LOCUS       NP_033257               1319 aa            linear   ROD 27-MAR-2025
DEFINITION  son of sevenless homolog 1 [Mus musculus].
ACCESSION   NP_033257
VERSION     NP_033257.2
DBSOURCE    REFSEQ: accession NM_009231.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1319)
  AUTHORS   Baltanas,F.C., Garcia-Navas,R., Rodriguez-Ramos,P., Calzada,N.,
            Cuesta,C., Borrajo,J., Fuentes-Mateos,R., Olarte-San Juan,A.,
            Vidana,N., Castellano,E. and Santos,E.
  TITLE     Critical requirement of SOS1 for tumor development and
            microenvironment modulation in KRASG12D-driven lung adenocarcinoma
  JOURNAL   Nat Commun 14 (1), 5856 (2023)
   PUBMED   37730692
  REMARK    GeneRIF: Critical requirement of SOS1 for tumor development and
            microenvironment modulation in KRAS[G12D]-driven lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1319)
  AUTHORS   Ni,Q.Z., Zhu,B., Ji,Y., Zheng,Q.W., Liang,X., Ma,N., Jiang,H.,
            Zhang,F.K., Shang,Y.R., Wang,Y.K., Xu,S., Zhang,E.B., Yuan,Y.M.,
            Chen,T.W., Yin,F.F., Cao,H.J., Huang,J.Y., Xia,J., Ding,X.F.,
            Qiu,X.S., Ding,K., Song,C., Zhou,W.T., Wu,M., Wang,K., Lui,R.,
            Lin,Q., Chen,W., Li,Z.G., Cheng,S.Q., Wang,X.F., Xie,D. and Li,J.J.
  TITLE     PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic
            Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
  JOURNAL   Adv Sci (Weinh) 10 (2), e2202448 (2023)
   PUBMED   36453576
  REMARK    GeneRIF: PPDPF Promotes the Development of Mutant KRAS-Driven
            Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of
            SOS1.
REFERENCE   3  (residues 1 to 1319)
  AUTHORS   Padmanabhan,R.A., Zyju,D.P., Subramaniam,A.G., Nautiyal,J. and
            Laloraya,M.
  TITLE     Son of sevenless 1 (SOS1), the RasGEF, interacts with ERalpha and
            STAT3 during embryo implantation
  JOURNAL   J Mol Endocrinol 70 (1), e220089 (2022)
   PUBMED   36103132
  REMARK    GeneRIF: Son of sevenless 1 (SOS1), the RasGEF, interacts with
            ERalpha and STAT3 during embryo implantation.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1319)
  AUTHORS   Gomez,C., Garcia-Navas,R., Baltanas,F.C., Fuentes-Mateos,R.,
            Fernandez-Medarde,A., Calzada,N. and Santos,E.
  TITLE     Critical Requirement of SOS1 for Development of BCR/ABL-Driven
            Chronic Myelogenous Leukemia
  JOURNAL   Cancers (Basel) 14 (16), 3893 (2022)
   PUBMED   36010887
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1319)
  AUTHORS   Geng,X., Chen,L., Srinivasan,R.S., Kylat,R.J., Witte,M.H. and
            Erickson,R.J.
  TITLE     Lack of embryonic homozygous or adult heterozygous lymphatic
            phenotypes for a Sos1 mutation and lack of lymphatic embryonic
            phenotypes for a homozygous Cx47 mutation in mice
  JOURNAL   Lymphology 55 (3), 129-134 (2022)
   PUBMED   36446400
  REMARK    GeneRIF: Lack of embryonic homozygous or adult heterozygous
            lymphatic phenotypes for a Sos1 mutation and lack of lymphatic
            embryonic phenotypes for a homozygous Cx47 mutation in mice.
REFERENCE   6  (residues 1 to 1319)
  AUTHORS   Oliver,G., Wehr,R., Jenkins,N.A., Copeland,N.G., Cheyette,B.N.,
            Hartenstein,V., Zipursky,S.L. and Gruss,P.
  TITLE     Homeobox genes and connective tissue patterning
  JOURNAL   Development 121 (3), 693-705 (1995)
   PUBMED   7720577
REFERENCE   7  (residues 1 to 1319)
  AUTHORS   Sakaue,M., Bowtell,D. and Kasuga,M.
  TITLE     A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras
            activation and reveals Ras-dependent and -independent insulin
            signaling pathways
  JOURNAL   Mol Cell Biol 15 (1), 379-388 (1995)
   PUBMED   7799946
REFERENCE   8  (residues 1 to 1319)
  AUTHORS   Mathew,P., Morris,S.W., Kane,J.R., Shurtleff,S.A., Pasquini,M.,
            Jenkins,N.A., Gilbert,D.J. and Copeland,N.G.
  TITLE     Localization of the murine homolog of the anaplastic lymphoma
            kinase (AlK) gene on mouse chromosome 17
  JOURNAL   Cytogenet Cell Genet 70 (1-2), 143-144 (1995)
   PUBMED   7736780
REFERENCE   9  (residues 1 to 1319)
  AUTHORS   den Hertog,J., Tracy,S. and Hunter,T.
  TITLE     Phosphorylation of receptor protein-tyrosine phosphatase alpha on
            Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in
            vivo
  JOURNAL   EMBO J 13 (13), 3020-3032 (1994)
   PUBMED   7518772
REFERENCE   10 (residues 1 to 1319)
  AUTHORS   Bowtell,D., Fu,P., Simon,M. and Senior,P.
  TITLE     Identification of murine homologues of the Drosophila son of
            sevenless gene: potential activators of ras
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6511-6515 (1992)
   PUBMED   1631150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140310.1, CB521016.1 and AC161447.6.
            
            On Nov 3, 2006 this sequence version replaced NP_033257.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995047.1077988.1,
                                           SRR7652917.1248123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.67 cM"
     Protein         1..1319
                     /product="son of sevenless homolog 1"
                     /note="guanine nucleotide releasing factor;
                     son-of-sevenless 1; ras guanine exchange factor"
                     /calculated_mol_wt=150753
     Region          18..95
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          104..177
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          204..389
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(207,211,312,340..341,344..345,347..348,351..352,
                     355..356,359,384,388)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          439..545
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          597..741
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(616,683,687..688,691,694..695,728..729,732,739)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          776..1015
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(809..811,821..822,824..826,828..829,832..833,836,
                     869,872..873,875..877,879..882,884..885,905,911..913,916,
                     929..931,934..936,938..940,942..945,963,967,1007,
                     1010..1011)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          <1017..1305
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          1019..1101
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1078
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1082
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1120
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RPS6KA3.
                     /evidence=ECO:0000250|UniProtKB:Q07889; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     Region          1121..1319
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1147
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RPS6KA3.
                     /evidence=ECO:0000250|UniProtKB:Q07889; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1164
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07889; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1196
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07889; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07889; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     Site            1261
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q62245.2)"
     CDS             1..1319
                     /gene="Sos1"
                     /gene_synonym="4430401P03Rik; 9630010N06"
                     /coded_by="NM_009231.2:531..4490"
                     /db_xref="CCDS:CCDS37704.1"
                     /db_xref="GeneID:20662"
                     /db_xref="MGI:MGI:98354"
ORIGIN      
        1 mqaqqlpyef fseenapkwr gllvpalkkv qgqvhptles nddalqyvee lilqllnmlc
       61 qaqprsasdv eervqksfph pidkwaiada qsaiekrkrr nplslpaeri hhllrevlgy
      121 kidhqvsvyi vavleyisad ilklvgnyvr nirhyeitkq dikvamcadk vlmdmfhqdv
      181 edinilsltd eepstsgeqt yydlvkafma eirqyireln liikvfrepf vsnsklfssn
      241 dvenifsriv dihelsvkll ghiedtvemt degsphplvg scfedlaeel afdpyesyar
      301 dilrpgfhgh flsqlskpga alylqsigeg fkeavqyvlp rlllapvyhc lhyfellkql
      361 eeksedqedk ecmkqaital lnvqsgmeki cskslakrrl sesacrfysq qmkgkqlaik
      421 kmneiqknid gwegkdigqc cnefimegtl trvgakherh iflfdglmic cksnhgqprl
      481 pgassaeyrl kekffmrkvq indkddtsey khafeiilkd gnsvifsaks aeeknnwmaa
      541 lislqyrstl ermldvtvlq eekeeqmrlp saevyrfaep dseenilfee nvqpkagipi
      601 ikagtvlkli erltyhmyad pnfvrtfltt yrsfcrpqel lsllierfei pepepteadr
      661 iaiengdqpl saelkrfrke yiqpvqlrvl nvcrhwvehh fydferdadl lqrmeefigt
      721 vrgkamkkwv esitkiiqrk kiardngpgh nitfqssppt vewhisrpgh ietfdlltlh
      781 pieiarqltl lesdlyravq pselvgsvwt kedkeinspn llkmirhttn ltlwfekciv
      841 etenleerva vvsriieilq vfqelnnfng vlevvsamns spvyrldhtf eqipsrqkki
      901 leeahelsed hykkylaklr sinppcvpff giyltnilkt eegnpevlrr hgkelinfsk
      961 rrrvaeitge iqqyqnqpyc lrvepdikrf fenlnpmgns mekeftdylf nksleieprh
     1021 pkplprfpkk ysyplkspgv rpsnprpgtm rhptplqqep rkisysripe setestasap
     1081 nsprtpltpp pasgtssntd vcsvfdsdhs aspfhsrsas vssislskgt devpvpppvp
     1141 prrrpesapa esspskimsk hldsppaipp rqptskaysp rysisdrtsi sdppesppll
     1201 pprepvrtpd vfsssplhlq ppplgkksdh gnaffpnsps pftppppqtp sphgtrrhlp
     1261 sppltqemdl hsiagppvpp rqstsqlipk lppktykreh thpsmhrdgp pllenahss
//
