LOCUS       NM_011437               2713 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus SRY (sex determining region Y)-box 10 (Sox10), mRNA.
ACCESSION   NM_011437 XM_128139 XM_985075
VERSION     NM_011437.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2713)
  AUTHORS   Fimiani,C., Pereira,J.A., Gerber,J., Berg,I., DeGeer,J.,
            Bachofner,S., Fischer,J.S., Kauffmann,M. and Suter,U.
  TITLE     The E3 ubiquitin ligase Nedd4 fosters developmental myelination in
            the mouse central and peripheral nervous system
  JOURNAL   Glia 73 (2), 422-444 (2025)
   PUBMED   39511974
REFERENCE   2  (bases 1 to 2713)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   3  (bases 1 to 2713)
  AUTHORS   Chen,Y., Li,H., Wang,J., Yang,S., Su,Z., Wang,W., Rao,C. and Hou,L.
  TITLE     The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast
            proliferation during early development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39555938
REFERENCE   4  (bases 1 to 2713)
  AUTHORS   Omura,S., Ogawa,R., Kawachi,T., Ogawa,A., Arai,Y., Takayama,N.,
            Masui,A., Kondo,K., Sugimoto,H., Shinohara,H.M., Takahashi,T.,
            Maeda,H. and Ohyama,K.
  TITLE     Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the
            neurovascular unit in the developing mouse hippocampus
  JOURNAL   Front Cell Neurosci 18, 1464402 (2024)
   PUBMED   39484182
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2713)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   6  (bases 1 to 2713)
  AUTHORS   Davisson,M.T., Roderick,T.H., Akeson,E.C., Hawes,N.L. and
            Sweet,H.O.
  TITLE     The hairy ears (Eh) mutation is closely associated with a
            chromosomal rearrangement in mouse chromosome 15
  JOURNAL   Genet Res 56 (2-3), 167-178 (1990)
   PUBMED   2272507
REFERENCE   7  (bases 1 to 2713)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
REFERENCE   8  (bases 1 to 2713)
  AUTHORS   Beier,D.R., Morton,C.C., Leder,A., Wallace,R. and Leder,P.
  TITLE     Perinatal lethality (ple): a mutation caused by integration of a
            transgene into distal mouse chromosome 15
  JOURNAL   Genomics 4 (4), 498-504 (1989)
   PUBMED   2744761
REFERENCE   9  (bases 1 to 2713)
  AUTHORS   Hoffman,P.M., Rohwer,R.G., MacAuley,C., Bilello,J.A., Hartley,J.W.
            and Morse,H.C. 3rd.
  TITLE     Transmission in NFS/N mice of the heritable spongiform
            encephalopathy associated with the gray tremor mutation
  JOURNAL   Proc Natl Acad Sci U S A 84 (11), 3866-3870 (1987)
   PUBMED   3473486
REFERENCE   10 (bases 1 to 2713)
  AUTHORS   Kinney,H.C. and Sidman,R.L.
  TITLE     Pathology of the spongiform encephalopathy in the Gray tremor
            mutant mouse
  JOURNAL   J Neuropathol Exp Neurol 45 (2), 108-126 (1986)
   PUBMED   3512779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591921.6.
            
            On or before Apr 8, 2009 this sequence version replaced
            XM_985075.2, XM_128139.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042542.1, AK043220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AL591921.6         88132-88340
            210-715             AL591921.6         88828-89333
            716-984             AL591921.6         93219-93487
            985-2713            AL591921.6         95981-97709
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..2713
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /note="SRY (sex determining region Y)-box 10"
                     /db_xref="GeneID:20665"
                     /db_xref="MGI:MGI:98358"
     exon            1..209
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /inference="alignment:Splign:2.1.0"
     exon            210..715
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1688
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /note="transcription factor SOX-M; dominant megacolon;
                     SRY-box containing gene 10"
                     /codon_start=1
                     /product="transcription factor SOX-10"
                     /protein_id="NP_035567.1"
                     /db_xref="CCDS:CCDS49668.1"
                     /db_xref="GeneID:20665"
                     /db_xref="MGI:MGI:98358"
                     /translation="MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRA
                     SPGPGELGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKP
                     HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERL
                     RMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGEAEQGGAAAIQAHYKSAHLDHRHPE
                     EGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNV
                     DIGEISHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLGSALAVASGHSAWI
                     SKPPGVALPTVSPPGVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAF
                     PSISRPQFDYSDHQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSH
                     SPTHWEQPVYTTLSRP"
     exon            716..984
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /inference="alignment:Splign:2.1.0"
     exon            985..2713
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2523..2528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /note="hexamer: AATAAA"
     polyA_site      2549
                     /gene="Sox10"
                     /gene_synonym="Dom; gt; Sox21"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtctc ggctgtccag ccagggtgtt tggtggtgag gattcaggct ccgtccagac
       61 aaggcagtgg cctgaggctc agggcccccc agcccctccc tcccagtcca tcagcgtcac
      121 tccccagccc cgagctggac cgcacacctt gggacacggt tttccacttc ctcaggacga
      181 gccccagact ggaggagagg tcggaggagg tgggcgttgg gctcttcacg aggaccccgg
      241 cggcgggccc gggggaggcg gccgaagcgg cggcggccgg gagcgacatg gccgaggaac
      301 aagacctatc agaggtggag ctgagccctg tgggctcgga ggaaccccgc tgcctgtccc
      361 caggcagcgc gccgtcgctg ggacccgacg gcggcggcgg tggctcgggc ttgcgagcca
      421 gcccggggcc cggtgaactg ggcaaggtca agaaggaaca gcaggacggc gaggcggacg
      481 atgacaagtt ccccgtgtgc atccgcgagg cggtcagcca ggtgctcagc ggctacgact
      541 ggacgctggt gcccatgccc gtgcgcgtca acggtgccag caagagcaag ccgcacgtca
      601 agaggcccat gaacgccttc atggtgtggg cacaggcggc acgcagaaag ctagccgacc
      661 agtaccctca cctccacaat gctgagctca gcaagacact aggcaagctc tggaggttgc
      721 tgaacgaaag tgacaagcgc cccttcattg aggaggctga gaggctccgg atgcagcaca
      781 aaaaggacca tccggactac aagtaccaac ctcggcggcg gaagaacggg aaggcagccc
      841 agggggaggc agaatgccca ggcggggaag ccgagcaagg aggggctgct gctattcagg
      901 ctcactacaa gagtgcccac ctggaccacc ggcacccaga agaaggctcc cccatgtcag
      961 atgggaaccc agagcacccc tcaggccaga gccatggccc cccaacccct ccaaccaccc
     1021 caaagacaga gctgcagtcc ggcaaggcag accccaaaag ggatgggcgc tccttggggg
     1081 agggcgggaa gccccacatc gacttcggca acgtggacat cggggagatc agccacgagg
     1141 taatgtccaa catggaaacc tttgatgtga ctgagctgga ccaatacctg ccacccaacg
     1201 ggcacccagg ccatgtgggt agctactcgg cagctggcta cgggctgggc agtgccctgg
     1261 ctgtggccag tggacactct gcctggatct ccaagccacc aggtgtggct ctgcccacgg
     1321 tctcgccccc tggtgtggat gccaaagccc aggtgaagac agagaccaca ggcccccagg
     1381 gacccccaca ctacaccgac cagccgtcca cttcccagat cgcctacact tccctcagtc
     1441 tgccccacta cggctccgcc ttcccctcca tctcacgacc ccagtttgac tattctgacc
     1501 atcagccctc aggaccctat tatggccatg caggccaggc ctctggcctc tattcagcct
     1561 tttcttacat ggggccctcc cagcggcccc tctacactgc catctctgac cccagcccct
     1621 cagggcccca atcccacagt cccacacact gggagcagcc agtatatacg actctatccc
     1681 gaccttagag gggccctgtc accaccagtg cccacagggc cttggggccc cttcccccag
     1741 cctgtgtgcc ctgctcctca tcagcctcag gcttggcagt ggaggaggct gcagaggctg
     1801 acagcagcag gaaggcttct gccagctcct gccctgatga cctccaccca ccccggctct
     1861 ggaggccaag ccctgactga gctggcaaag gaagtttggt ggctctccca gactgagggt
     1921 gaggggccac ccttccccag aaatgaccct ctatcccagg acctgagagt cctgctcagt
     1981 ccttcaggga ggcaggaagg gttagggtag gaggcctcac tgctcctgtt atctccttgg
     2041 agagcaaggg gcccgtgtgc tactgtgtca ttgcctaaga gctaagctgc ccagggacct
     2101 gcctcaaagc ctggagctgg ttctgtcctg tcactaagga cgcactgagg acagctttga
     2161 acagctttgt aaagagcagg gtgggacact ctgatccttt ctccgccccc tcttcacctg
     2221 aatgtgggaa ctggtcgagg tccccagatc cagttccgtg tcaataacct catcccttgc
     2281 ctaactgagg agagtcccca tgttcttccc atcccacccc aggtgaggag ccaggggctc
     2341 caggaaagag tcagaggcaa tccacctagc cttcttctcg ccttctgtca gcctcaagcc
     2401 cccaggctca gagttagcat ggcacggccc tagcccctgg gttgctggca gcaggctgga
     2461 cactaaaccc ctgccatgta cagtctacct ttgccttgca ccctttgctc cagcgatacc
     2521 ttaataaagt acgtagctct gtctccccat ctcctgtctg cagcccagtc cacatgtaac
     2581 acatcgctgc ccctttattt atctccatag tcgccatgtt cctatccctc tagctactcc
     2641 agccccgatt aacttgcatt aagcactcca agtaataaaa tcaatgcttc tggttgcctg
     2701 cttggtggcc tga
//
