LOCUS       NM_025312               1751 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus sclerostin domain containing 1 (Sostdc1), mRNA.
ACCESSION   NM_025312 XM_914279
VERSION     NM_025312.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1751)
  AUTHORS   Wang,Y., Wang,J., Xu,T., Yang,S., Wang,X., Zhu,L., Li,N., Liu,B.,
            Xiao,J. and Liu,C.
  TITLE     Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor
            Agenesis and Molar Microdontia
  JOURNAL   Int J Mol Sci 25 (13), 7045 (2024)
   PUBMED   39000154
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1751)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1751)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   4  (bases 1 to 1751)
  AUTHORS   Choi,R.B., Hoggatt,A.M., Horan,D.J., Rogers,E.Z., Loots,G.G. and
            Robling,A.G.
  TITLE     Sostdc1 Suppression in the Absence of Sclerostin Potentiates
            Anabolic Action of Cortical Bone in Mice
  JOURNAL   J Bone Miner Res 38 (5), 765-774 (2023)
   PUBMED   36891756
  REMARK    GeneRIF: Sostdc1 Suppression in the Absence of Sclerostin
            Potentiates Anabolic Action of Cortical Bone in Mice.
REFERENCE   5  (bases 1 to 1751)
  AUTHORS   Van Otterloo,E., Milanda,I., Pike,H., Thompson,J.A., Li,H.,
            Jones,K.L. and Williams,T.
  TITLE     AP-2alpha and AP-2beta cooperatively function in the craniofacial
            surface ectoderm to regulate chromatin and gene expression dynamics
            during facial development
  JOURNAL   Elife 11, e70511 (2022)
   PUBMED   35333176
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1751)
  AUTHORS   Bouma,G.J., Hart,G.T., Washburn,L.L., Recknagel,A.K. and
            Eicher,E.M.
  TITLE     Using real time RT-PCR analysis to determine multiple gene
            expression patterns during XX and XY mouse fetal gonad development
  JOURNAL   Gene Expr Patterns 5 (1), 141-149 (2004)
   PUBMED   15533830
REFERENCE   7  (bases 1 to 1751)
  AUTHORS   Yanagita,M., Oka,M., Watabe,T., Iguchi,H., Niida,A., Takahashi,S.,
            Akiyama,T., Miyazono,K., Yanagisawa,M. and Sakurai,T.
  TITLE     USAG-1: a bone morphogenetic protein antagonist abundantly
            expressed in the kidney
  JOURNAL   Biochem Biophys Res Commun 316 (2), 490-500 (2004)
   PUBMED   15020244
REFERENCE   8  (bases 1 to 1751)
  AUTHORS   Laurikkala,J., Kassai,Y., Pakkasjarvi,L., Thesleff,I. and Itoh,N.
  TITLE     Identification of a secreted BMP antagonist, ectodin, integrating
            BMP, FGF, and SHH signals from the tooth enamel knot
  JOURNAL   Dev Biol 264 (1), 91-105 (2003)
   PUBMED   14623234
  REMARK    GeneRIF: Data suggest that ectodin is a novel bone morphogenetic
            protein (BMP) inhibitor which integrates BMP signaling with the SHH
            and FGF signal pathways
REFERENCE   9  (bases 1 to 1751)
  AUTHORS   Menke,D.B. and Page,D.C.
  TITLE     Sexually dimorphic gene expression in the developing mouse gonad
  JOURNAL   Gene Expr Patterns 2 (3-4), 359-367 (2002)
   PUBMED   12617826
REFERENCE   10 (bases 1 to 1751)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            GH455028.1, AK002396.1 and AK002240.1.
            
            On May 14, 2009 this sequence version replaced NM_025312.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002240.1, AK007967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               GH455028.1         103-435
            334-1666            AK002396.1         278-1610
            1667-1751           AK002240.1         1606-1690
FEATURES             Location/Qualifiers
     source          1..1751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.82 cM"
     gene            1..1751
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /note="sclerostin domain containing 1"
                     /db_xref="GeneID:66042"
                     /db_xref="MGI:MGI:1913292"
     exon            1..330
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..746
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /note="uterine sensitization-associated protein 1;
                     sclerostin domain-containing protein 1; ectodermal BMP
                     inhibitor; cystine-knot containing secreted protein;
                     sclerostin-like protein; uterine sensitization-associated
                     gene 1 protein"
                     /codon_start=1
                     /product="sclerostin domain-containing protein 1
                     precursor"
                     /protein_id="NP_079588.1"
                     /db_xref="CCDS:CCDS25887.1"
                     /db_xref="GeneID:66042"
                     /db_xref="MGI:MGI:1913292"
                     /translation="MLPPAIHLSLIPLLCILMRNCLAFKNDATEILYSHVVKPVPAHP
                     SSNSTLNQARNGGRHFSSTGLDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAG
                     ECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVV
                     TACKCKRYTRQHNESSHNFESVSPAKPAQHHRERKRASKSSKHSLS"
     exon            331..1751
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /note="hexamer: AATAAA"
     polyA_site      1670
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /note="major polyA site"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /note="hexamer: AATAAA"
     polyA_site      1747
                     /gene="Sostdc1"
                     /gene_synonym="0610006G05Rik; ectodin; Sostl; USAG-1;
                     Wise"
                     /note="major polyA site"
ORIGIN      
        1 cctgaatgaa cgccaagcct ctggctatat aaagggaacc ttgggaaggg attccacagt
       61 ccacagtgca gaagcaaggg ggaaagaatt agcggctcct cagcccagca aatcctccac
      121 tcatcatgct tcctcctgcc attcatctct ctctcattcc cctgctctgc atcctgatga
      181 gaaactgttt ggcttttaaa aatgatgcca cagaaatcct ttattcacat gtggttaaac
      241 ctgtcccggc acaccccagc agcaacagca ccctgaatca agccaggaat ggaggcaggc
      301 atttcagtag cactggactg gatcgaaaca gtcgagttca agtgggctgc agggaactgc
      361 ggtccaccaa atacatttcg gacggccagt gcaccagcat cagccctctg aaggagctgg
      421 tgtgcgcggg cgagtgcttg cccctgccgg tgcttcccaa ctggatcgga ggaggctatg
      481 gaacaaagta ctggagccgg aggagctctc aggagtggcg gtgtgtcaac gacaagacgc
      541 gcacccagag gatccagctg cagtgtcagg acggcagcac gcgcacctac aaaatcaccg
      601 tggtcacggc gtgcaagtgc aagaggtaca cccgtcagca caacgagtcc agccacaact
      661 ttgaaagcgt gtcgcccgcc aagcccgccc agcaccacag agagcggaag agagccagca
      721 aatccagcaa gcacagtctg agctagacct ggactgacta gaaagcatct gctacccaga
      781 tttgattgct tggaagactc tctctcgagc ctgccattgc tctttcctca cttgaaagta
      841 tatgctttct gctttgatca agcccagcag gctgtccttc tctgggacta gcttttcctt
      901 tgcaagtgtc tcaagatgta atgagtagtt tgcagtgaaa gccaggcatc ctgtagtttc
      961 catcccctcc cccatcccag tcatttcttt aaaagcacct gatgctgcat tctgttacag
     1021 tttaaaaaaa aaaaaaaaca aaaaacgctc ctttccctaa accccttccc aaactaaatc
     1081 cctccgaacc agagaagttc gtggaaaaaa atgtatcttc ccagaacatt tcagaaaggg
     1141 gcttttccag tcgtttttat gggaatagtt tgacagccag gggttagttt tgaaagagag
     1201 gcaaaccttg tgacatttca cttcaaaaaa cagcccggtg gcatttttcc agtctcagtg
     1261 tgaaattatc cccctgaatg ttgacctctc tgggagtgga atgccagcaa ttcatggcag
     1321 cagctaatag gtaaagccgg ttatttattt gtcaatgttg ttatttaatg agctcttgca
     1381 tgtgattttt tttcaaaatg ttaatttttt ttatgttttg aagctttttc atgtacctaa
     1441 atatttccca atacgatttg tggttggtct agaaatatga aaatatctgt tgtagatatg
     1501 taaaataaat gttttactct ccgtatatat tgcacggttc accatcatca ttagcgtggt
     1561 tttctgtaaa gctgaagtat gtaatacttt attatttagt ccatgaaatc agatggcagc
     1621 ttgatcttca atgccattgg tttcctttaa taaacataaa cactgctcaa cgctgttgtc
     1681 cttgcctcta acatgtataa aaaggtacat gcttgcagac attgtaaaat aaagttatac
     1741 gctgtaatcg c
//
