LOCUS       NM_001135559            5612 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus SOS Ras/Rho guanine nucleotide exchange factor 2
            (Sos2), mRNA.
ACCESSION   NM_001135559 XM_127051 XM_916574
VERSION     NM_001135559.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5612)
  AUTHORS   Gomez,C., Garcia-Navas,R., Baltanas,F.C., Fuentes-Mateos,R.,
            Fernandez-Medarde,A., Calzada,N. and Santos,E.
  TITLE     Critical Requirement of SOS1 for Development of BCR/ABL-Driven
            Chronic Myelogenous Leukemia
  JOURNAL   Cancers (Basel) 14 (16), 3893 (2022)
   PUBMED   36010887
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5612)
  AUTHORS   Baltanas,F.C., Garcia-Navas,R. and Santos,E.
  TITLE     SOS2 Comes to the Fore: Differential Functionalities in Physiology
            and Pathology
  JOURNAL   Int J Mol Sci 22 (12), 6613 (2021)
   PUBMED   34205562
  REMARK    GeneRIF: SOS2 Comes to the Fore: Differential Functionalities in
            Physiology and Pathology.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5612)
  AUTHORS   Suire,S., Baltanas,F.C., Segonds-Pichon,A., Davidson,K., Santos,E.,
            Hawkins,P.T. and Stephens,L.R.
  TITLE     Frontline Science: TNF-alpha and GM-CSF1 priming augments the role
            of SOS1/2 in driving activation of Ras, PI3K-gamma, and neutrophil
            proinflammatory responses
  JOURNAL   J Leukoc Biol 106 (4), 815-822 (2019)
   PUBMED   30720883
REFERENCE   4  (bases 1 to 5612)
  AUTHORS   Jun,J.E., Kulhanek,K.R., Chen,H., Chakraborty,A. and Roose,J.P.
  TITLE     Alternative ZAP70-p38 signals prime a classical p38 pathway through
            LAT and SOS to support regulatory T cell differentiation
  JOURNAL   Sci Signal 12 (591) (2019)
   PUBMED   31337738
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5612)
  AUTHORS   Sheffels,E., Sealover,N.E., Wang,C., Kim,D.H., Vazirani,I.A.,
            Lee,E., M Terrell,E., Morrison,D.K., Luo,J. and Kortum,R.L.
  TITLE     Oncogenic RAS isoforms show a hierarchical requirement for the
            guanine nucleotide exchange factor SOS2 to mediate cell
            transformation
  JOURNAL   Sci Signal 11 (546) (2018)
   PUBMED   30181243
  REMARK    GeneRIF: Results indicat son of sevenless homolog 2 protein (SOS2)
            critically mediated mutant KRAS-driven, but not HRAS-driven,
            transformation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5612)
  AUTHORS   Oliver,G., Wehr,R., Jenkins,N.A., Copeland,N.G., Cheyette,B.N.,
            Hartenstein,V., Zipursky,S.L. and Gruss,P.
  TITLE     Homeobox genes and connective tissue patterning
  JOURNAL   Development 121 (3), 693-705 (1995)
   PUBMED   7720577
REFERENCE   7  (bases 1 to 5612)
  AUTHORS   Cherniack,A.D., Klarlund,J.K., Conway,B.R. and Czech,M.P.
  TITLE     Disassembly of Son-of-sevenless proteins from Grb2 during p21ras
            desensitization by insulin
  JOURNAL   J Biol Chem 270 (4), 1485-1488 (1995)
   PUBMED   7829473
REFERENCE   8  (bases 1 to 5612)
  AUTHORS   Avraham,K.B., Fletcher,C., Overdier,D.G., Clevidence,D.E., Lai,E.,
            Costa,R.H., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of eight members of the hepatocyte
            nuclear factor 3/fork head winged helix family of transcription
            factors
  JOURNAL   Genomics 25 (2), 388-393 (1995)
   PUBMED   7789972
REFERENCE   9  (bases 1 to 5612)
  AUTHORS   Chardin,P. and Mattei,M.G.
  TITLE     Chromosomal localization of two genes encoding human ras exchange
            factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the
            14q21-->q22 region of the human genome
  JOURNAL   Cytogenet Cell Genet 66 (1), 68-69 (1994)
   PUBMED   8275713
REFERENCE   10 (bases 1 to 5612)
  AUTHORS   Bowtell,D., Fu,P., Simon,M. and Senior,P.
  TITLE     Identification of murine homologues of the Drosophila son of
            sevenless gene: potential activators of ras
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6511-6515 (1992)
   PUBMED   1631150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141560.4, AC133949.4 and AC153658.4.
            
            On or before Oct 3, 2008 this sequence version replaced
            XM_916574.3, XM_127051.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC141560.4         40148-40485         c
            339-464             AC133949.4         7124-7249
            465-596             AC133949.4         14471-14602
            597-761             AC133949.4         16586-16750
            762-968             AC153658.4         961-1167
            969-1112            AC153658.4         5496-5639
            1113-1223           AC153658.4         9051-9161
            1224-1322           AC153658.4         13906-14004
            1323-1447           AC153658.4         23041-23165
            1448-2103           AC153658.4         23712-24367
            2104-2185           AC153658.4         24857-24938
            2186-2308           AC153658.4         26463-26585
            2309-2412           AC153658.4         30395-30498
            2413-2635           AC153658.4         33809-34031
            2636-2755           AC153658.4         37317-37436
            2756-2918           AC153658.4         37583-37745
            2919-3036           AC153658.4         42328-42445
            3037-3209           AC153658.4         44405-44577
            3210-3326           AC153658.4         48173-48289
            3327-3588           AC153658.4         50265-50526
            3589-3630           AC153658.4         52480-52521
            3631-3740           AC153658.4         54503-54612
            3741-5612           AC153658.4         55589-57460
FEATURES             Location/Qualifiers
     source          1..5612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.93 cM"
     gene            1..5612
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /note="SOS Ras/Rho guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:20663"
                     /db_xref="MGI:MGI:98355"
     exon            1..338
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..4250
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /codon_start=1
                     /product="son of sevenless homolog 2"
                     /protein_id="NP_001129031.1"
                     /db_xref="CCDS:CCDS59573.1"
                     /db_xref="GeneID:20663"
                     /db_xref="MGI:MGI:98355"
                     /translation="MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEES
                     LYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNP
                     LLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQ
                     DIKVSMCADKVLMDMFDQDDDIGLVSLCEDEPCSSGELNYYDLVRTEIAEERQYLREL
                     NMIIKVFREAFLLDRKLFKPSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHP
                     LAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIADGFKEAV
                     RYVLPRLMLVPVYHCWHYFELLKLKACSEEQEDKECLNQAITALMNLQGSMDRIYKQH
                     SPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTR
                     IGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEY
                     RHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLR
                     LPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRT
                     FLTTYRSFCKPQELLNLLIERFEIPEPEPTEADKLALEKGEQPISADLKRFRKEYVQP
                     VQLRVLNVFRHWVEHHYYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQ
                     AQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLHPIEIARQLTLLESDLYRKVQ
                     PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVEI
                     LQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILDDAVELSQDHFKKYL
                     VKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQY
                     QNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRFPRKST
                     FSLKSPGIRPNAGRHGSTSGTLRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNT
                     PSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKTFFSSCGSLHKLSEEPLIP
                     PPLPPRKKFDHDALNSKGAVKSDDDPPAIPPRQPPPPKVKPRVPVLMGTFDGPVPSPP
                     PPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPSTP
                     PTTPSPRIPRSCHLLSSSHSSLAHLPAPPVPPRQNSSPLLPKLPPKTYKRELSHPPLY
                     RLPLLENAETPQ"
     exon            339..464
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..596
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..761
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..968
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1112
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1223
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1322
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1447
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..2103
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2185
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2308
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2412
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2635
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2755
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2918
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3036
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3209
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3326
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3588
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3589..3630
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3740
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..5612
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5582..5587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /note="hexamer: AATAAA"
     polyA_site      5611
                     /gene="Sos2"
                     /gene_synonym="mSOS-2; SOS-2"
                     /note="major polyA site"
ORIGIN      
        1 ggaggagcct cgggccagcg ggccggcgcc gcggggacag caggacgcct cgggccgccg
       61 cgcttcctcg gggctgcggg gccgccaagc ctcggcgaac gcccgcccgc cggcgccgcc
      121 cccgagcgct cggccggagc tgcggcccgg gcgggaggcg gcggccgggg cgaggcgagg
      181 cgaggcggcc ggcgccctgc ctgtcaggcc accggcccgg cctccgatgc ggaggcgctg
      241 cggccggggc catgcagcag gcgccgcagc cctacgagtt cttcagcgaa gaaaacagcc
      301 cgaaatggcg gggactattg gtcccggccc tgcggaaggt tcaggagcaa gtacatccca
      361 ccctctcagc taatgaagag tctctctatt atattgaaga actgattttt cagctgctta
      421 ataagctatg catggctcaa ccaaggactg ttcaagatgt tgaggaacga gttcaaaaga
      481 cctttcctca tcctattgat aaatgggcaa ttgctgatgc acaatctgct atagagaaac
      541 gaaaacgaag aaatcctctc ttactacctg tggacaaaat ccatccttcc ttgaaggaag
      601 ttttggggta taaagtggac taccatgtgt ccctctacat tgtggctgta ttggagtata
      661 tctcagcaga tattttgaaa ttggctggta attatgtttt taatatccgg cattatgaaa
      721 tatctcagca agacattaaa gtgtccatgt gtgcagataa ggttttgatg gacatgttcg
      781 atcaggatga tgatataggc ttggtttctc tctgtgaaga tgagccttgt tcttctggtg
      841 agctaaacta ttatgacctc gtcaggactg aaattgcaga agaaagacag tatctacggg
      901 agctgaatat gatcattaaa gtgttccggg aagcctttct cttggacaga aagttgttca
      961 agccttctga aattgaaaag attttcagta acatttcaga tatacatgaa ttgactgtga
     1021 aacttttagg tttaattgaa gacacagtag aaatgacaga tgaaagtagt cctcatccat
     1081 tagctggtag ctgttttgaa gatttagcag aggagcaagc gtttgatccc tatgaaacat
     1141 tatcacagga cattcttgca ccagagttta atgaccactt cagcaagttg atggccagac
     1201 ctgcagtcgc tctacatttt cagtccattg ctgacggctt taaggaggct gttcgttatg
     1261 tccttccacg cctcatgctg gttcccgtgt atcactgttg gcattacttt gaattattaa
     1321 agttgaaggc atgcagtgaa gagcaggagg acaaagagtg cttgaatcag gctataactg
     1381 ccctcatgaa cctccaaggc agcatggacc gcatttacaa gcagcactcc cccagacgcc
     1441 ggcctgggga tccagtttgc cttttttaca atcgtcaatt aagaagcaaa cacctggcta
     1501 tcaaaaaaat gaatgaaatt cagaaaaaca tagatgggtg ggaaggcaaa gatatcggac
     1561 agtgttgtaa tgagttcata atggaggggc cactgaccag aattggtgct aaacacgaaa
     1621 ggcatatctt tctctttgat ggcttaatga tcagctgtaa acccaatcat ggccagaccc
     1681 ggcttccagg atatagcagt gcagaataca gattaaagga gaagtttgtc atgaggaaaa
     1741 ttcaaatctg tgataaggaa gacgcctgtg agtacagaca tgcttttgaa ttagtgtcca
     1801 aagatgaaaa cagtgtaata tttgctgcca aatcagctga agagaaaaac aactggatgg
     1861 cagccctcat ttccctgcac tatcgcagca ctctagacag aatgctggac tctgtgctgc
     1921 tgaaagaaga gaatgagcag cccctgaggc tacccagtcc agatatgtat cgctttgtgg
     1981 taacagactc tgaggaaaac attgtgtttg aagacaactt gcaaagcaga agtgggatcc
     2041 ccataattaa aggaggcact gtggtgaagt tgatcgaaag gctaacatac cacatgtatg
     2101 cagatcccaa ttttgttcgt acttttctta ctacatatcg ttcattttgt aaaccacagg
     2161 aattgctaaa cttgctgata gaacggtttg aaattccaga accagaacct actgaggcag
     2221 acaagctggc gttagaaaaa ggcgagcagc caatcagcgc agatctgaaa agattccgca
     2281 aggaatacgt ccaacctgtg cagcttaggg tcttgaatgt ctttcgccac tgggttgagc
     2341 atcattatta tgactttgaa agagacttgg aactgcttga aagactagaa tccttcattt
     2401 caagtgtaag agggaaagcc atgaagaaat gggtagaatc cattgctaaa ataatcaaga
     2461 ggaagaagca agctcaggca aatggaataa gccataatat cacctttgaa agttcccccc
     2521 caccagtgga atggcacatc agtagaacag gacagttcga aacatttgac cttatgacac
     2581 ttcatccaat agagatcgca cggcagctaa cacttttgga atctgacctc tacaggaaag
     2641 tccagccctc tgaacttgta gggagtgtct ggaccaaaga agataaagaa ataaattctc
     2701 caaacttatt aaaaatgatt cgccatacaa caaacctcac cctatggttt gagaaatgca
     2761 ttgtggaagc agaaaacttt gaagaacggg tggcagtgct cagcagaata gtagaaattc
     2821 tgcaagtatt tcaagacttg aataatttca atggcgtgtt ggagatagtg agtgcagtca
     2881 actccgtgtc agtgtacagg ctagaccaca cgtttgaggc actgcaggaa aggaagcgga
     2941 gaattttgga tgacgctgtg gaactaagtc aggaccactt taaaaagtac ctagtaaaac
     3001 ttaagtcaat caatccgcct tgtgtgcctt tttttggaat atatttaaca aatattctga
     3061 agactgaaga agggaacagt gactttctaa agaggaaagg gaaagatttg atcaatttca
     3121 gtaagaggag gaaagtggct gaaataactg gagagatcca gcagtatcag aaccaaccgt
     3181 actgcttacg gacagaacca gaaatgagga gattctttga aaacctcaac cccatgggaa
     3241 ttttatctga aaaagagttt acagattatt tgttcaacaa atcattagaa atcgaacccc
     3301 gaaactgcaa acaaccacct cgatttccta ggaagtcaac cttttcctta aaatctcctg
     3361 gaataaggcc caatgctggc cgccatggct ctacctcagg cacgctacga ggtcacccaa
     3421 cgcctctgga aagagagcct tataagataa gctttagccg gatcgctgag acagagctag
     3481 aatcaacagt gtctgcacca acctccccca acactccatc caccccacca gtgtctgctt
     3541 cttcagacca cagcgtgttt ctagatgtgg acctcaatag ctcctgtggc agcaacacca
     3601 tctttgctcc agtcctcttg ccacactcaa agactttctt cagctcatgt ggaagtttac
     3661 acaaactgag tgaagagcca ctaattcctc ctccgcttcc ccctcggaaa aagtttgatc
     3721 atgatgctct caattccaag ggagctgtga aatctgatga tgaccctcct gctattccac
     3781 caagacagcc ccctcctccg aaggtaaagc caagagttcc tgtcctcatg ggtacatttg
     3841 atgggcctgt gcccagtcca cctccacctc ctccaagaga ccctcttcct gatacccctc
     3901 caccagttcc tcttcggcct ccggaacact ttataaactg tccatttaat cttcagccgc
     3961 ctccactggg ccatcctcac agagacccag actggctcag agacgtcagc acgtgtccta
     4021 actcaccaag cactcctccc actacgccct ctccacggat tccacgcagc tgtcacttgc
     4081 tcagctccag tcacagcagc cttgctcatc ttccagctcc tcctgtccca ccaaggcaga
     4141 attcaagccc tctcttacca aagctgccac caaagactta caaacgggag ctttcccacc
     4201 cgccactgta tagactgcct ctgctggaaa atgcagaaac tcctcaatga ccttggccat
     4261 atgtagtcat tgacactgga atagtatttg taaaggtttt taatttattc aaaaagacat
     4321 agtattttag tactttttac agaaatgcta ctgattaaat aagctcttaa gaattagtaa
     4381 acttgttgga tggcagtggc ccacagctgt aatcccagca ccctggttgc aggggcaggt
     4441 gggcttcagg gtttgagagc agcctggtct acagagcaag tcccaggaca gccagggcta
     4501 cacaaaaaaa ccttgtctca aaagtcaaaa tacaaacaaa agagagaaaa ggaaggaagg
     4561 aaagaatttg aaatattaaa atgcaaaagc ccttcaccat agcccccagg tgatcagcag
     4621 cattgcttcc tcggctcccc agtgctgccc taggccagta taaagactct gtattgcact
     4681 gtagactctg ctagcagacg gcactgagag gagccagcgc tcgagggcgt tctcacgcct
     4741 gactgataga taccttttta gggtgatgaa cttacacaga tgcagaagat atggggtggt
     4801 ggtcctgggt tttaaccctc tgaccgtctt ctagcttcta attttgtttg gtttttacat
     4861 ctaggagact taggaataat acccactgtt cttaaactct ttgagaccat gtcttaaatg
     4921 tcagtatttg ctgctgaaga caaaaacgga aaatagaatg aaataataga atgcactgtg
     4981 tttattattt tgttaaaatt ataaacagtt ctacataacc tgattataga agaagggcat
     5041 gtgttcatta agatgtgcct tttgttttgc agtgtatggt gtttagctaa tcattgttta
     5101 gctaatgatt tgcctattat ttgggaagac aaaattaata tgccatatat gtacagttta
     5161 tttatattgt atatatttaa agataatgct aataacctct ataaatgtaa gtgacttgag
     5221 gcctataata caatctgcta tttgactaat ttgtaagtct ggaacaaaag tgtcttatgg
     5281 cataagaacc aactgccatt gtcaaaccta ttaactgtct ttaatctcgt gttaactgaa
     5341 atttttgaaa agtttttcca gattagtaat atttaaacag aaaatacttt aaaaagcttt
     5401 attaaatttt ttaatcagga taaagctttg ccatttggat actatcattc aaagtgatca
     5461 aggtatgtat gttatgctga tagtgcagta gcagccattg taaagtagcc aaaagccacg
     5521 ttgtttatct actggtctgt ggccttttac tgtgctttgt atcagagttc ttaacaagat
     5581 taataaatca cctcagtctt aatttgtaaa ag
//
