LOCUS       NM_019972               6851 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sortilin 1 (Sort1), transcript variant 2, mRNA.
ACCESSION   NM_019972
VERSION     NM_019972.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6851)
  AUTHORS   Wu,C., Ji,C., Qian,D., Li,C., Chen,J., Zhang,J., Bao,G., Xu,G. and
            Cui,Z.
  TITLE     Contribution of ApoB-100/SORT1-Mediated Immune Microenvironment in
            Regulating Oxidative Stress, Inflammation, and Ferroptosis After
            Spinal Cord Injury
  JOURNAL   Mol Neurobiol 61 (9), 6675-6687 (2024)
   PUBMED   38337131
  REMARK    GeneRIF: Contribution of ApoB-100/SORT1-Mediated Immune
            Microenvironment in Regulating Oxidative Stress, Inflammation, and
            Ferroptosis After Spinal Cord Injury.
REFERENCE   2  (bases 1 to 6851)
  AUTHORS   Hubel,E., Neumann,A., Fishman,S., Schaffer,O., Erez,N.,
            Shrkihe,B.A., Shteingard,Y., Gross,T., Shibolet,O., Varol,C. and
            Zvibel,I.
  TITLE     Sortilin in Biliary Epithelial Cells Promotes Ductular Reaction and
            Fibrosis during Cholestatic Injury
  JOURNAL   Am J Pathol 194 (6), 941-957 (2024)
   PUBMED   38493927
  REMARK    GeneRIF: Sortilin in Biliary Epithelial Cells Promotes Ductular
            Reaction and Fibrosis during Cholestatic Injury.
REFERENCE   3  (bases 1 to 6851)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6851)
  AUTHORS   Zaarur,N., Meriin,A.B., Singh,M., Goel,R.K., Zaia,J. and
            Kandror,K.V.
  TITLE     Akt may associate with insulin-responsive vesicles via interaction
            with sortilin
  JOURNAL   FEBS Lett 598 (4), 390-399 (2024)
   PUBMED   38105115
REFERENCE   5  (bases 1 to 6851)
  AUTHORS   Ishiyama,S., Hasegawa,T., Sugeno,N., Kobayashi,J., Yoshida,S.,
            Miki,Y., Wakabayashi,K., Fukuda,M., Kawata,Y., Nakamura,T.,
            Sato,K., Ezura,M., Kikuchi,A., Takeda,A. and Aoki,M.
  TITLE     Sortilin acts as an endocytic receptor for alpha-synuclein fibril
  JOURNAL   FASEB J 37 (7), e23017 (2023)
   PUBMED   37272890
  REMARK    GeneRIF: Sortilin acts as an endocytic receptor for alpha-synuclein
            fibril.
REFERENCE   6  (bases 1 to 6851)
  AUTHORS   Hashiramoto,M. and James,D.E.
  TITLE     Characterization of insulin-responsive GLUT4 storage vesicles
            isolated from 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 20 (1), 416-427 (2000)
   PUBMED   10594043
REFERENCE   7  (bases 1 to 6851)
  AUTHORS   Vincent,J.P., Mazella,J. and Kitabgi,P.
  TITLE     Neurotensin and neurotensin receptors
  JOURNAL   Trends Pharmacol Sci 20 (7), 302-309 (1999)
   PUBMED   10390649
  REMARK    Review article
REFERENCE   8  (bases 1 to 6851)
  AUTHORS   Nielsen,M.S., Jacobsen,C., Olivecrona,G., Gliemann,J. and
            Petersen,C.M.
  TITLE     Sortilin/neurotensin receptor-3 binds and mediates degradation of
            lipoprotein lipase
  JOURNAL   J Biol Chem 274 (13), 8832-8836 (1999)
   PUBMED   10085125
REFERENCE   9  (bases 1 to 6851)
  AUTHORS   Hermans-Borgmeyer,I., Hermey,G., Nykjaer,A. and Schaller,C.
  TITLE     Expression of the 100-kDa neurotensin receptor sortilin during
            mouse embryonal development
  JOURNAL   Brain Res Mol Brain Res 65 (2), 216-219 (1999)
   PUBMED   10064893
REFERENCE   10 (bases 1 to 6851)
  AUTHORS   Morris,N.J., Ross,S.A., Lane,W.S., Moestrup,S.K., Petersen,C.M.,
            Keller,S.R. and Lienhard,G.E.
  TITLE     Sortilin is the major 110-kDa protein in GLUT4 vesicles from
            adipocytes
  JOURNAL   J Biol Chem 273 (6), 3582-3587 (1998)
   PUBMED   9452485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ177243.1, BC056343.1 and BP762146.1.
            
            On Oct 20, 2012 this sequence version replaced NM_019972.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056343.1, AF175279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                CJ177243.1         1-68
            69-6823             BC056343.1         1-6755
            6824-6851           BP762146.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..6851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.9 cM"
     gene            1..6851
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /note="sortilin 1"
                     /db_xref="GeneID:20661"
                     /db_xref="MGI:MGI:1338015"
     exon            1..377
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2555
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; mNTR3; neurotensin receptor 3"
                     /codon_start=1
                     /product="sortilin isoform 2 precursor"
                     /protein_id="NP_064356.2"
                     /db_xref="CCDS:CCDS17756.1"
                     /db_xref="GeneID:20661"
                     /db_xref="MGI:MGI:1338015"
                     /translation="MERPRGAADGLLRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPP
                     LLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHV
                     FDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLIN
                     NTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQM
                     MYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCK
                     ADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDT
                     WSMAQLPSVGQEQFYSILAANEDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHL
                     YTTTGGETDFTNVTSLRGVYITSTLSEDNSIQSMITFDQGGRWEHLRKPENSKCDATA
                     KNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDD
                     GGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFTQEPIY
                     FTGLASEPGARSMNISIWGFTESFITRQWVSYTVDFKDILERNCEEDDYTTWLAHSTD
                     PGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQPSVCPCSLEDFLCDFGYFRPEN
                     ASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDKCQGGMNPAREVKDLKKKCTS
                     NFLNPTKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAE
                     ADGVEALDSTSHAKSGYHDDSDEDLLE"
     exon            378..437
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..511
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..614
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..779
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..853
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..903
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1034
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1179
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1335
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1442
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1545
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1714
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1905
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2095
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2212
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2321
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2428
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2540
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..6831
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6730..6735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /note="hexamer: AATAAA"
     polyA_site      6755
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /note="major polyA site"
     regulatory      6796..6801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /note="hexamer: AATAAA"
     polyA_site      6828
                     /gene="Sort1"
                     /gene_synonym="2900053A11Rik; Ntr3; Ntsr3"
                     /note="major polyA site"
ORIGIN      
        1 ggggtgtggc gcagcgccgg cgggggtggg cgggcgcgcc gggtggcagg tgtcagcggc
       61 gtctgcattc ggcagcgatg gagcggcccc ggggagctgc ggacggcctt ttgcgctggc
      121 ccctcggcct cctcctgctc cttcaactgc tgcctcctgc cgccgtcggc caggaccggc
      181 tggacgcgcc gccgccgccc gcgcctcctc tgctgcgctg ggccggtccg gtcggggtga
      241 gctgggggct gcgcgccgcc gcgcccgggg gccccgtccc ccgcgctggc cgttggcgcc
      301 gcggcgcgcc cgccgaggac caagactgcg gccgcctccc ggacttcatc gccaagctga
      361 ccaacaatac gcaccagcat gtctttgatg acctcagtgg ctcagtgtcc ttgtcctggg
      421 ttggagacag cactggggtt attctcgtcc tgaccacttt ccaagtgcct ctggtaattg
      481 tgagctttgg acagtccaag ttgtatcgaa gtgaggatta tggaaagaac tttaaggata
      541 ttacaaatct catcaataac accttcattc ggacggaatt tggcatggct attggtcctg
      601 agaactctgg aaaggtgata ctaacagcgg aggtgtccgg gggaagccga ggcggaagag
      661 tgttcaggtc atcagacttt gccaagaact ttgtgcaaac agatctcccc tttcatcctc
      721 tgacgcagat gatgtacagc cctcagaatt ctgattacct gttagctctc agcaccgaaa
      781 atggcctgtg ggtgtccaag aattttgggg aaaaatggga agaaatccac aaagcagtat
      841 gtttggccaa atggggacca aacaacatca tcttctttac cacccatgtg aatggctcct
      901 gcaaagctga tcttggtgcc ctggaattat ggagaacatc cgacttggga aaaaccttca
      961 aaaccattgg tgtgaaaatc tactcctttg gtcttggggg ccgtttcctt tttgcctctg
     1021 tgatggctga taaggacaca acaagaagga tccatgtgtc aacagaccag ggggacacat
     1081 ggagcatggc acaacttcct tctgtgggac aggaacagtt ctactccatc ctggcagcca
     1141 atgaggacat ggtcttcatg catgtagatg aacctggaga taccgggttt ggcaccatct
     1201 ttacctctga tgatcgaggc attgtctact ccaagtctct ggacagacat ctctatacca
     1261 ccacaggcgg ggagacggac tttaccaacg tgacttccct ccgtggggtc tatataacaa
     1321 gcacgctctc agaagataac tctattcaga gcatgatcac ttttgaccag ggaggacggt
     1381 gggagcacct gcggaagccg gagaacagca agtgcgacgc taccgcaaag aacaagaacg
     1441 agtgcagcct tcatatccat gcttcttata gcatctccca gaagctaaac gttccaatgg
     1501 ccccactttc cgagcccaat gctgtgggca tagtcatcgc tcacggtagt gtgggagatg
     1561 ccatctcggt gatggtccca gatgtgtaca tctcagatga tgggggttac tcctgggcga
     1621 agatgctaga aggaccacat tactatacca tcctggactc tggaggcatc attgtggcca
     1681 ttgagcacag caaccgtcct atcaatgtga ttaagttctc cacagatgaa ggccagtgct
     1741 ggcagagcta tgtgttcaca caggagccca tctacttcac tgggcttgct tccgagcctg
     1801 gagccaggtc catgaacatc agcatctggg gattcacaga gtctttcatt acccgccagt
     1861 gggtctccta cacagtcgat ttcaaagaca tccttgagcg gaattgtgaa gaggatgact
     1921 ataccacgtg gctggcacac tccacagacc ctggagatta caaagacggc tgcattttgg
     1981 gctataaaga acagttccta cggctacgga agtcatccgt ctgtcagaat ggtcgagact
     2041 atgttgtggc caagcagcca tccgtctgtc cgtgttccct ggaggacttc ctctgtgact
     2101 ttggctactt ccgtccggag aacgcctcag agtgcgtgga gcagcctgaa ctgaaggggc
     2161 atgagttaga gttctgtctg tacggcaagg aggagcacct gacaacaaat gggtaccgga
     2221 aaatcccagg agacaaatgc caaggtggga tgaatcccgc cagagaagta aaagacttga
     2281 aaaagaaatg cacaagcaac ttcttgaacc ccacaaagca gaattccaag tcaaattctg
     2341 tccctattat cctggccatc gtgggactga tgcttgtcac agtcgtagca ggagtcctca
     2401 ttgtgaagaa atatgtctgt ggcggaaggt tcctggtgca ccggtactcg gtgctacagc
     2461 agcacgcaga ggctgacggc gtagaggctt tggattcaac ctcccacgct aaaagcggat
     2521 atcacgacga ctcagatgag gacctcctgg aatagctctt cagaggagct gggactgcgt
     2581 gtgcgtggag ccacagtacc tcctacactc cctgaggctc cgacttgggg aaataaattt
     2641 cccacctcgt cggccccagc tctgtttctg ccactcctgt ccaagcccaa aggacctaca
     2701 ctaaagaaag caggatgggg gtgggggacc ccgactgacc tcacagttgg ctctgaggag
     2761 aggggggaaa ttttaaattc tttaacattt ttgtttcaat ttctgtcttt tgtaagactg
     2821 tgggctttag gcttctcttg gtttgttttg tgcattaagg gacataactt gggactcaaa
     2881 gggattgttt cgctgacccc gctcttgtgt gttccctctg gtgcccaccc cagggcatct
     2941 gccaactcca gcatcaactc aactcccacc gcatacctgg tgctgtccct gggctctgct
     3001 ggtcatgtga ggcagcctcg gagaaggaag cagagggtgt aatgactggc acacctggac
     3061 agcttttctc catccgcaga cagccctgtt cagagagtac cgagcaccag ccctgtgcgg
     3121 cttcctcatc cccacctcac ccccaaccac tactgtaggg cacaatgact tttcttttcc
     3181 cgtttaatta ggcaataccc ttgttaattg cccgttggca actaacttaa tcatgtgctt
     3241 ccaacacact aaatagggaa aacttacagg gcaatatttt taacttgtgg caagagggag
     3301 gcagagaatt gactagctct gacacctatt aaagacaaaa ctggctgctt ctgagctctt
     3361 tcaggctgta ctttgtgctg tgccagtggc tctgcccagg ctccgccatc cctttactgg
     3421 agttcattgg tcagtgcaca gtgcagccac aggactgacc gtcgtaggct tccatttttc
     3481 ccatcaccca ctgtaaaggc tcagagttga actaccactg tggctgctta ttgcttcctc
     3541 ctaagttgct actgttcata gaactgggac tgggaatgtt ttcaggttga tggacttttt
     3601 caagctcaaa gttatgttcc cagactatcc tcacccttcc cctagttttg ctgagttatt
     3661 tgttgtccag aacctgttgg ctaaccccac tgaaggcaca tttctagatg atgccgtgtg
     3721 tggtcaatac attgctttca tgttttaaat ttaaggaaaa attttatctg atatttttcc
     3781 aaattaaata agttagagaa tgcaatcggc ggatgtgggg gcggccatct ggtagtggaa
     3841 agctgtagcg atctgagtac agcttagatg ttagctggag aggaagatgg tgtggcaggt
     3901 ctctggtctc cctacccctg ctgtgctgat cacagtccct cccagttacc actaggacat
     3961 tctctagtag atccattttg ctgtcacttt attctatggc tagaaagtca gtggaaagta
     4021 aatgtgccaa actcacttgt cagaacacac gagcagatgg cagagtcctc ctccccagca
     4081 ggaacaaacg gcatcaggga aagaggggga ggaagaggag ggagaagaag aggagggaga
     4141 gccaaagaga tgtcaactgc agctcagtga gtcatggaac gtcagttaga aaacgaagtt
     4201 agggtcgttt ctgggaagag aatcaatacc tgttagagcc agaatgctcc aagtctttta
     4261 gcttgttcat tttgtaatga ttctaaaata attccaaaga tatagcagct cataaattta
     4321 tcaaaagttc tgtccaccct cacctcctgc caaggggaga gatctatttc tactacacgc
     4381 tgtctctccc agtacatccc cggattggtg tgggtagata ggccaacgta tggtgatctc
     4441 ccctagtgtc tggatggact taatgctcat ccctgaccag agactagggt gctctgcctc
     4501 taatggtttc tgggatttct gtagagcttg gcagtttctg gctcatttct cttgagcacc
     4561 gcactattct tgccatagag agagcccagg agccaacgct gaatcaggtg cccggagtct
     4621 ttggagctct gaaactctcg gctatgcaag accccgggtc cttgcagcag agcttctcat
     4681 gggtggcttg ctggggccgg gccgaggact cctcagaggc gtttcctgca gagccattat
     4741 tttgacgcct ttttgttttc tttttgaaaa acaaaatatt attcccctgc ttcatggctg
     4801 aaataaaagg tgatggtaac tgggggcacc ccctctccct gggatagcca ctgtcgggga
     4861 gcacaggacc agcctctgga tcagtccctc tctgcccctt cacttctgtc tctagctcac
     4921 tggctctgtg ggcttgggct ctgcccctac aacggctctc agaagcattc acacgcacag
     4981 atgtgcaacc tcagccagaa gttgaagctc tttaagccat tttatttatt ttgtttttta
     5041 cagaatttgt gctttggttt gccctgcgca gccttggagc atcataagcc tggctggtgg
     5101 gcatagttat tctcagcatt gtggtggcaa atgacgttgg ttctagagac ttagagactt
     5161 gggcaatagg atttaacact gctaggtagc tcagacatat cagaaaatcc atagtggcct
     5221 gagttgtaaa tccaaaacat atttttgttg gcttgggacg ttaggggctt ggggttttcc
     5281 tgaggcaaga ggtcatggct gaatgggcct gtgccgtgaa ttgaatggaa cactactttg
     5341 aggcccttgg agagtgacag cagctatagg gtggactcag gagctgtcag tcttaacagc
     5401 tgagccttgg accccactgc ctctgagtct acattctggc aggcagtccc atgctctggg
     5461 ccttacctct agtcccctgc ctgctcacac ctggtcccct agccttttct cttgggcagt
     5521 gtagtagtat gggcgagcca ccctcagctc ttttattggc cggggctata aaccatggct
     5581 gggcataact attccgaact gtccccccat caggatacaa gatgctgaga gggctgcagg
     5641 gccattccat caagccccag ggtgaaaggg ctggcatggc atcgctcatt ttattgctct
     5701 gcaggtaaac tgtataggta tagagtcctc cagtgctctg aagagccctg cctctatgca
     5761 cgcccccggc aaagggcttg tcagtaggtc cccctcaact ccatactcaa cagggatgca
     5821 caggattgct aacagagggc ggggcacacc tcagttttct atcaccttcc taccagaggg
     5881 gaaagtaacc tgaactttaa tgtcttttgg aacaaaacca aagtttaaga tttgccatat
     5941 gacgacgtgg tgaccgggaa gtccagagtc ggcaagcagg tgccagattt tctatcccat
     6001 cagccagtgc ttcaccaggt gcaggctgct atgggcttgt ggaaaccaca ggtacaggtg
     6061 ggatttcatg ggtccatgtg ttacaaaaat aagaattgga gcattaactt gaaattgtct
     6121 tcaaggactt gctatgtgca cttcttcaca ccggtacatt ctctgcatct gtttatatga
     6181 aataacacaa gctaatctgt acctttatat atatgtgtgt gtacatatat acatgtataa
     6241 actgtatagt gtacatgtta atgatttatc agtatgcccc gaattcctag tgcagttctc
     6301 attctccgca tgccctcagc tgtggtcagg tgacttcctg tcccctggca gctctgctga
     6361 gtccctgtgt ttgagcctcc agggagaagg gtttgggctg cattcttctt atccccatgc
     6421 acagaaacgc tcagggtccc cacgtgcctg ttgtcctccc ctctagtcct ttgttccctt
     6481 tctgagcatg tggcccctcc cccggctgtg aggggcagcc gccttcctag gaaagtgtaa
     6541 tgcaggatca agaccaccac tgcatgtgta ctgaaaactg cagacttctg cccgcttggg
     6601 acagaacatt gcatgtgagg tgggattatc aagtttcaaa gacctgtgtc aaccatacag
     6661 caaaggcaga ccccataacg acgtcccaca aaatggaaat aaaacgcaaa atctctttag
     6721 cattgtgtaa ataaatctgg atgtgtttaa ctttgtactg gtaattttct gtatatttgc
     6781 aatatttggg ttagaaataa acagcctgga ctttggtacc taacctacta aaaaaaaaaa
     6841 aaaaaaaaaa a
//
