LOCUS       NM_009233               4037 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus SRY (sex determining region Y)-box 1 (Sox1), mRNA.
ACCESSION   NM_009233
VERSION     NM_009233.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4037)
  AUTHORS   Pelenyi,A., Atterton,C., Jones,J., Currey,L., Al-Khalily,M.,
            Wright,L., Kurniawan,N.D., Thor,S. and Piper,M.
  TITLE     Expression of the Hippo pathway effector, TEAD1, within the
            developing murine forebrain
  JOURNAL   Gene Expr Patterns 54, 119384 (2024)
   PUBMED   39557142
REFERENCE   2  (bases 1 to 4037)
  AUTHORS   Gong,M., Li,J., Qin,Z., Machado Bressan Wilke,M.V., Liu,Y., Li,Q.,
            Liu,H., Liang,C., Morales-Rosado,J.A., Cohen,A.S.A., Hughes,S.S.,
            Sullivan,B.R., Waddell,V., van den Boogaard,M.H., van
            Jaarsveld,R.H., van Binsbergen,E., van Gassen,K.L., Wang,T.,
            Hiatt,S.M., Amaral,M.D., Kelley,W.V., Zhao,J., Feng,W., Ren,C.,
            Yu,Y., Boczek,N.J., Ferber,M.J., Lahner,C., Elliott,S., Ruan,Y.,
            Mignot,C., Keren,B., Xie,H., Wang,X., Popp,B., Zweier,C., Piard,J.,
            Coubes,C., Mau-Them,F.T., Safraou,H., Innes,A.M., Gauthier,J.,
            Michaud,J.L., Koboldt,D.C., Sylvie,O., Willems,M., Tan,W.H.,
            Cogne,B., Rieubland,C., Braun,D., McLean,S.D., Platzer,K.,
            Zacher,P., Oppermann,H., Evenepoel,L., Blanc,P., El Khattabi,L.,
            Haque,N., Dsouza,N.R., Zimmermann,M.T., Urrutia,R., Klee,E.W.,
            Shen,Y., Du,H., Rappaport,L., Liu,C.M. and Chen,X.
  TITLE     MARK2 variants cause autism spectrum disorder via the
            downregulation of WNT/beta-catenin signaling pathway
  JOURNAL   Am J Hum Genet 111 (11), 2392-2410 (2024)
   PUBMED   39419027
REFERENCE   3  (bases 1 to 4037)
  AUTHORS   Renaux,E., Baudouin,C., Schakman,O., Gay,O., Martin,M.,
            Marchese,D., Achouri,Y., Rezsohazy,R., Gofflot,F. and Clotman,F.
  TITLE     Arid3c identifies an uncharacterized subpopulation of V2
            interneurons during embryonic spinal cord development
  JOURNAL   Front Cell Neurosci 18, 1466056 (2024)
   PUBMED   39479525
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4037)
  AUTHORS   Arekatla,G., Skylaki,S., Corredor Suarez,D., Jackson,H.,
            Schapiro,D., Engler,S., Auler,M., Camargo Ortega,G., Hastreiter,S.,
            Reimann,A., Loeffler,D., Bodenmiller,B. and Schroeder,T.
  TITLE     Identification of an embryonic differentiation stage marked by Sox1
            and FoxA2 co-expression using combined cell tracking and high
            dimensional protein imaging
  JOURNAL   Nat Commun 15 (1), 7860 (2024)
   PUBMED   39251590
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4037)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4037)
  AUTHORS   Malas,S., Sartor,M., Duthie,S., Hadjantonakis,K., Lovell-Badge,R.
            and Episkopou,V.
  TITLE     Genetic and physical mapping of the murine Sox1 gene
  JOURNAL   Mamm Genome 7 (8), 620-621 (1996)
   PUBMED   8678988
REFERENCE   7  (bases 1 to 4037)
  AUTHORS   Collignon,J., Sockanathan,S., Hacker,A., Cohen-Tannoudji,M.,
            Norris,D., Rastan,S., Stevanovic,M., Goodfellow,P.N. and
            Lovell-Badge,R.
  TITLE     A comparison of the properties of Sox-3 with Sry and two related
            genes, Sox-1 and Sox-2
  JOURNAL   Development 122 (2), 509-520 (1996)
   PUBMED   8625802
REFERENCE   8  (bases 1 to 4037)
  AUTHORS   Behlke,M.A., Bogan,J.S., Beer-Romero,P. and Page,D.C.
  TITLE     Evidence that the SRY protein is encoded by a single exon on the
            human Y chromosome
  JOURNAL   Genomics 17 (3), 736-739 (1993)
   PUBMED   8244390
REFERENCE   9  (bases 1 to 4037)
  AUTHORS   Wright,E.M., Snopek,B. and Koopman,P.
  TITLE     Seven new members of the Sox gene family expressed during mouse
            development
  JOURNAL   Nucleic Acids Res 21 (3), 744 (1993)
   PUBMED   8441686
REFERENCE   10 (bases 1 to 4037)
  AUTHORS   Gubbay,J., Collignon,J., Koopman,P., Capel,B., Economou,A.,
            Munsterberg,A., Vivian,N., Goodfellow,P. and Lovell-Badge,R.
  TITLE     A gene mapping to the sex-determining region of the mouse Y
            chromosome is a member of a novel family of embryonically expressed
            genes
  JOURNAL   Nature 346 (6281), 245-250 (1990)
   PUBMED   2374589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102525.8.
            
            On Jan 12, 2008 this sequence version replaced NM_009233.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB108672.1, SRR7345562.2438268.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4037              AC102525.8         152991-157027
FEATURES             Location/Qualifiers
     source          1..4037
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..4037
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
                     /note="SRY (sex determining region Y)-box 1"
                     /db_xref="GeneID:20664"
                     /db_xref="MGI:MGI:98357"
     exon            1..4037
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             843..2018
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
                     /note="SRY-box containing gene 1"
                     /codon_start=1
                     /product="transcription factor SOX-1"
                     /protein_id="NP_033259.2"
                     /db_xref="CCDS:CCDS57605.1"
                     /db_xref="GeneID:20664"
                     /db_xref="MGI:MGI:98357"
                     /translation="MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGT
                     KANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFID
                     EAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVG
                     VGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPG
                     AGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGI
                     PYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRA
                     PCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3648
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
                     /note="major polyA site"
     regulatory      3881..3886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
                     /note="hexamer: TATAAA"
     polyA_site      3904
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
     regulatory      4012..4017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
                     /note="hexamer: AATAAA"
     polyA_site      4037
                     /gene="Sox1"
                     /gene_synonym="Sox-1"
ORIGIN      
        1 gtcactcgcc agcgcgccat gcaaatcacc gccgccgccg gttcccattg gccgcggcgc
       61 gctcatttaa tggcagcccg ggcccggcgt atggctgctg ggccccccgc gccaccggcc
      121 ccgcgtgcgc ctccgctccg agcgcacggc ctcgggcagg cagcggacag cttgtcctgg
      181 gcacagcggc acagctctct ggctctctgc tcgcgttggc actcccactg ctgtccctaa
      241 ccccctccct ggctgcaccg cgatcgcccc ctccgaaccc ccctccgagt ccccctcagc
      301 gcctggctcc ccccaggcac ctgggaccag cacatgccca gcgcacgcgg cgcaccgcct
      361 tgctagaagt tgcggtccca gagttggaag ccgccaagga agccagcaca ggaacggaga
      421 cttcgagccg acaagaggag gcagcgaacc ctgcgtcggg cccaggggca ccgcttcaga
      481 cccagaaagt ggagcctcaa cttggccacg actgcacctg tttgcacagt tcagccctga
      541 gtgaccggac ggcagcaatc aacctggcca tcggcctctt tggcaagtgg tttgtgcacc
      601 gggagaaact ttccacctgc gagctggacc cgcgctaagt gcgtgtgctt ttgcctcttt
      661 tttgttgttg ttgttgttgt ggcctccacc caaccccctt ctctccgcta ggcacccacc
      721 gcacacacac cccccccccc agtctctctg ggctgatcct ctctccaccc acccaccccc
      781 acccggccgt ctatgctcca ggccctctct ttgcggtacc ggtgaacccg ctagccgccc
      841 agatgtacag catgatgatg gagaccgacc tgcactcgcc cggcggcgcc caggcgccca
      901 cgaacctctc gggcccggcc ggggcgggcg ggggcggcgg tgggggcggg ggcggcggcg
      961 gcggcggggg caccaaggcc aaccaggatc gggtcaagcg gcccatgaac gccttcatgg
     1021 tgtggtcccg cggacagcgg cgcaagatgg cccaggaaaa ccccaagatg cacaactcgg
     1081 agatcagcaa gcgcctcggg gccgagtgga aggtcatgtc cgaggccgag aagcggccgt
     1141 tcatcgacga ggccaagaga ctgcgcgcgc tgcacatgaa ggaacacccg gattacaagt
     1201 accggccgcg ccgcaagacc aagacgctgc tcaagaagga caagtactcg ctggccggcg
     1261 ggctgctagc ggccggcgcg ggtggcggcg gcgcggccgt ggccatgggt gtgggcgtgg
     1321 gcgtcggggc ggcggcggtg ggccagcgct tggagagccc aggcggcgcg gcgggaggag
     1381 gctacgcgca tgtcaacggc tgggctaacg gcgcctaccc cggctcggtg gccgcggcgg
     1441 ctgcggccgc ggccatgatg caggaggcac agctggccta cgggcagcac ccaggcgcgg
     1501 gcggcgcgca cccgcacgca cacccggcgc acccgcaccc gcaccatccg cacgcgcatc
     1561 ctcacaaccc gcagcccatg caccgctacg acatgggcgc gctgcagtac agccccatct
     1621 ccaactctca gggctacatg agcgcgtcgc cttcgggcta cggcggcatc ccttacggcg
     1681 ccgcggccgc cgccgccgcc gctgcgggcg gcgcgcacca gaactcggcg gtggcggcag
     1741 cggcagccgc ggcagccgcg tcgtcggggg ccctgggcgc cctcggatct ctggtcaagt
     1801 cggagccgag cggcagtccg ccggccccgg ctcactcacg ggcaccgtgt cccggggacc
     1861 tgcgcgagat gatcagcatg tacctgcccg ccggcgaggg tggcgacccg gcggcggcag
     1921 cggctgcggc ggcccaaagc cggctgcact cgctgccaca gcactaccag ggcgcgggcg
     1981 cgggcgtcaa cggcacggtg cccctgacgc acatctagcg ccgcggggac gccggggaca
     2041 ctgcggctta aggccggcgc cccggcgacg aagagcgagg cctgcgcccc agcctccaga
     2101 gcccgacttt gtaccgaggt ccccgcgctc tcgataaaag gccgctctgg agagccgagc
     2161 gccaggtgac atctgccccc atcaccttcc ccaggactcc gaggcgctga caccagactg
     2221 gcctcttaga ctgaactttg gtgttttcat gagacctttt gtacagtatt tatcgtccgc
     2281 agaggaggca cacagcgttt tctcggcttc ggaggacaaa agacaaaaac ccagcgaggc
     2341 gatgccaact tttgtatgac tgccggctct gtaacttttt ccggggttta cttcccgcca
     2401 gctcttctgc ctgaggccga gtgacggacc tcgagccctt ctcacttgtt ataaatctaa
     2461 gtaaggcaga tccaaacatt tacaagtttt ttgtagttgt taccgctctt ttgggttggt
     2521 tggttaattt ataccgcaat cccctctcag acggtggagt tatattctgg gttttgtaaa
     2581 tctctgtatc cgagcatttc caattttttg ttttgttttg tattatttct tgtaaatgcg
     2641 ttgtgacatt tttattttag gcgttgcgat acggggggaa gaggagtcgg atgttgtaca
     2701 tagcctgcaa gtctttcatc taaaagcaaa aaacaaagag agataccccc aaaatgcatc
     2761 aaatttgaat caatacattt aagagagaaa agcccgtttc cctgtgaaat cgaaacgtgc
     2821 taattttata tgcatgtttt atgagttcaa aatacaatta gcaatctgtt ggaggagaaa
     2881 ttatctgcag ggcccaagag taaggaaatc ccaccaagcg gagtgcagcg tttccgtgac
     2941 tttattcggt ggggaaagag aaatcttaaa ctccatagat tattttgtag agttcaagtt
     3001 gacacagaag ggaagtaatt acaaaatgct tcctaatggt ttagcgtttt aactgccatg
     3061 gccctggctt attttttttt gcatttcttt cctgtggttc tgccttttgc atactgtagc
     3121 agttttgagg cagctgggtc tcagaaggag gatgggttgt gctcagtggt gggacaaggc
     3181 caaggatagg gacaacagcc accgccaaga cagcgtgcct ttgatttctc tgtaattgga
     3241 attgtaagtg aaattatctt cctgtgcttc aaggaagcaa tcctgaccca gacctcacca
     3301 ccacagagtc tctcacccag gtcttatccc atcccctccc gattcctctc tgggaaaatc
     3361 caacataatt ctaccgattt tcttacacac acacacacac acacacacac acacactctc
     3421 tcctgtgtga accgggatgc agattgccag ggaatgtaaa cacagaatgc tgtgtttatc
     3481 attcctgacc agatcttgag gttgtttgat gctttaaata tttttaatta tattttttct
     3541 aggtgtttat tggtatattg caggtccccc ccccctggaa tttaaagttc cctgtaaaac
     3601 tttgtcttca agtaatctga cagcattaaa tattgcattt aaaagttata ctgtagcaaa
     3661 tatgttttaa aattaatcat gacattagaa tgaaattcta tttttgaagg aaattttctt
     3721 taagtccaga tggggaatga tactattttc agcatccttt cccctgattt tttcccaatt
     3781 tcttttcttg gaatgaatat ggactagcca ttcaaaagtg gacttaatct agcaattcag
     3841 taagaccaga gctcaaccta cattggagaa tatctttcag tataaatgct aatattacaa
     3901 gtgacacgtg tgattttttt taaagtcatt taatgatttt gcttaaaccc ctcattcctt
     3961 aaagtgattg caagagattc aagaatgacg cccactgctt tctgatgagg taataaaaga
     4021 acacccctcc ctttttc
//
