss KM.
  TITLE     Numerous members of the Sox family of HMG box-containing genes are
            expressed in developing mouse teeth
  JOURNAL   Genomics 37 (2), 234-237 (1996)
   PUBMED   8921394
REFERENCE   10 (bases 1 to 4071)
  AUTHORS   Kanai Y, Kanai-Azuma M, Noce T, Saido TC, Shiroishi T, Hayashi Y
            and Yazaki K.
  TITLE     Identification of two Sox17 messenger RNA isoforms, with and
            without the high mobility group box region, and their differential
            expression in mouse spermatogenesis
  JOURNAL   J Cell Biol 133 (3), 667-681 (1996)
   PUBMED   8636240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK076707.1, AK004781.1 and
            AC129937.8.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_011441.6.
            
            On Jan 23, 2014 this sequence version replaced NM_011441.4.
            
            Summary: This gene encodes a member of the Sox (Sry-related high
            mobility group box) family of transcription factors involved in the
            regulation of embryonic development. The encoded protein plays a
            role in the determination of cell fate and in maintaining cell
            identity. This gene regulates tumor angiogenesis and tumor
            progression. Mutations in the human gene are associated with
            vesicoureteral reflux, characterized by the backward flow of urine
            from the bladder into the ureters or the kidney. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as Sox17;
            PMID 8636240). Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004781.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-941               AK076707.1         2-942
            942-1178            AK004781.1         2-238
            1179-1180           AC129937.8         123741-123742       c
            1181-2991           AK004781.1         242-2052
            2992-2992           AC129937.8         119921-119921       c
            2993-4071           AK004781.1         2054-3132
FEATURES             Location/Qualifiers
     source          1..4071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.65 cM"
     gene            1..4071
                     /gene="Sox17"
                     /note="SRY (sex determining region Y)-box 17"
                     /db_xref="GeneID:20671"
                     /db_xref="MGI:MGI:107543"
     exon            1..1064
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1871
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1963
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2330
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     CDS             2024..3283
                     /gene="Sox17"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription factor SOX-17; SRY-box containing gene 17"
                     /codon_start=1
                     /product="transcription factor SOX-17 isoform a"
                     /protein_id="NP_035571.1"
                     /db_xref="CCDS:CCDS14805.1"
                     /db_xref="GeneID:20671"
                     /db_xref="MGI:MGI:107543"
                     /translation="MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSPLGDVKV
                     KGEVVASSGAPAGTSGRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKML
                     GKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALV
                     EPQAGALGPEGGRVAMDGLGLPFPEPGYPAGPPLMSPHMGPHYRDCQGLGAPALDGYP
                     LPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGTYTYAPVSDYAVSVEPPAGPMRVGPDP
                     SGPAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQAPPPPPQQQHPAHG
                     PGQPSPPPEALPCRDGTESNQPTELLGEVDRTEFEQYLPFVYKPEMGLPYQGHDCGVN
                     LSDSHGAISSVVSDASSAVYYCNYPDI"
     exon            2331..4071
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgggagagg ctagcaaagc gaagattgca gggtctggcc tgaatgttct gggccaccgt
       61 gggggccggt gatcactgtc tttcttgcca ctctttcctc tcaagttccc gaatttccat
      121 ctccacctcc gacccactgg ggactgacca gggactggaa agagcgcgaa aggtataaag
      181 gggagaagag actgcgcctt ttggtgcccg ggtgaaaggt gccaatcgac cgcatcgctc
      241 tgcgtggccc tacctgggag gtgcggagcc cggggcacga cgctcggtgt tctcagaggc
      301 agactctgag gcacgtattt tagaccgtcc agtggtacta ttgtctctgt tatcttagag
      361 tccgccgggg gctgtctccg tgatgacagc ccacgctccc ttttccgccc tcatgaactt
      421 gctctccaca gaccacggat ctgcttgagt gcccacggat cctgtgcaat tggacttgaa
      481 tgtcctttaa caggccttgg ccatcagaac accaaaacca taaaaccttc gagaaatcaa
      541 ccactcactc tgaggctcgc tgtagaagag tggcttagac tctcccactt cggagtccca
      601 gttgatcacc aacccgcttg ctacaggccc caaatggtta cgggcacagc ttctagttac
      661 attagacgct tccttgcccc agcctttcga gcctcaggtc tgctttgggg atgtggctta
      721 ggcagtagcc acctagaaat cctgcactgt ttgagtgtga taccgctgcg gactacagca
      781 gacaggcgtg ccaggcttct agtccagata cccaccccca ccccagtaaa tctctagtgt
      841 tgagggaagc aaggcttgca ggaagccgct ccggatgttt gcttctttac ttgtggcatt
      901 tgtggctggc tttgataacg tcgtgagctc ggcttccaac acccatttag tgaagaaact
      961 gaaatatggc ccactcacac tgctggcggg tctgaagtgc ggttggcccc aacactcctc
     1021 ccaaagtatc tatcaagaga atggtcagca gaagttagat ctagttttta gagaaatcaa
     1081 ccaagacagg gaagacagag aaaatgcatt ctggacccgc tactgttttc aatcgtcatt
     1141 tcaaacaaaa cccgtagttt atttaaaaaa aaaaaaaaca cggaaagaga aaattaggcc
     1201 ctgagatctt tgaaaagatg cccattacta gatacaaaag agaagagtca ctgtggaggt
     1261 gagggactgc gtccctgctt ctgagaggca ggagagctac atggggagac tgtctcaaaa
     1321 ctaacaacag aagagataga attttttttt tcttaaagag cacctggcta gagaatcgat
     1381 ttgtaaaatt gctatttcta cccttagagt ttccttgatt aaacatctga aatgcatttt
     1441 ttttgtttta ctttcaagct aatgtttttc agaaaaaaat aaaaagcttt gaggaaaagc
     1501 acattatcag ttagatttaa gaccaattgc ttttaaatta ccaatttaaa atatcatttt
     1561 ttttatttct taaagcagat ttaattttac cccctttgta tgaatcttac agacctggag
     1621 ttttaactac tatcactgat ctctacacac aacctccagc tttaaatggg agggagggtc
     1681 accactgctt tataacataa caaattagag aaaagctggc ttctgtatga gttctttgga
     1741 gacaaagtag ctccagaaac tgcagaccag aagctatcaa aatctctgtg cttttttgga
     1801 acctccagta agccagattt ggtctctgaa ataatacagg aaaacctcag catgtcacct
     1861 catggataca atgagcagca cctccagaca tctgaatttc agccttccta tttccccaag
     1921 aggtcttggc gccagcgccc ggctccagcc agttttcccc aagggtcggg ggaagcggcg
     1981 tgtcccgtgg ccatagcaga gctcggggtc ggtctggaga gccatgagca gcccggatgc
     2041 gggatacgcc agtgacgacc agagccagcc ccggagcgcg cagcccgcgg tgatggcagg
     2101 gttgggcccc tgtccctggg ccgagtccct gagccccctc ggggatgtaa aggtgaaagg
     2161 cgaggtggtg gcgagtagcg gggcgccagc cgggacgtcg ggccgagcca aagcggagtc
     2221 tcgcatccgg cggccgatga acgcctttat ggtgtgggcc aaagacgaac gcaagcggtt
     2281 ggcacagcag aacccagatc tgcacaacgc agagctaagc aagatgctag gcaagtcttg
     2341 gaaggcgttg accttggcag agaagcggcc cttcgtggaa gaggccgagc ggctgcgcgt
     2401 gcagcatatg caggaccacc ccaactacaa gtaccggccg cggcggcgca agcaggtgaa
     2461 gcgcatgaag cgggtggagg gaggcttcct gcacgctctc gtcgagcccc aggccggcgc
     2521 gcttggtccc gagggcggcc gcgtggccat ggatggcctg ggtctgcctt tcccggagcc
     2581 gggctatccg gccggtcctc cgctgatgtc tccgcacatg ggcccccact atcgggactg
     2641 ccagggactg ggcgctcccg cgctcgacgg ctaccctctg cccactccgg acacatcccc
     2701 gctggatggc gtggagcagg acccggcttt ctttgcagcc ccgctgccag gggactgccc
     2761 ggcggccggc acctacactt acgctccagt ctcggactat gcagtgtccg tagagccgcc
     2821 cgctggcccc atgcgagtgg ggccggaccc ctcgggccct gcgatgccgg ggatcctggc
     2881 gccccccagc gctctgcacc tgtactacgg cgcgatgggc tcgcccgccg caagtgcggg
     2941 gcgcggtttc cacgcgcaac cccagcagcc gctgcaaccg caggcaccgc cgccgccacc
     3001 gcagcagcag cacccagcgc acggccccgg gcaaccttcg ccccctcccg aggctctgcc
     3061 ctgccgggat ggcacggaat ccaaccagcc cactgagctc ctaggggagg tggaccgcac
     3121 ggaattcgaa cagtatctgc cctttgtgta taagcccgag atgggtcttc cctaccaggg
     3181 acacgactgc ggagtgaacc tctcagacag ccacggagcc atttcctccg tggtgtccga
     3241 cgctagctca gcggtctact attgcaacta ccccgacatt tgacggttgc cgacccgacc
     3301 tgagggccag aagcagtgtt acacacttcc tggaagcgct aaggaaatcc ttagcgtcaa
     3361 gctgttttgt ttttaagttg ccttggcata taatttatgg taatttattt tgtctgccac
     3421 ttgaacagtt gaggggctac acgagatttt tgttttaaat gccttgaggg acttgctccc
     3481 cacaatcact gtccagtttt agccagtttt aaaatatctc actgacttat tccatttctt
     3541 gaaagtgtat tgatctagag aaattttgtc atgcgtgttt tctcaatctt aaataaatcc
     3601 tggaatcttt ttaaaatctc tcgcatcgat ttttatcaaa ttaaagatca acagtaagta
     3661 ttatacaatt agaagtgtat acttaattgt aaaattttca tttttcttac aatggtaaga
     3721 aaatgcatct aagaaaccct aaacacaaac agcggggtgt tcaaatgtga tataattgtt
     3781 ctgagaaaaa ttctcaaaag atgaacttgt tatgtacatt ccaaatattg gtttctaaaa
     3841 atgatactgt aaatgttttt aattctgtac actttaatga ggctgttcaa aaatttcgga
     3901 ttttcagtca tctcgacacc tgccaaaaga gcttttcaga tataactctt tcctgtttgt
     3961 cttttcttcc aaaagtcttg atcccacttc ccacaaaatt tgcctttaat tcctacaatt
     4021 ttagagtcag agaaactaat caaaataaag tttgtgttgt gactgttagt g
//
