LOCUS       NM_011438               4436 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus SRY (sex determining region Y)-box 12 (Sox12), mRNA.
ACCESSION   NM_011438 XM_357227
VERSION     NM_011438.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4436)
  AUTHORS   Wang,X., Llamas,J., Trecek,T., Shi,T., Tao,L., Makmura,W.,
            Crump,J.G., Segil,N. and Gnedeva,K.
  TITLE     SoxC transcription factors shape the epigenetic landscape to
            establish competence for sensory differentiation in the mammalian
            organ of Corti
  JOURNAL   Proc Natl Acad Sci U S A 120 (34), e2301301120 (2023)
   PUBMED   37585469
REFERENCE   2  (bases 1 to 4436)
  AUTHORS   Angelozzi,M., Pellegrino da Silva,R., Gonzalez,M.V. and Lefebvre,V.
  TITLE     Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly
            proliferative, and myofibroblast-like osteodermal progenitors
  JOURNAL   Cell Rep 40 (2), 111045 (2022)
   PUBMED   35830813
REFERENCE   3  (bases 1 to 4436)
  AUTHORS   Suehiro,K.I., Suto,A., Suga,K., Furuya,H., Iwata,A., Iwamoto,T.,
            Tanaka,S., Kageyama,T., Suzuki,K., Hirose,K., Lefebvre,V. and
            Nakajima,H.
  TITLE     Sox12 enhances Fbw7-mediated ubiquitination and degradation of
            GATA3 in Th2 cells
  JOURNAL   Cell Mol Immunol 18 (7), 1729-1738 (2021)
   PUBMED   32152552
  REMARK    GeneRIF: Sox12 enhances Fbw7-mediated ubiquitination and
            degradation of GATA3 in Th2 cells.
REFERENCE   4  (bases 1 to 4436)
  AUTHORS   Ji,S., Yang,Z., Gozali,L., Kenney,T., Kocabas,A., Jinsook Park,C.
            and Hynes,M.
  TITLE     Distinct expression of select and transcriptome-wide isolated
            3'UTRs suggests critical roles in development and transition states
  JOURNAL   PLoS One 16 (5), e0250669 (2021)
   PUBMED   33951080
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4436)
  AUTHORS   Miao,Q., Hill,M.C., Chen,F., Mo,Q., Ku,A.T., Ramos,C., Sock,E.,
            Lefebvre,V. and Nguyen,H.
  TITLE     SOX11 and SOX4 drive the reactivation of an embryonic gene program
            during murine wound repair
  JOURNAL   Nat Commun 10 (1), 4042 (2019)
   PUBMED   31492871
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4436)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   7  (bases 1 to 4436)
  AUTHORS   Lioubinski,O., Muller,M., Wegner,M. and Sander,M.
  TITLE     Expression of Sox transcription factors in the developing mouse
            pancreas
  JOURNAL   Dev Dyn 227 (3), 402-408 (2003)
   PUBMED   12815626
REFERENCE   8  (bases 1 to 4436)
  AUTHORS   Stock,D.W., Buchanan,A.V., Zhao,Z. and Weiss,K.M.
  TITLE     Numerous members of the Sox family of HMG box-containing genes are
            expressed in developing mouse teeth
  JOURNAL   Genomics 37 (2), 234-237 (1996)
   PUBMED   8921394
REFERENCE   9  (bases 1 to 4436)
  AUTHORS   Yuan,H., Corbi,N., Basilico,C. and Dailey,L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   10 (bases 1 to 4436)
  AUTHORS   Wright,E.M., Snopek,B. and Koopman,P.
  TITLE     Seven new members of the Sox gene family expressed during mouse
            development
  JOURNAL   Nucleic Acids Res 21 (3), 744 (1993)
   PUBMED   8441686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB245116.1, BQ180104.1, BG228657.1, CA749985.1 and AL928568.17.
            
            On Mar 9, 2007 this sequence version replaced NM_011438.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-605               CB245116.1         1-605
            606-1030            BQ180104.1         170-594
            1031-1379           BG228657.1         53-401
            1380-1701           CA749985.1         337-658
            1702-4436           AL928568.17        67691-70425         c
FEATURES             Location/Qualifiers
     source          1..4436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.94 cM"
     gene            1..4436
                     /gene="Sox12"
                     /gene_synonym="2010205A02Rik"
                     /note="SRY (sex determining region Y)-box 12"
                     /db_xref="GeneID:20667"
                     /db_xref="MGI:MGI:98360"
     exon            1..4436
                     /gene="Sox12"
                     /gene_synonym="2010205A02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1293
                     /gene="Sox12"
                     /gene_synonym="2010205A02Rik"
                     /note="SRY-box containing gene 12"
                     /codon_start=1
                     /product="transcription factor SOX-12"
                     /protein_id="NP_035568.1"
                     /db_xref="CCDS:CCDS38274.1"
                     /db_xref="GeneID:20667"
                     /db_xref="MGI:MGI:98360"
                     /translation="MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPM
                     NAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMA
                     DYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRASGGPLGGGAA
                     APEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSGEGAAASAASP
                     TLSEDEEPEEEEEEAATAEEGEEETVVSGEEPLGFLSRMPPGPAGLDCSALDRDPDLL
                     PPSGTSHFEFPDYCTPEVTEMIAGDWRSSSIADLVFTY"
     regulatory      3125..3130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox12"
                     /gene_synonym="2010205A02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3145
                     /gene="Sox12"
                     /gene_synonym="2010205A02Rik"
                     /note="major polyA site"
     regulatory      4415..4420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox12"
                     /gene_synonym="2010205A02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4436
                     /gene="Sox12"
                     /gene_synonym="2010205A02Rik"
ORIGIN      
        1 ggcggcgggc gggcaagcgc gcgcggggcc gcggagagcc aggccgcgac cggagcccgc
       61 aggagcccac gaggctcgag tccttggccc tgcaaaacaa tgcgcggcgc gcggaggagc
      121 tctactggcc cggggcggcg gggacgcgcg gagccctctt gagcccgcgc cactgacctc
      181 cccctcgcac agacggcccg agcgccggct gccgcgctcc cagctcgcgg gggccgggcc
      241 gagccgcggg gcggggccgc ccctccgtcg ccgctgcctc ctcccccacc gccgccgcgg
      301 aggatgcgga cggcccccgg cggcgtctag cggcccgggc ccggcacgat ggtgcagcag
      361 cggggcgcgc gggccaagcg ggacggcggg ccgccgcccc cggggcccgg gccggccgcc
      421 gagggggcgc gcgagccagg ctggtgcaag accccgagcg gccacattaa gcggccgatg
      481 aacgcgttca tggtgtggtc gcagcacgag cggagaaaaa tcatggacca gtggcccgac
      541 atgcacaacg ctgagatctc caagcgcctg ggccgccgct ggcagctgct gcaggactcg
      601 gagaagatcc cgttcgtgcg ggaggcggag cggctgcgcc tcaagcacat ggcggactac
      661 ccggactaca agtaccggcc tcgcaagaag agcaaggggg cgcccgccaa ggcgcggccc
      721 cgcccccccg gaggcggcgg tggtggcagt cggctgaaac ccgggccaca gctgccgggc
      781 cgcgggggcc gccgagcgtc gggaggacct ctggggggcg gcgcggcggc gccggaggac
      841 gacgacgaag acgaagagga ggagctgctg gaagtacgcc tgctggagac ccccgggcgc
      901 gagctgtgga ggatggtccc ggcggggcgc gccgcccgcg gacccgcgga gcgcgcgcag
      961 gggccatccg gcgagggggc ggccgccagc gccgcctctc cgaccctgtc cgaggacgag
     1021 gagccggagg aagaggagga ggaggcggct acagcagagg agggcgaaga ggagacggtg
     1081 gtatctgggg aggagccact gggctttctg tccaggatgc ccccgggccc cgccggcctg
     1141 gactgcagtg ccctggaccg tgacccggac ctgctgcccc cttcgggcac gtcacatttc
     1201 gaattcccgg actattgcac ccccgaggtt accgagatga tcgcagggga ctggcgctcg
     1261 tctagtatcg ccgacctggt tttcacctac tgagcccacc gtcagcgggg cgcgcacgcc
     1321 cccaaaccag ctgtttacat acaggaatca ggtattgggg cccctcggag gccgaggctg
     1381 gcaccccatc tcccgcgcag cctcccccct cctagttgtg cccatccccc cacaaatcca
     1441 gacatacccc tcccccgcag acacacccca aggcagccca acccccactt tctccctgac
     1501 atctaagccc ctccccattc agtcctgtcc cgcgtagcca ccagcagcca gcccccctcg
     1561 gatacacctc gttcctccta cataccttaa cccctccccc tcactttgca cacgcccctc
     1621 ctcgtgtccg gacggcacgc cccttcgctc cagaatccct ccgccctctc ctgggcctgc
     1681 cttggtagtt aagggggcgc tgcagtctag cggttcagcg ctcctcccag tcccctcctc
     1741 ttctgggggg gaagggagcc atccctcccc ccctggatct caaggcccca cccctcagct
     1801 tgaaccatcc ctcccccccc ttcttgcgca tgcttgatgc ttcttggagg gggcaggtcc
     1861 cagttaagct gcaggcctct gttgccaact ccgaaaggga gggggcgatt atagagtgat
     1921 ctaagaaatc ctttgatccc gaagcctgta gcttactctc aacccaaagg ggcgtcactg
     1981 ccttaatggg aggcgcactc aaagggagag atagaaacta gctagcccta aactctgcaa
     2041 gtgtcaaccc cttttctatg aaggggtcac ccacgcccac caccaccctc caccgcgtga
     2101 ctgcctttac agcccatctt ggtcgccgga aacttgattt ccccaagtgg gaatttagaa
     2161 ttcggtcttt ggaaatccac caagatggga ttgtccaaga gaactcagaa ccaagacacc
     2221 taccagtctg gggacagagt tcctgctgcc ccctcaatcc ccctcctcgg gaagcgccct
     2281 atcagctcag ggcatcctct ctgcctgggc tcctccctaa gtccatcacc ccttcctatc
     2341 actcaaatcc agtctcagca accacaactg cagtattcag tgggagaaac tgaagcacgt
     2401 tgttgctagg gtttaggaca ggcataccag cagccgggtg gcaagaatga ggaccatgtc
     2461 taaacaaact tggcttgagg agagaccagg ccaggggacg gtggcagagc tagtagtgga
     2521 cttgggtgct ttgcacctcg gtctgccctt gtgagaaatg gggtggcact gctgtagtta
     2581 ggaagctgtg ttgagattag gttgccaagt ctgctccact ggtctcccgc tccagccccg
     2641 cccctccagc ctccccatcc tccctctgcc ctcactacct gtatctcacc ggcgtgtgtc
     2701 caccctctgg gtggttcaca cacactcatt cacacacaca caaatctcag gaacaaacgg
     2761 tcccagagtc ctcctcgacc cctgccctgg gtctctgcag gtctctgccc cacgcgttcc
     2821 cttcgctgac aacgccacca gctgcctcct ttaaagcttg gtgctccggc tctgggcctt
     2881 tcttgcgctc tttctctatt tctctttctg ttttcttcct tttttttttt ctttttttct
     2941 tttttaagaa aacaaaacaa aaaaaaagac aatgaaaaaa aaaaaaacgg aaaacgtcat
     3001 gtgagtgaag agatgtcact gtctgtggtc tttggagaac tagtctcgta gctgagggga
     3061 ggggattccc tcctctgggg cgctggcacc cacagcagga ctcgccagtc tgatgccagg
     3121 actgaataaa gtgtatttgc cccgaccttg ccctgtggtt ctgcatgtgt acttctcacc
     3181 ctggccagct tcaaagtgcc tagagtatgg gctggtgcag ggagaacggg ttctctttac
     3241 ccctggccag cttcaaagtg cctagagtat gggctggtgc agggagagcg ggttctcttt
     3301 aggcctctgt tatcctctat ctcaggaatc cctgccttca ttaagaatgg caaactcatc
     3361 ttcacagtgg ctaagcatcg taactgggag gactggggtg ggtgctgatg tcacagtgca
     3421 agggtgcaag cctctgtaga cagccatata ttccaagaga tgcaggaaac cagtcattgt
     3481 gcttgttaag tctcattagg tcagacgaga caagcatgca tgcaggcagg actgatcatc
     3541 cggggtcaat tccactgttt aataaaggat tgggaagcaa aattggtagc tttgctcaga
     3601 gcctatgttc tgagcagctc tacagtgtgt gtcttctaag gatcaacatg gtattttcag
     3661 tgggaaacca tgcttgaggt aagcagtatt taaggtggtg tgctccataa attgtgttcc
     3721 ttcatttcca gagtaggaag ctggggagag gggtccccat caagcaacca tggctagaag
     3781 tattctgagg tatccctcaa atgtgttgtc ccatgctgag aggtggccta ggacctgact
     3841 tacaagggcc tgcagtgtaa gcctaccaca ggaccagagg gcaacagacc gagagttttc
     3901 tcctgaggtt ctactcagtt cttcctcggc gcattcgttg tacctttctc ccccatgcgt
     3961 tgccttgtcc agtgaatgtc actgctcaag aaacgcccat tttcctaata agccaggact
     4021 gggtgtggat cttttcaggg catcttctct gcttctggtt ggaagcaaac tgggaggaaa
     4081 tcatgagtag ataacattga gaaagggagg acagggcctg tgccaaacag aagtcagttc
     4141 aaggaagggt ttctttccct agaccatagg aaacagggtc aatgaataac ctccagcaag
     4201 gtcagcccct gaagtcggtc tgcccaaggc cacacccttc cccctggtag gcctgcccca
     4261 gtgtctaagc taggttgttt tagtgctttg tggggcaaac tgtcaagcat ttcttccacc
     4321 agactcccct gtggtccctg tgcagggacc ggccagggct ttgtcagact gccttcatgc
     4381 ccaacactgc cttttttcca caggtgttta tcctaataaa cgtcttaaca cccaaa
//
